Particle systems with a singular mean-field self-excitation. Application to neuronal networks

We discuss the construction and approximation of solutions to a nonlinear McKean-Vlasov equation driven by a singular self-excitatory interaction of the mean-field type. Such an equation is intended to describe an infinite population of neurons which interact with one another. Each time a proportion of neurons 'spike', the whole network instantaneously receives an excitatory kick. The instantaneous nature of the excitation makes the system singular and prevents the application of standard results from the literature. Making use of the Skorohod M1 topology, we prove that, for the right notion of a 'physical' solution, the nonlinear equation can be approximated either by a finite particle system or by a delayed equation. As a by-product, we obtain the existence of 'synchronized' solutions, for which a macroscopic proportion of neurons may spike at the same time

Earth resources evaluation for New Mexico by LANDSAT-2

The author has identified the following significant results. The Middle Rio Grande project has not yet progressed to the point where mineral exploration sites can be chosen; however, there does appear to be some correlation between the known structure and mineral deposits and the LANDSAT lineament map. A circular feature identified in the southern Magdalena Mountains on LANDSAT-1 imagery agrees well with the location of a newly proposed caldron complex. Several recognized and unrecognized circular features were identified on imagery of the Mogollon-Datil volcanic field. A check of aeromagnetic maps for New Mexico found that the circular features on the LANDSAT imagery showed up as areas of generally high magnetic intensity

Instrumental oscillations in RHESSI count rates during solar flares

Aims: We seek to illustrate the analysis problems posed by RHESSI spacecraft motion by studying persistent instrumental oscillations found in the lightcurves measured by RHESSI's X-ray detectors in the 6-12 keV and 12-25 keV energy range during the decay phase of the flares of 2004 November 4 and 6. Methods: The various motions of the RHESSI spacecraft which may contribute to the manifestation of oscillations are studied. The response of each detector in turn is also investigated. Results: We find that on 2004 November 6 the observed oscillations correspond to the nutation period of the RHESSI instrument. These oscillations are also of greatest amplitude for detector 5, while in the lightcurves of many other detectors the oscillations are small or undetectable. We also find that the variation in detector pointing is much larger during this flare than the counterexample of 2004 November 4. Conclusions: Sufficiently large nutation motions of the RHESSI spacecraft lead to clearly observable oscillations in count rates, posing a significant hazard for data analysis. This issue is particularly problematic for detector 5 due to its design characteristics. Dynamic correction of the RHESSI counts, accounting for the livetime, data gaps, and the transmission of the bi-grid collimator of each detector, is required to overcome this issue. These corrections should be applied to all future oscillation studies.Comment: 8 pages, 10 figure

Jumble Java Byte Code to Measure the Effectiveness of Unit Tests

Jumble is a byte code level mutation testing tool for Java which inter-operates with JUnit. It has been designed to operate in an industrial setting with large projects. Heuristics have been included to speed the checking of mutations, for example, noting which test fails for each mutation and running this first in subsequent mutation checks. Significant effort has been put into ensuring that it can test code which uses custom class loading and reflection. This requires careful attention to class path handling and coexistence with foreign class-loaders. Jumble is currently used on a continuous basis within an agile programming environment with approximately 370,000 lines of Java code under source control. This checks out project code every fifteen minutes and runs an incremental set of unit tests and mutation tests for modified classes. Jumble is being made available as open source

Geologic analysis of ERTS-1 imagery for the State of New Mexico

There are no author-identified significant results in this report

Synthesis of novel and potent vorapaxar analogues

Vorapaxar is a first-in-class PAR-1 antagonistic drug based on the ent-himbacine scaffold. Detailed in this article are enantioselective and racemic routes to various novel vorapaxar analogues. Biological testing revealed these compounds to have moderate to excellent potencies against PAR-1 with the most potent analogue demonstrating an IC50 of 27 nM

