Gobernanza territorial y gestión de espacios turísticos en contextos de fuerte presión inmobiliaria. Análisis de buenas prácticas locales en la costa de Cádiz (España)

En la actualidad, el diagnóstico de los problemas que el desmesurado crecimiento urbano ha signifi cado para los espacios turísticos españoles está muy avanzado. Una línea novedosa de investigación será el análisis de los escasos ejemplos en los que, a diferencia de la tendencia general, desde las instancias locales se ha optado por un modelo de desarrollo turístico ajeno al mero crecimiento inmobiliario. Los casos de buenas prácticas seleccionados en la Costa de Cádiz muestran que estos surgen vinculados a dinámicas de escala local, en las que la aplicación de nuevos enfoques de gobernanza territorial ha jugado un papel esencial. A partir de esta constatación se realiza una aproximación al debate teórico sobre la gobernanza territorial, un análisis crítico de los documentos de planificación incidentes, una valoración de los procesos de participación desarrollados y, fi nalmente, a través del tratamiento con SIG de ortofotografías de diferentes años, una cuantificación en términos superfi ciales de la realidad territorial resultante en el ámbito de estudio.Diagnosis of the problems that excessive urban growth has meant for tourist destinations is Spain is currently well underway. A new line of research focuses on the analysis of the few examples where, bucking the general trend, local authorities have opted for a model of touristic development beyond mere real estate growth. Selected case studies of best practices along the Cadiz Coast show that their emergence is related to local dynamics, wherein the application of new approaches to territorial governance has played a core role. This fi nding is taken as the basis for an approach to the theoretical debate on territorial governance. In this work we provide a critical analysis of related planning documents, an assessment of the participation processes conducted, and fi nally, quantifi cation of the territorial reality, based on surfi cial land use, in the study area based on GIS processing of orthophotos from various years

La salida itinerante de Geografía

La Salida Itinerante de Geografía es un proyecto educativo transversal y extracurricular, consistente en la realización de una salida de campo de varios días de duración. A pie y por un espacio de carácter natural y rural, profesores y alumnos de la titulación de Geografía de la Universidad de Sevilla, previamente organizados en grupos de trabajo, analizan las principales claves territoriales del ámbito recorrido. Hasta la fecha se han realizado nueve ediciones, una en cada curso académico desde 2008. El objetivo de esta comunicación es mostrar las principales aportaciones didácticas de esta actividad, detectar sus fortalezas y debilidades, y exponer perspectivas de mejora en el futuro

Impact of the expression of human CTCF protein in 3D organization of the Saccharomyces cerevisiae genome

Motivation: Transcriptional regulation is particularly complex in animals and depends on long-range interactions between multiple distal enhancers and their target promoters. Thus, the 3D organization of the chromatin is critical to guarantee this interactions and to avoid the spurious ones. In different groups of animals, such as humans and other vertebrates, the protein CTCF works as an essential factor to control the 3D structure of the genome, regulating cohesin-mediated chromatin interactions and the formation of loops between distal enhancers and their target promoters. In contrast, this type of long-range cis-regulation and its associated 3D chromatin organization have not been observed in other eukaryotic lineages such as plants and fungi. Interestingly, CTCF is also absent from the genome of these non-animal species. To investigate how the origin of CTCF could have contributed to the evolution of long-range chromatin interactions in animals, we have used the model organism Saccharomyces cerevisiae to study the effects that the expression of CTCF may have on the 3D organization of a fungal genome that does not have distal cis-regulation.Methods: We are generating two different yeast strains. Both of them contain a plasmid expressing human CTCF under the control of the inducible galactose promoter, but one of the strains will be further modified by the introduction of a sequence containing binding sites for human CTCF through homologous recombination using sigma LTR sequences from the Ty3 retrotransposon.Results: We have already generated a yeast strain to express human CTCF, and this strain is able to survive when we induce CTCF expression with galactose. Furthermore, to confirm the expression of CTCF we have done a western blot. Finally, we have designed the sigma Ty3 construct to introduce CTCF binding sites by selecting a human DNA sequence associated to chromatin loop border.Conclusions: We have confirmed that S.cerevisiae is still viable when it expresses the CTCF protein. The CTCF protein. The next steps will be i) to synthetize the sigma Ty3 construct with CTCF sites and introduce it in the yeast genome, ii) to analize by ChIP-seq if CTCF is able to bind endogenous yeast regions or if it can only bind those sites introduced using the sigma Ty3 construct and iii) to study how the presence of CTCF with and without the insertion of human CTCF binding sites affects the 3D chromatin organization of S.cerevisiae

