Using ultra-thin parylene films as an organic gate insulator in nanowire field-effect transistors

We report the development of nanowire field-effect transistors featuring an ultra-thin parylene film as a polymer gate insulator. The room temperature, gas-phase deposition of parylene is an attractive alternative to oxide insulators prepared at high temperatures using atomic layer deposition. We discuss our custom-built parylene deposition system, which is designed for reliable and controlled deposition of <100 nm thick parylene films on III-V nanowires standing vertically on a growth substrate or horizontally on a device substrate. The former case gives conformally-coated nanowires, which we used to produce functional $\Omega$-gate and gate-all-around structures. These give sub-threshold swings as low as 140 mV/dec and on/off ratios exceeding $10^3$ at room temperature. For the gate-all-around structure, we developed a novel fabrication strategy that overcomes some of the limitations with previous lateral wrap-gate nanowire transistors. Finally, we show that parylene can be deposited over chemically-treated nanowire surfaces; a feature generally not possible with oxides produced by atomic layer deposition due to the surface `self-cleaning' effect. Our results highlight the potential for parylene as an alternative ultra-thin insulator in nanoscale electronic devices more broadly, with potential applications extending into nanobioelectronics due to parylene's well-established biocompatible properties

Biases in Cometary Catalogues and Planet X

Two sets of investigators -- Murray (1999) and Matese, Whitman & Whitmire (1999) -- have recently claimed evidence for an undiscovered Solar System planet from possible great circle alignments in the aphelia directions of the long period comets. However, comet discoveries are bedevilled by selection effects. These include anomalies caused by the excess of observers in the northern as against the southern hemisphere, seasonal and diurnal biases, directional effects which make it harder to discover comets in certain regions of the sky, as well as sociological biases. The stream proposed by Murray is shown on an equal area Hammer-Aitoff projection. The addition of newer data weakens the case for the alignment. There is also evidence that the subsample in the stream is affected by seasonal and north-south biases. The stream proposed by Matese et al. is most obvious in the sample of dynamically new comets, and especially in those whose orbits are best known. The most recent data continues to maintain the overpopulation in this great circle. This pattern in the data occurs about once in a thousand times by chance. Numerical integrations are used to demonstrate that a planet by itself can reduce the perihelia of comets in its orbital plane to sufficiently small values so that they could be discovered from the Earth. There is a need for a sample of long period comets that is free from unknown or hard-to-model selection effects. Such will be provided by the European Space Agency satellite GAIA.Comment: 16 pages, 14 figures, MNRAS in pres

Trapped: Experiences of unpaid carers of clinically vulnerable people "shielding" during the coronavirus disease 2019 pandemic

This is the final version. Available from SAGE Publications via the DOI in this record. Summary: Unpaid carers were profoundly impacted by the coronavirus disease 2019 pandemic and public health responses. In the UK, in March 2020, people identified as clinically extremely vulnerable and their household members were advised to “shield” for an initial 12-week period, which meant minimizing all contacts from outside the household and not leaving the house at all, unless in an emergency. In a modified form, shielding guidance remained in place until August 2020 and was reinstituted from December 2020 until April 1, 2021. This article, reporting on qualitative interviews with 47 unpaid carers in Wales, thematically analyzed using a coding framework, explores the experiences of unpaid carers affected by this shielding guidance and their wider implications for social work with unpaid carers in the future. Findings: Participants in our study described ways in which their caring role expanded, due to the need to provide additional practical and emotional support for loved ones who were shielding, and who lost access to other avenues of support. Some also described their caring role as becoming more involved and complex due to the declining health or self-care capacity of the person cared-for as a direct consequence of shielding restrictions. Alongside the increase in their caring responsibilities, carers reported losing access to important avenues of support for their own well-being. Applications: We draw on ecological systems theory to highlight the importance during care planning and management of exploring the carer's mesosystem to identify and optimize sustaining forces, and of attending to the microsystem involving the carer and person cared-for.Public Health Wale

Thermodynamics of a black hole in a cavity

We present a unified thermodynamical description of the configurations consisting on self-gravitating radiation with or without a black hole. We compute the thermal fluctuations and evaluate where will they induce a transition from metastable configurations towards stable ones. We show that the probability of finding such a transition is exponentially small. This indicates that, in a sequence of quasi equilibrium configurations, the system will remain in the metastable states till it approaches very closely the critical point beyond which no metastable configuration exists. Near that point, we relate the divergence of the local temperature fluctuations to the approach of the instability of the whole system, thereby generalizing the usual fluctuations analysis in the cases where long range forces are present. When angular momentum is added to the cavity, the above picture is slightly modified. Nevertheless, at high angular momentum, the black hole loses most of its mass before it reaches the critical point at which it evaporates completely.Comment: 27 pages, latex file, contains 3 figures available on request at [email protected]

Stellar Evolution with Enriched Surface Convection Zones I. General Effects of Planet Consumption

