Vertical variation in the amplitude of the seasonal isotopic content of rainfall as a tool to jointly estimate the groundwater recharge zone and transit times in the Ordesa and Monte Perdido National Park aquifer system, north-eastern Spain

The time series of stable water isotope composition relative to meteorological stations and springs located in the high mountainous zone of the Ordesa and Monte Perdido National Park are analyzed in order to study how the seasonal isotopic content of precipitation propagates through the hydrogeological system in terms of the aquifer recharge zone elevation and transit time. The amplitude of the seasonal isotopic composition of precipitation and the mean isotopic content in rainfall vary along a vertical transect, with altitudinal slopes for d18O of 0.9‰/km for seasonal amplitude and - 2.2‰/km for isotopic content. The main recharge zone elevation for the sampled springs is between 1950 and 2600 m·a.s.l. The water transit time for the sampled springs ranges from 1.1 to 4.5 yr, with an average value of 1.85 yr and a standard deviation of 0.8 yr. The hydrological system tends to behave as a mixing reservoir.Peer ReviewedPostprint (author's final draft

Dental profile of patients with Gaucher disease

BACKGROUND: This study was conducted to determine whether patients with Gaucher disease had significant dental pathology because of abnormal bone structure, pancytopenia, and coagulation abnormalities. METHODS: Each patient received a complete oral and periodontal examination in addition to a routine hematological evaluation. RESULTS: Gaucher patients had significantly fewer carious lesions than otherwise healthy carriers. Despite prevalence of anemia, there was no increase in gingival disease; despite the high incidence of thrombocytopenia, gingival bleeding was not noted; and despite radiological evidence of bone involvement, there was no greater incidence loss of teeth or clinical tooth mobility. CONCLUSIONS: These data represent the first survey of the oral health of a large cohort of patients with Gaucher disease. It is a pilot study of a unique population and the results of the investigation are indications for further research. Based on our findings, we recommend regular oral examinations with appropriate dental treatment for patients with Gaucher disease as for other individuals. Consultation between the dentist and physician, preferably one with experience with Gaucher disease, should be considered when surgical procedures are planned

Low-density lipoprotein cholesterol goal achievement in patients with familial hypercholesterolemia in countries outside Western Europe: the International ChoLesterol management Practice Study

Santos, Raul D./0000-0002-9860-6582; Al-Rasadi, Khalid/0000-0003-0460-1236WOS: 000488415700012PubMed: 31208705BACKGROUND: the cross-sectional observational International ChoLesterol management Practice Study study assessed achievement of European Society of Cardiology/European Atherosclerosis Society low-density lipoprotein cholesterol (LDL-C) targets in patients outside Western Europe. OBJECTIVE: the aim of the study was to assess LDL-C goal achievement in International ChoLesterol management Practice Study participants with familial hypercholesterolemia (FH). METHODS: A total of 334 patients (aged >= 18 years) with definite or probable FH (Dutch Lipid Clinic Network score >= 6; 43.1% genetically confirmed) who had been receiving stable lipid modifying therapy (LMT) for >= 3 months were enrolled. RESULTS: the mean standard deviation age of the patients was 58.5 +/- 13.1 years, 49.1% were male, and 48.2% had coronary artery disease. Most were receiving statin (similar to 99%). of these, 57.6% were on high-intensity statin therapy, 49.1% on the highest dose available, and 13.0% used a statin together with a cholesterol absorption inhibitor (CAI). Mean +/- standard deviation LDL-C level was 5.6 +/- 3.0 mmol/L before LMT and 3.3 +/- 2.0 mmol/L at enrollment. Overall, 32.0% of patients achieved their LDL-C target. Target achievement rates were 36.6% for patients with coronary artery disease, and 27.5% for those without, and 27.9%, 28.0%, and 37.5% for patients treated with a statin plus CAI, highest-dose statin (no CAI), and lower-dose statin (no CAI), respectively. CONCLUSIONS: LDL-C target achievement rates were low in patients with FH, even in those receiving intensive LMT. Factors that are likely to have contributed to the low LDL-C target achievement rates include high baseline LDL-C, inadequate statin dosages, and low use of CAI. Many patients would have been eligible for proprotein convertase subtilisin/kexin type 9 inhibitor therapy. (C) 2019 National Lipid Association. Published by Elsevier Inc.Sanofi, FranceSanofi-AventisThis work was supported by Sanofi, France

Vertical variation in the amplitude of the seasonal isotopic content of rainfall as a tool to jointly estimate the groundwater recharge zone and transit times in the Ordesa and Monte Perdido National Park aquifer system, north-eastern Spain

The time series of stable water isotope composition relative to meteorological stations and springs located in the high mountainous zone of the Ordesa and Monte Perdido National Park are analyzed in order to study how the seasonal isotopic content of precipitation propagates through the hydrogeological system in terms of the aquifer recharge zone elevation and transit time. The amplitude of the seasonal isotopic composition of precipitation and the mean isotopic content in rainfall vary along a vertical transect, with altitudinal slopes for d18O of 0.9‰/km for seasonal amplitude and - 2.2‰/km for isotopic content. The main recharge zone elevation for the sampled springs is between 1950 and 2600 m·a.s.l. The water transit time for the sampled springs ranges from 1.1 to 4.5 yr, with an average value of 1.85 yr and a standard deviation of 0.8 yr. The hydrological system tends to behave as a mixing reservoir.Peer Reviewe