The relative Whitney trick and its applications

We introduce a geometric operation, which we call the relative Whitney trick, that removes a single double point between properly immersed surfaces in a $4$-manifold with boundary. Using the relative Whitney trick we prove that every link in a homology sphere is homotopic to a link that is topologically slice in a contractible topological $4$-manifold. We further prove that any link in a homology sphere is order $k$ Whitney tower concordant to a link in $S^3$ for all $k$. Finally, we explore the minimum Gordian distance from a link in $S^3$ to a homotopically trivial link. Extending this notion to links in homology spheres, we use the relative Whitney trick to make explicit computations for 3-component links and establish bounds in general

Renal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturia

Renal cortical mitochondrial aconitase is regulated in hypo- and hypercitraturia.BackgroundChronic metabolic acidosis and K+ deficiency increase, while alkali feeding decreases proximal tubule citrate absorption and metabolism. The present studies examined the regulation of mitochondrial aconitase (m-aconitase), the first step in mitochondrial citrate metabolism, in these conditions.MethodsRats were fed appropriate diets, and m-aconitase activity and protein abundance measured.ResultsIn chronic metabolic acidosis and chronic K+ deficiency, renal cortical m-aconitase activity was increased 17% and 43%, respectively. This was associated with respective 90% and 221% increases in renal cortical m-aconitase protein abundance. With chronic alkali feeding, there was a 12% decrease in renal cortical m-aconitase activity, associated with a 35% decrease in m-aconitase protein abundance. Hepatic m-aconitase activity was not regulated in a similar manner. There was no regulation of citrate synthase, the enzyme responsible for mitochondrial citrate synthesis.ConclusionsThese studies demonstrate tissue specific chronic regulation of renal cortical m-aconitase activity and protein abundance, which likely contributes to the hypocitraturia and hypercitraturia seen in these conditions. As m-aconitase is the only step in citrate transport and metabolism found to be regulated in alkali feeding, its regulation likely plays a significant role in mediating the hypercitraturia seen in this condition

Single-crystalline PbTe film growth through reorientation

Heteroepitaxy enables the engineering of novel properties, which do not exist in a single material. Two principle growth modes are identified for material combinations with large lattice mismatch, Volmer-Weber and Stranski-Krastanov. Both lead to the formation of three-dimensional islands, hampering the growth of flat defect-free thin films. This limits the number of viable material combinations. Here, we report a distinct growth mode found in molecular beam epitaxy of PbTe on InP initiated by pre-growth surface treatments. Early nucleation forms islands analogous to the Volmer-Weber growth mode, but film closure exhibits a flat surface with atomic terracing. Remarkably, despite multiple distinct crystal orientations found in the initial islands, the final film is single-crystalline. This is possible due to a reorientation process occurring during island coalescence, facilitating high quality heteroepitaxy despite the large lattice mismatch, difference in crystal structures and diverging thermal expansion coefficients of PbTe and InP. This growth mode offers a new strategy for the heteroepitaxy of dissimilar materials and expands the realm of possible material combinations

Saltmarsh archives of vegetation and land use change from Big River Marsh, SW Newfoundland, Canada

Pollen and plant macrofossils are often well-preserved in coastal sediments, providing a palaeoenvironmental record of sea-level and landscape change. In this study, we examine the pollen and plant macrofossil assemblages of a well-dated saltmarsh sediment core from southwest Newfoundland, Canada, to establish recent coastal vegetation and land use change, to increase the knowledge of anthropogenic activities in the area and develop pollen chronozones for reconstructing marsh accumulation rates and to examine the representation of plant macrofossil remains in the wetland pollen profile. Grouping the pollen record into upland and wetland assemblages allows local events related to hydrological change to be separated from landscape-scale changes. The wetland pollen and plant macrofossil records indicate a general acceleration in sea-level rise ca. ad 1700. The sedge pollen and plant macrofossil records attest to multiple phases of rhizome encroachment during inferred periods of marine regression. Two chronozones are identified from the upland pollen profile; the first associated with the settlement of St. George’s Bay ca. ad 1800, signalled by increases in Plantago lanceolata and Ambrosia pollen; the second with the permanent settlement of the Port au Port peninsula ca. ad 1850, indicated by increased P. lanceolata and Rumex pollen. Comparison of the plant macrofossil and wetland pollen profiles highlights the underrepresentation of grass pollen preserved in the saltmarsh sediments and a need for further analysis of the zonation, pollen dispersal and macrofossil representation of sedge species in saltmarshes

Reconstructing the accumulation history of a saltmarsh sediment core: which age-depth model is best?

