One-step generation of high-quality squeezed and EPR states in cavity QED

We show how to generate bilinear (quadratic) Hamiltonians in cavity quantum electrodynamics (QED) through the interaction of a single driven three-level atom with two (one) cavity modes. With this scheme it is possible to generate one-mode mesoscopic squeezed superpositions, two-mode entanglements, and two-mode squeezed vacuum states (such the original EPR state), without the need for Ramsey zones and external parametric amplification. The degree of squeezing achieved is up to 99% with currently feasible experimental parameters and the errors due to dissipative mechanisms become practically negligible

Hard scattering and jets--from p-p collisions in the 1970's to Au+Au collisions at RHIC

Hard scattering in p-p collisions, discovered at the CERN ISR in 1972 by the method of leading particles, proved that the partons of Deeply Inelastic Scattering strongly interacted with each other. Further ISR measurements utilizing inclusive single or pairs of hadrons established that high pT particles are produced from states with two roughly back-to-back jets which are the result of scattering of constituents of the nucleons as described by Quantum Chromodynamics (QCD), which was developed during the course of these measurements. These techniques, which are the only practical method to study hard-scattering and jet phenomena in Au+Au central collisions, are reviewed, with application to measurements at RHIC.Comment: 4 pages, 5 figures, Proceedings of Hard Probes 2004, International Conference on Hard and Electromagnetic Probes of High Energy Nuclear Collisions, Nov 4-10, 2004, to appear in EPJ

Higher-Order Corrections to Instantons

The energy levels of the double-well potential receive, beyond perturbation theory, contributions which are non-analytic in the coupling strength; these are related to instanton effects. For example, the separation between the energies of odd- and even-parity states is given at leading order by the one-instanton contribution. However to determine the energies more accurately multi-instanton configurations have also to be taken into account. We investigate here the two-instanton contributions. First we calculate analytically higher-order corrections to multi-instanton effects. We then verify that the difference betweeen numerically determined energy eigenvalues, and the generalized Borel sum of the perturbation series can be described to very high accuracy by two-instanton contributions. We also calculate higher-order corrections to the leading factorial growth of the perturbative coefficients and show that these are consistent with analytic results for the two-instanton effect and with exact data for the first 200 perturbative coefficients.Comment: 7 pages, LaTe

Robust and fragile Werner states in the collective dephasing

We investigate the concurrence and Bell violation of the standard Werner state or Werner-like states in the presence of collective dephasing. It is shown that the standard Werner state and certain kinds of Werner-like states are robust against the collective dephasing, and some kinds of Werner-like states is fragile and becomes completely disentangled in a finite-time. The threshold time of complete disentanglement of the fragile Werner-like states is given. The influence of external driving field on the finite-time disentanglement of the standard Werner state or Werner-like states is discussed. Furthermore, we present a simple method to control the stationary state entanglement and Bell violation of two qubits. Finally, we show that the theoretical calculations of fidelity based on the initial Werner state assumption well agree with previous experimental results.Comment: 7 pages, 6 figures, 1 table, RevTex4, Accepted by EPJ

Author Correction: CHD3 helicase domain mutations cause a neurodevelopmental syndrome with macrocephaly and impaired speech and language.

© 2019, The Author(s). The original version of this Article contained an error in the spelling of the author Laurence Faivre, which was incorrectly given as Laurence Faive. This has now been corrected in both the PDF and HTML versions of the Article

Longitudinal Changes in Health-Related Quality of Life in Primary Glomerular Disease: Results From the CureGN Study

