192 research outputs found
Superconductivity and Spin Fluctuations in the Electron-Doped Infinitely-Layered High Tc Superconductor SrLaCuO (Tc=42K)
This paper describes the first 63-Cu NMR study of an electron-doped
infinitely-layered high Tc superconductor SrLaCuO (Tc=42K). The
spin dynamics in the normal state above Tc exhibits qualitatively the same
behavior as some hole-doped materials with significantly enhanced spin
fluctuations. Below Tc, we observed no signature of a Hebel-Slichter coherence
peak, suggesting an unconventional nature of the symmetry of the
superconducting order parameter.Comment: Invited Paper to SNS-95 Conference (Spectroscopies on Novel
Superconductors 1995 at Stanford). Also presented at Aspen Winter Conference
on Superconductivity and Grenoble M^2S-HTSC in 199
A molecular dynamics simulation of polymer crystallization from oriented amorphous state
Molecular process of crystallization from an oriented amorphous state was
reproduced by molecular dynamics simulation for a realistic polyethylene model.
Initial oriented amorphous state was obtained by uniaxial drawing an isotropic
glassy state at 100 K. By the temperature jump from 100 K to 330 K, there
occurred the crystallization into the fiber structure, during the process of
which we observed the developments of various order parameters. The real space
image and its Fourier transform revealed that a hexagonally ordered domain was
initially formed, and then highly ordered crystalline state with stacked
lamellae developed after further adjustment of the relative heights of the
chains along their axes.Comment: 4 pages, 3 figure
Infrared Spectra and Visibilities as Probes of the Outer Atmospheres of Red Supergiant Stars
In the light of the recent results of the stellar interferometry, we examine
the nature of the extra molecular layer outside the photosphere of red super-
giant stars, so far studied mostly with the use of the infrared spectra.
Although the visibility data are more direct probes of the spatial structure of
the outer atmosphere, it is essential that they are analyzed in combination
with the spectral data of a wide spectral coverage. In the case of the M2
supergiant mu Cephei, several sets of data, both spectra and visibilities,
strongly suggested the presence of an extra-molecular layer, and its basic
parameters are estimated to be: excitation temperature T_ex = 1600 K, column
densities of CO and H2O N_col = 3.0d+20/cm2, and inner radius R_in = 2.0R*. The
result shows reasonable agreement with the one based on the infrared spectra
alone, and this may be because the infrared spectra already include some
information on the spatial structure of the outer atmosphere. It is important,
however, that the model inferred from the spectra is now fully supported with
the recent visibility data. In the case of the M2 supergiant alpha Orionis, the
infrared spectra and visibilities show a consistent picture in that its
molecular layer is closer to the photosphere (R_in = 1.3R*) with higher gas
temperature (T_ex = 2250 K) and lower gas column density (N_col = 1.0d+20/cm2),
compared with that of mu Cephei. Some controversy on the interpretation of the
mid infrared data of alpha Orionis can be reconciled.Comment: 47 pages, 14 Postscript figures, to be published in the Astrophysical
Journa
Estrogen Prevents Bone Loss via Estrogen Receptor α and Induction of Fas Ligand in Osteoclasts
SummaryEstrogen prevents osteoporotic bone loss by attenuating bone resorption; however, the molecular basis for this is unknown. Here, we report a critical role for the osteoclastic estrogen receptor α (ERα) in mediating estrogen-dependent bone maintenance in female mice. We selectively ablated ERα in differentiated osteoclasts (ERαΔOc/ΔOc) and found that ERαΔOc/ΔOc females, but not males, exhibited trabecular bone loss, similar to the osteoporotic bone phenotype in postmenopausal women. Further, we show that estrogen induced apoptosis and upregulation of Fas ligand (FasL) expression in osteoclasts of the trabecular bones of WT but not ERαΔOc/ΔOc mice. The expression of ERα was also required for the induction of apoptosis by tamoxifen and estrogen in cultured osteoclasts. Our results support a model in which estrogen regulates the life span of mature osteoclasts via the induction of the Fas/FasL system, thereby providing an explanation for the osteoprotective function of estrogen as well as SERMs
The role of the RACK1 ortholog Cpc2p in modulating pheromone-induced cell cycle arrest in fission yeast
The detection and amplification of extracellular signals requires the involvement of multiple protein components. In mammalian cells the receptor of activated C kinase (RACK1) is an important scaffolding protein for signal transduction networks. Further, it also performs a critical function in regulating the cell cycle by modulating the G1/S transition. Many eukaryotic cells express RACK1 orthologs, with one example being Cpc2p in the fission yeast Schizosaccharomyces pombe. In contrast to RACK1, Cpc2p has been described to positively regulate, at the ribosomal level, cells entry into M phase. In addition, Cpc2p controls the stress response pathways through an interaction with Msa2p, and sexual development by modulating Ran1p/Pat1p. Here we describe investigations into the role, which Cpc2p performs in controlling the G protein-mediated mating response pathway. Despite structural similarity to Gβ-like subunits, Cpc2p appears not to function at the G protein level. However, upon pheromone stimulation, cells overexpressing Cpc2p display substantial cell morphology defects, disorientation of septum formation and a significantly protracted G1 arrest. Cpc2p has the potential to function at multiple positions within the pheromone response pathway. We provide a mechanistic interpretation of this novel data by linking Cpc2p function, during the mating response, with its previous described interactions with Ran1p/Pat1p. We suggest that overexpressing Cpc2p prolongs the stimulated state of pheromone-induced cells by increasing ste11 gene expression. These data indicate that Cpc2p regulates the pheromone-induced cell cycle arrest in fission yeast by delaying cells entry into S phase
Laughter and humor as complementary and alternative medicines for dementia patients
<p>Abstract</p> <p>Background</p> <p>The number of dementia patients has increased worldwide, with an estimated 13.7 million dementia patients in the Asia Pacific region alone. This number is expected to increase to 64.6 million by the year 2050.</p> <p>Discussion</p> <p>As a result of advances in research, there several pharmacological therapies available for the treatment of dementia patients. However, current treatments do not suppress the disease process and cannot prevent dementia, and it will be some time before these goals are realized. In the meantime, complementary and alternative medicine (CAM) is an important aspect in the treatment of dementia patients to improve their quality of life throughout the long course of the disease. Considering the individuality of dementia patients, applicability of laughter and humor therapy is discussed. Even though there are many things that need to be elucidated regarding the mechanisms underlying the beneficial effects of laughter and humor, both may be good CAM for dementia patients if they are applied carefully and properly.</p> <p>Summary</p> <p>In this debate article, the physiological basis and actual application of laughter and humor in the treatment of dementia patients are presented for discussion on the applicability to dementia patients.</p
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