Entanglement without nonlocality

We consider the characterization of entanglement from the perspective of a Heisenberg formalism. We derive an original two-party generalized separability criteria, and from this describe a novel physical understanding of entanglement. We find that entanglement may be considered as fundamentally a local effect, and therefore as a separable computational resource from nonlocality. We show how entanglement differs from correlation physically, and explore the implications of this new conception of entanglement for the notion of classicality. We find that this understanding of entanglement extends naturally to multipartite cases.Comment: 9 pages. Expanded introduction and sections on physical entanglement and localit

Using inactivating mutations to provide insight into drug action

The role of ezetimibe in lowering plasma cholesterol has been established; however, controversy remains about its clinical benefit. A recent study utilizes naturally occurring genetic variation within the NPC1-like 1 gene (NPC1L1) to demonstrate the potential for pharmacologic inhibition of the protein to reduce the risk of coronary heart disease. This research demonstrates the application of the concept of genocopy to a population-based validation of NPC1L1 as a therapeutic target

How is there a Physics of Information? On characterising physical evolution as information processing.

We have a conundrum. The physical basis of information is clearly a highly active research area. Yet the power of information theory comes precisely from separating it from the detailed problems of building physical systems to perform information processing tasks. Developments in quantum information over the last two decades seem to have undermined this separation, leading to suggestions that information is itself a physical entity and must be part of our physical theories, with resource-cost implications. We will consider a variety of ways in which physics seems to a affect computation, but will ultimately argue to the contrary: rejecting the claims that information is physical provides a better basis for understanding the fertile relationship between information theory and physics. instead, we will argue that the physical resource costs of information processing are to be understood through the need to consider physically embodied agents for whom information processing tasks are performed. Doing so sheds light on what it takes for something to be implementing a computational or information processing task of a given kind

Monitoring the dynamics of Src activity in response to anti-invasive dasatinib treatment at a subcellular level using dual intravital imaging

Optimising response to tyrosine kinase inhibitors in cancer remains an extensive field of research. Intravital imaging is an emerging tool, which can be used in drug discovery to facilitate and fine-tune maximum drug response in live tumors. A greater understanding of intratumoural delivery and pharmacodynamics of a drug can be obtained by imaging drug target-specific fluorescence resonance energy transfer (FRET) biosensors in real time. Here, we outline our recent work using a Src-FRET biosensor as a readout of Src activity to gauge optimal tyrosine kinase inhibition in response to dasatinib treatment regimens in vivo. By simultaneously monitoring both the inhibition of Src using FRET imaging, and the modulation of the surrounding extracellular matrix using second harmonic generation (SHG) imaging, we were able to show enhanced drug penetrance and delivery to live pancreatic tumors. We discuss the implications of this dual intravital imaging approach in the context of altered tumor-stromal interactions, while summarising how this approach could be applied to assess other combination strategies or tyrosine kinase inhibitors in a preclinical setting

How is there a Physics of Information? On characterising physical evolution as information processing.

We have a conundrum. The physical basis of information is clearly a highly active research area. Yet the power of information theory comes precisely from separating it from the detailed problems of building physical systems to perform information processing tasks. Developments in quantum information over the last two decades seem to have undermined this separation, leading to suggestions that information is itself a physical entity and must be part of our physical theories, with resource-cost implications. We will consider a variety of ways in which physics seems to a affect computation, but will ultimately argue to the contrary: rejecting the claims that information is physical provides a better basis for understanding the fertile relationship between information theory and physics. instead, we will argue that the physical resource costs of information processing are to be understood through the need to consider physically embodied agents for whom information processing tasks are performed. Doing so sheds light on what it takes for something to be implementing a computational or information processing task of a given kind

Unraveling the directional link between adiposity and inflammation: a bidirectional mendelian randomization approach

