Social support at work and at home: Dual-buffering effects in the work-family conflict process

Using experience-sampling methodology, the present study offers a within-individual test of the buffering model of social support in the daily work-family conflict process. Building on the conceptualization of social support as a volatile resource, we examine how daily fluctuations in social support at work and at home influence the process through which work interferes with family life. A total of 112 employees participated in the study and were asked to respond to daily surveys in the work and home domains. Results showed that social support at work and at home—as volatile resources—buffered the daily work-family conflict process within their respective domains. First, a supportive supervisor mitigated the within-individual effect of workload on emotional exhaustion. Second, a supportive spouse protected the strained employee from the effect of emotional exhaustion on work-family conflict, and spousal support also moderated the indirect effect from workload to work-family conflict through emotional exhaustion. The findings suggest that enacting a dual social support system can effectively reduce the adverse effects of excessive job demands on exhaustion and work-family conflict, but buffering effects are highly dependent on the timely availability of social support

Pancreatic Cancer, Leptin, and Chemoresistance: Current Challenges

Pancreatic cancer (PC) remains a leading cause of cancer-related deaths. Currently, conventional chemotherapies have showed only limited benefits for PC patients. Main factors affecting PC treatment failures are due to late detection, lack of early symptoms and biomarkers, and the development of desmoplasia and chemoresistance. Various mechanisms have been implicated in PC chemoresistance that includes stem cells, epigenetic changes, and alteration of signaling pathways, among others. Obesity is a modifiable factor for PC risk, which is characterized by high levels of the adipokine leptin that is a proinflammatory, proangiogenic, survival factor that affects chemotherapy effectiveness. Here, we will discuss on the mechanisms of PC chemoresistance and the influence of obesity and leptin signaling. Furthermore, the potential use of nontoxic leptin antagonists as a novel sensitization strategy for PC chemotherapeutics will also be discussed

Arbeidsmigratie in vieren. Bulgaren en Roemenen vergeleken met Polen.

In januari 2007 traden Bulgarije en Roemenie toe tot de Europese Unie (EU). De toetreding van beide landen leidde tot een toename van het aantal Bulgaren en Roemenen in Nederland. Omdat velen van hen zich niet registreren in de GBA is het lastig om exacte cijfers te noemen. Van der Heijden et al. (2011) schatten het aantal Bulgaren dat in 2008 in Nederland verbleef op tussen de 39.000 en 51.000 en het aantal Roemenen op tussen de 40.000 en 51.000. Deze cijfers moeten wel met grote voorzichtigheid worden benaderd. Dat geldt ook voor de schatting van het aantal Polen dat tussen de 144.000 en 170.000 zou liggen. Niettemin geven deze cijfers een indicatie van een groeiende groep van arbeidsmigranten uit Midden- en Oost-Europa (MOE-landen) in de Nederlandse samenleving. In deze studie staan de Bulgaren en Roemenen centraal. Naar deze groep is tot nog toe amper onderzoek gedaan. Om hun positie beter te begrijpen is een systematische vergelijking gemaakt met Poolse arbeidsmigranten. De Polen hebben sinds mei 2007 volledig toegang tot de Nederlandse arbeidsmarkt, terwijl de Bulgaren en Roemenen nog onderhevig zijn aan een overgangsregime. Zij hebben een tewerkstellingsvergunning nodig om op de reguliere arbeidsmarkt te kunnen werken. Deze studie schetst een beeld van de maatschappelijke positie van Bulgaren, Roemenen en Polen, evenals van patronen van arbeidsmigratie en –integratie. Het is gebaseerd op onderzoek in negen Nederlandse gemeenten, waaronder twee grote steden (Rotterdam en Den Haag), drie middelgrote steden (Dordrecht, Breda en Westland) en vier kleinere gemeenten (Moerdijk, Zundert, Oostland en Hillegom). In deze gemeenten zijn 164 Bulgaren, 112 Roemenen en 353 Polen geïnterviewd. Naast een kwantitatieve analyse en beschrijving van de kenmerken van de maatschappelijke positie van Bulgaren en Roemenen in vergelijking met Polen, wordt in het slothoofdstuk een meer kwalitatieve, interpretatieve analyse gemaakt van de bevindingen voor het beleid

