Essential Collaborative Technology Tools for the 21st Century: FMCS TAGS System

Mediators employed by the Federal Mediation and Conciliation Service ( FMCS ) utilize a powerful set of technology tools that helps groups more effectively solve problems, make decisions and implement those decisions more successfully. FMCS mediators use these tools to help customers conduct collective bargaining negotiations, strategic planning sessions, grievance meetings, internal elections, large conferences, as well as remote meetings and online surveys via the Internet. Known as the FMCS TAGS System, this network of Internet servers, mobile computers, electronic conferencing facilities, customized software and external partners has demonstrated significant achievements during its first two years of operation. FMCS customers report that TAGS helps them better prepare for meetings and negotiations, retain better records, communicate better with constituents, minimize the impact of geographic separation and save time, travel and money. FMCS mediators integrate TAGS technology tools with their traditional skill set to help participants engage more openly and honestly, share knowledge and opinions more constructively, generate better ideas and build a stronger commitment to joint action. As a result, TAGS technology tools help FMCS customers conduct shorter, more productive, problem-focused meetings and help minimize transaction costs associated with group decision-making. This article describes the reasons that FMCS invests in technology tools, identifies the hardware and software solutions adopted by FMCS, postulates why those solutions have been successfully applied by FMCS mediators and explores several factors that any group should consider before using such leading edge tools

2D and 3D seismic simulation for fault modeling: exploratory revision from the Gullfaks field

2D and 3D seismic data have emerged as a key tool in the oil and gas industry to visualize and understand subsurface morphology and boundaries. In addition to providing excellent structural images, the dense sampling of 2D and 3D survey can sometimes make it possible to map reservoir quality and the distribution of hydrocarbon with well-marked limitations. Here we use 2D and 3D seismic data to map and interpret basic structures and fault lines to construct 2D and 3D base fault models of the Gullfaks field, while avoiding common pitfalls. This work also highlights important concepts and principles that allow selection, interpretation and simulation of particular areas containing hydrocarbon traps through the comparison of different maps such as time structure, amplitude and coherence. The field covers an area of approximately 50 km(2) entirely confined within block 34/10 in the Norwegian sector of the North Sea. The area of the seismic lines extends to 4875 m laterally and vertically up to 4.5 s. Based on all the selected horizons, constructed maps and dominant fault construction models (2D and 3D), we show the presence of a major fault that cuts five horizons of the area of interest. The structural features include antiform and a set of extensional faults with master, antithetic and synthetic faults with opposite sense of shear (dip direction and angle similar to 60A degrees). Ductile deformation at the bottom of seismic lines shows the fluctuation of amplitude of acoustic signals in seismic lines. Our results demonstrate uplift along the major fault during extension indicated by chaotic distortion at the bottom, which reveals a gas trap. In the Gullfaks field, termination of fault movement and subsequent deformation appears to have occurred for a long period of time. This illustrates the use of 2D and 3D visualization with horizon attributes that can conveniently provide massive amounts of data which elucidates the trapping mechanism of faults

Chemopreventive potential of β-Sitosterol in experimental colon cancer model - an In vitro and In vivo study

<p>Abstract</p> <p>Background</p> <p><it>Asclepias curassavica </it>Linn. is a traditional medicinal plant used by tribal people in the western ghats, India, to treat piles, gonorrhoea, roundworm infestation and abdominal tumours. We have determined the protective effect of β-sitosterol isolated from <it>A. curassavica </it>in colon cancer, using <it>in vitro </it>and <it>in vivo </it>models.</p> <p>Methods</p> <p>The active molecule was isolated, based upon bioassay guided fractionation, and identified as β-sitosterol on spectral evidence. The ability to induce apoptosis was determined by its <it>in vitro </it>antiradical activity, cytotoxic studies using human colon adenocarcinoma and normal monkey kidney cell lines, and the expression of β-catenin and proliferating cell nuclear antigen (PCNA) in human colon cancer cell lines (COLO 320 DM). The chemopreventive potential of β-sitosterol in colon carcinogenesis was assessed by injecting 1,2-dimethylhydrazine (DMH, 20 mg/kg b.w.) into male Wistar rats and supplementing this with β-sitosterol throughout the experimental period of 16 weeks at 5, 10, and 20 mg/kg b.w.</p> <p>Results</p> <p>β-sitosterol induced significant dose-dependent growth inhibition of COLO 320 DM cells (IC₅₀266.2 μM), induced apoptosis by scavenging reactive oxygen species, and suppressed the expression of β-catenin and PCNA antigens in human colon cancer cells. β-sitosterol supplementation reduced the number of aberrant crypt and crypt multiplicity in DMH-initiated rats in a dose-dependent manner with no toxic effects.</p> <p>Conclusion</p> <p>We found doses of 10-20 mg/kg b.w. β-sitosterol to be effective for future <it>in vivo </it>studies. β-sitosterol had chemopreventive potential by virtue of its radical quenching ability <it>in vitro</it>, with minimal toxicity to normal cells. It also attenuated β-catenin and PCNA expression, making it a potential anticancer drug for colon carcinogenesis.</p

