580 research outputs found
Recommended from our members
Measurement and Computation of the Higher Order Modes of the ALS 500 MHz Accelerating Cavities
Generation of angular-momentum-dominated electron beams from a photoinjector
Various projects under study require an angular-momentum-dominated electron
beam generated by a photoinjector. Some of the proposals directly use the
angular-momentum-dominated beams (e.g. electron cooling of heavy ions), while
others require the beam to be transformed into a flat beam (e.g. possible
electron injectors for light sources and linear colliders). In this paper, we
report our experimental study of an angular-momentum-dominated beam produced in
a photoinjector, addressing the dependencies of angular momentum on initial
conditions. We also briefly discuss the removal of angular momentum. The
results of the experiment, carried out at the Fermilab/NICADD Photoinjector
Laboratory, are found to be in good agreement with theoretical and numerical
models.Comment: 8 pages, 7 figures, submitted to Phys. Rev. ST Accel. Beam
Recommended from our members
The surface temperatures of Earth: steps towards integrated understanding of variability and change
Surface temperature is a key aspect of weather and climate, but the term may refer to different quantities that play interconnected roles and are observed by different means. In a community-based activity in June 2012, the EarthTemp Network brought together 55 researchers from five continents to improve the interaction between scientific communities who focus on surface temperature in particular domains, to exploit the strengths of different observing systems and to better meet the needs of different communities. The workshop identified key needs for progress towards meeting scientific and societal requirements for surface temperature understanding and information, which are presented in this community paper. A "whole-Earth" perspective is required with more integrated, collaborative approaches to observing and understanding Earth's various surface temperatures. It is necessary to build understanding of the relationships between different surface temperatures, where presently inadequate, and undertake large-scale systematic intercomparisons. Datasets need to be easier to obtain and exploit for a wide constituency of users, with the differences and complementarities communicated in readily understood terms, and realistic and consistent uncertainty information provided. Steps were also recommended to curate and make available data that are presently inaccessible, develop new observing systems and build capacities to accelerate progress in the accuracy and usability of surface temperature datasets
Recommended from our members
A plan for the development of superconducting Undulator prototypes for LCLS-II and future FELs
Undulators serve as the primary source of radiation for modern storage rings, and more recently for the advent of Free-Electron Lasers (FELs). The performance of future FELs can be greatly enhanced using the much higher magnetic fields of superconducting undulators (SCU) [1]. For example, the LCLS-II hard x-ray undulator can be shortened by up to 70 m using an SCU in place of a PMU (permanent magnet undulator), or its spectral performance can be critically improved when using a similar length. In addition, SCUs are expected to be orders of magnitude less sensitive to radiation dose; a major issue at LCLS-II with its 1-MHz electron bunch rate. We present a funded R&D collaboration between SLAC, ANL, and LBNL, which aims to demonstrate the viability of superconducting undulators for FELs by building, testing, measuring, and tuning two 1.5-m long planar SCU prototypes using two different technologies: NbTi at ANL and Nb Sn at LBNL. Our goal is to review and reassess the LCLS-II HXR baseline plans (PMU) in July of 2015, after the development and evaluation of both prototypes, possibly in favor of an SCU for LCLS-II.
30% land conservation and climate action reduces tropical extinction risk by more than 50%
Limiting climate change to less than 2°C is the focus of international policy under the climate convention (UNFCCC), and is essential to preventing extinctions, a focus of the Convention on Biological Diversity (CBD). The post‐2020 biodiversity framework drafted by the CBD proposes conserving 30% of both land and oceans by 2030. However, the combined impact on extinction risk of species from limiting climate change and increasing the extent of protected and conserved areas has not been assessed. Here we create conservation spatial plans to minimize extinction risk in the tropics using data on 289 219 species and modeling two future greenhouse gas concentration pathways (RCP2.6 and 8.5) while varying the extent of terrestrial protected land and conserved areas from <17% to 50%. We find that limiting climate change to 2°C and conserving 30% of terrestrial area could more than halve aggregate extinction risk compared with uncontrolled climate change and no increase in conserved area
Tuning the binding affinity and selectivity of perfluoroaryl-stapled peptides by cysteine-editing.
A growing number of approaches to 'staple' α-helical peptides into a bioactive conformation using cysteine cross-linking are emerging. Here we explore the replacement of L-cysteine with 'cysteine analogues' in combinations of different stereochemistry, side chain length and beta-carbon substitution, to examine the influence that the thiol-containing residue(s) has on target protein-binding affinity in a well explored model system, p53-MDM2/MDMX. In some cases, replacement of one or more L-cysteine residues afforded significant changes in the measured binding affinity and target selectivity of the peptide. Computationally constructed homology models indicate that some modifications, such as incorporating two D-cysteines favourably alter the positions of key functional amino acid side chains, which is likely to cause changes in binding affinity, in agreement with measured SPR data
Recommended from our members
When passive feels active - delusion-proneness alters self-recognition in the moving rubber hand illusion
Psychotic patients have problems with bodily self-recognition such as the experience of self-produced actions (sense of agency) and the perception of the body as their own (sense of ownership). While it has been shown that such impairments in psychotic patients can be explained by hypersalient processing of external sensory input it has also been suggested that they lack normal efference copy in voluntary action. However, it is not known how problems with motor predictions like efference copy contribute to impaired sense of agency and ownership in psychosis or psychosis-related states. We used a rubber hand illusion based on finger movements and measured sense of agency and ownership to compute a bodily self-recognition score in delusion-proneness (indexed by Peters’ Delusion Inventory - PDI). A group of healthy subjects (n=71) experienced active movements (involving motor predictions) or passive movements (lacking motor predictions). We observed a highly significant correlation between delusion-proneness and self-recognition in the passive conditions, while no such effect was observed in the active conditions. This was seen for both ownership and agency scores. The result suggests that delusion-proneness is associated with hypersalient external input in passive conditions, resulting in an abnormal experience of the illusion. We hypothesize that this effect is not present in the active condition because deficient motor predictions counteract hypersalience in psychosis proneness
- …