© 2020 Introduction: Prior cross-sectional studies suggest that health-related quality of life (HRQOL) worsens with more severe glomerular disease. This longitudinal analysis was conducted to assess changes in HRQOL with changing disease status. Methods: Cure Glomerulonephropathy (CureGN) is a cohort of patients with minimal change disease, focal seNorthwell Healthntal glomerulosclerosis, membranous nephropathy, IgA vasculitis, or IgA nephropathy. HRQOL was assessed at enrollment and follow-up visits 1 to 3 times annually for up to 5 years with the Patient-Reported Outcomes Measurement Information System (PROMIS). Global health, anxiety, and fatigue domains were measured in all; mobility was measured in children; and sleep-related impairment was measured in adults. Linear mixed effects models were used to evaluate HRQOL responsiveness to changes in disease status. Results: A total of 469 children and 1146 adults with PROMIS scores were included in the analysis. HRQOL improved over time in nearly all domains, though group-level changes were modest. Edema was most consistently associated with worse HRQOL across domains among children and adults. A greater number of symptoms also predicted worse HRQOL in all domains. Sex, age, obesity, and serum albumin were associated with some HRQOL domains. The estimated glomerular filtration rate (eGFR) was only associated with fatigue and adult physical health; proteinuria was not associated with any HRQOL domain in adjusted models. Conclusion: HRQOL measures were responsive to changes in disease activity, as indicated by edema. HRQOL over time was not predicted by laboratory-based markers of disease. Patient-reported edema and number of symptoms were the strongest predictors of HRQOL, highlighting the importance of the patient experience in glomerular disease. HRQOL outcomes inform understanding of the patient experience for children and adults with glomerular diseases

Electric and magnetic form factors of strange baryons

Predictions for the electromagnetic form factors of the Lambda$, Sigma and Xi hyperons are presented. The numerical calculations are performed within the framework of the fully relativistic constituent-quark model developed by the Bonn group. The computed magnetic moments compare favorably with the experimentally known values. Most magnetic form factors G_M(Q^2) can be parametrized in terms of a dipole with cutoff masses ranging from 0.79 to 1.14 GeV.Comment: 15 pages, 8 figures, 3 tables, submitted to Eur. Phys. J.

The BIN1 rs744373 SNP is associated with increased tau-PET levels and impaired memory

© 2019, The Author(s). The single nucleotide polymorphism (SNP) rs744373 in the bridging integrator-1 gene (BIN1) is a risk factor for Alzheimer’s disease (AD). In the brain, BIN1 is involved in endocytosis and sustaining cytoskeleton integrity. Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown. Here we find in 89 older individuals without dementia, that BIN1 rs744373 risk-allele carriers show higher AV1451 tau-PET across brain regions corresponding to Braak stages II–VI. In contrast, the BIN1 rs744373 SNP was not associated with AV45 amyloid-PET uptake. Furthermore, the rs744373 risk-allele was associated with worse memory performance, mediated by increased global tau levels. Together, our findings suggest that the BIN1 rs744373 SNP is associated with increased tau but not beta-amyloid pathology, suggesting that alterations in BIN1 may contribute to memory deficits via increased tau pathology

S_3 Flavor Symmetry and Leptogenesis

We consider leptogenesis in a minimal S_3 extension of the standard model with an additional Z_2 symmetry in the leptonic sector. It is found that the CP phase appearing in the neutrino mixing is the same as that for the CP asymmetries responsible for leptogenesis. Because of the discrete S_3 x Z_2 flavor symmetries, the CP asymmetries are strongly suppressed. We therefore assume that the resonant enhancement of the CP asymmetries takes place to obtain a realistic size of baryon number asymmetry in theuniverse. Three degenerate right-handed neutrino masses of O(10) TeV are theoretically expected in this model.Comment: 25 pages, 3 figure

AMPA receptor GluA2 subunit defects are a cause of neurodevelopmental disorders

© 2019, The Author(s). AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4 subunits encoded by GRIA1-4 genes. GluA2 has an especially important role because, following post-transcriptional editing at the Q607 site, it renders heteromultimeric AMPARs Ca2+-impermeable, with a linear relationship between current and trans-membrane voltage. Here, we report heterozygous de novo GRIA2 mutations in 28 unrelated patients with intellectual disability (ID) and neurodevelopmental abnormalities including autism spectrum disorder (ASD), Rett syndrome-like features, and seizures or developmental epileptic encephalopathy (DEE). In functional expression studies, mutations lead to a decrease in agonist-evoked current mediated by mutant subunits compared to wild-type channels. When GluA2 subunits are co-expressed with GluA1, most GRIA2 mutations cause a decreased current amplitude and some also affect voltage rectification. Our results show that de-novo variants in GRIA2 can cause neurodevelopmental disorders, complementing evidence that other genetic causes of ID, ASD and DEE also disrupt glutamatergic synaptic transmission