1,175 research outputs found
Mindfulness-based stress reduction in Parkinson’s disease: a systematic review
Background:
Mindfulness based stress reduction (MBSR) is increasingly being used to improve outcomes such as stress and depression in a range of long-term conditions (LTCs). While systematic reviews on MBSR have taken place for a number of conditions there remains limited information on its impact on individuals with Parkinson’s disease (PD).
Methods:
Medline, Central, Embase, Amed, CINAHAL were searched in March 2016. These databases were searched using a combination of MeSH subject headings where available and keywords in the title and abstracts. We also searched the reference lists of related reviews. Study quality was assessed based on questions from the Cochrane Collaboration risk of bias tool.
Results:
Two interventions and three papers with a total of 66 participants were included. The interventions were undertaken in Belgium (n = 27) and the USA (n = 39). One study reported significantly increased grey matter density (GMD) in the brains of the MBSR group compared to the usual care group. Significant improvements were reported in one study for a number of outcomes including PD outcomes, depression, mindfulness, and quality of life indicators. Only one intervention was of reasonable quality and both interventions failed to control for potential confounders in the analysis. Adverse events and reasons for drop-outs were not reported. There was also no reporting on the costs/benefits of the intervention or how they affected health service utilisation.
Conclusion:
This systematic review found limited and inconclusive evidence of the effectiveness of MBSR for PD patients. Both of the included interventions claimed positive effects for PD patients but significant outcomes were often contradicted by other results. Further trials with larger sample sizes, control groups and longer follow-ups are needed before the evidence for MBSR in PD can be conclusively judged
The protein structure initiative structural genomics knowledgebase
The Protein Structure Initiative Structural Genomics Knowledgebase (PSI SGKB, http://kb.psi-structuralgenomics.org) has been created to turn the products of the PSI structural genomics effort into knowledge that can be used by the biological research community to understand living systems and disease. This resource provides central access to structures in the Protein Data Bank (PDB), along with functional annotations, associated homology models, worldwide protein target tracking information, available protocols and the potential to obtain DNA materials for many of the targets. It also offers the ability to search all of the structural and methodological publications and the innovative technologies that were catalyzed by the PSI's high-throughput research efforts. In collaboration with the Nature Publishing Group, the PSI SGKB provides a research library, editorials about new research advances, news and an events calendar to present a broader view of structural biology and structural genomics. By making these resources freely available, the PSI SGKB serves as a bridge to connect the structural biology and the greater biomedical communitie
Les Houches 2011: Physics at TeV Colliders New Physics Working Group Report
We present the activities of the "New Physics" working group for the "Physics
at TeV Colliders" workshop (Les Houches, France, 30 May-17 June, 2011). Our
report includes new agreements on formats for interfaces between computational
tools, new tool developments, important signatures for searches at the LHC,
recommendations for presentation of LHC search results, as well as additional
phenomenological studies.Comment: 243 pages, report of the Les Houches 2011 New Physics Group; fix
three figure
Examining mindfulness and its relation to self-differentiation and alexithymia
Published online first in 10 July 2013Research supports the association between
mindfulness, emotion regulation, stress reduction, and
interpersonal/relational wellness. The present study evaluated
the potential effect of mindfulness on some indicators of psychological
imbalance such as low self-differentiation and
alexithymia. In this cross-sectional study, a sample of 168 undergraduates
(72 % women) completed measures of perceived
mindfulness (CAMS-R and PHLMS), self-differentiation (SIPI),
and alexithymia (TAS-20). Results revealed positive
correlations between the different dimensions of mindfulness
and negative correlations between those dimensions, selfdifferentiation,
and alexithymia. The dimensions of quality of
mindfulness and acceptance were mediators in the relationship
between self-differentiation and alexithymia. A nonsignificant
interaction between gender and alexithymia was found. All
mindfulness dimensions, but self-differentiation, contributed
to explain the allocation of the non-alexithymic group. These
results indicate that mindfulness seems to be a construct with
great therapeutic and research potential at different levels,
suggesting that some aspects of mindfulness seem to promote
a better self-differentiation and prevent alexithymia
Glycaemic index: did Health Canada get it wrong? Position from the International Carbohydrate Quality Consortium (ICQC)
Body silhouette, menstrual function at adolescence and breast cancer risk in the E3N cohort study