Self-Administered Computer Therapy for Apraxia of Speech

Background and Purpose There is currently little evidence on effective interventions for poststroke apraxia of speech. We report outcomes of a trial of self-administered computer therapy for apraxia of speech. Methods Effects of speech intervention on naming and repetition of treated and untreated words were compared with those of a visuospatial sham program. The study used a parallel-group, 2-period, crossover design, with participants receiving 2 interventions. Fifty participants with chronic and stable apraxia of speech were randomly allocated to 1 of 2 order conditions: speech-first condition versus sham-first condition. Period 1 design was equivalent to a randomized controlled trial. We report results for this period and profile the effect of the period 2 crossover. Results Period 1 results revealed significant improvement in naming and repetition only in the speech-first group. The sham-first group displayed improvement in speech production after speech intervention in period 2. Significant improvement of treated words was found in both naming and repetition, with little generalization to structurally similar and dissimilar untreated words. Speech gains were largely maintained after withdrawal of intervention. There was a significant relationship between treatment dose and response. However, average self-administered dose was modest for both groups. Future software design would benefit from incorporation of social and gaming components to boost motivation. Conclusions Single-word production can be improved in chronic apraxia of speech with behavioral intervention. Self-administered computerized therapy is a promising method for delivering high-intensity speech/language rehabilitation

Identification of an active metabolite of PAR-1 antagonist RWJ-58259 and synthesis of analogues to enhance its metabolic stability

The discontinuation of PAR-1 antagonist RWJ-58259 beyond use as a biological probe is most likely due to it's short half-life in vivo. However, retention of significant in vivo activity beyond the point where most of the RWJ-58259 had been consumed implies the generation of an active metabolite. Herein we describe the biological activity of a predicted metabolite of RWJ-58259 and the synthesis of analogues designed to enhance the metabolic stability of RWJ-58259

Effects of crack tip geometry on dislocation emission and cleavage: A possible path to enhanced ductility

We present a systematic study of the effect of crack blunting on subsequent crack propagation and dislocation emission. We show that the stress intensity factor required to propagate the crack is increased as the crack is blunted by up to thirteen atomic layers, but only by a relatively modest amount for a crack with a sharp 60$^\circ$ corner. The effect of the blunting is far less than would be expected from a smoothly blunted crack; the sharp corners preserve the stress concentration, reducing the effect of the blunting. However, for some material parameters blunting changes the preferred deformation mode from brittle cleavage to dislocation emission. In such materials, the absorption of preexisting dislocations by the crack tip can cause the crack tip to be locally arrested, causing a significant increase in the microscopic toughness of the crack tip. Continuum plasticity models have shown that even a moderate increase in the microscopic toughness can lead to an increase in the macroscopic fracture toughness of the material by several orders of magnitude. We thus propose an atomic-scale mechanism at the crack tip, that ultimately may lead to a high fracture toughness in some materials where a sharp crack would seem to be able to propagate in a brittle manner. Results for blunt cracks loaded in mode II are also presented.Comment: 12 pages, REVTeX using epsfig.sty. 13 PostScript figures. Final version to appear in Phys. Rev. B. Main changes: Discussion slightly shortened, one figure remove

Investigating on the nuclear obscuration in two types of Seyfert 2 galaxies

We build a large sample of Seyfert 2 galaxies (Sy2s) with both optical spectropolarimetric and X-ray data available, in which 29 Sy2s with the detection of polarized broad emission line (PBL) and 25 without. We find that for luminous Sy2s with L_[OIII] > 10^41 erg/s, sources with PBL have smaller X-ray absorption column density comparing with those without PBL (at 92.3% confidence level): most of the Sy2s with N_H<10^23.8 cm^-2 show PBL (86%, 12 out 14), while the fraction is much smaller for sources with heavier obscuration (54%, 15 out 28). The confidence level of the difference in absorption bounces up to 99.1% while using the "T" ratio (F_2-10keV/F_[O III]) as an indicator. We rule out observation or selection bias as the origin for the difference. Our results, for the first time with high statistical confidence, show that, in additional to the nuclei activity, the nuclear obscuration also plays an important role in the visibility of PBL in Sy2s. These results can be interpreted in the framework of the unified model. We can reach these results in the unified model if: a) the absorption column density is higher at large inclinations and b) the scattering region is obscured at large inclinations.Comment: 28 pages, including 7 figures and 3 tables, ApJ accepte