890 research outputs found
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Advising on career image: perspectives, practice and politics
This article analyses qualitative data gathered from a survey of career practitioners on the issue of career image (nâ=â355, 75% female, 89% white and 78% from the UK). Findings reveal three key themes which represent how career image relates to practitionersâ values and beliefs, how practitioners make decisions about whether to address the topic in their practice and the strategies they use to address career image with their clients. Findings are discussed with reference to Wattsâs socio-political ideologies of guidance. The data indicate that career practitioners are often uncomfortable about discussing career image, but address it where they believe that it is important to their clientsâ success. While some practitioners believe the existing structures to be unjust, they generally seek to address this injustice at the individual level rather than seeking any kind of social transformation
Thermal versus quantum fluctuations of optical-lattice fermions
We show that, for fermionic atoms in a one-dimensional optical lattice, the fraction of atoms in doubly occupied sites is a highly nonmonotonic function of temperature. We demonstrate that this property persists even in the presence of realistic harmonic confinement, and that it leads to a suppression of entropy at intermediate temperatures that offers a route to adiabatic cooling. Our interpretation of the suppression is that such intermediate temperatures are simultaneously too high for quantum coherence and too low for significant thermal excitation of double occupancy thus offering a clear indicator of the onset of quantum fluctuations.Publisher PDFPeer reviewe
High fidelity sorting of remarkably similar components via metal-mediated assembly.
Subtle differences in ligand coordination angle and rigidity lead to high fidelity sorting between individual components displaying identical coordination motifs upon metal-mediated self-assembly. Narcissistic self-sorting can be achieved between highly similar ligands that vary minimally in rigidity and internal coordination angle upon combination with Fe(ii) ions and 2-formylpyridine. Selective, sequential cage formation can be precisely controlled in a single flask from a mix of three different core ligands (and 33 total components) differing only in the hybridization of one group that is uninvolved in the metal coordination process
Good looks and good practice: the attitudes of career practitioners to attractiveness and appearance
Empirical evidence attests the impact that career image has on objective career success, yet little is known of how career practitioners conceptualise and operationalise this information. This article presents the quantitative findings of an online survey of career practitioners (nâ=â399, 74% female, 89% white and 75% from the U.K.) exploring their attitudes and practices towards issues of appearance and attractiveness. Career practitioners who participated in this survey acknowledged that beauty, self-presentation and interpersonal skills influence career success, and 96% of them considered conversations about career image as part of their professional remit. The career practitioners felt relatively comfortable and well informed in their discussions in this arena, but would welcome further guidance and training to inform their practice. Ethical and practical implications for the profession are considered
Customer orientation and innovativeness:differing roles in new and old Europe
Burgess and Steenkamp [Burgess, S. M., & Steenkamp, J. (2006). Marketing renaissance: How research in emerging markets advances marketing science and practice. International Journal of Research in Marketing, 23(4), 337-356.] have pointed out that marketing knowledge derives almost exclusively from research conducted in high income, industrialized countries. However, the generalizability of marketing knowledge should also be tested in emerging markets. We demonstrate that returns on customer orientation and organizational innovativeness play out differently in New versus Old Europe. Contrary to previous research, we find that customer focus is at least as important in New Europe as in our Old European country, while organizational innovativeness appears more important in New Europe to drive both customer service and financial performance
A Golgi and tonoplast localized S-acyl transferase is involved in cell expansion, cell division, vascular patterning and fertility in Arabidopsis
Sâacylation of eukaryotic proteins is the reversible attachment of palmitic or stearic acid to cysteine residues, catalysed by protein Sâacyl transferases that share an AspâHisâHisâCys (DHHC) motif. Previous evidence suggests that in Arabidopsis Sâacylation is involved in the control of cell size, polarity and the growth of pollen tubes and root hairs.
Using a combination of yeast genetics, biochemistry, cell biology and loss of function genetics the roles of a member of the protein Sâacyl transferase PAT family, AtPAT10 (At3g51390), have been explored.
In keeping with its role as a PAT, AtPAT10 autoâSâacylates, and partially complements the yeast akr1 PAT mutant, and this requires Cys192 of the DHHC motif. In Arabidopsis AtPAT10 is localized in the Golgi stack, transâGolgi network/early endosome and tonoplast. Lossâofâfunction mutants have a pleiotropic phenotype involving cell expansion and division, vascular patterning, and fertility that is rescued by wildâtype AtPAT10 but not by catalytically inactive AtPAT10C192A. This supports the hypothesis that AtPAT10 is functionally independent of the other Arabidopsis PATs.
Our findings demonstrate a growing importance of protein Sâacylation in plants, and reveal a Golgi and tonoplast located Sâacylation mechanism that affects a range of events during growth and development in Arabidopsis
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Site selective reading of epigenetic markers by a dual-mode synthetic receptor array.
Variably functionalized self-folding deep cavitands form an arrayed, fluorescent indicator displacement assay system for the detection of post-translationally modified (PTM) histone peptides. The hosts bind trimethyllysine (KMe3) groups, and use secondary upper rim interactions to provide more sensitive discrimination between targets with identical KMe3 binding handles. The sensor array uses multiple different recognition modes to distinguish between miniscule differences in target, such as identical lysine modifications at different sites of histone peptides. In addition, the sensor is affected by global changes in structure, so it is capable of discriminating between identical PTMs, at identical positions on amino acid fragments that vary only in peptide backbone length, and can be applied to detect non-methylation modifications such as acetylation and phosphorylations located multiple residues away from the targeted binding site. The synergistic application of multiple variables allows dual-mode deep cavitands to approach levels of recognition selectivity usually only seen with antibodies
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