Endothelial C-type natriuretic peptide maintains vascular homeostasis

PMCID: PMC4151218Wellcome Trust (084449/Z/07/Z and 078496/Z/05/Z

Análisis arqueosismológico del conjunto arqueológico romano de Mulva- Munigua (Sevilla, España). Resultados preliminares

El conjunto arqueológico romano de Mulva-Munigua (Sevilla, España) presenta daños en las edificaciones que pueden ser interpretadas como resultado de la ocurrencia de un evento sísmico (Efectos Arqueológicos de los Terremotos: EAEs) a finales del siglo III A.D., fecha coincidente con el inicio del periodo de declive económico de este asentamiento romano. Para intentar establecer el posible origen sísmico de las deformaciones, se ha procedido al inventario y análisis de las estructuras deformadas presentes en el yacimiento. No obstante, algunas de estas deformaciones también se pueden interpretar como resultado de procesos gravitaciones asociados a la ladera Este de la colina sobre la que se sitúa parte del yacimiento. Las direcciones de máxima deformación (ey) obtenidas del análisis de EAEs indica dos direcciones preferentes de la deformación (o movimiento preferente del terreno): NNO-SSE y ENEOSO. Aunque los datos presentan una dispersión importante, se puede establecer que la orientación principal NNO-SSE es compatible con un evento sísmico situado en el borde norte del Valle del Guadalquivir. La orientación ENE-OSO podría relacionarse con un evento posterior, o más seguramente con procesos de ladera de carácter cosísmico o no.The Roman archaeological site of Mulva-Munigua (Sevilla, Spain) displays building damage features suggesting a seismic origin (Earthquake Archaeological Effects: EAEs). The proposed seismic event could be tentatively dated in the late 3rd century AD, coinciding with the beginning of the economic fall of the Roman Empire at Iberia. However, some of the recorded EAEs can be also interpreted as a result of intervening slope movements in the eastern hillslope of this roman site. The inventory and analysis of the proposed EAEs make possible to discern between seismic oriented damage and other causes. In spite of the data show a significant dispersion, their analysis result in two different orientations of maximum deformation (ey) or preferential ground movement: NNW-SSE and ENE-WSW. The main ey orientation (NNW-SSE) can be tentatively related to a seismic event occurred in the environs of the northern border of the Guadalquivir Depression. The secondary orientation (ENE-WSW) can be interpreted as a consequence of latter slope movements triggered (or not) by other ancient earthquakes

Game-based Networked Learning

Designing and analyzing learning experiences in non-formal contexts can be challenging, even for those with educational training. The challenge is more significant if the priorities include educational ideological bases or an specific type of educational vision. The DALI project (Data Literacy for Citizens) has the primary goal of offering Data Literacy learning experiences specifically designed for adults in non-formal educational contexts. With this goal in mind, and considering the social and material realities of the target participants –their needs, diversity, interests and cultures– the project combines two of the most promising pedagogical approaches nowadays: networked learning and playful learning. This short paper outlines the pedagogical vision underpinning our efforts to integrate both approaches into a set of strategies and resources, in other words, the principles and ideas driving the design of what is called in the project: Game-based Networked Learning (GBNL) experiences. In particular, we draw on both the Activity Centred Analysis and Design (ACAD) framework and the Transdisciplinary Model for Developing Game-Based Interventions. After reviewing key aspects of the theoretical grounds that define our understanding of educational uses of technology and game-based learning, the paper addresses critical considerations underpinning the adaptation of the ACAD framework in the planning of playful learning experiences. Thus, the paper outlines the main principles guiding the design of DALI experiences, dividing them into the three design areas established by ACAD: set design, epistemic design and social design. The ambition of this approach is to serve as a pedagogical and educational statement to guide valuable actions to improve other adult learning approaches

A First Approach to a Fuzzy Classification System for Age Estimation based on the Pubic Bone

