Assessment of different types of intra oral scanners and 3D printers on the accuracy of printed models : an in vitro study

3D printing technology is a reality in Dentistry and presents several ways to obtain a printed model. The aim of this study was to verify the influence of different types of intraoral scanners and 3D printers on the accuracy of printed models in comparis

Effects of sandblasting of prosthetic abutment surfaces on the tensile strength of cement-retained crowns, using a cementing technique: an in vitro study

Objective: The tensile strength effects on the sandblasting of the abutment associated with a cementing technique are not well documented. The objective of this study is to analyze the tensile strength of prosthetic crowns cemented on standard and sandblasted abutments, using a cementing technique. Methods: Experimental groups were formed according to ce­menting technique (control and practice abutment technique) and prosthetic abutment roughness (standard and sandblas­ted), totaling forty specimens. The crowns were cemented with Zinc Phosphate cement. Statistical analysis was conducted with an α at 0.05. Results: Considering the cementation techniques analysis, there were no statistically significant differen­ces between the groups, with mean tensile strength values of 157.83±22.16 N for the control technique, and 159.95±46.40 N for the practice abutment technique on the standard surface. Result analysis of the control technique (626.23±34.80 N) and practice abutment technique (642.62±94.00 N) indicated no significant differences on the sandblasted surface. Consi­dering the surface roughness analysis, significant differences were observed, with values of 157.83±22.16 N for the control technique/standard surface group and 626.23±34.80 N for the control technique/sandblasted surface group. Significant differences were observed in the practice abutment technique/standard surface group with 159.95±46.40 N values, compa­red to the 642.62±94.00 N value for the practice abutment technique/sandblasted group. Conclusions: The practice abut­ment cementing technique showed no significant differences with the control technique, regarding to the tensile strength, in the two surfaces (standard and sandblasted) used in the study. The sandblasting of prosthetic abutments led to a signifi­cant increase on the tensile strength considering the two studied cementation techniques.Objetivos: Os efeitos de resistência à tração no jateamento do pilar associado a uma técnica de cimentação não estão bem documentados. O objetivo deste estudo é analisar a resistência à tração de coroas protéticas cimentadas em munhões padrões e asperizados, utilizando uma técnica de cimentação. Métodos: Os grupos experimentais foram formados de acordo com a técnica de cimentação (técnica de controle e prática de pilares) e a rugosidade do pilar protético (padrão e asperizado), totalizando quarenta espécimes. As coroas foram cimentadas com cimento de fosfato de zinco. A análise estatística foi conduzida a um valor de α=0,05. Resultados: Na análise das técnicas de cimentação não houve diferenças estatisticamente significativas entre os grupos, com valores médios de resistência à tração de 157,83±22,16 N para a técnica controle e 159,95±46,40 N para a técnica practice abutment na superfície padrão. A análise dos resultados na técnica controle (626,23±34,80 N) e na técnica practice abutment (642,62±94,00 N), na superfície jateada, também não indicaram diferenças significativas. Na análise da rugosidade da superfície, observaram-se diferenças significativas, com valores de 157,83±22,16 N para o grupo técnica controle/superfície padrão e 626,23±34,80 N para o grupo técnica controle/superfície asperizada. Foram observadas diferenças significativas no grupo técnica Practice abutment/ superfície padrão com valores de 159,95±46,40 N comparado com o grupo técnica Practice abutment/grupo jateado, com valores de 642,62±94,00 N. Conclusões: A técnica de cimentação Practice abutment não mostrou diferenças significativas com a técnica controle, em relação à resistência à tração, nas duas superfícies (padrão e asperizada) usadas no estudo. O jateamento dos munhões protéticos levou a um aumento significativo da resistência à tração nas duas técnicas de cimentação estudadas

Venous thromboembolism risk score during hospitalization in pregnancy: results of 10694 prospective evaluations in a clinical trial