<b>Context</b>: Associations between adiposity and circulating inflammation markers are assumed to be causal, although the direction of the relationship has not been proven. <b>Objective</b>: The aim of the study was to explore the causal direction of the relationship between adiposity and inflammation using a bidirectional Mendelian randomization approach. <b>Methods</b>: In the PROSPER study of 5804 elderly patients, we related C-reactive protein (CRP) single nucleotide polymorphisms (SNPs) (rs1800947 and rs1205) and adiposity SNPs (FTO and MC4R) to body mass index (BMI) as well as circulating levels of CRP and leptin. We gave each individual two allele scores ranging from zero to 4, counting each pair of alleles related to CRP levels or BMI. <b>Results</b>: With increasing CRP allele score, there was a stepwise decrease in CRP levels (P for trend < 0.0001) and a 1.98 mg/liter difference between extremes of the allele score distribution, but there was no associated change in BMI or leptin levels (P ≥ 0.89). By contrast, adiposity allele score was associated with 1) an increase in BMI (1.2 kg/m2 difference between extremes; P for trend 0.002); 2) an increase in circulating leptin (5.77 ng/ml difference between extremes; P for trend 0.0027); and 3) increased CRP levels (1.24 mg/liter difference between extremes; P for trend 0.002). <b>Conclusions</b>: Greater adiposity conferred by FTO and MC4R SNPs led to higher CRP levels, with no evidence for any reverse pathway. Future studies should extend our findings to other circulating inflammatory parameters. This study illustrates the potential power of Mendelian randomization to dissect directions of causality between intercorrelated metabolic factors

Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohorts

Objectives: To assess the associations between both uric acid levels and hyperuricaemia, with ischaemic heart disease and blood pressure, and to explore the potentially confounding role of body mass index. Design: Mendelian randomisation analysis, using variation at specific genes (SLC2A9 (rs7442295) as an instrument for uric acid; and FTO (rs9939609), MC4R (rs17782313), and TMEM18 (rs6548238) for body mass index). Setting: Two large, prospective cohort studies in Denmark. Participants: We measured levels of uric acid and related covariables in 58 072 participants from the Copenhagen General Population Study and 10 602 from the Copenhagen City Heart Study, comprising 4890 and 2282 cases of ischaemic heart disease, respectively. Main outcome: Blood pressure and prospectively assessed ischaemic heart disease. Results: Estimates confirmed known observational associations between plasma uric acid and hyperuricaemia with risk of ischaemic heart disease and diastolic and systolic blood pressure. However, when using genotypic instruments for uric acid and hyperuricaemia, we saw no evidence for causal associations between uric acid, ischaemic heart disease, and blood pressure. We used genetic instruments to investigate body mass index as a potentially confounding factor in observational associations, and saw a causal effect on uric acid levels. Every four unit increase of body mass index saw a rise in uric acid of 0.03 mmol/L (95% confidence interval 0.02 to 0.04), and an increase in risk of hyperuricaemia of 7.5% (3.9% to 11.1%). Conclusion: By contrast with observational findings, there is no strong evidence for causal associations between uric acid and ischaemic heart disease or blood pressure. However, evidence supports a causal effect between body mass index and uric acid level and hyperuricaemia. This finding strongly suggests body mass index as a confounder in observational associations, and suggests a role for elevated body mass index or obesity in the development of uric acid related conditions

Temperature Considerations in Solar Arrays

Temperature is an important consideration in the operation of photovoltaic (PV) arrays. In particular, daily and seasonal temperature variations are a limitation on the application of solar power to homes. At lower temperatures, PV systems produce more power. For higher temperatures, optimum operation requires modification of electrical load and removal of excess heat. Several technologies and approaches are available. To pursue this system optimization, PV cells were investigated at different temperatures. These investigations are compared with simulated theoretical results to draw more specific conclusions that can be applied to a solar house. A temperature reduction of 60⁰C improved the power by up to twenty-seven percent with the current test cell. The simulations matched this conclusion and can be applied to the PV array used on a house. The University of Missouri-Rolla (UMR) and Rolla Technical Institute (RTI) jointly built a solar house for the 2002 National Solar Decathlon Competition. This house is the motivation and testbed for our research. The first application is to cool the cell; then compare the additional amount of power produced with the amount of power required to cool the cell. The feasibility of cooling the array is discussed. This paper first gives a description of the UMR/RTI solar house, a literature review, and overview. Temperature-dependence theory and experiments is given next. The third portion shows simulations including current-voltage curves and an analysis of load lines and temperature. The direct application of this research to the solar house and proposals for design considerations are summarized