Corrosion resistance of protective coatings against molten nitrate salts for thermal energy storage and their environmental impact in CSP technology

Sol-gel ZrO2–3%molY2O3 coating deposited by means of a dip-coating application on P91 steel was statically tested at 500 °C in contact with Solar Salt (60% wt.% NaNO3/40 wt.% of KNO3) for 1000 h. This work assessed the behaviour of the coated P91 steel both from a technical and environmental point of view. Both studies were compared to those obtained with AISI 304 steel, which is currently used in commercial CSP plants. In terms of corrosion evaluation, the behaviour of the coated P91 was directly comparable to that of the uncoated AISI 304, SEM micrographs revealing the better behaviour of coated samples and the maintenance of a compact coating layer, with a thickness ranging between 1 and 1.4 μm. Furthermore, environmental analyses revealed the environmental benefits obtained by using lower Cr-Ni content steel coated with ZrO2–Y2O3 compared to AISI 304 alloy, since this coating had a negligible environmental impact (its influence is below 0.03%). Thus, the proposed scenario seems to be workable in CSP high-temperature applications both from technical and environmental points of view. The linked technical-environmental quantification provided in this paper highlights the importance of considering the whole assessment when conducting material selection for CSP applications.Publicad

Variable magmatic features of Oligocene-early Miocene Patagonian magmatism as result of subduction-induced mantle dynamics

New geochemical and geochronological data reveal that late Oligocene-early Miocene time isa break point in the evolution of Andean magmatism. The Patagonian Andes registered theonset of arc volcanism since the late Eocene forming part of the El Maitén Belt, whosedevelopment was driven by the subduction of the Farallón/Nazca plates beneath the Andeanmargin (Rapela et al., 1988). New data indicate that during the Oligocene El Maitén Belt showa change from tholeiitic to calc-alkaline compositions, reflecting a more mature stage in arcevolution. Toward the early Miocene, Andean arc magmatism turned into basic tholeiitic lavaflows, which intercalate with marine deposits, suggesting their development under extensionaltectonics (e.g., Bechis et al., 2014). These rocks resemble E-MORB-like and OIB compositionswith primitive mantle sources, which strongly contrast with previous arc products. By this time,a global plate reorganization event would have caused an increase in convergence rates,accelerated roll back and a more orthogonal subduction geometry, triggering a widespreadmagmatism and the development of extensional basins in the upper plate (e.g., Fennell et al.,2018; Lonsdale, 2005; Muñoz et al., 2000). Records of volcanic associations with arc signatureduring the early Miocene can be found only in the western slope of the Andes, suggesting theretreat of the volcanic front toward the trench (e.g., Encinas et al., 2016; Muñoz et al., 2000).The proposed model suggests that slab rollback would have caused vigorous mantleconvection allowing the coexistence of arc related magmatism with deep-sourced intrusions.Fil: Fernández Paz, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Bechis, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Diversidad Cultural y Procesos de Cambio. Universidad Nacional de Río Negro. Instituto de Investigaciones en Diversidad Cultural y Procesos de Cambio; ArgentinaFil: Litvak, Vanesa Dafne. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Echaurren Gonzalez, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Ciencias Geológicas; ArgentinaFil: Encinas, Alfonso. Universidad de Concepción; ChileFil: Gonzalez, J.. Universidad de Concepción; ChileFil: Lucassen, Friedrich. Universitat Bremen; AlemaniaFil: Oliveros, Verónica. Universidad de Concepción; ChileFil: Valencia, Victor. Washington State University; Estados UnidosFil: Folguera Telichevsky, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentina8th International Symposium on Andean GeodynamicsQuitoEcuadorEscuela Politécnica NacionalInstitut de Recherche pour le Développemen

Constraints on Trenchward Arc Migration and Backarc Magmatism in the North Patagonian Andes in the Context of Nazca Plate Rollback

Geochemical and geochronological data reveal that late Oligocene-early Miocene time is a break point in the evolution of Andean magmatism. The Patagonian Andes registered the onset of arc volcanism since the late Eocene forming part of the El Maitén Belt, whose development was driven by the subduction of the Farallon/Nazca plates beneath the Andean margin. During the Oligocene, the El Maitén Belt shows a change in the geochemical signature of its magmas from tholeiitic to calc-alkaline compositions, reflecting a more mature stage in the magmatic arc evolution. Toward the early Miocene, a striking event is registered in Andean volcanic sequences as mafic tholeiitic lava flows of the El Maitén are interbedded with marine deposits, suggesting their development in the context of a fast subsiding regime. Geochemical analyses presented in this paper show that these rocks resemble enriched mid-ocean ridge basalt-like and ocean island basalt compositions, isotopically depleted, which strongly contrast with previous arc products. By this time, a global plate reorganization event had caused an increase in convergence rates, accelerated rollback, and a more orthogonal geometry of subduction, triggering widespread magmatism and the development of extensional basins in the overriding plate. Arc-related volcanism during the early Miocene can be found only in the western slope of the Andes, suggesting the retreat of the volcanic front toward the trench. The proposed model highlights a strong linkage between the geochemical signature of magmatic products and changes in the subduction zone configuration and mantle dynamics during the evolution of the Patagonian Andes (41–44°S).Fil: Fernández Paz, Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Bechis, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte. Instituto de Investigaciones en Diversidad Cultural y Procesos de Cambio. Universidad Nacional de Río Negro. Instituto de Investigaciones en Diversidad Cultural y Procesos de Cambio; ArgentinaFil: Litvak, Vanesa Dafne. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Echaurren Gonzalez, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; ArgentinaFil: Encinas, A.. Universidad de Concepción; ChileFil: González, J.. Universidad de Concepción; ChileFil: Lucassen, F.. Universitat Bremen; AlemaniaFil: Oliveros, V.. Universidad de Concepción; ChileFil: Valencia, V.. Washington State University; Estados UnidosFil: Folguera Telichevsky, Andres. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Estudios Andinos "Don Pablo Groeber". Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Estudios Andinos "Don Pablo Groeber"; Argentin

