The contribution of multiparametric pelvic and whole-body MRI to interpretation of \u3csup\u3e18\u3c/sup\u3eF-fluoromethylcholine or \u3csup\u3e68\u3c/sup\u3eGa-HBED-CC PSMA-11 PET/CT in patients with biochemical failure after radical prostatectomy

Our purpose was to assess whether the addition of data from multiparametric pelvic MRI (mpMR) and whole-body MRI (wbMR) to the interpretation of F-fluoromethylcholine ( F-FCH) or Ga-HBED-CC PSMA-11 ( Ga-PSMA) PET/CT (5PET) improves the detection of local tumor recurrence or of nodal and distant metastases in patients after radical prostatectomy with biochemical failure. Methods: The current analysis was performed as part of a prospective, multicenter trial on F-FCH or Ga-PSMA PET, mpMR, and wbMR. Eligible men had an elevated level of prostate-specific antigen (PSA) (.0.2 ng/mL) and high-risk features (Gleason score . 7, PSA doubling time, 10 mo, or PSA . 1.0 ng/mL) with negative or equivocal conventional imaging results. PET was interpreted with mpMR and wbMR in consensus by 2 radiologists and compared with prospective interpretation of PET or MRI alone. Performance measures of each modality (PET, MRI, and PET/mpMR-wbMR) were compared for each radiotracer and each individual patient (for F-FCH, or Ga-PSMA for patients who had Ga-PSMA PET) and to a composite reference standard. Results: There were 86 patients with PET ( F-FCH [n 5 76] and/or Ga-PSMA [n 5 26]) who had mpMR and wbMR. Local tumor recurrence was detected in 20 of 76 (26.3%) on F-FCH PET/ mpMR, versus 11 of 76 (14.5%) on F-FCH PET (P 5 0.039), and in 11 of 26 (42.3%) on Ga-PSMA PET/mpMR, versus 6 of 26 (23.1%) on Ga-PSMA PET (P 5 0.074). Per patient, PET/ mpMR was more often positive for local tumor recurrence than PET (P 5 0.039) or mpMR (P 5 0.019). There were 20 of 86 patients (23.3%) with regional nodal metastases on both PET/wbMR and PET (P 5 1.0) but only 12 of 86 (14%) on wbMR (P 5 0.061). Similarly, there were more nonregional metastases detected on PET/wbMR than on PET (P 5 0.683) or wbMR (P 5 0.074), but these differences did not reach significance. Compared with the composite reference standard for the detection of disease beyond the prostatic fossa, PET/wbMR, PET, and wbMR had sensitivity of 50%, 50%, and 8.3%, respectively, and specificity of 97.1%, 97.1%, and 94.1%, respectively. Conclusion: Interpretation of PET/mpMR resulted in a higher detection rate for local tumor recurrence in the prostatic bed in men with biochemical failure after radical prostatectomy. However, the addition of wbMR to F-FCH or Ga-PSMA PET did not improve detection of regional or distant metastases. 18 18 68 68 18 68 18 68 68 18 68 18 18 68 68 18 6