Schadenfreude: a counternormative observer response to workplace mistreatment

This is the author accepted manuscript. The final version is available from the publisher via the DOI in this recordAlthough almost all employees have heard of or witnessed colleagues being mistreated, we have an incomplete understanding of how employees perceive and respond to such events. In previous research scholars established that observer emotions can be congruent with victim emotions, but we examine observer schadenfreude, an incongruent emotion that is also prevalent in organizations. Based on appraisal theories of emotion, we propose a process model of schadenfreude emergence and development: initial schadenfreude occurs when observers appraise mistreatment incidents as relevant and conducive to their goals; this initial feeling evolves into either righteous or ambivalent schadenfreude, depending on observers’ secondary appraisals of victim deservingness. We also address the implications of schadenfreude for observer behavior and the moderating effects of observers’ moral foundations and organizational civility climate. Our model extends current knowledge about observer reactions and helps us understand the persistence and pervasiveness of workplace mistreatment

Arbeidsmigranten uit Bulgarije, Polen, en Roemenie in Rotterdam: sociale leefsituatie, arbeidspositie en toekomstperspectief

Aims: To assess longer-term outcomes of a drop-in rolling-group model of behavioural support for smoking cessation and the factors that influence cessation outcomes. Design: Prospective observational cohort study. Setting: Fag Ends NHS Stop Smoking Service in Liverpool and Knowsley, UK. Participants: A total of 2585 clients, aged 16 or over, setting a quit date. Measurements: Routine monitoring data were collected from Fag Ends service users and were supplemented by survey data on socio-economic circumstances, smoking-related behaviour and self-report and carbon monoxide (CO)-validated smoking status at 52-week follow-up. Findings: The CO-validated prolonged abstinence rate at 52 weeks for smokers attending the groups was 5.6%, compared with 30.7% at 4 weeks (a relapse rate of 78.2%). The sample was particularly disadvantaged: 68% resided in the most deprived decile of the English Index of Multiple Deprivation. Higher socio-economic status within the sample was a predictor of quitting. Other predictors of long-term cessation in multivariate analysis included older age, being female, lower levels of nicotine dependence, having a live-in partner, stronger determination to quit and use of varenicline versus other medication. Conclusions: A wholly state-reimbursed clinical stop-smoking service providing behavioural support and medication in a region of high economic and social disadvantage has reached a significant proportion of the smoking population. Long-term success rates are lower than are found typically in clinical trials, but higher than would be expected if the smokers were to try and quit unaided. Research is needed into how to improve on the success rates achieved

Novel Role for the Golgi Membrane Protein TMEM165 in Control of Migration and Invasion for Breast Carcinoma

The TMEM165 gene encodes for a multiple pass membrane protein localized in the Golgi that has been linked to congenital disorders of glycosylation. The TMEM165 protein is a putative ion transporter that regulates H+/Ca++/Mn++ homeostasis and pH in the Golgi. Previously, we identified TMEM165 as a potential biomarker for breast carcinoma in a glycoproteomic study using late stage invasive ductal carcinoma tissues with patient-matched adjacent normal tissues. The TMEM165 protein was not detected in non-malignant matched breast tissues and was detected in invasive ductal breast carcinoma tissues by mass spectrometry. Our hypothesis is that the TMEM165 protein confers a growth advantage to breast cancer. In this preliminary study we have investigated the expression of TMEM165 in earlier stage invasive ductal carcinoma and ductal carcinoma in situ cases. We created a CRISPR/Cas9 knockout of TMEM165 in the human invasive breast cancer cell line MDAMB231. Our results indicate that removal of TMEM165 in these cells results in a significant reduction of cell migration, tumor growth, and tumor vascularization in vivo. Furthermore, we find that TMEM165 expression alters the glycosylation of breast cancer cells and these changes promote the invasion and growth of breast cancer by altering the expression levels of key glycoproteins involved in regulation of the epithelial to mesenchymal transition such as E-cadherin. These studies illustrate new potential functions for this Golgi membrane protein in the control of breast cancer growth and invasion

