Planning strategies for inter-fractional robustness in pancreatic patients treated with scanned carbon therapy

Background: Managing inter-fractional anatomy changes is a challenging task in radiotherapy of pancreatic tumors, especially in scanned carbon-ion delivery. This treatment planning study aims to focus on clinically feasible solutions, such as the beam angle selection and margin design to increase the robustness against inter-fractional uncertainties. Methods: This study included 10 patients with weekly 3D-CT imaging and physician-approved Clinical Target Volume (CTV). The study was directed to keep the CTV-coverage using six beam angle configurations in combination with different Internal Target Volume (ITV) concepts. These were: geometric-margin (symmetric 3 and 5 mm margin); range-equivalent margins with an isotropic HU replacement; and to evaluate the need of asymmetric margins the water-equivalent range path (WEPL) was determined per patient from the set of CTs. Plan optimization and forward dose calculation in each week-CT were performed with the research treatment planning system TRiP98 and the plan quality evaluated in terms of CTV coverage (V95CTV) and homogeneity dose (HCTV = D5-D95). Results: The beam geometry had a substantial impact on the target irradiation over the treatment course, with the single posterior or two beams showing the best average coverage of the CTV. The use of geometric margins for the more robust beam geometries showed acceptable results, with a V95CTV of (99.2 ± 1.2)% for the 5 mm-margin. For the non-robust configurations, due to substantial changes in the radiological depth, the use of this margin results in a V95CTV that might be below 80%, only showing improvement when the range changes are included. Conclusions: Selection of adequate beam configurations and treatment margins in ion-beam therapy of pancreatic tumors is of great importance. For a single posterior beam or two beam configurations, application of geometrical margins compensate for dose degradation induced by inter-fractional anatomy changes for the majority of the analyzed treatment fractions

Complex Classical Fields: A Framework for Reflection Positivity

We explore a framework for complex classical fields, appropriate for describing quantum field theories. Our fields are linear transformations on a Hilbert space, so they are more general than random variables for a probability measure. Our method generalizes Osterwalder and Schrader's construction of Euclidean fields. We allow complex-valued classical fields in the case of quantum field theories that describe neutral particles. From an analytic point-of-view, the key to using our method is reflection positivity. We investigate conditions on the Fourier representation of the fields to ensure that reflection positivity holds. We also show how reflection positivity is preserved by various space-time compactifications of Euclidean space.Comment: 30 page

Influence of local surface albedo variability and ice crystal shape on passive remote sensing of thin cirrus

Airborne measurements of solar spectral radiance reflected by cirrus are performed with the HALO-Solar Radiation (HALO-SR) instrument onboard the High Altitude and Long Range Research Aircraft (HALO) in November 2010. The data are used to quantify the influence of surface albedo variability on the retrieval of cirrus optical thickness and crystal effective radius. The applied retrieval of cirrus optical properties is based on a standard two-wavelength approach utilizing measured and simulated reflected radiance in the visible and near-infrared spectral region. Frequency distributions of the surface albedos from Moderate resolution Imaging Spectroradiometer (MODIS) satellite observations are used to compile surface-albedo-dependent lookup tables of reflected radiance. For each assumed surface albedo the cirrus optical thickness and effective crystal radius are retrieved as a function of the assumed surface albedo. The results for the cirrus optical thickness are compared to measurements from the High Spectral Resolution Lidar (HSRL). The uncertainty in cirrus optical thickness due to local variability of surface albedo in the specific case study investigated here is below 0.1 and thus less than that caused by the measurement uncertainty of both instruments. It is concluded that for the retrieval of cirrus optical thickness the surface albedo variability is negligible. However, for the retrieval of crystal effective radius, the surface albedo variability is of major importance, introducing uncertainties up to 50%. Furthermore, the influence of the bidirectional reflectance distribution function (BRDF) on the retrieval of crystal effective radius was investigated and quantified with uncertainties below 10%, which ranges below the uncertainty caused by the surface albedo variability. The comparison with the independent lidar data allowed for investigation of the role of the crystal shape in the retrieval. It is found that if assuming aggregate ice crystals, the HSRL observations fit best with the retrieved optical thickness from HALO-SR

Forest albedo in the context of different cloud situations derived from irradiance measurements at the Leipzig floodplain crane: A pilot study