Objectives: Hospitalization during pregnancy and childbirth increases the risk of Venous Thromboembolism Risk (VTE). This study applied a VTE risk score to all hospitalized pregnant women to ascertain its effectiveness in preventing maternal death from VTE until 3 months after discharge. Methods: In this interventional study, patients were classified as low- or high-risk according to the VTE risk score (Clinics Hospital risk score). High-risk patients (score ≥ 3) were scheduled for pharmacological Thromboprophylaxis (TPX). Interaction analysis of the main risk factors was performed using Odds Ratio (OR) and Poisson regression with robust variance. Results: The data of 10694 cases (7212 patients) were analyzed; 1626 (15.2%, 1000 patients) and 9068 (84.8%, 6212 patients) cases were classified as high-risk (score ≥ 3) and low-risk (score < 3), respectively. The main risk factors (Odds Ratio, 95% Confidence Interval) for VTE were age ≥ 35 and < 40 years (1.6, 1.4–1.8), parity ≥ 3 (3.5, 3.0–4.0), age ≥ 40 years (4.8, 4.1–5.6), multiple pregnancies (2.1, 1.7–2.5), BMI ≥ 40 kg/m2 (5.1, 4.3–6.0), severe infection (4.1, 3.3–5.1), and cancer (12.3, 8.8–17.2). There were 10 cases of VTE: 7/1636 (0.4%) and 3/9068 (0.03%) in the high- and low-risk groups, respectively. No patient died of VTE. The intervention reduced the VTE risk by 87%; the number needed to treat was 3. Conclusions: This VTE risk score was effective in preventing maternal deaths from VTE, with a low indication for TPX. Maternal age, multiparity, obesity, severe infections, multiple pregnancies, and cancer were the main risk factors for VTE

Psychosocial Factors and Chronic Illness as Predictors for Anxiety and Depression in Adolescence

Adolescence is a challenging time when emotional difficulties often arise. Self-esteem, good relationships with peers, and emotional competences can buffer the effects of these difficulties. The difficulties can be even greater when coupled with the presence of a chronic physical illness (CD). Our goal is to analyze psychosocial factors and CD as predictors for anxiety and depression. It was compared the results of structural equation models (SEM) with models based on qualitative comparative analysis (QCA) to analyze the possible influence of these variables on levels of anxiety-depression in adolescents with and without CD. The sample consisted of 681 adolescents, between 12 and 16 years old (M = 13.94, SD = 1.32). 61.50% were girls and 13.40% (n = 222) presented a CD (mainly pneumo-allergic and endocrine). They were evaluated by the Hospital Anxiety and Depression Scale, the Self-esteem Questionnaire, the Emotional Competences Questionnaire and the Strengths and Difficulties Questionnaire. The results obtained by SEM show that low self-esteem, problems with peers and low emotional competencies predict anxiety in 41% of the variance and depression in 72%. The results obtained by QCA show that the different combinations of these variables explain between 24 and 61% of low levels of anxiety and depression and 47-55% of high levels. Our data show how the presence of a CD, low self-esteem, problems with peers and problems in emotional skills play a fundamental role in explaining levels of anxiety and depression. These aspects will help provide increased resources for emotional adjustment in the educational context, facilitating the transitions to be made by adolescents

Proposed clinical phases for the improvement of personalized treatment of checkpoint inhibitor–related pneumonitis

BackgroundCheckpoint inhibitor–related pneumonitis (CIP) is a lethal immune-related adverse event. However, the development process of CIP, which may provide insight into more effective management, has not been extensively examined.MethodsWe conducted a multicenter retrospective analysis of 56 patients who developed CIP. Clinical characteristics, radiological features, histologic features, and laboratory tests were analyzed. After a comprehensive analysis, we proposed acute, subacute, and chronic phases of CIP and summarized each phase’s characteristics.ResultsThere were 51 patients in the acute phase, 22 in the subacute phase, and 11 in the chronic phase. The median interval time from the beginning of CIP to the different phases was calculated (acute phase: ≤4.9 weeks; subacute phase: 4.9~13.1 weeks; and chronic phase: ≥13.1 weeks). The symptoms relieved from the acute phase to the chronic phase, and the CIP grade and Performance Status score decreased (P<0.05). The main change in radiologic features was the absorption of the lesions, and 3 (3/11) patients in the chronic phase had persistent traction bronchiectasis. For histologic features, most patients had acute fibrinous pneumonitis in the acute phase (5/8), and most had organizing pneumonia in the subacute phase (5/6). Other histologic changes advanced over time, with the lesions entering a state of fibrosis. Moreover, the levels of interleukin-6, interleukin-10 and high-sensitivity C-reactive protein (hsCRP) increased in the acute phase and decreased as CIP progressed (IL-6: 17.9 vs. 9.8 vs. 5.7, P=0.018; IL-10: 4.6 vs 3.0 vs. 2.0, P=0.041; hsCRP: 88.2 vs. 19.4 vs. 14.4, P=0.005).ConclusionsThe general development process of CIP can be divided into acute, subacute, and chronic phases, upon which a better management strategy might be based devised