Interactions between thresholds and spatial discretizations of snow: insights from estimates of wolverine denning habitat in the Colorado Rocky Mountains

Thresholds can be used to interpret environmental data in a way that is easily communicated and useful for decision-making purposes. However, thresholds are often developed for specific data products and time periods, changing findings when the same threshold is applied to datasets or periods with different characteristics. Here, we test the impact of different spatial discretizations of snow on annual estimates of wolverine denning opportunities in the Colorado Rocky Mountains, defined using a snow water equivalent (SWE) threshold (0.20 m) and threshold date (15 May) from previous habitat assessments. Annual potential wolverine denning area (PWDA) was thresholded from a 36-year (1985–2020) snow reanalysis model with three different spatial discretizations: (1) 480 m grid cells (D480), (2) 90 m grid cells (D90), and (3) 480 m grid cells with implicit representations of subgrid snow spatial heterogeneity (S480). Relative to the D480 and S480 discretizations, D90 resolved shallower snow deposits on slopes between 3050 and 3350 m elevation, decreasing PWDA by 10 %, on average. In years with warmer and/or drier winters, S480 discretizations with subgrid representations of snow heterogeneity increased PWDA, even within grid cells where mean 15 May SWE was less than the SWE threshold. These simulations increased PWDA by upwards of 30 % in low-snow years, as compared to the D480 and D90 simulations without subgrid snow heterogeneity. Despite PWDA sensitivity to different snow spatial discretizations, PWDA was controlled more by annual variations in winter precipitation and temperature. However, small changes to the SWE threshold (±0.07 m) and threshold date (±2 weeks) also affected PWDA by as much as 82 %. Across these threshold ranges, PWDA was approximately 18 % more sensitive to the SWE threshold than the threshold date. However, the sensitivity to the threshold date was larger in years with late spring snowfall, when PWDA depended on whether modeled SWE was thresholded before, during, or after spring snow accumulation. Our results demonstrate that snow thresholds are useful but may not always provide a complete picture of the annual variability in snow-adapted wildlife denning opportunities. Studies thresholding spatiotemporal datasets could be improved by including (1) information about the fidelity of thresholds across multiple spatial discretizations and (2) uncertainties related to ranges of realistic thresholds.</p

Leveraging ICESat, ICESat‐2, and Landsat for Global‐Scale, Multi‐Decadal Reconstruction of Lake Water Levels

Lakes provide important water resources and many essential ecosystem services. Some of Earth's largest lakes recently reached record‐low levels, suggesting increasing threats from climate change and anthropogenic activities. Yet, continuous monitoring of lake levels is challenging at a global scale due to the sparse in situ gauging network and the limited spatial or temporal coverage of satellite altimeters. A few pioneering studies used water areas and hypsometric curves to reconstruct water levels but suffered from large uncertainties due to the lack of high‐quality hypsometry data. Here, we propose a novel proxy‐based method to reconstruct multi‐decadal water levels from 1992 to 2018 for both large and small lakes using Landsat images and ICESat (2003–2009) and recently launched ICESat‐2 (2018+) laser altimeters. Using the new method, we evaluate reconstructed levels of 342 lakes worldwide, with sizes ranging from 1 to 81,844 km 2 . Reconstructed water levels have a median root‐mean‐square error (RMSE) of 0.66 m, equivalent to 57% of the standard deviation of monthly level variability. Compared with two recently reconstructed water level data sets, the proposed method reduces the median RMSE by 27%–32%. The improvement is attributable to the new method's robust construction of high‐quality hypsometry, with a median R 2 value of 0.92. Most reconstructed water level time series have a bi‐monthly or higher frequency. Given that ICESat‐2 and Landsat can observe hundreds of thousands of water bodies, this method can be applied to conduct an improved global inventory of time‐varying lake levels and thus inform water resource management more broadly than existing methods. Key Points Landsat images and laser altimeters were leveraged to reconstruct multi‐decadal lake levels of both large and small lakes Reconstructed water levels were validated against observed levels on 342 global lakes with a median error of 0.66 m Most of the reconstructed lake level time series have a bi‐monthly or higher frequenc

Adjustment to colostomy: stoma acceptance, stoma care self-efficacy and interpersonal relationships

‘The definitive version is available at www.blackwell-synergy.com.’ Copyright Blackwell Publishing. DOI: 10.1111/j.1365-2648.2007.04446.xThis paper is a report of a study to examine adjustment and its relationship with stoma acceptance and social interaction, and the link between stoma care self-efficacy and adjustment in the presence of acceptance and social interactions.Peer reviewe

