Analisis Kualitas Layanan dan Kepuasan Nasabah PT. Cimb Niaga Cabang Denpasar (Studi Komparasi Sebelum dan Setelah Merger)

Penelitian ini dilakukan untuk mengetahui perbedaan kualitas layanan dan kepuasan nasabah PT. CIMB Niaga Cabang Denpasar sebelum dan setelah penggabungan (merger), serta untuk mengetahui apakah setelah penggabungan (merger) kepuasan nasabah berbeda menurut beberapa karakteristik sosial demografi, seperti usia, jenis kelamin, pendidikan, pendapatan dan pekerjaan. Responden penelitian adalah 200 nasabah dan data yang diperoleh dianalisis dengan menggunakan alat analisis marginal homogeneity dan chi square. Hasil penelitian menunjukkan bahwa terdapat peningkatan pada seluruh dimensi yang terdapat pada variabel kualitas layanan serta kepuasan nasabah sebelum dan setelah merger. Penelitian menunjukkan terdapat perbedaan pada kepuasan nasabah pada karakteristik sosial demografi usia, pendidikan dan pendapata

Analisa Konduksi Transient Pada Suhu Kandang Ayam

Konduksi transient bisa dimanfaatkan pada penerapan perpindahan kalor yang secara konduksi dengan melibatkan waktu didalamnya. Penerapan Analisa ini diharapkan bisa membantu dalam pengukuran suatu ruangan untuk mencapai keseragaman temperature. Biasanya ruang ayam Ras seperti hewan ayam yang wajib dipertahankan adalah temperatur badan ayam harus selalu terjaga kondisinya pada temperature tertentu. Sangatlah wajar bila ruangan pada ayam dijaga temperaturnya jangan sampai terjadi penurunan yang akan mengakibatkan kondisi ayam rentan terhadap penyakit tidak dilindungi kehangatannya. Beberapa kendala temperature yang tidak seragam pada suatu ruangan kandang ayam akan  berdampak pada penyusutan produktivitas. pemeliharaan ayam pada fase strarter, ialah semenjak usia satu hari hingga usia 14 hari hal mana perlu temperatur ruang yang sama atau mendekati kondisi temperatur pada indukan. Kebutuhan kondisi temperatur diatas ini dapat terpenuhi dengan bantuan memakai peralatan pemanas. Permasalahan di lapangan yang ada disaat ini belum tercapainya keseragaman temperature ruangan sehingga ayam yang ada dikandang juga terpengaruh juga temperaturnya. Penelitian dilakukan dengan membuat ruangan sebagai aplikasi konduksi transientnya di ruangan volume 9 m3 . Penyekatan untuk menempatkan alat ukur thermometer dan posisi sumbu x,y,z sebagai titik pengukuran penempatan alat pemanas ruangan dan blower diatur 3 variasi kecepatan, Pada penelitian ini nantinya menggunakan dua variabel yaitu penempatan pemanas dan kecepatan blower, yang mana pada variabel kecepatan blower terdapat 3 variasi yaitu 6 m./s, 8 m/s dan 10 m/s dan 3 variabel penempatan pemanas dengan koordinat x, y, z pada ruangan. Tujuan penelitian ini adalah untuk menganalisa keseragaman panasnya dengan menggunakan konduksi transient guna mendapatkan keseragaman paling optimal melalui pengamatan 21 titik thermometer yang di letakkan pada ruangan. Dari hasil analisa dapat disimpulkan bahwa pada posisi P3 atau H1 (X : 53,56cm) (Y : 100cm) (Z : 125cm), H2 (X : 125cm) (Y : 100cm) (Z : 125cm) dan H3 (X : 196,44cm) (Y : 100cm) (Z : 125cm) pada kecepatan blower 10m/s menghasilkan suhu sebesar 32,7⁰C dengan menghasilkan keseragaman suhu 32-35⁰C pada tiap titik thermometer sebesar 17 dari 21 titik thermometer dengan keseragaman temperature terbanyak 81% untuk fase brooding dan waktu mencapai keseragaman 12 menit. Kata kunci: Konduksi transient, Temperatur,  Sistem Pemanas

Rancang Bangun Vacuum Cleaner Dengan Pengendali Nirkabel Menggunakan Modul Rf Data Transceiver Ys-1020ub Berbasis Mikrokontroler At89s52

Kebersihan merupakan hal yang sangat penting untuk menjaga kesehatan kita, khususnya kebersihan rumah. Rumah yang bersih sangat mempengaruhi kesehatan para penghuninya. Debu adalah kotoran yang paling sering mengotori rumah kita terutama pada bagian lantai. Setiap hari kita harus membersihkan rumah dari debu yang ada pada lantai untuk menjaga kebersihan sekaligus kesehatan kita. Dalam membersihkan lantai rumah dari  debu sering menyita banyak waktu dan tenaga. Vacuum cleaner terkendali nirkabel menggunakan Modul RF Data Transceiver YS-1020UB berbasis mikrokontroler AT89S52 merupakan salah satu solusi untuk membersihkan lantai rumah dari kotoran debu.  Vacuum cleaner ini menggunakan enam buah motor DC yaitu dua motor DC penyedot debu, dua motor DC penentu arah maju, mundur, belok kanan, dan belok kiri, serta dua motor DC penentu arah geser kanan dan geser kiri.  Vacuum cleaner ini dapat dikendalikan dengan dua mode operasi yaitu mode manual dan otomatis. Pada mode manual vacuum cleaner ini dikendalikan menggunakan remote control, dengan tranmisi nirkabel memakai transceiver YS-1020UB. Sedangkan pada mode otomatis  vacuum cleaner ini menggunakan empat buah sensor jarak untuk menghindari tabrakan pada dinding.  Vacuum cleaner dengan pengendali nirkabel menggunakan modul RF Data Transceiver YS-1020UB berbasis mikrokontroler AT89S52 sudah bisa membersihkan debu lantai sehingga lantai bersih dari debu.</p

