2,300 research outputs found
On the stability of some linear nonautonomous systems
Stability of linear nonautonomous systems described by differential equations with time varying coefficient
An invariance principle for dynamical systems on Banach space - Application to the general problem of thermoelastic stability
Invariance principle on Banach space for generalized thermoelastic stability analysi
An invariance principle for dynamical systems in Hilbert spaces
Invariance method for extending Liapunov function to distributed parameter syste
On the stability of some continuous systems subjected to random excitation
Conditions determined for sure stability of continuous systems subjected to random excitatio
On the stability of a column subjected to a time-dependent axial load
Exponential bounds and stability conditions for linear elastic column subjected to time varying axial loa
Strain-driven elastic and orbital-ordering effects on thickness-dependent properties of manganite thin films
We report on the structural and magnetic characterization of (110) and (001)
La2/3Ca1/3MnO3 (LCMO) epitaxial thin films simultaneously grown on (110) and
(001)SrTiO3 substrates, with thicknesses t varying between 8 nm and 150 nm. It
is found that while the in-plane interplanar distances of the (001) films are
strongly clamped to those of the substrate and the films remain strained up to
well above t=100 nm, the (110) films relax much earlier. Accurate determination
of the in-plane and out-of-plane interplanar distances has allowed concluding
that in all cases the unit cell volume of the manganite reduces gradually when
increasing thickness, approaching the bulk value. It is observed that the
magnetic properties (Curie temperature and saturation magnetization) of the
(110) films are significantly improved compared to those of (001) films. These
observations, combined with 55Mn-nuclear magnetic resonance data and X-ray
photoemission spectroscopy, signal that the depression of the magnetic
properties of the more strained (001)LCMO films is not caused by an elastic
deformation of the perovskite lattice but rather due to the electronic and
chemical phase separation caused by the substrate-induced strain. On the
contrary, the thickness dependence of the magnetic properties of the less
strained (110)LCMO films are simply described by the elastic deformation of the
manganite lattice. We will argue that the different behavior of (001) and
(110)LCMO films is a consequence of the dissimilar electronic structure of
these interfaces.Comment: 16 pages, 15 figure
The rna-binding ubiquitin ligase mex3a affects glioblastoma tumorigenesis by inducing ubiquitylation and degradation of rig-i
Glioblastoma multiforme (GB) is the most malignant primary brain tumor in humans, with an overall survival of approximatively 15 months. The molecular heterogeneity of GB, as well as its rapid progression, invasiveness and the occurrence of drug-resistant cancer stem cells, limits the efficacy of the current treatments. In order to develop an innovative therapeutic strategy, it is mandatory to identify and characterize new molecular players responsible for the GB malignant phenotype. In this study, the RNA-binding ubiquitin ligase MEX3A was selected from a gene expression analysis performed on publicly available datasets, to assess its biological and still-unknown activity in GB tumorigenesis. We find that MEX3A is strongly up-regulated in GB specimens, and this correlates with very low protein levels of RIG-I, a tumor suppressor involved in differentiation, apoptosis and innate immune response. We demonstrate that MEX3A binds RIG-I and induces its ubiquitylation and proteasome-dependent degradation. Further, the genetic depletion of MEX3A leads to an increase of RIG-I protein levels and results in the suppression of GB cell growth. Our findings unveil a novel molecular mechanism involved in GB tumorigenesis and suggest MEX3A and RIG-I as promising therapeutic targets in GB
Research in the general area of non-linear dynamical systems Final report, 8 Jun. 1965 - 8 Jun. 1967
Nonlinear dynamical systems research on systems stability, invariance principles, Liapunov functions, and Volterra and functional integral equation
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