Abundance analyses of stars with planets have revealed that their metallicities are enhanced relative to field stars. Such a trend was originally suggested to be due to accretion of iron-rich planetary material. Based on this assumption, we have developed a stellar evolution code to model stars with non-uniform metallicity distributions. We have calculated ``polluted'' stellar evolution tracks for stars with M=0.9-1.2 M_sun. Our models encompass a range of initial metal content from Z=0.01 to 0.03, and include metallicity enhancements within the stellar convection zone corresponding to Delta-Z=0.005-0.03. We find that the primary effects of metal enhancement on stellar structure and evolution are expansion of the convection zone and downward shift of effective temperature. In addition, we have computed the surface metallicities expected for stars of different mass for fixed quantities of pollution; there appears to be no correlation with present observational data on the metallicities of stars known to harbor planets.Comment: 29 pages, 10 figures, accepted for publication by the Astrophysical Journal; one reference correcte

On the accumulation of planetesimals near disc gaps created by protoplanets

We have performed three-dimensional two-fluid (gas-dust) hydrodynamical models of circumstellar discs with embedded protoplanets (3 - 333 M\oplu) and small solid bodies (radii 10cm to 10m). We find that high mass planets (\gtrsim Saturn mass) open sufficiently deep gaps in the gas disc such that the density maximum at the outer edge of the gap can very efficiently trap metre-sized solid bodies. This allows the accumulation of solids at the outer edge of the gap as solids from large radii spiral inwards to the trapping region. This process of accumulation occurs fastest for those bodies that spiral inwards most rapidly, typically metre-sized boulders, whilst smaller and larger objects will not migrate sufficiently rapidly in the discs lifetime to benefit from the process. Around a Jupiter mass planet we find that bound clumps of solid material, as large as several Earth masses, may form, potentially collapsing under self-gravity to form planets or planetesimals. These results are in agreement with Lyra et al. (2009), supporting their finding that the formation of a second generation of planetesimals or of terrestrial mass planets may be triggered by the presence of a high mass planet.Comment: 14 pages, 10 figures. Accepted for publication in MNRA

Acupuncture to improve live birth rates for women undergoing in vitro fertilization: a protocol for a randomized controlled trial

BACKGROUND: IVF is a costly treatment option for women, their partners, and the public. Therefore new therapies that improve reproductive and health outcomes are highly desirable. There is a growing body of research evaluating the effect of acupuncture administered during IVF, and specifically on the day of embryo transfer (ET). Many trials are heterogeneous and results inconsistent. There remains insufficient evidence to determine if acupuncture can enhance live birth rates when used as an adjunct to IVF treatment. The study will determine the clinical effectiveness of acupuncture with improving the proportion of women undergoing IVF having live births. Other objectives include: determination of the cost effectiveness of IVF with acupuncture; and examination of the personal and social context of acupuncture in IVF patients, and examining the reasons why the acupuncture may or may not have worked. METHODS: We will conduct a randomized controlled trial of acupuncture compared to placebo acupuncture. Inclusion criteria include: women aged less than 43 years; undergoing a fresh IVF or ICSI cycle; and restricted to women with the potential for a lower live birth rate defined as two or more previous unsuccessful ETs; and unsuccessful clinical pregnancies of quality embryos deemed by the embryologist to have been suitable for freezing by standard criteria. Women will be randomized to acupuncture or placebo acupuncture. Treatment is administered on days 6 to 8 of the stimulated cycle and two treatments on the day of ET. A non-randomized cohort of women not using acupuncture will be recruited to the study. The primary study outcome is the proportion of women reporting a live birth. Secondary outcomes include the proportion of women reporting a clinical pregnancy miscarriage prior to 12 weeks, quality of life, and self-efficacy. The sample size of the study is 1,168 women, with the aim of detecting a 7% difference in live births between groups (P = 0.05, 80% power). DISCUSSION: There remains a need for further research to add significant new knowledge to defining the exact role of certain acupuncture protocols in the management of infertility requiring IVF from a clinical and cost-effectiveness perspective.Caroline A. Smith, Sheryl de Lacey, Michael Chapman, Julie Ratcliffe, Robert J. Norman, Neil Johnson, Gavin Sacks, Jane Lyttleton and Clare Boothroy

Prenatal and early life influences on epigenetic age in children:a study of mother-offspring pairs from two cohort studies

DNA methylation-based biomarkers of aging are highly correlated with actual age. Departures of methylation-estimated age from actual age can be used to define epigenetic measures of child development or age acceleration (AA) in adults. Very little is known about genetic or environmental determinants of these epigenetic measures of aging. We obtained DNA methylation profiles using Infinium HumanMethylation450 BeadChips across five time-points in 1018 mother-child pairs from the Avon Longitudinal Study of Parents and Children. Using the Horvath age estimation method, we calculated epigenetic age for these samples. AA was defined as the residuals from regressing epigenetic age on actual age. AA was tested for associations with cross-sectional clinical variables in children. We identified associations between AA and sex, birth weight, birth by caesarean section and several maternal characteristics in pregnancy, namely smoking, weight, BMI, selenium and cholesterol level. Offspring of non-drinkers had higher AA on average but this difference appeared to resolve during childhood. The associations between sex, birth weight and AA found in ARIES were replicated in an independent cohort (GOYA). In children, epigenetic AA measures are associated with several clinically relevant variables, and early life exposures appear to be associated with changes in AA during adolescence. Further research into epigenetic aging, including the use of causal inference methods, is required to better our understanding of aging