10,156 research outputs found
Challenges of Incorporating Digital Health Technology Outcomes in a Clinical Trial: Experiences from PD STAT.
Digital health technologies (DHTs) have great potential for use as clinical trial outcomes; however, practical issues need to be addressed in order to maximise their benefit. We describe our experience of incorporating two DHTs as secondary/exploratory outcome measures in PD STAT, a randomised clinical trial of simvastatin in people with Parkinson's disease. We found much higher rates of missing data in the DHTs than the traditional outcome measures, in particular due to technical and software difficulties. We discuss methods to address these obstacles in terms of protocol design, workforce training and data management
VLBA Imaging of the OH Maser in IIIZw35
We present a parsec-scale image of the OH maser in the nucleus of the active
galaxy IIIZw35, made using the Very Long Baseline Array at a wavelength of 18
cm. We detected two distinct components, with a projected separation of 50 pc
(for D=110 Mpc) and a separation in Doppler velocity of 70 km/s, which contain
50% of the total maser flux. Velocity gradients within these components could
indicate rotation of clouds with binding mass densities of ~7000 solar masses
per cubic parsec, or total masses of more than 500,000 solar masses. Emission
in the 1665-MHz OH line is roughly coincident in position with that in the
1667-MHz line, although the lines peak at different Doppler velocities. We
detected no 18 cm continuum emission; our upper limit implies a peak apparent
optical depth greater than 3.4, assuming the maser is an unsaturated amplifier
of continuum radiation.Comment: 10 pages, 3 figure
Challenges of Incorporating Digital Health Technology Outcomes in a Clinical Trial: Experiences from PD STAT
\ua9 2022 - The authors. Published by IOS Press.Digital health technologies (DHTs) have great potential for use as clinical trial outcomes; however, practical issues need to be addressed in order to maximise their benefit. We describe our experience of incorporating two DHTs as secondary/exploratory outcome measures in PD STAT, a randomised clinical trial of simvastatin in people with Parkinson\u27s disease. We found much higher rates of missing data in the DHTs than the traditional outcome measures, in particular due to technical and software difficulties. We discuss methods to address these obstacles in terms of protocol design, workforce training and data management
Superheating fields of superconductors: Asymptotic analysis and numerical results
The superheated Meissner state in type-I superconductors is studied both
analytically and numerically within the framework of Ginzburg-Landau theory.
Using the method of matched asymptotic expansions we have developed a
systematic expansion for the solutions of the Ginzburg-Landau equations in the
limit of small , and have determined the maximum superheating field
for the existence of the metastable, superheated Meissner state as
an expansion in powers of . Our numerical solutions of these
equations agree quite well with the asymptotic solutions for . The
same asymptotic methods are also used to study the stability of the solutions,
as well as a modified version of the Ginzburg-Landau equations which
incorporates nonlocal electrodynamics. Finally, we compare our numerical
results for the superheating field for large- against recent asymptotic
results for large-, and again find a close agreement. Our results
demonstrate the efficacy of the method of matched asymptotic expansions for
dealing with problems in inhomogeneous superconductivity involving boundary
layers.Comment: 14 pages, 8 uuencoded figures, Revtex 3.
Spitzer observations of extended Lyman-alpha Clouds in the SSA22 field
We present the results of a Spitzer IRAC and MIPS 24 micron study of extended
Lyman-alpha clouds (or Lyman-alpha Blobs, LABs) within the SSA22 filamentary
structure at z = 3.09. We detect 6/26 LABs in all IRAC filters, four of which
are also detected at 24 micron, and find good correspondence with the 850
micron measurements of Geach et al. 2005. An analysis of the rest-frame
ultraviolet, optical, near- and mid-infrared colors reveals that these six
systems exhibit signs of nuclear activity (AGN)and/or extreme star formation.
Notably, they have properties that bridge galaxies dominated by star formation
(Lyman-break galaxies; LBGs) and those with AGNs (LBGs classified as QSOs). The
LAB systems not detected in all four IRAC bands, on the other hand, are, as a
group, consistent with pure star forming systems, similar to the majority of
the LBGs within the filament. These results indicate that the galaxies within
LABs do not comprise a homogeneous population, though they are also consistent
with scenarios in which the gas halos are ionized through a common mechanism
such as galaxy-scale winds driven by the galaxies within them, or gravitational
heating of the collapsing cloud itself.Comment: 11 pages, 6 figures, accepted for publication in the Astrophysical
Journa
Herschel Multitiered Extragalactic Survey: clusters of dusty galaxies uncovered by Herschel and Planck
The potential for Planck to detect clusters of dusty, star-forming galaxies at z > 1 is tested by examining the Herschel-SPIRE images of Planck Early Release Compact Source Catalog sources lying in fields observed by the Herschel Multitiered Extragalactic Survey. Of the 16 Planck sources that lie in the ∼90 sq. deg. examined, we find that 12 are associated with single bright Herschel sources. The remaining four are associated with overdensities of Herschel sources, making them candidate clusters of dusty, star-forming galaxies. We use complementary optical/near-IR data for these ‘clumps’ to test this idea, and find evidence for the presence of galaxy clusters in all four cases. We use photometric redshifts and red sequence galaxies to estimate the redshifts of these clusters, finding that they range from 0.8 to 2.3. These redshifts imply that the Herschel sources in these clusters, which contribute to the detected Planck flux, are forming stars very rapidly, with typical total cluster star formation rates >1000M ? yr −1 . The high-redshift clusters discovered in these observations are used to constrain the epoch of cluster galaxy formation, finding that the galaxies in our clusters are 1–1.5 Gyr old at z ∼ 1–2. Prospects for the discovery of further clusters of dusty galaxies are discussed, using not only all sky Planck surveys, but also deeper, smaller area, Herschel surveys
Identification of potential serum peptide biomarkers of biliary tract cancer using MALDI MS profiling.
The aim of this discovery study was the identification of peptide serum biomarkers for detecting biliary tract cancer (BTC) using samples from healthy volunteers and benign cases of biliary disease as control groups. This work was based on the hypothesis that cancer-specific exopeptidase activities in serum can generate cancer-predictive peptide fragments from circulating proteins during coagulation
AEGIS: Infrared Spectroscopy of An Infrared Luminous Lyman Break Galaxy at z=3.01
We report the detection of rest--frame 6.2 and 7.7 \micron emission features
arising from Polycyclic Aromatic Hydrocarbons (PAH) in the Spitzer/IRS spectrum
of an infrared-luminous Lyman break galaxy at z=3.01. This is currently the
highest redshift galaxy where these PAH emission features have been detected.
The total infrared luminosity inferred from the MIPS 24 \micron and radio flux
density is 2 L, which qualifies this object as a
so--called hyperluminous infrared galaxy (HyLIRG). However, unlike local
HyLIRGs which are generally associated with QSO/AGNs and have weak or absent
PAH emission features, this HyLIRG has very strong 6.2 and 7.7 \micron PAH
emission. We argue that intense star formation dominates the infrared emission
of this source, although we cannot rule out the presence of a deeply obscured
AGN. This LBG appears to be a distorted system in the HST ACS F606W and F814W
images, possibly indicating that a significant merger or interaction is driving
the large IR luminosity
Spectroscopic studies of Dy-168,170 using CLARA and PRISMA
Preliminary results from an experiment aiming at Dy-170. Submitted to the LNL
Annual Report 2008.Comment: 2 pages, 4 figures, Submitted to the LNL Annual Report 200
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