Impact of COVID-19 on cardiovascular testing in the United States versus the rest of the world

Objectives: This study sought to quantify and compare the decline in volumes of cardiovascular procedures between the United States and non-US institutions during the early phase of the coronavirus disease-2019 (COVID-19) pandemic. Background: The COVID-19 pandemic has disrupted the care of many non-COVID-19 illnesses. Reductions in diagnostic cardiovascular testing around the world have led to concerns over the implications of reduced testing for cardiovascular disease (CVD) morbidity and mortality. Methods: Data were submitted to the INCAPS-COVID (International Atomic Energy Agency Non-Invasive Cardiology Protocols Study of COVID-19), a multinational registry comprising 909 institutions in 108 countries (including 155 facilities in 40 U.S. states), assessing the impact of the COVID-19 pandemic on volumes of diagnostic cardiovascular procedures. Data were obtained for April 2020 and compared with volumes of baseline procedures from March 2019. We compared laboratory characteristics, practices, and procedure volumes between U.S. and non-U.S. facilities and between U.S. geographic regions and identified factors associated with volume reduction in the United States. Results: Reductions in the volumes of procedures in the United States were similar to those in non-U.S. facilities (68% vs. 63%, respectively; p = 0.237), although U.S. facilities reported greater reductions in invasive coronary angiography (69% vs. 53%, respectively; p < 0.001). Significantly more U.S. facilities reported increased use of telehealth and patient screening measures than non-U.S. facilities, such as temperature checks, symptom screenings, and COVID-19 testing. Reductions in volumes of procedures differed between U.S. regions, with larger declines observed in the Northeast (76%) and Midwest (74%) than in the South (62%) and West (44%). Prevalence of COVID-19, staff redeployments, outpatient centers, and urban centers were associated with greater reductions in volume in U.S. facilities in a multivariable analysis. Conclusions: We observed marked reductions in U.S. cardiovascular testing in the early phase of the pandemic and significant variability between U.S. regions. The association between reductions of volumes and COVID-19 prevalence in the United States highlighted the need for proactive efforts to maintain access to cardiovascular testing in areas most affected by outbreaks of COVID-19 infection

Total hip arthroplasty for congenital dysplasia or dislocation of the hip: Survivorship analysis and long-term results

Two hundred and thirty-two total hip replacements with cement were performed between 1965 and 1987 in 190 patients who had osteoarthrosis secondary to acetabular dysplasia resulting from congenital dysplasia or dislocation of the hip. Forty-nine patients (fifty hips) who died or who did not have at least three years of clinical and radiographic follow-up were excluded; therefore, the study comprised 141 patients (182 hips), 125 of whom were women and sixteen of whom were men. The mean age at the time of the operation was 42.5 years (range, 19.5 to 76.5 years), and the mean duration of follow-up was 9.9 years (range, 3.1 to 22.8 years). A Charnley low- friction prosthesis with a 22.25 millimeter femoral head was used in all hips. A trochanteric osteotomy was performed in 164 hips. A direct lateral approach was used only when there was a limb-length discrepancy of less than two centimeters. Bulk autogenous graft was not used to augment the fixation of the acetabular component. The hips

Onshore Sandstone Facies Characteristics and Reservoir Quality of Nyalau Formation, Sarawak, East Malaysia: An Analogue to Subsurface Reservoir Quality Evaluation