Temperature-dependent Raman study of CeFeAsO0.9F0.1 Superconductor: Crystal field excitations, phonons and their coupling

We report temperature-dependent Raman spectra of CeFeAsO0.9F0.1 from 4 K to 300 K in spectral range of 60 to 1800 cm-1 and interpret them using estimates of phonon frequencies obtained from first-principles density functional calculations. We find evidence for a strong coupling between the phonons and crystal field excitations; in particular Ce3+ crystal field excitation at 432 cm-1 couples strongly with Eg oxygen vibration at 389 cm-1 . Below the superconducting transition temperature, the phonon mode near 280 cm-1 shows softening, signaling its coupling with the superconducting gap. The ratio of the superconducting gap to Tc thus estimated to be ~ 10 suggests CeFeAsO0.9F0.1 as a strong coupling superconductor. In addition, two high frequency modes observed at 1342 cm-1 and 1600 cm-

Familial Mediterranean Fever and Hyperimmunoglobulinemia D syndrome: two diseases with distinct clinical, serologic, and genetic features

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Satellites reveal widespread decline in global lake water storage

Climate change and human activities increasingly threaten lakes that store 87% of Earth's liquid surface fresh water. Yet, recent trends and drivers of lake volume change remain largely unknown globally. Here, we analyze the 1972 largest global lakes using three decades of satellite observations, climate data, and hydrologic models, finding statistically significant storage declines for 53% of these water bodies over the period 1992-2020. The net volume loss in natural lakes is largely attributable to climate warming, increasing evaporative demand, and human water consumption, whereas sedimentation dominates storage losses in reservoirs. We estimate that roughly one-quarter of the world's population resides in a basin of a drying lake, underscoring the necessity of incorporating climate change and sedimentation impacts into sustainable water resources management

Familial Mediterranean fever, Inflammation and Nephrotic Syndrome: Fibrillary Glomerulopathy and the M680I Missense Mutation

BACKGROUND: Familial Mediterranean fever (FMF) is an autosomal recessive disease characterized by inflammatory serositis (fever, peritonitis, synovitis and pleuritis). The gene locus responsible for FMF was identified in 1992 and localized to the short arm of chromosome 16. In 1997, a specific FMF gene locus, MEFV, was discovered to encode for a protein, pyrin that mediates inflammation. To date, more than forty missense mutations are known to exist. The diversity of mutations identified has provided insight into the variability of clinical presentation and disease progression. CASE REPORT: We report an individual heterozygous for the M680I gene mutation with a clinical diagnosis of FMF using the Tel-Hashomer criteria. Subsequently, the patient developed nephrotic syndrome with biopsy-confirmed fibrillary glomerulonephritis (FGN). Further diagnostic studies were unremarkable with clinical workup negative for amyloidosis or other secondary causes of nephrotic syndrome. DISCUSSION: Individuals with FMF are at greater risk for developing nephrotic syndrome. The most serious etiology is amyloidosis (AA variant) with renal involvement, ultimately progressing to end-stage renal disease. Other known renal diseases in the FMF population include IgA nephropathy, IgM nephropathy, Henoch-Schönlein purpura as well as polyarteritis nodosa. CONCLUSION: To our knowledge, this is the first association between FMF and the M680I mutation later complicated by nephrotic syndrome and fibrillary glomerulonephritis

Generation and screening of a comprehensive \u3ci\u3eMycobacterium avium\u3c/i\u3e subsp. \u3ci\u3eparatuberculosis\u3c/i\u3e transposon mutant bank

Mycobacterium avium subsp. paratuberculosis (MAP) is the etiologic agent of Johne’s Disease in ruminants. This enteritis has significant economic impact and world wide distribution. Vaccination is one of the most cost effective infectious disease control measures. Unfortunately, current vaccines reduce clinical disease and shedding, but are of limited efficacy and do not provide long-term protective immunity. Several strategies have been followed to mine the MAP genome for virulence determinants that could be applied to vaccine and diagnostic assay developent. In this study, a comprehensive mutant bank of 13,536 MAP K-10 Tn5367 mutants (P\u3e95% )was constructed and screened in vitro for phenotypes related to virulence. This strategy was designated to maximize identification of genes important to MAP pathogenesis without relying on studies of other mycobacterial species that may not translate into similar effects in MAP. This bank was screened for mutants with colony morphology alterations, susceptibility to D-cycloserine, impairment in siderophore production or secretion, reduced cell association, and decreased biofilm and clump formation. Mutants with interesting phenotypes were analyzed by PCR, Southern blotting and DNA sequencing to determine transposon insertion sites. These insertion sites mapped up stream from the MAP1152-MAP1156 cluster, internal to either the Mod operon gene MAP1566 or within the coding sequence of lsr2, and several intergenic regions. Growth curves in broth cultures, invasion assays and kinetics of survival and replication in primary bovine macrophages were also determined. The ability of vectors carrying Tn5370 to generate stable MAP mutants was also investigated