The study of human remains suffers from a lack of information for determining a reliable estimation of the age of an individual. One of the most extended methods for this task was proposed in the twenties of the past century and is based on the analysis of the pubic bone. The method describes some age changes occurring in the pubic bone and establishes ten different age ranges with a description of the morphological aspect of the bone in each one of them. These descriptions are sometimes vague and there is not a systematic way for using the method. In this contribution we propose two different preliminary fuzzy rule-based classification system designs for age estimation from the pubic bone that consider the main morphological characteristics of the bone as independent and linguistic variables. So, we have identified the problem variables and we have defined the corresponding linguistic labels making use of forensic expert knowledge, that is also considered to design a decision support fuzzy system. A brief collection of pubic bones labeled by forensic anthropologists has been used for learning the second fuzzy rule-based classification system by means of a fuzzy decision tree. The experiments developed report a best performance of the latter approach

Short communication: The main factors affecting somatic cell count in organic dairy farming

Preventive management practices are essential for maintaining acceptable udder health status, especially in organic farming, in which the use of antimicrobials is restricted. The contribution of the following factors to somatic cell count (SCC) was assessed in 788 cows from 15 organically reared herds in northern Spain: milk production, lactation number, treatments applied, selective dry cow therapy and teat dipping routines. The data were examined by linear logistic regression. Lactation number was the main factor affecting logSCC (β= 0.339, p<0.001) followed in order of importance by milk production (β= -0.205, p<0.001), use of alternative treatments (β=0.153, p<0.001), selective dry cow therapy (β=0.120, p=0.005) and teat dipping routines (β=-0.076, p=0.028). However, the model only explained 17.0% of the total variation in SCC. This variable depends on factors other than those considered here, amongst which udder infection is probably one of the most important. Nonetheless, the study findings enabled us to determine the contribution of the main management factors that should be taken into account to improve udder health status on organic farms

Glucosa oral y leche materna como estrategia para reducción del dolor durante el procedimiento de punción del talón en recién nacidos

Introduction: This paper presents the results of a study on pain reduction in newborns that undergo painful medical procedures. This research analyzed the reactions of babies before and after the heel lance procedure, a diagnostic test performed to detect phenylketonuria. This test involved the extraction of a capillary blood sample with a heel lance, a medical procedure that is painful for neonates. Objective: The main objective of this research was to evaluate the effectiveness of a 24% oral glucose solution and breastfeeding during heal lance. Method: An experimental study was thus conducted on a sample of 93 newborns in the San Cecilio University Hospital in Granada in 2010. The babies in the sample were divided into three groups, depending on what they ingested during the heal lance. Results: The results obtained showed that there was an association between the difference in HR and the time before the newborn’s HR returned to normal after the heel lance (r = 0.562; p = 0.000). Moreover, a positive relation was found between the absolute difference in HR and the difference in oxygen saturation (OS) (r = 0.538; p = 0.000). Conclusion: The OS was found to be greater in the group of newborns that received breast milk.Introducción: Para la detección de la fenilcetonuria, se realiza la prueba diagnóstica que consiste en la extracción de una muestra de sangre capilar, mediante la punción del talón al recién nacido. Este proceder es muy doloroso para el neonato. Objetivo: Valorar la efectividad de la administración de glucosa oral al 24 % y lactancia materna durante la punción del talón en el recién nacido. Método: Se realizó un estudio experimental en una muestra de 93 recién nacidos del Hospital Clínico “San Cecilio” de Granada durante el año 2010. La muestra se distribuyó en tres grupos en función del tipo de ingesta administrada en la realización de la prueba del talón. Resultados: El estudio pone de manifiesto que existe asociación en la diferencia de la FC con el tiempo transcurrido hasta alcanzar la normalidad después de la punción (r = 0,562; p = 0,000). También se halló una relación positiva entre la diferencia absoluta en la FC y la diferencia en la Saturación de Oxígeno (SO) (r = 0,538; p = 0,000). Conclusión: La SO es mayor en el grupo de lactancia materna que en el resto; así como en el de glucosa oral 24% que en el de control

Embarazada con asma : ¿se puede tratar?

págs.: 127-141Capítulo incluido en el libro: Optimizando el abordaje del asma bronquial. Manuel Alcántara Villar (coordinador). Sevilla: Universidad Internacional de Andalucía, 2023. ISBN: 978-84-7993-396-8. Enlace: http://hdl.handle.net/10334/737