My Authentic Self: A Learning Journey of Self-Discovery, Acceptance, and New Beginnings

Submitted to the Program of Organizational Dynamics, College of Liberal and Professional Studies in the School of Arts and Sciences in Partial Fulfillment of the Requirements for the Degree of Master of Science in Organizational Dynamics at the University of Pennsylvania Advisor: Charline S. Russ

Volcanism and faulting along the northern margin of Oregon’s High Lava Plains : Hampton Butte to Dry Mountain

Oregon’s High Lava Plains Province (HLP) has strongly bimodal basalt and rhyolitic volcanism. The Province caps the northern margin of the Basin and Range Province and serves as a transitional region between westward extension of the Basin and Range Province and unextended crust to the north . The High Lava Plains overlap an area dominated by abundant minor northwest-striking faults of the Brothers Fault Zone. About 10 million years ago, silicic volcanism began at the eastern end of the HLP and spread west, younging towards the Cascade arc. Basalts erupted along the HLP are not age progressive. Most work in the High Lava Plains and Blue Mountains has left the interface between the two provinces as a nondescript region with few data capable to provide insight into processes active within this transitional region. This thesis focuses on the transition near Hampton Butte. New 40Ar-30Ar ages for Hampton Butte and adjacent Cougar Butte definitively assign both to volcanism during the emplacement of the John Day Formation and indicates a common origin. These units underlie basalts and an andesite that have ages consistent with a pulse of basaltic volcanism along the High Lava Plains around 8 Ma. An ignimbrite with composition and age (3.8 ± 0.6 Ma) consistent with outcrops at Espeland Draw, near the town of Hampton, has a probable origin at Frederick Butte and is grouped here as the Hampton Tuff. Further east, along the northern margin of the HLP, an age of 4.18 (± 0.14 Ma) was obtained for the basaltic andesite scoria cone of Grassy Butte. At Dry Mountain a summit sample produced an age of 7.91 ± 0.12 Ma and is basaltic, a contradiction with previous reports. A sample of rhyolite from Potato Hills, adjacent to Hat Butte, yielded an age of 6.52 ±.07 Ma. Basaltic melts of this study appear to be near direct partial melts of the mantle and are part of the volcanism of the High Lava Plains related to fault propagation and extension. More evolved magmas of the High Lava Plains originate from isobaric fractionation in isolated small magma chambers with little if any assimilation. The eruption of these lavas may be a result of the timing between northeast to southwest extension and Basin and Range east to west extension. The older (> 20 Ma) high silica rocks of Hampton Buttes are the result of diverse fractional crystallization paths from a common basaltic source with little or no assimilation

Acercamiento a la historización de la subjetividad: modos de estar y habitar la Facultad de Psicologia de la Universidad Nacional de La Plata

Serán abordadas las diversas modalidades de estar y habitar (Grupo 12, 2003) la Facultad de Psicología de la Universidad Nacional de La Plata (FP– UNLP) adoptadas por los estudiantes desde la apertura de la carrera hasta la actualidad, vinculándolas con la producción de subjetividad (Lewkovitz, 2004). Se llama “habitar” (Grupo 12, 2003)] a la subjetivación autónoma respecto de la lógica mercantil, mientras que “estar”, a la subjetivación que responde a aquella. De esta manera, se da continuidad al abordaje de la temática iniciado en el año 2007. Durante aquel acercamiento, nos surgieron interrogantes que fueron retomados al año siguiente en la cursada del Seminario Psicología Experimental.Eje temático: Enseñanza de la psicologíaFacultad de Psicologí

Acercamiento a la historización de la subjetividad: modos de estar y habitar la Facultad de Psicologia de la Universidad Nacional de La Plata

Serán abordadas las diversas modalidades de estar y habitar (Grupo 12, 2003) la Facultad de Psicología de la Universidad Nacional de La Plata (FP– UNLP) adoptadas por los estudiantes desde la apertura de la carrera hasta la actualidad, vinculándolas con la producción de subjetividad (Lewkovitz, 2004). Se llama “habitar” (Grupo 12, 2003)] a la subjetivación autónoma respecto de la lógica mercantil, mientras que “estar”, a la subjetivación que responde a aquella. De esta manera, se da continuidad al abordaje de la temática iniciado en el año 2007. Durante aquel acercamiento, nos surgieron interrogantes que fueron retomados al año siguiente en la cursada del Seminario Psicología Experimental.Eje temático: Enseñanza de la psicologíaFacultad de Psicologí

Producción de subjetividades en el ámbito institucional de la carrera de Psicología en la UNLP

El trabajo que a continuación se presenta es la producción de un grupo de estudiantes de la Facultad de Psicología de la Universidad Nacional de La Plata, integrantes de la Comisión de Estudiantes de la misma. Articulan su iniciación en el campo de la investigación con su participación en la de-construcción (Derrida, 1989) y construcción de la Facultad. Se propone abordar las diversas modalidades de habitar este espacio adoptadas por el conjunto de estudiantes de dicha facultad, considerando la articulación que presenta con los procesos de subjetivación actuales. Esto a la luz de un análisis histórico, que posibilite comprender el estado actual de la temática, abordada como decantación de distintos factores que hacen al contexto socio-histórico e institucional en que se entrama.Eje temático: Psicología Social, Institucional y ComunitariaFacultad de Psicologí

Producción de subjetividades en el ámbito institucional de la carrera de Psicología en la UNLP