Effects of Snow Water Storage on Hydrologic Partitioning Across the Mountainous, Western United States

In the montane western United States, where the majority of downstream water resources are derived from snowmelt, a warming climate threatens the timing and amount of future water availability. It is expected that the fraction of precipitation falling as snow will continue decreasing and the timing of snowmelt will continue shifting earlier in the year with unknown impacts on partitioning between evapotranspiration and streamflow. To assess this, we employ a Snow Storage Index (SSI) to represent the annual temporal phase difference between daily precipitation and daily modeled surface water inputs (SWI, the sum of rainfall and snowmelt), weighted by the respective amounts. We coupled the SSI metric with a Budyko-based framework to determine the effect of snow water storage on relative hydrologic partitioning across snow-influenced watersheds in the western U.S. Greater snow water storage was positively correlated with greater hydrologic partitioning to streamflow, particularly in the North Cascades/Cascades (r2: 0.62), Blue Mountains (r2: 0.56), Canadian Rockies (r2: 0.55), Idaho Batholith, (r2: 0.48), and Columbia Mountains/Northern Rockies (r2: 0.45). The weekly SWI:P ratio was an equally strong predictor for hydrologic partitioning, particularly in mid-spring (e.g., March/April) in the same mountainous areas (r2: 0.62&ndash;0.74, across the same eco-regions). The retention of snow water storage and subsequent release of stored water in summer months resulted in increased hydrologic partitioning to streamflow. If SSI decreases with future warming, the volume of water partitioned streamflow will decrease non-uniformly across the western U.S. with substantial implications for ecosystems and agricultural, industrial, and domestic water supplies. &nbsp;</p

International Retrospective Chart Review of Treatment Patterns in Severe Familial Mediterranean Fever, Tumor Necrosis Factor Receptor–Associated Periodic Syndrome, and Mevalonate Kinase Deficiency/Hyperimmunoglobulinemia D Syndrome

Objective: Periodic fever syndrome (PFS) conditions are characterized by recurrent attacks of fever and localized inflammation. This study examined the diagnostic pathway and treatments at tertiary centers for familial Mediterranean fever (FMF), tumor necrosis factor receptor–associated periodic syndrome (TRAPS), and mevalonate kinase deficiency (MKD)/hyperimmunoglobulinemia D syndrome (HIDS). Methods: PFS specialists at medical centers in the US, the European Union, and the eastern Mediterranean participated in a retrospective chart review, providing de‐identified data in an electronic case report form. Patients were treated between 2008 and 2012, with at least 1 year of followup; all had clinical and/or genetically proven disease and were on/eligible for biologic treatment. Results: A total of 134 patients were analyzed: FMF (n = 49), TRAPS (n = 47), and MKD/HIDS (n = 38). Fever was commonly reported as severe across all indications. Other frequently reported severe symptoms were serositis for FMF patients and elevated acute‐phase reactants and gastrointestinal upset for TRAPS and MKD/HIDS. A long delay from disease onset to diagnosis was seen within TRAPS and MKD/HIDS (5.8 and 7.1 years, respectively) compared to a 1.8‐year delay in FMF patients. An equal proportion of TRAPS patients first received anti–interleukin‐1 (anti‐IL‐1) and anti–tumor necrosis factor (anti‐TNF) biologic agents, whereas IL‐1 blockade was the main choice for FMF patients resistant to colchicine and MKD/HIDS patients. For TRAPS patients, treatment with anakinra versus anti‐TNF treatments as first biologic agent resulted in significantly higher clinical and biochemical responses (P = 0.03 and P < 0.01, respectively). No significant differences in responses were observed between biologic agents among other cohorts. Conclusion: Referral patterns and diagnostic delays highlight the need for greater awareness and improved diagnostics for PFS. This real‐world treatment assessment supports the need for further refinement of treatment practices