International audienceShallow marine sandstones are substantial hydrocarbon reservoirs located around the globe and in Southeast Asia. Understanding the internal characteristics, distribution, geometry and lateral extent of these sandstones are essential parts of successful exploration and production strategy. This study presents the first detailed work on reservoir sandstone facies including textural characteristics of shallow marine sandstones (well-exposed outcrops) of the Nyalau Formation (Oligocene–Middle Miocene), Bintulu area, Sarawak, East Malaysia. This formation is the onshore equivalent of the offshore cycles II and III. We examined five different major types of sandstone facies on the basis of sedimentological characteristics, grain size distribution, porosity (ϕ) and permeability (k). The analyzed sandstone facies are: (1) hummocky cross-stratified sandstones (ϕ = 32.07 %, k = 20.78 md; thickness from 1 to 2 m); (2) herringbone cross-bedded sandstones (ϕ = 31.31 %, k = 7.7 m; thickness from 1 to 10 m); (3) trough cross-bedded sandstones (ϕ = 35.80 %, k = 5.97 md; thickness from 0.5 to 1 m); (4) wavy- to flaser-bedded sandstones (ϕ = 19.84 %, k = 2.31 md; thickness from 0.5 to 3.5 m); and (5) bioturbated sandstones (ϕ = 8.21 %, k = 3.46 md; thickness from 1 to 2 m). By integrating these parameters, we observed that the best reservoir quality sandstones are hummocky cross-stratified sandstone and herringbone cross-bedded sandstone, because they have better porosity–permeability than that of other sandstone facies, despite having similar grain distribution with probability curves having steep trends and almost same grain size, roundness and sorting. Upon comparing the different facies, inferences can be made that porosity–permeability is distributed randomly. We conclude that there exist heterogeneities within different sandstone facies which may apply to the reservoir properties in the subsurface

Depositional Setting Interpretation from Outcrop Lithofacies Analysis of Some Shallow-marine Sequences of Nyalau Formation, Sarawak, East Malaysia

International audienc

High resolution facies architecture and digital outcrop modeling of the Sandakan formation sandstone reservoir, Borneo: Implications for reservoir characterization and flow simulation

Advances in photogrammetry have eased the acquisition of high-resolution digital information from outcrops, enabling faster, non-destructive data capturing and improved reservoir modeling. Geocellular models for flow dynamics with in the virtual outcrop in siliciclastic deposits at different sets of sandstone facies architecture remain, however, a challenge. Digital maps of bedding, lithological contrast, spatial-temporal variations of bedding and permeability characteristics make it more easy to understand flow tortuosity in a particular architecture. An ability to precisely model these properties can improve reservoir characterization and flow modeling at different scales. Here we demonstrate the construction of realistic 2D sandstone facies based models for a pragmatic simulation of flow dynamics using a combination of digital point clouds dataset acquired from LiDAR and field investigation of the Sandakan Formation, Sabah, Borneo. Additionally, we present methods for enhancing the accuracy of outcrop digital datasets for producing high resolution flow simulation. A well-exposed outcrop from the Sandakan Formation, Sabah, northwest Borneo having a lateral extent of 750 m was chosen in order to implement our research approach. Sandstone facies and its connectivity are well constrained by outcrop observations, data from air-permeability measurements, bilinear interpolation of permeability, grid construction and water vector analysis for flow dynamics. These proportions were then enumerated in terms of static digital outcrop model (DOM) and facies model based on sandstone facies bedding characteristics. Flow simulation of water vector analysis through each of the four sandstone facies types show persistent spatial correlation of permeability that align with either cross-bedded orientation or straight with more dispersion high quality sandstone (porosity 21.25%–41.2% and permeability 1265.20–5986.25 mD) and moderate quality sandstone (porosity 10.44%–28.75% and permeability 21.44–1023.33 mD). Whereas, in more heterolithic sandstone (wavy- to flaser-bedded and bioturbated sandstone), lateral variations in permeability show spatially non-correlated patterns over centimeters to tens of meters with mostly of low quality sandstone (porosity 3.4%–12.31% and permeability < 1 mD to 3.21 mD). These variations reflect the lateral juxtaposition in flow dynamics. It has also been resulted that the vertical connectivity and heterogeneities in terms of flow are mostly pragmatic due to the interconnected sandstone rather than the quality of sandstone. Keywords: Siliciclastic sandstone facies, Connectivity, Heterogeneity, Digital outcrop model, Flow dynamic