Hydrothermal monitoring using embedded sensors of the actual roof system of the prado museum

El Prado Museum in Madrid has been recently submitted to a refurbishment of its roof which from been made with the traditional tiles has been changed to the use of modern waterproofing layers covered with a metallic lead finishing. Due to an unexpected damp patch that produced leaking in the hall in which Las Meninas by Velázquez was exhibited, the authors were commissioned by the Ministry of Education and Culture to study the suitability of the roof and its waterproofing properties. The study led to suggestions of modifications in the design of the roof layers, which are out of the scope of present paper. In present paper are given the behaviour of the sensors embedded in two specific areas of the roof. The sensors installed were of: temperature, relative humidity, measurement of local strain and detection of liquid water. The liquid water sensors reveal that some water is withheld in the layer just below the thermal insulation material, although it is standing. The results of over four years of readings show that the temperature attenuates over distance away from the outermost layer, where the readings are very high in summer, due to it consists of lead. During the colder seasons, in turn, the temperature in the inner layers of the roof is higher than in the outer layers. The strain recorded follows the logical evolution of temperature with no abnormal behaviour being detected. Some of relative humidity sensors had measuring problems due to water condensing on them. In summary however, if the behaviour in this area is extrapolated to the rest of the roof, it can be considered to perform correctly as intended. No more leaking events have been detected from the design modifications were incorporated to the existing roof

Asymptotics for Jacobi–Sobolev orthogonal polynomials associated with non-coherent pairs of measures

AbstractWe consider the Sobolev inner product 〈f,g〉=∫−11f(x)g(x)dψ(α,β)(x)+∫f′(x)g′(x)dψ(x), where dψ(α,β)(x)=(1−x)α(1+x)βdx with α,β>−1, and ψ is a measure involving a rational modification of a Jacobi weight and with a mass point outside the interval (−1,1). We study the asymptotic behaviour of the polynomials which are orthogonal with respect to this inner product on different regions of the complex plane. In fact, we obtain the outer and inner strong asymptotics for these polynomials as well as the Mehler–Heine asymptotics which allow us to obtain the asymptotics of the largest zeros of these polynomials. We also show that in a certain sense the above inner product is also equilibrated

Nutritional epigenomics: bioactive dietary compounds in the epigenetic regulation of osteoarthritis

Review[Abstract] Nutritional epigenomics is exceptionally important because it describes the complex interactions among food compounds and epigenome modifications. Phytonutrients or bioactive compounds, which are secondary metabolites of plants, can protect against osteoarthritis by suppressing the expression of inflammatory and catabolic mediators, modulating epigenetic changes in DNA methylation, and the histone or chromatin remodelling of key inflammatory genes and noncoding RNAs. The combination of natural epigenetic modulators is crucial because of their additive and synergistic effects, safety and therapeutic efficacy, and lower adverse effects than conventional pharmacology in the treatment of osteoarthritis. In this review, we have summarized the chondroprotective properties of bioactive compounds used for the management, treatment, or prevention of osteoarthritis in both human and animal studies. However, further research is needed into bioactive compounds used as epigenetic modulators in osteoarthritis, in order to determine their potential value for future clinical applications in osteoarthritic patients as well as their relation with the genomic and nutritional environment, in order to personalize food and nutrition together with disease prevention.This study has been funded by Instituto de Salud Carlos III (ISCIII) through the projects “PI19/01213” and “RICORSREI-RD21/0002/0009”, and co-funded by the European Union; and grants IN607D2022/12 and IN607A2021/07 from Xunta de Galicia, Axencia Galega de Innovación GAIN.info:eu-repo/grantAgreement/ISCIII/Programa Estatal de Generación de Conocimiento y Fortalecimiento del Sistema Español de I+D+I/PI19%2F01213/ES/EPIOA: ESTUDIO DEL PAPEL TERAPEUTICO DE MODIFICADORES EPIGENETICOS Y NUTRACEUTICOS EN LA ARTROSISInstituto de Salud Carlos III; RICORSREI-RD21/0002/0009Xunta de Galicia; IN607D2022/12Xunta de Galicia; IN607A2021/0

