A History of Bishop Clarkson Memorial Hospital

The evolution of Bishop Clarkson memorial Hospital from a fragile, limited undertaking in 1869 to its present substantial status occurred in the most productive and inventive era so far experienced in medical care. The hospital flourished, resulting in accomplishments worthy of recording, which is the purpose of this chronicle. H.J.L.https://digitalcommons.unmc.edu/hist_books/1003/thumbnail.jp

Bit Penetration Into Rock-A Finite Element Study

The sequence of rock failure mechanisms and quantitative information on stress, displacement and material failure in the process of bit penetration have been obtained through computer simulation. A finite element approach has been developed to simulate bit penetration from bit-rock interaction to chip formation. A mathematical rock failure model, based on available rock failure experiments, has been proposed to represent post-failure rock behavior and applied in the penetration simulations. The finite element code was developed for two-dimensional plane strain problems to consider non-linear material properties, geometric non-linearity, and fracture propagation. An anistropic element as well as variable stiffness and stress release methods have been used. An iteration method, using an incremental displacement approach, has been applied for continuous penetration with modification of material properties and displacements. The simulation results of the blunt point bit are in reasonable agreement with penetration experiments on Limestone. Wedge and cylinder bit profiles have also been presented to demonstrate their shape effects. © 1976

Belted Work Machine

A heavy duty belt laying work machine includes a frame, a driver wheel mounted in supporting relation to the frame on each lateral side thereof, an idler wheel assembly disposed on each lateral side of the frame. The idler wheel assembly includes an idler wheel and a carry-roller, each of which is rotatably connected to an idler support arm that is pivotally mounted in supporting relation to the frame. A mid-roller is disposed on each lateral side of the frame between the driver wheel and the idler wheel assembly and rotatably connected to a mid-roller support arm mounted in supporting relation to the frame. An endless, inextensible belt is entrained about each respective idler wheel and driver wheel on each lateral side of the frame and contacts the mid-roller and the carry-roller. Apparatus are provided for controllably tensioning and urging each belt into frictional driven engagement with a corresponding one of the driver wheels

Timing Termination of a Biofumigant Cover Crop for Weed Suppression in Chile Pepper

Overwinter mustard cover crops incorporated into soil may suppress early-season weeds in chile pepper (Capsicum annuum). However, the potential for mustard cover crops to harbor beet leafhoppers (Circulifer tenellus) is a concern because beet leafhoppers transmit beet curly top virus to chile pepper. The objectives of this study were to determine the amounts of a biopesticidal compound (sinigrin) added to soil from ‘Caliente Rojo’ brown mustard (Brassica juncea) cover crops ended on three different days before beet leafhopper flights during spring and to determine the effects of the cover crop termination date on weed densities and hand-hoeing times for chile pepper. To address these objectives, a field study was conducted in southern New Mexico. In 2019–20, the cover crop was ended and incorporated into soil 45, 31, and 17 days before beet leafhopper flights. In 2020–21, cover crop termination occurred 36, 22, and 8 days before beet leafhopper flights. Treatments also included a no cover crop control. Cover crop biomass and sinigrin concentrations were determined at each termination. Chile pepper was seeded 28 days after the third termination date. Weed densities and hand-hoeing times were determined 28 and 56 days after chile pepper seeding. In 2019–20, the third termination (17 days before beet leafhopper flights) yielded the maximum cover crop biomass (820 g⋅m−2) and greatest sinigrin addition to soil (274 mmol⋅m−2). However, only the second termination (31 days before beet leafhopper flights) suppressed weeds in chile pepper. In 2020–21, the third termination (8 days before beet leafhopper flights) yielded the maximum cover crop biomass (591 g⋅m−2) and greatest sinigrin addition to soil (213 mmol⋅m−2), and it was the only treatment that suppressed weeds. No cover crop treatment reduced hand-hoeing times. These results indicate that overwinter mustard cover crops can be ended to evade beet leafhopper flights and suppress weeds in chile pepper