The surface albedo significantly modulates the atmospheric energy budget and, thus, vertical radiation, energy, and mass fluxes. Therefore, it regulates the local and regional effects of climate warming. Over a forest canopy, the surface albedo mainly depends on the seasonal leaf state. Furthermore, for certain surface types, such as snow, it has been shown that the surface albedo changes as a function of cloudiness. A similar effect is expected over forest surfaces, leading to complex feedback loops between forest surfaces and climate. To investigate these processes, a pilot study was performed at the Leipzig floodplain crane to observe the forest canopy albedo under different atmospheric conditions in 2021. First analyses revealed a dependency of the forest albedo from the cloud state, which is slightly stronger in the near-infrared wavelength range compared to the visible wavelength range.Der atmosphärische Strahlungshaushalt und damit auch die vertikale Strahlungsverteilung, Energie- und Massenflüsse werden signifikant durch die Bodenalbedo gesteuert. Diese regulieren somit lokale und regionale Effekte der Klimaerwärmung. Über einem Wald hängt die Bodenalbedo hauptsächlich vom saisonalen Blattstatus ab. Zudem wurde für bestimmte Bodentypen wie Schneeoberflächen gezeigt, dass die Bodenalbedo eine Funktion der Bewölkung ist. Ähnlicher Effekte werden für Waldoberflächen erwartet, welche zu komplexen Rückkopplungseffekten zwischenWaldoberflächen und dem Klima führen. Um diese Prozesse zu untersuchen wurde im Jahr 2021 eine Vorstudie am Leipziger Auwaldkran durchgeführt, um die Waldalbedo unter verschiedenen atmosphärischen Bedingungen zu beobachten. Erste Analysen zeigen, dass auch die Albedo des Waldes von den Bewölkungsbedingungen abhängt. Der Effekt ist dabei etwas stärker im nah-infrarotem als im sichtbaren Wellenlängenbereich zu beobachten

Parameterizing anisotropic reflectance of snow surfaces from airborne digital camera observations in Antarctica

The surface reflection of solar radiation comprises an important boundary condition for solar radiative transfer simulations. In polar regions above snow surfaces, the surface reflection is particularly anisotropic due to low Sun elevations and the highly anisotropic scattering phase function of the snow crystals. The characterization of this surface reflection anisotropy is essential for satellite remote sensing over both the Arctic and Antarctica. To quantify the angular snow reflection properties, the hemispherical-directional reflectance factor (HDRF) of snow surfaces was derived from airborne measurements in Antarctica during austral summer in 2013/14. For this purpose, a digital 180∘ fish-eye camera (green channel, 490–585 nm wavelength band) was used. The HDRF was measured for different surface roughness conditions, optical-equivalent snow grain sizes, and solar zenith angles. The airborne observations covered an area of around 1000 km × 1000 km in the vicinity of Kohnen Station (75∘0′ S, 0∘4′ E) at the outer part of the East Antarctic Plateau. The observations include regions with higher (coastal areas) and lower (inner Antarctica) precipitation amounts and frequencies. The digital camera provided upward, angular-dependent radiance measurements from the lower hemisphere. The comparison of the measured HDRF derived for smooth and rough snow surfaces (sastrugi) showed significant differences, which are superimposed on the diurnal cycle. By inverting a semi-empirical kernel-driven bidirectional reflectance distribution function (BRDF) model, the measured HDRF of snow surfaces was parameterized as a function of solar zenith angle, surface roughness, and optical-equivalent snow grain size. This allows a direct comparison of the HDRF measurements with the BRDF derived from the Moderate Resolution Imaging Spectroradiometer (MODIS) satellite product MCD43. For the analyzed cases, MODIS observations (545–565 nm wavelength band) generally underestimated the anisotropy of the surface reflection. The largest deviations were found for the volumetric model weight fvol (average underestimation by a factor of 10). These deviations are likely linked to short-term changes in snow properties

Influence of 68Ga-DOTATOC on sparing of normal tissue for radiation therapy of skull base meningioma: differential impact of photon and proton radiotherapy

Background: To evaluate the impact of 68Ga-DOTATOC-PET on treatment planning and sparing of normal tissue in the treatment of skull base meningioma with advanced photons and protons. Methods: From the institutional database consisting of 507 skull base meningiomas 10 patients were chosen randomly for the present analysis. Target volume definition was performed based on CT and MRI only, as well as with additional 68Ga-DOTATOC-PET. Treatment plans were performed for Intensity Modulated Radiotherapy (IMRT) and proton therapy using active raster scanning on both target volumes. We calculated doses to relevant organs at risk (OAR), conformity indices as well as differences in normal tissue sparing between both radiation modalities based on CT/MRI planning as well as CT/MRI/PET planning. Results: For photon treatment plans, PET-based treatment plans showed a reduction of brain stem Dmax and Dmedian for different levels of total dose. At the optic chiasm, use of 68Ga-DOTATOC significantly reduces Dmax; moreover, the Dmedian is reduced in most cases, too. For both right and left optic nerve, reduction of dose by addition of 68Ga-DOTATOC-PET is minimal and depends on the anatomical location of the meningioma. In protons, the impact of 68Ga-DOTATOC-PET is minimal compared to photons. Conclusion: Addition of 68Ga-DOTATOC-PET information into treatment planning for skull base meningiomas has a significant impact on target volumes. In most cases, PET-planning leads to significant reductions of the treatment volumes. Subsequently, reduced doses are applied to OAR. Using protons, the benefit of additional PET is smaller since target coverage is more conformal and dose to OAR is already reduced compared to photons. Therefore, PET-imaging has the greatest margin of benefit in advanced photon techniques, and combination of PET-planning and high-precision treatment leads to comparable treatment plans as with protons

