Proposed allocation of research catches in Divisions 58.4.1 and

At WG-SAM-15, it was noted that 5 members, Australia, France, Japan, Korea and Spain had notified to conduct research in the exploratory toothfish fisheries off East Antarctica, covered by CCAMLR Divisions 58.4.1 and 58.4.2. This proposal seeks to establish an arrangement whereby all notified members have a catch allocation to undertake research, thereby avoiding Olympic fishing

Quantitative and Qualitative Urinary Cellular Patterns Correlate with Progression of Murine Glomerulonephritis

The kidney is a nonregenerative organ composed of numerous functional nephrons and collecting ducts (CDs). Glomerular and tubulointerstitial damages decrease the number of functional nephrons and cause anatomical and physiological alterations resulting in renal dysfunction. It has recently been reported that nephron constituent cells are dropped into the urine in several pathological conditions associated with renal functional deterioration. We investigated the quantitative and qualitative urinary cellular patterns in a murine glomerulonephritis model and elucidated the correlation between cellular patterns and renal pathology

Finite-temperature phase transition of SU(3) gauge theory on Nt=4 and 6 lattices

The deconfining finite-temperature transition of SU(3) gauge theory is studied on the dedicated parallel computer QCDPAX. Monte Carlo simulations are performed on 122×24×4, 242×36×4, 203×6, 243×6, and 362×48×6 lattices with 376 000 to 1 112 000 iterations. The finite size scaling behavior of the first-order transition is confirmed both on the Nt=4 and Nt=6 lattices and clear two-phase structures are observed on spatially large lattices (242×36×4 and 362×48×6). The latent heat at the deconfining transition is estimated both by a direct measurement of the gap on the spatially large lattices and by applying a finite-size scaling law. The results obtained by these two independent methods are remarkably consistent with each other on both the Nt=4 lattices. The latent heat for Nt=6 is much smaller than that for Nt=4 and is about ⅓ of the Stefan-Boltzmann value 8π2/15. The details of the data and the error analysis are presented

Epitope Density Influences CD8+ Memory T Cell Differentiation

The generation of long-lived memory T cells is critical for successful vaccination but the factors controlling their differentiation are still poorly defined. We tested the hypothesis that the strength of T cell receptor (TCR) signaling contributed to memory CD8(+) T cell generation.We manipulated the density of antigenic epitope presented by dendritic cells to mouse naïve CD8(+) T cells, without varying TCR affinity. Our results show that a two-fold decrease in antigen dose selectively affects memory CD8(+) T cell generation without influencing T cell expansion and acquisition of effector functions. Moreover, we show that low antigen dose alters the duration of the interaction between T cells and dendritic cells and finely tunes the expression level of the transcription factors Eomes and Bcl6. Furthermore, we demonstrate that priming with higher epitope density results in a 2-fold decrease in the expression of Neuron-derived orphan nuclear receptor 1 (Nor-1) and this correlates with a lower level of conversion of Bcl-2 into a pro-apoptotic molecule and an increased number of memory T cells.Our results show that the amount of antigen encountered by naïve CD8(+) T cells following immunization with dendritic cells does not influence the generation of functional effector CD8(+) T cells but rather the number of CD8(+) memory T cells that persist in the host. Our data support a model where antigenic epitope density sensed by CD8(+) T cells at priming influences memory generation by modulating Bcl6, Eomes and Nor-1 expression

How do we best synergise climate mitigation actions to co-benefit biodiversity?

Acknowledgements We thank Yuka Otsuki Estrada for help in designing and producing the table, and all other authors of the IPBES-IPCC report on the scientific outcome of the IPBES-IPCC co-sponsored workshop on biodiversity and climate change (Pörtner et al., 2021) for cross-cutting discussions during preparation of this analysis. Although this paper is based on the report of the IPBES-IPCC co882 sponsored workshop, the views expressed here represent the individual views of the authors. We would also like to thank the scientific steering committee of the IPBES-IPCC co-sponsored workshop, review editors, the IPCC and IPBES Secretariat, especially Anne Larigauderie, and Technical Support Units. In memory of our friend and co-author, Bob Scholes, who sadly died during the preparation of this synthesis, and who will be sorely missed by all.Peer reviewedPostprin

Host phenotype characteristics and MC1R in relation to early-onset basal cell carcinoma.