Saltmarsh-based reconstructions of relative sea-level (RSL) change play a central role in current efforts seeking to quantify the relationship between climate and sea-level rise. The development of an accurate chronology is pivotal, since errors in age-depth relationships will propagate to the final record as alterations in both the timing and magnitude of reconstructed change. A range of age-depth modelling packages are available but differences in their theoretical basis and practical operation mean contrasting accumulation histories can be produced from the same dataset. We compare the performance of five age-depth modelling programs (Bacon, Bchron, Bpeat, Clam and OxCal) when applied to the kinds of data used in high resolution, saltmarsh-based RSL reconstructions. We investigate their relative performance by comparing modelled accumulation curves against known age-depth relationships generated from simulated stratigraphic sequences. Bpeat is particularly sensitive to non-linearities which, whilst maximising the detection of small rate changes, has the potential to generate spurious variations, particularly in the last 400 years. Bacon generally replicates the pattern and magnitude of change but with notable offsets in timing. Bchron and OxCal successfully constrain the known accumulation history within their error envelopes although the best-fit solutions tend to underestimate the magnitude of change. The best-fit solutions of Clam generally replicate the timing and magnitude of changes well, but are sensitive to the underlying shape of the calibration curve, performing poorly where plateaus in atmospheric 14C concentration exist. We employ an ensemble of age-depth models to reconstruct a 1500 year accumulation history for a saltmarsh core recovered from Connecticut, USA based on a composite chronology comprising 26 AMS radiocarbon dates, 210Pb, 137Cs radionuclides and an historical pollen chronohorizon. The resulting record reveals non-linear accumulation during the late Holocene with a marked increase in rate around AD1800. With the exception of the interval between AD1500 and AD1800, all modelsproduce accumulation curves that agree to within ~10 cm at the century-scale. The accumulation rate increase around AD1800 is associated with the transition from a radiocarbon-based to a 210Pb dominated chronology. Whilst repeat analysis excluding the 210Pb data alters the precise timing and magnitude of this acceleration, a shift to faster accumulation compared to the long-term rate is a robust feature of the record and not simply an artefact of the switch in dating methods. Simulation indicates that a rise of similar magnitude to the post-AD1800 increase (detrended increase of ~16 cm) is theoretically constrained and detectable within the radiocarbon-dated portion of the record. The absence of such a signal suggests that the recent rate of accumulation is unprecedented in the last 1500 years. Our results indicate that reliable (sub)century-scale age-depth models can be developed from saltmarsh sequences, and that the vertical uncertainties associated with them translate to RSL reconstruction errors that are typically smaller than those associated with the most precise microfossil-based estimates of palaeomarsh-surface elevation

Suppression of ectomycorrhizae on canopy tree seedlings in Rhododendron maximum L. (Ericaceae) thickets in the southern Appalachians

Abstract Thickets of Rhododendron maximum (Ericaceae) (Rm) in the southern Appalachians severely limit regeneration of hardwood and coniferous seedlings. Experimental blocks were established in and out of Rm thickets in a mature, mixed hardwood/conifer forest in Macon County, N.C. Litter and organic layer substrates were removed, composited and redistributed among plots within the blocks (except for control plots). Seedlings of northern red oak (Quercus rubra) and eastern hemlock (Tsuga canadensis) were planted in the plots and harvested at the end of the first and second growing seasons. Litter manipulation had no effect on total mycorrhizal colonization, but the distribution of Cenococcum geophilum mycorrhizae was altered. After the first year, percent mycorrhizal colonization of hemlocks not in Rm thickets (62%) was at least three times higher than in Rm thickets (19%), and the ramification index (no. of mycorrhizae cm' 1 ) had increased by more than a factor of four (2.83 versus 0.61). In addition, colonization of 1-year-old hemlocks by C. geophilum was significantly higher within blocks with (10.4%) than without (4.6%) Rm. Differences in mycorrhizal colonization, ramification indices and colonization by C. geophilum were absent or less pronounced on 2-year-old hemlocks and 1-and 2-year-old oak seedlings. The biomasses of first year oak roots and shoots and second year shoots were 50% less in Rm thickets. Biomasses of first year hemlock roots and second year shoots were also reduced. Mycorrhizal parameters were correlated with some growth parameters only for hemlock seedlings, but did not explain most of the variation observed

Conserving Coastal Wetlands Despite Sea Level Rise

Coastal wetlands provide valuable services such as flood protection and fisheries production to a global population that is increasingly concentrated near the coast and dependent on its resources. Many of the world\u27s coastal wetlands suffered significant losses during this century, and the creation of new wetland areas is not keeping pace with recent losses. Some destruction of wetland areas can be expected as a consequence of the continual reworking of the coastal zone by dynamic geologic processes. Yet human activities also play a role, both directly by encroaching on coastal wetlands and indirectly by influencing the hydrologic and geologic processes in the coastal zone

Metabolic diagnosis and medical prevention of calcium nephrolithiasis and its systemic manifestations: a consensus statement

Background: Recently published guidelines on the medical management of renal stone disease did not address relevant topics in the field of idiopathic calcium nephrolithiasis, which are important also for clinical research. Design: A steering committee identified 27 questions, which were proposed to a faculty of 44 experts in nephrolithiasis and allied fields. A systematic review of the literature was conducted and 5216 potentially relevant articles were selected; from these, 407 articles were deemed to provide useful scientific information. The Faculty, divided into working groups, analysed the relevant literature. Preliminary statements developed by each group were exhaustively discussed in plenary sessions and approved. Results: Statements were developed to inform clinicians on the identification of secondary forms of calcium nephrolithiasis and systemic complications; on the definition of idiopathic calcium nephrolithiasis; on the use of urinary tests of crystallization and of surgical observations during stone treatment in the management of these patients; on the identification of patients warranting preventive measures; on the role of fluid and nutritional measures and of drugs to prevent recurrent episodes of stones; and finally, on the cooperation between the urologist and nephrologist in the renal stone patients. Conclusions: This document has addressed idiopathic calcium nephrolithiasis from the perspective of a disease that can associate with systemic disorders, emphasizing the interplay needed between urologists and nephrologists. It is complementary to the American Urological Association and European Association of Urology guidelines. Future areas for research are identified