DEVELOPMENT OF SIMULATION-BASED FRAGILITY RELATIONSHIPS FOR THE SEISMIC RISK ASSESSMENT OF BUILDINGS

A number of driving engines are required for earthquake loss estimation and mitigation, including an inventory of exposed systems, seismic hazards of the study area and fragility relationships. The number of existing buildings in the UAE that may be at risk because of insufficient seismic design provisions cannot be underestimated. A crucial role in the recovery period following an earthquake is also played by emergency facilities. Therefore, a systematic seismic vulnerability assessment of a diverse range of reference structures representing pre-seismic code buildings and emergency facilities, in a highly populated and seismically active area in the UAE, has been conducted in this study. Detailed structural design and fiberbased modeling were carried out for nine reference structures. Forty earthquake records were selected to represent potential earthquake scenarios in the study area. Three limit states, namely Immediate Occupancy, Life Safety and Collapse Prevention, were selected based on inelastic analysis results as well as the values recommended in previous studies and code provisions. Over 8000 inelastic pushover and incremental dynamic analyses are performed to assess the lateral capacity and to derive a wide range of fragility relationships for the reference structures. Vulnerability functions were also developed for the buildings that proved to have unsatisfactory performance, and hence proposed to be retrofitted using different mitigation techniques. It was concluded that pre-code structures were significantly more vulnerable than emergency facilities. This is particularly true for low-rise buildings due to their inefficient lateral force resisting systems. Far-field records have much higher impact compared with near-source ground motions. The results reflect the pressing need for the seismic retrofit of pre-code structures to reduce the probability of collapse, and for certain emergency facilities to ensure their continued vii service. Four retrofit approaches are therefore assessed, namely reinforced concrete jacketing, fiber reinforced polymers wrapping, adding buckling restrained braces and installing externally unbonded steel plates. The highest positive impact of retrofit are observed on the pre-code buildings, especially frame structures, since they were only designed to resist gravity and wind loads. The reductions achieved in the vulnerability of the retrofitted structures confirmed the effectiveness of the techniques selected for upgrading the seismic performance of buildings and mitigating earthquake losses in the study area

Prevalence of Salmonella species from poultry eggs of local stores in Duhok

Background: Salmonellosis is one of the foodborne illness acquired by consumption of infected raw or undercooked eggs and causes major public health problem. The aim of this study was isolation and identification of Salmonella spp. from the eggshells and the egg contents samples.Methods: In this study, a total 350 eggs were randomly collected from five local stores in Duhok and Zakho city over a period of 6 months in summer of 2016. Eggs from each local store were collected and transferred to the microbiology laboratory. The conventional culture method used for detection of Salmonella spp.Results: Out of the 350 eggs, seventeen (4.85%) samples of eggshells contaminated with Salmonella spp. and none of the egg content samples were contaminated with Salmonella genus. Out of 17 positive eggs, three different Salmonella serotypes were identified including; Salmonella enteritidis (10 strains), Salmonella typhimurium (5 strains), Salmonella typhi (2 strains).Conclusions: The results of the present study provide the recent dataset of the prevalence of Salmonella spp. in eggs sold at local stores in the city. All isolates showed resistant to tetracycline, oxacillin and sulphadimethoxazole due to the indiscriminate use of these antibiotics in chicken at sub-therapeutic level or prophylactic doses which promotes selection of antimicrobial resistant strains and also increases the human health risks associated with consumption of contaminated quail eggs. To the best of our knowledge, this is the first study in Zakho- Duhok city, investigating the occurrence of Salmonella spp. in eggshell and content egg sold at local stores