Risk Factors for Mortality in Nursing Home Residents: An Observational Study

Purpose: Identifying mortality risk factors in people living in nursing homes could help healthcare professionals to individualize or develop specific plans for predicting future care demands and plan end-of-life care in this population. This study aims to identify mortality risk factors in elderly nursing home (NH) residents, based on variables adapted to this environment, routinely collected and easily accessible to their healthcare professionals. Methods: A prospective, longitudinal, observational study of NH residents aged 65 years and older was carried out collecting sociodemographic, functional and cognitive status, nutritional variables, comorbidities, and other health variables. These variables were analyzed as mortality risk factors by Cox proportional hazard models. Results: A total of 531 residents (75.3% female; average age 86.7 years (SD: 6.6)) were included: 25.6% had total dependence, 53.4% had moderate to severe cognitive impairment, 84.5% were malnourished or at risk of malnutrition, and 79.9% were polymedicated. Risk of mortality (hazard ratio, HR) increased in totally dependent residents (HR = 1.52; p = 0.02) and in those with moderate or severe cognitive impairment ((HR = 1.59; p = 0.031) and (HR = 1.93; p = 0.002), respectively). Male gender (HR = 1.88; p < 0.001), age 80 years (HR = 1.73; p = 0.034), hypertension (HR = 1.53; p = 0.012), atrial fibrillation/arrhythmia (HR = 1.43; p = 0.048), and previous record of pneumonia (HR = 1.65; p = 0.029) were also found to be mortality drivers. Conclusion: Age and male gender (due to the higher prevalence of associated comorbidity in these two variables), certain comorbidities (hypertension, atrial fibrillation/arrhythmia, and pneumonia), higher functional and cognitive impairment, and frequency of medical emergency service care increased the risk of mortality in our study. Given their importance and their easy identification by healthcare professionals in nursing homes, these clinical variables should be used for planning care in institutionalized older adults.Grupo Ballesol (Valencia, Spain) provided financial support for conducting the research and publishing the article. The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscriptEnfermerí

Epigenetics as a therapeutic target in osteoarthritis

Review[Abstract] Osteoarthritis (OA) is a heterogenous, complex disease affecting the integrity of diarthrodial joints that, despite its high prevalence worldwide, lacks effective treatment. In recent years it has been discovered that epigenetics may play an important role in OA. Our objective is to review the current knowledge of the three classical epigenetic mechanisms—DNA methylation, histone post-translational modifications (PTMs), and non-coding RNA (ncRNA) modifications, including microRNAs (miRNAs), circular RNAs (circRNAs), and long non-coding RNAs (lncRNAs)—in relation to the pathogenesis of OA and focusing on articular cartilage. The search for updated literature was carried out in the PubMed database. Evidence shows that dysregulation of numerous essential cartilage molecules is caused by aberrant epigenetic regulatory mechanisms, and it contributes to the development and progression of OA. This offers the opportunity to consider new candidates as therapeutic targets with the potential to attenuate OA or to be used as novel biomarkers of the disease.Instituto de Salud Carlos III; PI19/01213Xunta de Galicia; IN607D2022/12Xunta de Galicia; IN607A 2021/

Notas sobre flora y vegetación en el sector oriental del Sistema Central

Este trabajo contiene un total de 107 citas recogidas en el macizo de Ayilón y zonas próximas, acompañadas por una síntesis de la información previa disponible acerca de cada especie en la zona y por referencias mesológicas básicas de cada emplazamiento. En la segunda parte se incluye una descripción botánica de la l1arnada Acebeda de Becerril, ubicada en el monte núm. 64 del CUP de Segovia

Microbiota diversity in nonalcoholic fatty liver disease and in drug-induced liver injury