When Can Employees Have a Family Life? The Effects of Daily Workload and Affect on Work-Family Conflict and Social Behaviors at Home

This article presents a longitudinal examination of antecedents and outcomes of work-to-family conflict. A total of 106 employees participating in an experience-sampling study were asked to respond to daily surveys both at work and at home, and their spouses were interviewed daily via telephone for a period of 2 weeks. Intraindividual analyses revealed that employees ’ perceptions of workload predicted work-to-family conflict over time, even when controlling for the number of hours spent at work. Workload also influenced affect at work, which in turn influenced affect at home. Finally, perhaps the most interesting finding in this study was that employees ’ behaviors in the family domain (reported by spouses) were predicted by the employees ’ perceptions of work-to-family conflict and their positive affect at home

Wnt signaling in triple negative breast cancer is associated with metastasis

Background Triple Negative subset of (TN) Breast Cancers (BC), a close associate of the basal-like subtype (with limited discordance) is an aggressive form of the disease which convey unpredictable, and poor prognosis due to limited treatment options and lack of proven effective targeted therapies. Methods We conducted an expression study of 240 formalin-fixed, paraffin-embedded (FFPE) primary biopsies from two cohorts, including 130 TN tumors, to identify molecular mechanisms of TN disease. Results The annotation of differentially expressed genes in TN tumors contained an overrepresentation of canonical Wnt signaling components in our cohort and others. These observations were supported by upregulation of experimentally induced oncogenic Wnt/β-catenin genes in TN tumors, recapitulated using targets induced by Wnt3A. A functional blockade of Wnt/β-catenin pathway by either a pharmacological Wnt-antagonist, WntC59, sulidac sulfide, or β-catenin (functional read out of Wnt/β-catenin pathway) SiRNA mediated genetic manipulation demonstrated that a functional perturbation of the pathway is causal to the metastasis- associated phenotypes including fibronectin-directed migration, F-actin organization, and invasion in TNBC cells. A classifier, trained on microarray data from β-catenin transfected mammary cells, identified a disproportionate number of TNBC breast tumors as compared to other breast cancer subtypes in a meta-analysis of 11 studies and 1,878 breast cancer patients, including the two cohorts published here. Patients identified by the Wnt/β-catenin classifier had a greater risk of lung and brain, but not bone metastases. Conclusion These data implicate transcriptional Wnt signaling as a hallmark of TNBC disease associated with specific metastatic pathways

Making things happen : a model of proactive motivation

Being proactive is about making things happen, anticipating and preventing problems, and seizing opportunities. It involves self-initiated efforts to bring about change in the work environment and/or oneself to achieve a different future. The authors develop existing perspectives on this topic by identifying proactivity as a goal-driven process involving both the setting of a proactive goal (proactive goal generation) and striving to achieve that proactive goal (proactive goal striving). The authors identify a range of proactive goals that individuals can pursue in organizations. These vary on two dimensions: the future they aim to bring about (achieving a better personal fit within one’s work environment, improving the organization’s internal functioning, or enhancing the organization’s strategic fit with its environment) and whether the self or situation is being changed. The authors then identify “can do,” “reason to,” and “energized to” motivational states that prompt proactive goal generation and sustain goal striving. Can do motivation arises from perceptions of self-efficacy, control, and (low) cost. Reason to motivation relates to why someone is proactive, including reasons flowing from intrinsic, integrated, and identified motivation. Energized to motivation refers to activated positive affective states that prompt proactive goal processes. The authors suggest more distal antecedents, including individual differences (e.g., personality, values, knowledge and ability) as well as contextual variations in leadership, work design, and interpersonal climate, that influence the proactive motivational states and thereby boost or inhibit proactive goal processes. Finally, the authors summarize priorities for future researc