Neuropathology in Mice Expressing Mouse Alpha-Synuclein

α-Synuclein (αSN) in human is tightly linked both neuropathologically and genetically to Parkinson's disease (PD) and related disorders. Disease-causing properties in vivo of the wildtype mouse ortholog (mαSN), which carries a threonine at position 53 like the A53T human mutant version that is genetically linked to PD, were never reported. To this end we generated mouse lines that express mαSN in central neurons at levels reaching up to six-fold compared to endogenous mαSN. Unlike transgenic mice expressing human wildtype or mutant forms of αSN, these mαSN transgenic mice showed pronounced ubiquitin immunopathology in spinal cord and brainstem. Isoelectric separation of mαSN species revealed multiple isoforms including two Ser129-phosphorylated species in the most severely affected brain regions. Neuronal Ser129-phosphorylated αSN occured in granular and small fibrillar aggregates and pathological staining patterns in neurites occasionally revealed a striking ladder of small alternating segments staining either for Ser129-phosphorylated αSN or ubiquitin but not both. Axonal degeneration in long white matter tracts of the spinal cord, with breakdown of myelin sheaths and degeneration of neuromuscular junctions with loss of integrity of the presynaptic neurofilament network in mαSN transgenic mice, was similar to what we have reported for mice expressing human αSN wildtype or mutant forms. In hippocampal neurons, the mαSN protein accumulated and was phosphorylated but these neurons showed no ubiquitin immunopathology. In contrast to the early-onset motor abnormalities and muscle weakness observed in mice expressing human αSN, mαSN transgenic mice displayed only end-stage phenotypic alterations that manifested alongside with neuropathology. Altogether these findings show that increased levels of wildtype mαSN does not induce early-onset behavior changes, but drives end-stage pathophysiological changes in murine neurons that are strikingly similar to those evoked by expression of human wildtype or mutant forms

Validating Intelligent Power and Energy Systems { A Discussion of Educational Needs

Traditional power systems education and training is flanked by the demand for coping with the rising complexity of energy systems, like the integration of renewable and distributed generation, communication, control and information technology. A broad understanding of these topics by the current/future researchers and engineers is becoming more and more necessary. This paper identifies educational and training needs addressing the higher complexity of intelligent energy systems. Education needs and requirements are discussed, such as the development of systems-oriented skills and cross-disciplinary learning. Education and training possibilities and necessary tools are described focusing on classroom but also on laboratory-based learning methods. In this context, experiences of using notebooks, co-simulation approaches, hardware-in-the-loop methods and remote labs experiments are discussed.Comment: 8th International Conference on Industrial Applications of Holonic and Multi-Agent Systems (HoloMAS 2017

Long-term research challenges in wind energy – a research agenda by the European Academy of Wind Energy

The European Academy of Wind Energy (eawe), representing universities and institutes with a significant wind energy programme in 14 countries, has discussed the long-term research challenges in wind energy. In contrast to research agendas addressing short- to medium-term research activities, this eawe document takes a longer-term perspective, addressing the scientific knowledge base that is required to develop wind energy beyond the applications of today and tomorrow. In other words, this long-term research agenda is driven by problems and curiosity, addressing basic research and fundamental knowledge in 11 research areas, ranging from physics and design to environmental and societal aspects. Because of the very nature of this initiative, this document does not intend to be permanent or complete. It shows the vision of the experts of the eawe, but other views may be possible. We sincerely hope that it will spur an even more intensive discussion worldwide within the wind energy community

An Integrated Research Infrastructure for Validating Cyber-Physical Energy Systems

Renewables are key enablers in the plight to reduce greenhouse gas emissions and cope with anthropogenic global warming. The intermittent nature and limited storage capabilities of renewables culminate in new challenges that power system operators have to deal with in order to regulate power quality and ensure security of supply. At the same time, the increased availability of advanced automation and communication technologies provides new opportunities for the derivation of intelligent solutions to tackle the challenges. Previous work has shown various new methods of operating highly interconnected power grids, and their corresponding components, in a more effective way. As a consequence of these developments, the traditional power system is being transformed into a cyber-physical energy system, a smart grid. Previous and ongoing research have tended to mainly focus on how specific aspects of smart grids can be validated, but until there exists no integrated approach for the analysis and evaluation of complex cyber-physical systems configurations. This paper introduces integrated research infrastructure that provides methods and tools for validating smart grid systems in a holistic, cyber-physical manner. The corresponding concepts are currently being developed further in the European project ERIGrid.Comment: 8th International Conference on Industrial Applications of Holonic and Multi-Agent Systems (HoloMAS 2017