Comparison of intensity modulated radiotherapy (IMRT) with intensity modulated particle therapy (IMPT) using fixed beams or an ion gantry for the treatment of patients with skull base meningiomas

<p>Abstract</p> <p>Background</p> <p>To examine the potential improvement in treatment planning for patients with skull base meningioma using IMRT compared to carbon ion or proton beams with and without a gantry.</p> <p>Methods</p> <p>Five patients originally treated with photon IMRT were selected for the study. Ion beams were chosen using a horizontal beam or an ion gantry. Intensity controlled raster scanning and the intensity modulated particle therapy mode were used for plan optimization. The evaluation included analysis of dose-volume histograms of the target volumes and organs at risk.</p> <p>Results</p> <p>In comparison with carbon and proton beams only with horizontal beams, carbon ion treatment plans could spare the OARs more and concentrated on the target volumes more than proton and photon IMRT treatment plans. Using only a horizontal fixed beam, satisfactory plans could be achieved for skull base tumors.</p> <p>Conclusion</p> <p>The results of the case studies showed that using IMPT has the potential to overcome the lack of a gantry for skull base tumors. Carbon ion plans offered slightly better dose distributions than proton plans, but the differences were not clinically significant with established dose prescription concepts.</p

Adaption of the MODIS aerosol retrieval algorithm using airborne spectral surface reflectance measurements over urban areas: A case study

MODIS (MOderate-resolution Imaging Spectroradiometer) retrievals of aerosol optical depth (AOD) are biased over urban areas, primarily because the reflectance characteristics of urban surfaces are different than that assumed by the retrieval algorithm. Specifically, the operational "dark-target" retrieval is tuned towards vegetated (dark) surfaces and assumes a spectral relationship to estimate the surface reflectance in blue and red wavelengths. From airborne measurements of surface reflectance over the city of Zhongshan, China, were collected that could replace the assumptions within the MODIS retrieval algorithm. The subsequent impact was tested upon two versions of the operational algorithm, Collections 5 and 6 (C5 and C6). AOD retrieval results of the operational and modified algorithms were compared for a specific case study over Zhongshan to show minor differences between them all. However, the Zhongshan-based spectral surface relationship was applied to a much larger urban sample, specifically to the MODIS data taken over Beijing between 2010 and 2014. These results were compared directly to ground-based AERONET (AErosol RObotic NETwork) measurements of AOD. A significant reduction of the differences between the AOD retrieved by the modified algorithms and AERONET was found, whereby the mean difference decreased from 0.27±0.14 for the operational C5 and 0.19±0.12 for the operational C6 to 0.10±0.15 and -0.02±0.17 by using the modified C5 and C6 retrievals. Since the modified algorithms assume a higher contribution by the surface to the total measured reflectance from MODIS, consequently the overestimation of AOD by the operational methods is reduced. Furthermore, the sensitivity of the MODIS AOD retrieval with respect to different surface types was investigated. Radiative transfer simulations were performed to model reflectances at top of atmosphere for predefined aerosol properties. The reflectance data were used as input for the retrieval methods. It was shown that the operational MODIS AOD retrieval over land reproduces the AOD reference input of 0.85 for dark surface types (retrieved AOD = 0.87 (C5)). An overestimation of AOD = 0.99 is found for urban surfaces, whereas the modified C5 algorithm shows a good performance with a retrieved value of AOD = 0.86

Optimization of carbon ion and proton treatment plans using the raster-scanning technique for patients with unresectable pancreatic cancer

Background: The aim of the thesis is to improve radiation plans of patients with locally advanced, unresectable pancreatic cancer by using carbon ion and proton beams. Patients and methods: Using the treatment planning system Syngo RT Planning (Siemens, Erlangen, Germany) a total of 50 treatment plans have been created for five patients with the dose schedule 15 × 3 Gy(RBE). With reference to the anatomy, five field configurations were considered to be relevant. The plans were analyzed with respect to dose distribution and individual anatomy, and compared using a customized index. Results: Within the index the three-field configurations yielded the best results, though with a high variety of score points (field setup 5, carbon ion: median 74 (range 48–101)). The maximum dose in the myelon is low (e.g. case 3, carbon ion: 21.5 Gy(RBE)). A single posterior field generally spares the organs at risk, but the maximum dose in the myelon is high (e.g. case 3, carbon ion: 32.9 Gy(RBE)). Two oblique posterior fields resulted in acceptable maximum doses in the myelon (e.g. case 3, carbon ion: 26.9 Gy(RBE)). The single-field configuration and the two oblique posterior fields had a small score dispersion (carbon ion: median 66 and 58 (range 62–72 and 40–69)). In cases with topographic proximity of the organs at risk to the target volume, the single-field configuration scored as well as the three-field configurations. Conclusion: In summary, the three-field configurations showed the best dose distributions. A single posterior field seems to be robust and beneficial in case of difficult topographical conditions and topographical proximity of organs at risk to the target volume. A setup with two oblique posterior fields is a reasonable compromise between three-field and single-field configurations