The gut microbiota could play a significant role in the progression of nonalcoholic fatty liver disease (NAFLD); however, its relevance in drug-induced liver injury (DILI) remains unexplored. Since the two hepatic disorders may share damage pathways, we analysed the metagenomic profile of the gut microbiota in NAFLD, with or without significant liver fibrosis, and in DILI, and we identified the main associated bacterial metabolic pathways. In the NAFLD group, we found a decrease in Alistipes, Barnesiella, Eisenbergiella, Flavonifractor, Fusicatenibacter, Gemminger, Intestinimonas, Oscillibacter, Parasutterella, Saccharoferementans and Subdoligranulum abundances compared with those in both the DILI and control groups. Additionally, we detected an increase in Enterobacter, Klebsiella, Sarcina and Turicibacter abundances in NAFLD, with significant liver fibrosis, compared with those in NAFLD with no/mild liver fibrosis. The DILI group exhibited a lower microbial bacterial richness than the control group, and lower abundances of Acetobacteroides, Blautia, Caloramator, Coprococcus, Flavobacterium, Lachnospira, Natronincola, Oscillospira, Pseudobutyrivibrio, Shuttleworthia, Themicanus and Turicibacter compared with those in the NAFLD and control groups. We found seven bacterial metabolic pathways that were impaired only in DILI, most of which were associated with metabolic biosynthesis. In the NAFLD group, most of the differences in the bacterial metabolic pathways found in relation to those in the DILI and control groups were related to fatty acid and lipid biosynthesis. In conclusion, we identified a distinct bacterial profile with specific bacterial metabolic pathways for each type of liver disorder studied. These differences can provide further insight into the physiopathology and development of NAFLD and DILI.This work was supported in part by a grant from the Instituto de Salud Carlos III (Spain) (PI18/01804, PI19/00883, PI21/01248), from the Consejería de Economía, Conocimiento, Empresas y Universidad (Junta de Andalucía, Spain) (PI18–RT‐3364, UMA18-FEDERJA-194), and from the Consejería de Salud (Junta de Andalucía, Spain) (PI-0285–2016). This study has been co-funded by FEDER funds (“A way to make Europe”) (“Andalucía se mueve con Europa”). CRD is supported by a grant from the Consejería de Transformación Económica, Industria, Conocimiento y Universidades de Junta de Andalucía (Spain) (DOC_01610). FMR is supported by a grant from the ISCIII (Spain) (FI19/00189). AC is supported by a grant from the ISCIII (Spain) (IFI18/00047). EGF is supported by the Nicolas Monardes program from the Consejería de Salud de Andalucía (Spain) (C-0031–2016). Funding for open access charge: Universidad de Málaga / CBUA (Spain)

Detection of bipolar disorder in the prodromal phase: A systematic review of assessment instruments

Background: Early detection of prodromal symptoms may contribute to improving the prognosis of patients with bipolar disorder (BD). The main objective of this systematic review is to present the different procedures for the identification of initial and relapse prodromes in these patients. Methods: PsycINFO, Web of Science and PubMed databases were searched using a predetermined strategy, until January 4, 2022. Then, by means of a regulated process, studies that used a BD prodrome detection procedure, in English-language and all ages participants were selected. Quantitative and qualitative studies were assessed using a modified version of the Newcastle-Ottawa Scale and by Critical Appraisals Skills Programme checklist, respectively. Results: Forty-five studies were selected. Of these, 26 used procedures for identifying initial prodromes (n = 8014) and 19 used procedures for detecting relapse prodromes (n = 1136). The interview was the most used method in the detection of both types of prodromes (k = 30 papers, n = 4068). It was variable in its degree of structure. Mobile applications and digital technologies are gaining importance in the detection of the relapse prodromes. Limitations: A retrospective design in most papers, small samples sizes, existence of persistent subsyndromal symptoms and difficulty to identify the end of the prodrome and the onset of the disorder. Conclusions: There is a wide variety of assessment instruments to detect prodromes in BD, among which the clinical interview is most frequently used. Future research should consider development of a brief tool to be applied in different formats to patients and family members