44 research outputs found

    La reconstrucción de la lección : un estímulo para el aprendizaje de las ciencias en Educación Básica

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    The research reported below is an attempt to measure the value of "lesson reconstruction" as a didactic stimulus. More than one hundred students, belonging to three classes of the seventh year of Basic Education, participated in this study. The subject matter was Natural Sciences and, more specifically, Physics. The treatments of the two experimental groups were two different types of "lesson reconstruction", one of them based on the questioning by the teacher, and the other based on questionnaires applied to small groups of students. The third group of students was the control group. The results, reported for individuals and groups, show that these treatments can be effective after an accommodation period, more significantly in the treatment based on questionnaires

    La reconstrucción de la lección : un estímulo para el aprendizaje de las ciencias en Educación Básica

    Get PDF
    The research reported below is an attempt to measure the value of "lesson reconstruction" as a didactic stimulus. More than one hundred students, belonging to three classes of the seventh year of Basic Education, participated in this study. The subject matter was Natural Sciences and, more specifically, Physics. The treatments of the two experimental groups were two different types of "lesson reconstruction", one of them based on the questioning by the teacher, and the other based on questionnaires applied to small groups of students. The third group of students was the control group. The results, reported for individuals and groups, show that these treatments can be effective after an accommodation period, more significantly in the treatment based on questionnaires

    PR-LncRNA Signature Regulates Glioma Cell Activity Through Expression of SOX Factors

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    Long non-coding RNAs (LncRNAs) have emerged as a relevant class of genome regulators involved in a broad range of biological processes and with important roles in tumor initiation and malignant progression. We have previously identified a p53-regulated tumor suppressor signature of LncRNAs (PR-LncRNAs) in colorectal cancer. Our aim was to identify the expression and function of this signature in gliomas. We found that the expression of the four PR-LncRNAs tested was high in human low-grade glioma samples and diminished with increasing grade of disease, being the lowest in glioblastoma samples. Functional assays demonstrated that PR-LncRNA silencing increased glioma cell proliferation and oncosphere formation. Mechanistically, we found an inverse correlation between PR-LncRNA expression and SOX1, SOX2 and SOX9 stem cell factors in human glioma biopsies and in glioma cells in vitro. Moreover, knock-down of SOX activity abolished the effect of PR-LncRNA silencing in glioma cell activity. In conclusion, our results demonstrate that the expression and function of PR-LncRNAs are significantly altered in gliomagenesis and that their activity is mediated by SOX factors. These results may provide important insights into the mechanisms responsible for glioblastoma pathogenesis.PA, JA-I and AS-A were recipients of a predoctoral fellowship from the Spanish Association Against Cancer (AECC Gipuzkoa), Basque Government and Instituto Salud Carlos III. This work was supported by grants from the Carlos III Institute of Health and the European Regional Development Fund (PI13/02277, CP16/00039, DTS16/084, and PI16/01580) and Industry and Health Departments of the Basque Country

    La reconstrucción de la lección : un estímulo para el aprendizaje de las ciencias en Educación Básica

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    The research reported below is an attempt to measure the value of "lesson reconstruction" as a didactic stimulus. More than one hundred students, belonging to three classes of the seventh year of Basic Education, participated in this study. The subject matter was Natural Sciences and, more specifically, Physics. The treatments of the two experimental groups were two different types of "lesson reconstruction", one of them based on the questioning by the teacher, and the other based on questionnaires applied to small groups of students. The third group of students was the control group. The results, reported for individuals and groups, show that these treatments can be effective after an accommodation period, more significantly in the treatment based on questionnaires

    DNA extraction by zinc

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