Measuring habitual physical activity in adults with cystic fibrosis

SummaryBackgroundThe aim of the present study was to determine whether different methods of recording physical activity (PA), i.e., accelerometers vs questionnaires, provided similar information in adults with cystic fibrosis (CF).Methods20 CF (age 33 ± 8SD yrs, FEV1 68 ± 16% predicted) and 11 age-matched healthy controls completed the Habitual Activity Estimation Scale (HAES) questionnaire and wore a biaxial accelerometer (SenseWear Pro3 Armband). Exercise tolerance was measured in CF.ResultsPatients had similar values in PA compared with controls. None of PA categories estimated by HAES questionnaire correlated with PA categories measured by the accelerometer; in CF the HAES questionnaire overestimated the effective levels of PA measured by the accelerometer. There were no differences between weekdays and weekend days PA levels provided by the accelerometer. In CF the questionnaire detected different time reported during the “somewhat inactive” and “somewhat active” categories (z = 2.651; p = 0.008; z = −2.651; p = 0.008), weekdays vs weekend; patients reported more time spent in activity (somewhat active & very active) during the weekend (z = −2.203; p = 0.02). Peak oxygen uptake correlated with accelerometer activities of “moderate” (>4.8 metabolic equivalents (METS)) and “vigorous” (>7.2 METS) intensity (r = 0.503, p = 0.02; r = 0.545, p = 0.01).ConclusionsIn adults with cystic fibrosis PA levels are better evaluated by the accelerometer and are similar to the controls. PA measured by the accelerometer is similar during the week and correlates with exercise tolerance

Minute ventilation and heart rate relationship for estimation of the ventilatory compensation point at high altitude: a pilot study

The ventilatory compensation point (VCP) is an exercise threshold which has been used in the design of training programs in sports medicine and rehabilitation. We recently demonstrated that changes in the slope of the minute ventilation to heart rate relationship (ΔV˙E/ΔHR) can be utilized for estimation of the VCP during incremental exercise at sea level (SL). We hypothesized that in hypoxic conditions, such as high altitude (HA), VCP can be also reliably estimated by ΔV˙E/ΔHR

Relationship between daily physical activity and aerobic fitness in adults with cystic fibrosis

International audienceBackground: The best clinical practice to investigate aerobic fitness includes measurements obtained during cardiopulmonary exercise testing (CPET), however it remains an underutilised clinical measure in cystic fibrosis (CF). To investigate this further, different methods of quantifying exercise capacity in CF are required. The possibility that measuring physical activity (PA) by a portable accelerometer could be used to assess the CF aerobic state and could be added among the CPET surrogates has not been investigated. The aim of this study was to examine the relationship between PA and exercise fitness both at submaximal and maximal levels in clinically stable adults with CF. Methods: Thirty CF patients (FEV 1 71 ± 19% predicted) and fifteen healthy controls undertook an incremental CPET on a cycle ergometer. CPET-related measurements included: oxygen uptake (V'O 2), carbon dioxide production (V'CO 2), ventilatory profile, heart rate (HR) and oxygen pulse (V'O 2 /HR) throughout exercise and at lactic threshold (LT) and peak. LT measures represent submaximal exercise related data. PA was assessed using the accelerometer SenseWear Pro3 Armband. Results: Moderate (>4.8 metabolic equivalents (METS)) and moderate + vigorous (>7.2 METS) PA was related to V'O 2 (p = 0.005 and p = 0.009, respectively) and work rate (p = 0.004 and p = 0.002, respectively) at LT. Moderate PA or greater was positively related to peak V'O 2 (p = 0.005 and p = 0.003, respectively). Daily PA levels were similar in CF and healthy controls. Except for peak values, V'O 2 profile and the V'O 2 at LT were comparable between CF and healthy controls. Conclusions: In adult CF patients daily PA positively correlated with aerobic capacity. PA measurements are a valuable tool in the assessment of exercise performance in an adult CF population and could be used for interventional exercise trials to optimize exercise performance and health status. PA levels and parameters obtained at submaximal exercise are similar in CF and in healthy controls