El trabajo que a continuación se presenta es la producción de un grupo de estudiantes de la Facultad de Psicología de la Universidad Nacional de La Plata, integrantes de la Comisión de Estudiantes de la misma. Articulan su iniciación en el campo de la investigación con su participación en la de-construcción (Derrida, 1989) y construcción de la Facultad. Se propone abordar las diversas modalidades de habitar este espacio adoptadas por el conjunto de estudiantes de dicha facultad, considerando la articulación que presenta con los procesos de subjetivación actuales. Esto a la luz de un análisis histórico, que posibilite comprender el estado actual de la temática, abordada como decantación de distintos factores que hacen al contexto socio-histórico e institucional en que se entrama.Eje temático: Psicología Social, Institucional y ComunitariaFacultad de Psicologí

Clinical Research and Development of Tuberculosis Diagnostics: Moving From Silos to Synergy

The development, evaluation, and implementation of new and improved diagnostics have been identified as critical needs by human immunodeficiency virus (HIV) and tuberculosis researchers and clinicians alike. These needs exist in international and domestic settings and in adult and pediatric populations. Experts in tuberculosis and HIV care, researchers, healthcare providers, public health experts, and industry representatives, as well as representatives of pertinent US federal agencies (Centers for Disease Control and Prevention, Food and Drug Administration, National Institutes of Health, United States Agency for International Development) assembled at a workshop proposed by the Diagnostics Working Group of the Federal Tuberculosis Taskforce to review the state of tuberculosis diagnostics development in adult and pediatric populations

The VCAM-1 gene that encodes the vascular cell adhesion molecule is a target of the Sry-related high mobility group box gene, Sox18

VCAM-1 (vascular cell adhesion molecule-1) and Sox18 are involved in vascular development. VCAM-1 is an important adhesion molecule that is expressed on endothelial cells and has a critical role in endothelial activation, inflammation, lymphatic pathophysiology, and atherogenesis. The Sry-related high mobility group box factor Sox18 has previously been implicated in endothelial pathologies. Mutations in human and mouse Sox18 leads to hypotrichosis and lymphedema. Furthermore, both Sox18 and VCAM-1 have very similar spatio-temporal patterns of expression, which is suggestive of crosstalk. We use biochemical techniques, cell culture systems, and the ragged opossum (RaOP) mouse model with a naturally occurring mutation in Sox18 to demonstrate that VCAM-1 is an important target of Sox18. Transfection, site-specific mutagenesis, and gel shift analyses demonstrated that Sox18 directly targeted and trans-activated VCAM-1 expression. Importantly, the naturally occurring Sox18 mutant attenuates the expression and activation of VCAM-1 in vitro. Furthermore, in vivo quantitation of VCAM-1 mRNA levels in wild type and RaOP mice demonstrates that RaOP animals show a dramatic and significant reduction in VCAM-1 mRNA expression in lung, skin, and skeletal muscle. Our observation that the VCAM-1 gene is an important target of SOX18 provides the first molecular insights into the vascular abnormalities in the mouse mutant ragged and the human hypotrichosis-lymphedematelangiectasia disorder

Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis

Chronic inflammation is a common factor in the development of many gastrointestinal malignancies. Examples include inflammatory bowel disease predisposing to colorectal cancer, Barrett's esophagus as a precursor of esophageal adenocarcinoma, and Helicobacter pylori-induced gastric cancer. The classical activation pathway of NF-κB signaling has been identified as regulating several sporadic and inflammation-associated gastrointestinal tract malignancies. Emerging evidence suggests that the alternative NF-κB signaling pathway also exerts a distinct influence on these processes. This review brings together current knowledge of the role of the alternative NF-κB signaling pathway in the gastrointestinal tract, with a particular emphasis on inflammation-associated cancer development. members of the nuclear factor κ-light-chain-enhancer of activated B cells (NF-κB) family were initially described as transcription factors in B lymphocytes in 1986 (68). Since then, they have been shown to be widely expressed and are conserved across both vertebrates and invertebrates (5, 27). The conventional model of NF-κB signaling proposes two main arms of the pathway. These share similar features but are triggered independently and activate different target genes (76). The classical (canonical) NF-κB activation pathway is triggered by Th1 cytokines and is typified by the action of reticuloendotheliosis viral oncogene homolog A (RelA) (p65)-NF-κB1(p50) heterodimers, whereas the alternative (noncanonical) activation pathway signals through the adaptor protein NF-κB-inducing kinase (NIK). Activation of this mechanism leads to nuclear translocation of transcriptionally active v-rel avian reticuloendotheliosis viral oncogene homolog B (RelB)-NF-κB2(p52) heterodimers. Signaling through either pathway can influence multiple different cellular functions and can exert effects that may appear contradictory. For example, both pro- and anti-apoptotic effects, as well as proliferation (18) and senescence (70) signals, have been attributed to the classical activation pathway of NF-κB signaling. Because of the wide variation in outcomes following pathway activation, it is difficult to extrapolate the effects of NF-κB signaling from one context to another. Classical pathway NF-κB signaling has been identified as a key regulator of inflammation-associated carcinogenesis in several tissues since the early 2000s when Greten et al. demonstrated increased sensitivity to colitis-associated carcinogenesis in mice lacking IKK-β in intestinal epithelial cells (31), and, almost simultaneously Pikarsky et al. identified a similar increase in tumor burden in Mdr2 mice lacking IKK-β in hepatocytes (60). More recent evidence has established that alternative activation pathway NF-κB signaling is also important during the development of several gastrointestinal pathologies in mouse and humans. This article seeks to review this evidence and to establish questions for future research