113 research outputs found
Clinical and pharmacological profile of benznidazole for treatment of Chagas disease
Introduction: Chagas disease (CD) is one of the most neglected public health problems in the Americas, where <1% of the estimated 6 million people with the infection have been diagnosed and treated. The goal of treatment is to eliminate the parasite, decrease the probability of cardiomyopathy and other complications during the chronic stage of infection, and interrupt the cycle of disease transmission by preventing congenital infection. Currently, only benznidazole (BZN) and nifurtimox are recognized by the World Health Organization as effective drugs for treatment of CD. In this paper, we provide an overview of the clinical pharmacology of BZN. Areas covered: This review covers the historical background, chemistry, mechanism of action, pharmacokinetics, preclinical research, resistance, clinical research, toxicology, adverse effects, and current regulatory status of BZN. Expert commentary: Ongoing investigations aim to optimize BZN therapy by adjusting the current standard regimen or by combining BZN with new chemical entities. These studies are assessing alternatives that improve safety while maintaining or increasing the efficacy of BZN. Timely diagnosis and antitrypanosomal treatment are critical components of programs to eliminate CD as a public health problem, and can dramatically reduce the heavy burden of morbidity and mortality caused by the disease.Fil: Müller Kratz, Jadel. No especifíca;Fil: García Bournissen, Facundo. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Forsyth, Colin J.. No especifíca;Fil: Sosa-Estani, Sergio Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Centro de Investigaciones en Epidemiología y Salud Pública. Instituto de Efectividad Clínica y Sanitaria. Centro de Investigaciones en Epidemiología y Salud Pública; Argentin
Shell Effects in Nuclei with Vector Self-Coupling of Omega Meson in Relativistic Hartree-Bogoliubov Theory
Shell effects in nuclei about the stability line are investigated within the
framework of the Relativistic Hartree-Bogoliubov (RHB) theory with
self-consistent finite-range pairing. Using 2-neutron separation energies of Ni
and Sn isotopes, the role of - and -meson couplings on the
shell effects in nuclei is examined. It is observed that the existing
successful nuclear forces (Lagrangian parameter sets) based upon the nonlinear
scalar coupling of -meson exhibit shell effects which are stronger than
suggested by the experimental data. We have introduced nonlinear vector
self-coupling of -meson in the RHB theory. It is shown that the
inclusion of the vector self-coupling of -meson in addition to the
nonlinear scalar coupling of -meson provides a good agreement with the
experimental data on shell effects in nuclei about the stability line. A
comparison of the shell effects in the RHB theory is made with the Hartree-Fock
Bogoliubov approach using the Skyrme force SkP. It is shown that the
oft-discussed shell quenching with SkP is not consistent with the available
experimental data.Comment: 34 pages latex, 18 ps figures, replaced with minor corrections in
some figures, accepted for publication in Phys. Rev.
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DNA methylation-based classification of central nervous system tumours.
Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging-with substantial inter-observer variability in the histopathological diagnosis of many tumour types. Here we present a comprehensive approach for the DNA methylation-based classification of central nervous system tumours across all entities and age groups, and demonstrate its application in a routine diagnostic setting. We show that the availability of this method may have a substantial impact on diagnostic precision compared to standard methods, resulting in a change of diagnosis in up to 12% of prospective cases. For broader accessibility, we have designed a free online classifier tool, the use of which does not require any additional onsite data processing. Our results provide a blueprint for the generation of machine-learning-based tumour classifiers across other cancer entities, with the potential to fundamentally transform tumour pathology
Explosive Nucleosynthesis: What we learned and what we still do not understand
This review touches on historical aspects, going back to the early days of
nuclear astrophysics, initiated by BFH and Cameron, discusses (i) the
required nuclear input from reaction rates and decay properties up to the
nuclear equation of state, continues (ii) with the tools to perform
nucleosynthesis calculations and (iii) early parametrized nucleosynthesis
studies, before (iv) reliable stellar models became available for the late
stages of stellar evolution. It passes then through (v) explosive environments
from core-collapse supernovae to explosive events in binary systems (including
type Ia supernovae and compact binary mergers), and finally (vi) discusses the
role of all these nucleosynthesis production sites in the evolution of
galaxies. The focus is put on the comparison of early ideas and present, very
recent, understanding.Comment: 11 pages, to appear in Springer Proceedings in Physics (Proc. of
Intl. Conf. "Nuclei in the Cosmos XV", LNGS Assergi, Italy, June 2018
The Physics of Core-Collapse Supernovae
Supernovae are nature's grandest explosions and an astrophysical laboratory
in which unique conditions exist that are not achievable on Earth. They are
also the furnaces in which most of the elements heavier than carbon have been
forged. Scientists have argued for decades about the physical mechanism
responsible for these explosions. It is clear that the ultimate energy source
is gravity, but the relative roles of neutrinos, fluid instabilities, rotation
and magnetic fields continue to be debated.Comment: Review article; 17 pages, 5 figure
Measurement of the 92,93,94,100Mo(γ,n) reactions by Coulomb Dissociation
The Coulomb Dissociation (CD) cross sections of the stable isotopes 92,94,100Mo and of the unstable isotope 93Mo were measured at the LAND/R3B setup at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. Experimental data on these isotopes may help to explain the problem of the underproduction of 92,94Mo and 96,98Ru in the models of p-process nucleosynthesis. The CD cross sections obtained for the stable Mo isotopes are in good agreement with experiments performed with real photons, thus validating the method of Coulomb Dissociation. The result for the reaction 93Mo(γ,n) is especially important since the corresponding cross section has not been measured before. A preliminary integral Coulomb Dissociation cross section of the 94Mo(γ,n) reaction is presented. Further analysis will complete the experimental database for the (γ,n) production chain of the p-isotopes of molybdenum
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