Measuring habitual physical activity in adults with cystic fibrosis

Background: The aim of the present study was to determine whether different methods of recording physical activity (PA), i.e., accelerometers vs questionnaires, provided similar information in adults with cystic fibrosis (CF). Methods: 20 CF (age 33 +/- 8SD yrs, FEV1 68 +/- 16% predicted) and 11 age-matched healthy controls completed the Habitual Activity Estimation Scale (HAES) questionnaire and wore a biaxial accelerometer (SenseWear Pro3 Armband). Exercise tolerance was measured in CF. Results: Patients had similar values in PA compared with controls. None of PA categories estimated by HAES questionnaire correlated with PA categories measured by the accelerometer; in CF the HAES questionnaire overestimated the effective levels of PA measured by the accelerometer. There were no differences between weekdays and weekend days PA levels provided by the accelerometer. In CF the questionnaire detected different time reported during the "somewhat inactive" and "somewhat active" categories (z = -2.651; p = 0.008; z = -2.651; p = 0.008), weekdays vs weekend; patients reported more time spent in activity (somewhat active & very active) during the weekend (z = -2.203; p = 0.02). Peak oxygen uptake correlated with accelerometer activities of "moderate" (>4.8 metabolic equivalents (METS)) and "vigorous" (>7.2 METS) intensity (r = 0.503, p = 0.02; r = 0.545, p = 0.01). Conclusions: In adults with cystic fibrosis PA levels are better evaluated by the accelerometer and are similar to the controls. PA measured by the accelerometer is similar during the week and correlates with exercise tolerance. (C) 2013 Elsevier Ltd. All rights reserved.Abstract BACKGROUND: The aim of the present study was to determine whether different methods of recording physical activity (PA), i.e., accelerometers vs questionnaires, provided similar information in adults with cystic fibrosis (CF). METHODS: 20 CF (age 33 ± 8SD yrs, FEV1 68 ± 16% predicted) and 11 age-matched healthy controls completed the Habitual Activity Estimation Scale (HAES) questionnaire and wore a biaxial accelerometer (SenseWear Pro3 Armband). Exercise tolerance was measured in CF. RESULTS: Patients had similar values in PA compared with controls. None of PA categories estimated by HAES questionnaire correlated with PA categories measured by the accelerometer; in CF the HAES questionnaire overestimated the effective levels of PA measured by the accelerometer. There were no differences between weekdays and weekend days PA levels provided by the accelerometer. In CF the questionnaire detected different time reported during the "somewhat inactive" and "somewhat active" cat

Effect of acetazolamide on post-NIV metabolic alkalosis in acute exacerbated COPD patients

Non-invasive ventilation (NIV) is an effective treatment in patients with acute exacerbation of COPD (AECOPD). However, it may induce post-hypercapnic metabolic alkalosis (MA). This study aims to evaluate the effect of acetazolamide (ACET) in AECOPD patients treated with NIV

Impact of chronic obstructive pulmonary disease on exercise ventilatory efficiency in heart failure

Background: Heart failure (HF) and chronic obstructive pulmonary disease (COPD) coexistence increases morbidity and mortality. the intercept of ventilation ((V) over dotEint) on the (V) over dotE vs. carbon dioxide production ((V) over dot CO2) relationship during exercise has been found to vary in proportion with dead space (VD) in HF. Considering that increased VD is the key pathophysiological abnormality in COPD but a secondary finding in HF we hypothesized that a high (V) over dotEint would be useful in suggesting COPD as HF co-morbidity. Our aim was to assess whether an elevated (V) over dotEint suggests the presence of COPD in HF.Methods: in a multicenter retrospective study, the (V) over dotE-(V) over dotCO(2) relationship was analyzed both as slope and intercept in HF (n = 108), HF-COPD (n = 106) and COPD (n = 95). Patients with pulmonary arterial hypertension (PAH) (n= 85) and healthy subjects (HF) (n= 56) served as positive and negative controls relative to (V) over dotE-(V) over dotCO(2) abnormalities, respectively.Results: Slope and (V) over dotEint varied in opposite directions in all groups (p = 4.07 L/min identified patients with high probability of having COPD or HF-COPD (sensitivity of 71.6% and specificity of 72.0%).Conclusion: These data provide novel evidence that a high (V) over dotEint (>= 4.07 L/min) should be valued to suggest coexistent COPD in HF patients. (C) 2015 Elsevier Ireland Ltd. All rights reserved.Centro Cardiologico Monzino, IRCCS, Milano (Italy)IRCCS, Ctr Cardiol Monzino, Milan, ItalyHopital Univ Bicetre, AP HP, Serv Explorat Fonct Resp, Ctr Reference Hypertens Pulm Severe,DHU TORINO Th, Le Kremlin Bicetre, FranceUniv Paris 06, Univ Paris 04, UMR S Neurophysiol Resp Expt & Clin 1158, Paris, FranceINSERM, UMR S Neurophysiol Resp Expt & Clin 1158, Paris, FranceGrp Hosp Pitie Salpetriere Charles Foix, AP HP, Serv Explorat Fonct Resp Exercice & Dyspnee, Paris, FranceUniv Roma La Sapienza, Dipartimento Med Clin, Rome, ItalyUniv Belgrade, Fac Med, Div Cardiol, Belgrade 11000, SerbiaFdn Salvatore Maugeri, IRCCS, Sci Inst Milan, Cardiac Rehabil Unit, Turin, ItalyLa Sapienza, Dipartimento Sci Cardiovasc Resp Anestesiol Nefro, Rome, ItalyUniversidade Federal de São Paulo, Paulista Sch Med UNIFESP EPM, Dept Med, Div Resp, São Paulo, BrazilUniv Paris 11, Fac Med, Le Kremlin Bicetre, FranceINSERM, U999, LabEx LERMIT, Ctr Chirurg Marie Lannelongue, Le Plessis Robinson, FranceQueens Univ, Div Resp & Crit Care Med, Fac Hlth Sci, Kingston, ON, CanadaUniv Milan, Dept Clin Sci & Community Hlth, Cardiovasc Sect, I-20122 Milan, ItalyUniversidade Federal de São Paulo, Paulista Sch Med UNIFESP EPM, Dept Med, Div Resp, São Paulo, BrazilWeb of Scienc