Characteristics and outcome of adult patients with acute promyelocytic leukemia and increased body mass index treated with the PETHEMA Protocols

Objective The obesity/overweight may have an influence on APL outcomes. Methods This is the biggest multicentre analysis on 1320 APL patients treated with AIDA-induction and risk-adapted consolidation between 1996 and 2012. Patients body mass index (BMI) was classified as underweight (= 30 kg/m(2)) according to the World Health Organization (WHO) criteria. Results and conclusions Relationship between male gender, older age, and other known laboratory abnormalities in overweight/obese patients was significant. The induction mortality rate was significantly higher in APL with BMI >= 25 vs BMI = 25 had a trend to lower OS (74% vs 80%; P = .06). However, in the multivariate analysis, BMI did not retain the independent predictive value (P = .46). There was no higher incidence of differentiation syndrome with BMI >= 25, but there was a trend in obese. There was no difference in relapse rate according to the BMI. In summary, overweight/obesity does not represent an independent risk factor for APL outcomes. The influence of obesity in APL patients treated with chemotherapy-free regimens remains to be established

Multiple myeloma and SARS-CoV-2 infection : clinical characteristics and prognostic factors of inpatient mortality

There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes were compared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admitted at six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients were male; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity was moderate-severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was required by 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasive ventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifies predictors of inpatient mortality among MM patients hospitalized with COVID-19

Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality

There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiplemyeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes werecompared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admittedat six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients weremale; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity wasmoderate-severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was requiredby 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasiveventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients,inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM athospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independentprognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifiespredictors of inpatient mortality among MM patients hospitalized with COVID-19

A clinically compatible drug-screening platform based on organotypic cultures identifies vulnerabilities to prevent and treat brain metastasis

We report a medium‐throughput drug‐screening platform (METPlatform) based on organotypic cultures that allows to evaluate inhibitors against metastases growing in situ. By applying this approach to the unmet clinical need of brain metastasis, we identified several vulnerabilities. Among them, a blood–brain barrier permeable HSP90 inhibitor showed high potency against mouse and human brain metastases at clinically relevant stages of the disease, including a novel model of local relapse after neurosurgery. Furthermore, in situ proteomic analysis applied to metastases treated with the chaperone inhibitor uncovered a novel molecular program in brain metastasis, which includes biomarkers of poor prognosis and actionable mechanisms of resistance. Our work validates METPlatform as a potent resource for metastasis research integrating drug‐screening and unbiased omic approaches that is compatible with human samples. Thus, this clinically relevant strategy is aimed to personalize the management of metastatic disease in the brain and elsewhere

Global application of an unoccupied aerial vehicle photogrammetry protocol for predicting aboveground biomass in non‐forest ecosystems

P. 1-15Non-forest ecosystems, dominated by shrubs, grasses and herbaceous plants, provide ecosystem services including carbon sequestration and forage for grazing, and are highly sensitive to climatic changes. Yet these ecosystems are poorly represented in remotely sensed biomass products and are undersampled by in situ monitoring. Current global change threats emphasize the need for new tools to capture biomass change in non-forest ecosystems at appropriate scales. Here we developed and deployed a new protocol for photogrammetric height using unoccupied aerial vehicle (UAV) images to test its capability for delivering standardized measurements of biomass across a globally distributed field experiment. We assessed whether canopy height inferred from UAV photogrammetry allows the prediction of aboveground biomass (AGB) across low-stature plant species by conducting 38 photogrammetric surveys over 741 harvested plots to sample 50 species. We found mean canopy height was strongly predictive of AGB across species, with a median adjusted R2 of 0.87 (ranging from 0.46 to 0.99) and median prediction error from leave-one-out cross-validation of 3.9%. Biomass per-unit-of-height was similar within but different among, plant functional types. We found that photogrammetric reconstructions of canopy height were sensitive to wind speed but not sun elevation during surveys. We demonstrated that our photogrammetric approach produced generalizable measurements across growth forms and environmental settings and yielded accuracies as good as those obtained from in situ approaches. We demonstrate that using a standardized approach for UAV photogrammetry can deliver accurate AGB estimates across a wide range of dynamic and heterogeneous ecosystems. Many academic and land management institutions have the technical capacity to deploy these approaches over extents of 1–10 ha−1. Photogrammetric approaches could provide much-needed information required to calibrate and validate the vegetation models and satellite-derived biomass products that are essential to understand vulnerable and understudied non-forested ecosystems around the globe.S

Search for a vector-like quark T′ → tH via the diphoton decay mode of the Higgs boson in proton-proton collisions at s \sqrt{s} = 13 TeV

A search for the electroweak production of a vector-like quark T′, decaying to a top quark and a Higgs boson is presented. The search is based on a sample of proton-proton collision events recorded at the LHC at = 13 TeV, corresponding to an integrated luminosity of 138 fb−1. This is the first T′ search that exploits the Higgs boson decay to a pair of photons. For narrow isospin singlet T′ states with masses up to 1.1 TeV, the excellent diphoton invariant mass resolution of 1–2% results in an increased sensitivity compared to previous searches based on the same production mechanism. The electroweak production of a T′ quark with mass up to 960 GeV is excluded at 95% confidence level, assuming a coupling strength κT = 0.25 and a relative decay width Γ/MT′ < 5%