Computerized Schedule Effectiveness Technique /SET/ determines present and future schedule position

Computerized scheduling system calculates an index of overall schedule-effectiveness. The schedule-effectiveness index is a measurement of actual overall performance against the existing schedule, and a series of schedule-effectiveness values indicates the trend of actual performance. This computer program is written in Fortran 4

Educación de la libertad. un nuevo acercamiento para comprender la relación valores-educación en el contexto de pluralidad e incertidumbre del mundo actual

El horizonte de crisis-cambio-globalización en que se encuentra el mundo hace que el tema de los valores en la educación y sus concreciones en la llamada “educación en valores” adquieran cada vez mayor relevancia. El cambio de época que vivimos, justifica la preocupación por el tema pero este contexto mundial está marcado por dos elementos que se deben tomar en cuenta para plantear programas eficaces de educación moral y programas más pertinentes de investigación sobre el tema. Estos dos elementos son la incertidumbre y la pluralidad. En un contexto como este, es necesario buscar nuevos enfoques de formación e investigación sobre el tema de los valores que respondan al sujeto humano de hoy. Una distinción filosófica que puede ayudar a esta búsqueda es la que hacen Zubiri y Aranguren entre “moral como contenido” y “moral como estructura”. Una persona puede vivir al margen de los contenidos morales de su sociedad, pero ningún ser humano puede evitar ser “estructuralmente moral”. La propuesta de este trabajo consiste en que una educación moral para los tiempos de incertidumbre y pluralidad que hoy vivimos debe ser una propuesta basada en la “moral como estructura” y no, como la mayoría de los programas actuales, en la “moral como contenido”

Association of virulence plasmid and antibiotic resistance determinants with chromosomal multilocus genotypes in Mexican Salmonella enterica serovar Typhimurium strains

<p>Abstract</p> <p>Background</p> <p>Bacterial genomes are mosaic structures composed of genes present in every strain of the same species (core genome), and genes present in some but not all strains of a species (accessory genome). The aim of this study was to compare the genetic diversity of core and accessory genes of a <it>Salmonella enterica </it>subspecies <it>enterica </it>serovar Typhimurium (Typhimurium) population isolated from food-animal and human sources in four regions of Mexico. Multilocus sequence typing (MLST) and macrorestriction fingerprints by pulsed-field gel electrophoresis (PFGE) were used to address the core genetic variation, and genes involved in pathogenesis and antibiotic resistance were selected to evaluate the accessory genome.</p> <p>Results</p> <p>We found a low genetic diversity for both housekeeping and accessory genes. Sequence type 19 (ST19) was supported as the founder genotype of STs 213, 302 and 429. We found a temporal pattern in which the derived ST213 is replacing the founder ST19 in the four geographic regions analyzed and a geographic trend in the number of resistance determinants. The distribution of the accessory genes was not random among chromosomal genotypes. We detected strong associations among the different accessory genes and the multilocus chromosomal genotypes (STs). First, the <it>Salmonella </it>virulence plasmid (pSTV) was found mostly in ST19 isolates. Second, the plasmid-borne betalactamase <it>cmy-2 </it>was found only in ST213 isolates. Third, the most abundant integron, IP-1 (<it>dfrA12</it>, <it>orfF </it>and <it>aadA2</it>), was found only in ST213 isolates. Fourth, the <it>Salmonella </it>genomic island (SGI1) was found mainly in a subgroup of ST19 isolates carrying pSTV. The mapping of accessory genes and multilocus genotypes on the dendrogram derived from macrorestiction fingerprints allowed the establishment of genetic subgroups within the population.</p> <p>Conclusion</p> <p>Despite the low levels of genetic diversity of core and accessory genes, the non-random distribution of the accessory genes across chromosomal backgrounds allowed us to discover genetic subgroups within the population. This study provides information about the importance of the accessory genome in generating genetic variability within a bacterial population.</p

Does an L-glutamine-containing, Glucose-free, Oral Rehydration Solution Reduce Stool Output and Time to Rehydrate in Children with Acute Diarrhoea? A Double-blind Randomized Clinical Trial

This study assessed whether an oral rehydration solution (ORS) in which glucose is replaced by L-glutamine (L-glutamine ORS) is more effective than the standard glucose-based rehydration solution recommended by the World Health Organization (WHO-ORS) in reducing the stool volume and time to rehydrate in acute diarrhoea. In a double-blind, randomized controlled trial in a Mexican hospital, 147 dehydrated children, aged 1–60 month(s), were assigned either to the WHO-ORS (74 children), or to the L-glutamine ORS (73 children) and followed until successful rehydration. There were no significant differences between the groups in stool output during the first four hours, time to successful rehydration, volume of ORS required for rehydration, urinary output, and vomiting. This was independent of rotavirus-associated infection. An L-glutamine-containing glucose-free ORS seems not to offer greater clinical benefit than the standard WHO-ORS in mildly-to-moderately-dehydrated children with acute non-cholera diarrhoea

Reference Model for Improving the Process of Enterprise Software Product in the Ecuasis Company

This research work arose to improve the process of enterprise software products for the creation of software companies, through the development of a reference model based on lean startup proposed methodologies to the effect of selective and comparative study of the main methodologies of the entrepreneurship, the methodology to identify that best suits our purpose to generate the proposed model. Finally, generates and implements the proposed model and check the validity by applying a practical case study

Technical uncertainties in aquifer restoration, implications for remedial systems design, and Superfund policy implementation

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1997.Includes bibliographical references (leaves 120-126).by Enrique J. Lopez-Calva.M.S

Development of a Model for Quality Process Stage Development Software Applied Unit Systems UTMACH

In the present investigation discloses some models or standards focused on system development process. Pretending to give a solution to the user dissatisfaction that causes no profiling to develop quality system. And with reference to the systems unit of the Technical University of Machala and under the investigative process that took place it was detected that there is no order of development in the Unit, the various schedules that are performed many times outside the scope of work team. Due to this circumstance and aims these preliminary detected based on a comparative analysis of the various models or standards applied quality system to create a working environment that allows Systems Unit improve the system development process. Forming itself the quality model system that will engage the Systems Unit

Analysis pumping schemes for the extraction of contaminated groundwater at Cape Cod, Massachusetts, using 3-D numerical modeling

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Civil and Environmental Engineering, 1996.Includes bibliographical references (leaves 61-65).by Enrique J. Lopez-Calva.M.Eng

Discovery of SMAD4 promoters, transcription factor binding sites and deletions in juvenile polyposis patients

Inactivation of SMAD4 has been linked to several cancers and germline mutations cause juvenile polyposis (JP). We set out to identify the promoter(s) of SMAD4, evaluate their activity in cell lines and define possible transcription factor binding sites (TFBS). 5′-rapid amplification of cDNA ends (5′-RACE) and computational analyses were used to identify candidate promoters and corresponding TFBS and the activity of each was assessed by luciferase vectors in different cell lines. TFBS were disrupted by site-directed mutagenesis (SDM) to evaluate the effect on promoter activity. Four promoters were identified, two of which had significant activity in several cell lines, while two others had minimal activity. In silico analysis revealed multiple potentially important TFBS for each promoter. One promoter was deleted in the germline of two JP patients and SDM of several sites led to significant reduction in promoter activity. No mutations were found by sequencing this promoter in 65 JP probands. The predicted TFBS profiles for each of the four promoters shared few transcription factors in common, but were conserved across several species. The elucidation of these promoters and identification of TFBS has important implications for future studies in sporadic tumors from multiple sites, and in JP patients