Labrador Sea subsurface density as a precursor of multidecadal variability in the North Atlantic: a multi-model study

The subpolar North Atlantic (SPNA) is a region with prominent decadal variability that has experienced remarkable warming and cooling trends in the last few decades. These observed trends have been preceded by slow-paced increases and decreases in the Labrador Sea density (LSD), which are thought to be a precursor of large-scale ocean circulation changes. This article analyses the interrelationships between the LSD and the wider North Atlantic across an ensemble of coupled climate model simulations. In particular, it analyses the link between subsurface density and the deep boundary density, the Atlantic Meridional Overturning Circulation (AMOC), the subpolar gyre (SPG) circulation, and the upper-ocean temperature in the eastern SPNA. All simulations exhibit considerable multidecadal variability in the LSD and the ocean circulation indices, which are found to be interrelated. LSD is strongly linked to the strength of the subpolar AMOC and gyre circulation, and it is also linked to the subtropical AMOC, although the strength of this relationship is model-dependent and affected by the inclusion of the Ekman component. The connectivity of LSD with the subtropics is found to be sensitive to different model features, including the mean density stratification in the Labrador Sea, the strength and depth of the AMOC, and the depth at which the LSD propagates southward along the western boundary. Several of these quantities can also be computed from observations, and comparison with these observation-based quantities suggests that models representing a weaker link to the subtropical AMOC might be more realistic

No evidence for involvement of SDHD in neuroblastoma pathogenesis

BACKGROUND: Deletions in the long arm of chromosome 11 are observed in a subgroup of advanced stage neuroblastomas with poor outcome. The deleted region harbours the tumour suppressor gene SDHD that is frequently mutated in paraganglioma and pheochromocytoma, which are, like neuroblastoma, tumours originating from the neural crest. In this study, we sought for evidence for involvement of SDHD in neuroblastoma. METHODS: SDHD was investigated on the genome, transcriptome and proteome level using mutation screening, methylation specific PCR, real-time quantitative PCR based homozygous deletion screening and mRNA expression profiling, immunoblotting, functional protein analysis and ultrastructural imaging of the mitochondria. RESULTS: Analysis at the genomic level of 67 tumour samples and 37 cell lines revealed at least 2 bona-fide mutations in cell lines without allelic loss at 11q23: a 4bp-deletion causing skip of exon 3 resulting in a premature stop codon in cell line N206, and a Y93C mutation in cell line NMB located in a region affected by germline SDHD mutations causing hereditary paraganglioma. No evidence for hypermethylation of the SDHD promotor region was observed, nor could we detect homozygous deletions. Interestingly, SDHD mRNA expression was significantly reduced in SDHD mutated cell lines and cell lines with 11q allelic loss as compared to both cell lines without 11q allelic loss and normal foetal neuroblast cells. However, protein analyses and assessment of mitochondrial morphology presently do not provide clues as to the possible effect of reduced SDHD expression on the neuroblastoma tumour phenotype. CONCLUSIONS: Our study provides no indications for 2-hit involvement of SDHD in the pathogenesis of neuroblastoma. Also, although a haplo-insufficient mechanism for SDHD involvement in advanced stage neuroblastoma could be considered, the present data do not provide consistent evidence for this hypothesis

Energetic physiology mediates individual optimization of breeding phenology in a migratory Arctic Seabird

The influence of variation in individual state on key reproductive decisions impacting fitness is well appreciat

Geomorphic and archeological features of coastal caves in madre de dios archipelago (Patagonia, Chile)

International audienc

Geomorphic and archeological features of coastal caves in madre de dios archipelago (Patagonia, Chile)

International audienc

Geomorphic and archeological features of coastal caves in madre de dios archipelago (Patagonia, Chile)

International audienc

The European Modern Pollen Database (EMPD) project

Modern pollen samples provide an invaluable research tool for helping to interpret the quaternary fossil pollen record, allowing investigation of the relationship between pollen as the proxy and the environmental parameters such as vegetation, land-use, and climate that the pollen proxy represents. The European Modern Pollen Database (EMPD) is a new initiative within the European Pollen Database (EPD) to establish a publicly accessible repository of modern (surface sample) pollen data. This new database will complement the EPD, which at present holds only fossil sedimentary pollen data. The EMPD is freely available online to the scientific community and currently has information on almost 5,000 pollen samples from throughout the Euro-Siberian and Mediterranean regions, contributed by over 40 individuals and research groups. Here we describe how the EMPD was constructed, the various tables and their fields, problems and errors, quality controls, and continuing efforts to improve the available data