Basal cell carcinoma (BCC) incidence is increasing, particularly among adults under the age of 40 years. Pigment-related characteristics are associated with BCC in older populations, but epidemiologic studies among younger individuals and analyses of phenotype-genotype interactions are limited. We examined self-reported phenotypes and melanocortin 1 receptor gene (MC1R) variants in relation to early-onset BCC. BCC cases (n=377) and controls with benign skin conditions (n=390) under the age of 40 years were identified through Yale's Dermatopathology database. Factors most strongly associated with early-onset BCC were skin reaction to first summer sun for 1 hour (severe sunburn vs. tan odds ratio (OR)=12.27, 95% confidence interval (CI)=4.08-36.94) and skin color (very fair vs. olive OR=11.06, 95% CI=5.90-20.74). Individuals with two or more MC1R non-synonymous variants were 3.59 times (95% CI=2.37-5.43) more likely to have BCC than those without non-synonymous variants. All host characteristics and MC1R were more strongly associated with multiple BCC case status (37% of cases) than a single BCC case status. MC1R, number of moles, skin reaction to first summer sun for 1 hour, and hair and skin color were independently associated with BCC. BCC risk conferred by MC1R tended to be stronger among those with darker pigment phenotypes, traditionally considered to be at low risk of skin cancer

The Orbiting Carbon Observatory (OCO-2) Tracks 2-3 Peta-Gram Increase in Carbon Release to the Atmosphere During the 2014-2016 El Nino

The powerful El Nio event of 2015-2016 - the third most intense since the 1950s - has exerted a large impact on the Earth's natural climate system. The column-averaged CO2 dry-air mole fraction (XCO2) observations from satellites and ground based networks are analyzed together with in situ observations for the period of September 2014 to October 2016. From the differences between satellite (OCO-2) observations and simulations using an atmospheric chemistry-transport model, we estimate that, relative to the mean annual fluxes for 2014, the most recent El Nio has contributed to an excess CO2 emission from the Earth's surface (land+ocean) to the atmosphere in the range of 2.4+/-0.2 PgC (1 Pg = 10(exp 15) g) over the period of July 2015 to June 2016. The excess CO2 flux is resulted primarily from reduction in vegetation uptake due to drought, and to a lesser degree from increased biomass burning. It is about the half of the CO2 flux anomaly (range: 4.4-6.7 PgC) estimated for the 1997/1998 El Nio. The annual total sink is estimated to be 3.9+/-0.2 PgC for the assumed fossil fuel emission of 10.1 PgC. The major uncertainty in attribution arise from error in anthropogenic emission trends, satellite data and atmospheric transport

Hadron Masses and Decay Constants with Wilson Quarks at β=5.85\beta=5.85 and 6.0

We present results of a high statistics calculation of hadron masses and meson decay constants in the quenched approximation to lattice QCD with Wilson quarks at $\beta=$ 5.85 and 6.0 on $24^3 \times 54$ lattices. We analyze the data paying attention in particular to the systematic errors due to the choice of fitting range and due to the contamination from excited states. We find that the systematic errors for the hadron masses with quarks lighter than the strange quark amount to 1 --- 2 times the statistical errors. When the lattice scale is fixed from the $\rho$ meson mass, the masses of the $\Omega^{-}$ baryon and the $\phi$ meson at two $\beta$'s agree with experiment within about one standard deviation. On the other hand, the central value of the nucleon mass at $\beta=6.0$ (5.85) is larger than its experimental value by about 15\% (20\%) and that of the $\Delta$ mass by about 15\% (4\%): Even when the systematic errors are included, the baryon masses at $\beta=6.0$ do not agree with experiment. Vector meson decay constants at two values of $\beta$ agree well with each other and are consistent with experiment for a wide range of the quark mass, when we use current renormalization constants determined nonperturbatively by numerical simulations. The pion decay constant agrees with experiment albeit with large errors. Results for the masses of excited states of the $\rho$ meson and the nucleon are also presented.Comment: 50 pages, 30 figure