We analysed the relation between adult breast cancer risk and adiposity in ages 8–25, and among 90 509 women included in the E3N cohort study, and investigated the potential modification effect of certain factors. Participants completed a questionnaire that included a set of eight silhouettes corresponding to body shape at different ages. During the follow-up (mean=11.4 years), 3491 breast cancer cases were identified. Negative trends in risk of breast cancer with increasing body silhouettes at age 8 and at menarche were observed, irrespective of menopausal status, with relative risks of 0.73 (0.53–0.99) and 0.82 (0.66–1.02) for women who reported a silhouette equal or greater than the fifth silhouette at age 8 and at menarche, respectively. We observed no clear effect modification by age at menarche, delay between age at menarche, regular cycling, regularity of cycles in adult life or body mass index at baseline
Expression and subcellular localization of cyclin D1 protein in epithelial ovarian tumour cells
The expression of cyclin D1 protein in tumour sections from 81 patients with epithelial ovarian cancer was analysed using immunohistochemistry. The tumours that overexpressed cyclin D1 in more than 10% of neoplastic cells were considered positive. Thus overexpression of cyclin D1 was observed in 72/81 (89%) of the cases examined. Protein was detected in both the nucleus and the cytoplasm in 24/81 (30%) and localized exclusively in the cytoplasm in 48/81 (59%) of the tumours. Cyclin D1 was overexpressed in both borderline and invasive tumours. There was no association between protein overexpression and tumour stage and differentiation. Furthermore, no correlation between cyclin D1 expression and clinical outcome was observed. However, in tumours overexpressing cyclin D1 (n = 72), the proportion displaying exclusively cytoplasmic localization of protein was higher in those with serous compared with non-serous histology (P = 0.004, odds ratio 4.8, 95% confidence interval 1.4–19.1). Western analysis using a monoclonal antibody to cyclin D1 identified a 36 kDa protein in homogenates from seven tumours displaying cytoplasmic only and one tumour demonstrating both nuclear and cytoplasmic immunostaining. Using restriction fragment length polymorphism polymerase chain reaction and PCR-multiplex analysis, amplification of the cyclin D1 gene (CCNDI) was detected in 1/29 of the tumours demonstrating overexpression of cyclin D1 protein. We conclude that deregulation of CCND1 expression leading to both cytoplasmic and nuclear protein localization is a frequent event in ovarian cancer and occurs mainly in the absence of gene amplification. © 1999 Cancer Research Campaig
Neutron Majorana mass from exotic instantons
We show how a Majorana mass for the Neutron could result from
non-perturbative quantum gravity effects peculiar to string theory. In
particular, "exotic instantons" in un-oriented string compactifications with
D-branes extending the (supersymmetric) standard model could indirectly produce
an effective operator delta{m} n^t n+h.c. In a specific model with an extra
vector-like pair of `quarks', acquiring a large mass proportional to the string
mass scale (exponentially suppressed by a function of the string moduli
fields), delta{m} can turn out to be as low as 10^{-24}-10^{-25} eV. The
induced neutron-antineutron oscillations could take place with a time scale
tau_{n\bar{n}} > 10^8 s, that could be tested by the next generation of
experiments. On the other hand, proton decay and FCNC's are automatically
strongly suppressed and are compatible with the current experimental limits.
Depending on the number of brane intersections, the model may also lead to the
generation of Majorana masses for R-handed neutrini. Our proposal could also
suggest neutron-neutralino or neutron-axino oscillations, with implications in
UCN, Dark Matter Direct Detection, UHECR and Neutron-Antineutron oscillations.
This suggests to improve the limits on neutron-antineutron oscillations, as a
possible test of string theory and quantum gravity.Comment: 35 pages, 11 figures. More comments on neutron-neutralino mixin
Determinants of participation in a web-based health risk assessment and consequences for health promotion programs
Background: The health risk assessment (HRA) is a type of health promotion program frequently offered at the workplace. Insight into the underlying determinants of participation is needed to evaluate and implement these interventions. Objective: To analyze whether individual characteristics including demographics, health behavior, self-rated health, and work-related factors are associated with participation and nonparticipation in a Web-based HRA. Methods: Determinants of participation and nonparticipation were investigated in a cross-sectional study among individuals employed at five Dutch organizations. Multivariate logistic regression was performed to identify determinants of participation and nonparticipation in the HRA after controlling for organization and all other variables. Results: Of the 8431 employees who were invited, 31.9% (2686/8431) enrolled in the HRA. The online questionnaire was completed by 27.2% (1564/5745) of the nonparticipants. Determinants of participation were some periods of stress at home or work in the preceding year (OR 1.62, 95% CI 1.08-2.42), a decreasing number of weekdays on which at least 30 minutes were spent on moderate to vigorous physical activity (ORdayPA0.84, 95% CI 0.79-0.90), and increasing alcohol consumption. Determinants of nonparticipation were less-than-positive self-rated health (poor/very poor vs very good, OR 0.25, 95% CI 0.08-0.81) and tobacco use (at least weekly vs none, OR 0.65, 95% CI 0.46-0.90). Conclusions: This study showed that with regard to isolated health behaviors (insufficient physical activity, excess alcohol consumption, and stress), those who could benefit most from the HRA were more likely to participate. However, tobacco users and those who rate
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