From Ad-Hoc Data Analytics to DataOps

The collection of high-quality data provides a key competitive advantage to companies in their decision-making process. It helps to understand customer behavior and enables the usage and deployment of new technologies based on machine learning. However, the process from collecting the data, to clean and process it to be used by data scientists and applications is often manual, non-optimized and error-prone. This increases the time that the data takes to deliver value for the business. To reduce this time companies are looking into automation and validation of the data processes. Data processes are the operational side of data analytic workflow.DataOps, a recently coined term by data scientists, data analysts and data engineers refer to a general process aimed to shorten the end-to-end data analytic life-cycle time by introducing automation in the data collection, validation, and verification process. Despite its increasing popularity among practitioners, research on this topic has been limited and does not provide a clear definition for the term or how a data analytic process evolves from ad-hoc data collection to fully automated data analytics as envisioned by DataOps.This research provides three main contributions. First, utilizing multi-vocal literature we provide a definition and a scope for the general process referred to as DataOps. Second, based on a case study with a large mobile telecommunication organization, we analyze how multiple data analytic teams evolve their infrastructure and processes towards DataOps. Also, we provide a stairway showing the different stages of the evolution process. With this evolution model, companies can identify the stage which they belong to and also, can try to move to the next stage by overcoming the challenges they encounter in the current stage

Histone deacetylase inhibitors in Hodgkin lymphoma

Although Hodgkin lymphoma (HL) is considered one of the most curable human cancers, the treatment of patients with relapsed and refractory disease, especially those who relapse after autologous stem cell transplantation, remains challenging. Furthermore, because of the young age of these patients, the impact of early mortality on the number of years lost from productive life is remarkable. Patients with relapsed HL post stem cell transplantation currently have no curative therapy, and are in need for new drugs and novel treatment strategies. While no new drugs have been approved for the treatment of patients with HL in more than three decades, several new agents are demonstrating promising results in early clinical trials. This review will focus on the emerging role of histone deacetylase inhibitors in patients with relapsed HL

In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs

Comment in Lowering the High Cost of Cancer Drugs--III. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--I. [Mayo Clin Proc. 2016] Lowering the High Cost of Cancer Drugs--IV. [Mayo Clin Proc. 2016] In Reply--Lowering the High Cost of Cancer Drugs. [Mayo Clin Proc. 2016] US oncologists call for government regulation to curb drug price rises. [BMJ. 2015

Impact of opioid-free analgesia on pain severity and patient satisfaction after discharge from surgery: multispecialty, prospective cohort study in 25 countries

Background: Balancing opioid stewardship and the need for adequate analgesia following discharge after surgery is challenging. This study aimed to compare the outcomes for patients discharged with opioid versus opioid-free analgesia after common surgical procedures.Methods: This international, multicentre, prospective cohort study collected data from patients undergoing common acute and elective general surgical, urological, gynaecological, and orthopaedic procedures. The primary outcomes were patient-reported time in severe pain measured on a numerical analogue scale from 0 to 100% and patient-reported satisfaction with pain relief during the first week following discharge. Data were collected by in-hospital chart review and patient telephone interview 1 week after discharge.Results: The study recruited 4273 patients from 144 centres in 25 countries; 1311 patients (30.7%) were prescribed opioid analgesia at discharge. Patients reported being in severe pain for 10 (i.q.r. 1-30)% of the first week after discharge and rated satisfaction with analgesia as 90 (i.q.r. 80-100) of 100. After adjustment for confounders, opioid analgesia on discharge was independently associated with increased pain severity (risk ratio 1.52, 95% c.i. 1.31 to 1.76; P < 0.001) and re-presentation to healthcare providers owing to side-effects of medication (OR 2.38, 95% c.i. 1.36 to 4.17; P = 0.004), but not with satisfaction with analgesia (beta coefficient 0.92, 95% c.i. -1.52 to 3.36; P = 0.468) compared with opioid-free analgesia. Although opioid prescribing varied greatly between high-income and low- and middle-income countries, patient-reported outcomes did not.Conclusion: Opioid analgesia prescription on surgical discharge is associated with a higher risk of re-presentation owing to side-effects of medication and increased patient-reported pain, but not with changes in patient-reported satisfaction. Opioid-free discharge analgesia should be adopted routinely