Common Variants in Alzheimer’s Disease and Risk Stratification by Polygenic Risk Scores

Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n=409,435 and validation size n=58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease.The present work has been performed as part of the doctoral program of I. de Rojas at the Universitat de Barcelona (Barcelona, Spain) supported by national grant from the Instituto de Salud Carlos III FI20/00215. The Genome Research @ Fundació ACE project (GR@ACE) is supported by Grifols SA, Fundación bancaria “La Caixa”, Fundació ACE, and CIBERNED. A.R. and M.B. receive support from the European Union/EFPIA Innovative Medicines Initiative Joint undertaking ADAPTED and MOPEAD projects (grant numbers 115975 and 115985, respectively). M.B. and A.R. are also supported by national grants PI13/02434, PI16/01861, PI17/01474, PI19/01240 and PI19/01301. Acción Estratégica en Salud is integrated into the Spanish National R + D + I Plan and funded by ISCIII (Instituto de Salud Carlos III)—Subdirección General de Evaluación and the Fondo Europeo de Desarrollo Regional (FEDER—“Una manera de hacer Europa”). The Alzheimer Center Amsterdam is supported by Stichting Alzheimer Nederland and Stichting VUmc fonds. The clinical database structure was developed with funding from Stichting Dioraphte. Genotyping of the Dutch case-control samples was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND FP-829-029 (ZonMW project number 733051061). 100-Plus study. This work was supported by Stichting Alzheimer Nederland (WE09.2014-03), Stichting Diorapthe, horstingstuit foundation, Memorabel (ZonMW project number 733050814, 733050512) and Stichting VUmc Fonds. Genotyping of the 100-Plus Study was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND FP-829-029 (ZonMW project numb 733051061). Longitudinal Aging Study Amsterdam (LASA) is largely supported by a grant from the Netherlands Ministry of Health, Welfare and Sports, Directorate of LongTerm Care. This work was supported by a grant (European Alzheimer DNA BioBank, EADB) from the EU Joint Program—Neurodegenerative Disease Research (JPND) and also funded by Inserm, Institut Pasteur de Lille, the Lille Métropole Communauté Urbaine, the French government’s LABEX DISTALZ program (development of innovative strategies for a transdisciplinary approach to AD). Genotyping of the German case-control samples was performed in the context of EADB (European Alzheimer DNA biobank) funded by the JPco-fuND (German Federal Ministry of Education and Research, BMBF: 01ED1619A). The i–Select chips was funded by the French National Foundation on AD and related disorders. EADI was supported by the LABEX (laboratory of excellence program investment for the future) DISTALZ grant, Inserm, Institut Pasteur de Lille, Université de Lille 2 and the Lille University Hospital. GERAD was supported by the Medical Research Council (Grant n° 503480), Alzheimer’s Research UK (Grant n° 503176), the Wellcome Trust (Grant n° 082604/2/07/Z) and German Federal Ministry of Education and Research (BMBF): Competence Network Dementia (CND) grant n° 01GI0102, 01GI0711, 01GI0420. CHARGE was partly supported by the NIA/NHLBI grants AG049505, AG058589, HL105756 and AGES contract N01–AG–12100, the Icelandic Heart Association, and the Erasmus Medical Center and Erasmus University. ADGC was supported by the NIH/NIA grants: U01 AG032984, U24 AG021886, U01 AG016976, and the Alzheimer’s Association grant ADGC–10–19672

Shared genetic contribution to Ischaemic Stroke and Alzheimer's Disease.

OBJECTIVE: Increasing evidence suggests epidemiological and pathological links between Alzheimer's disease (AD) and Ischaemic Stroke (IS). We investigated the evidence that shared genetic factors underpin the two diseases. METHODS: Using genome wide association study (GWAS) data from METASTROKE+ (15,916 IS cases and 68,826 controls) and IGAP (17,008 AD cases and 37,154 controls), we evaluated known associations with AD and IS. On the subset of data for which we could obtain compatible genotype-level data (4,610 IS cases, 1,281 AD cases and 14,320 controls), we estimated the genome-wide genetic correlation (rG) between AD and IS, and the three subtypes (cardioembolic, small vessel, large vessel), using genome-wide SNP data. We then performed a meta-analysis and pathway analysis in the combined AD and small vessel stroke datasets to identify the SNPs and molecular pathways through which disease risk may be conferred. RESULTS: We found evidence of a shared genetic contribution between AD and small vessel stroke (rG(SE)=0.37(0.17); p=0.011). Conversely, there was no evidence to support shared genetic factors in AD and IS overall, or with the other stroke subtypes. Of the known GWAS associations with IS or AD, none reached significance for association with the other trait (or stroke subtypes). A meta-analysis of AD IGAP and METASTROKE+ small vessel stroke GWAS data highlighted a region (ATP5H/KCTD2/ICT1), associated with both diseases (p=1.8x10-8 ). A pathway analysis identified four associated pathways, involving cholesterol transport and immune response. INTERPRETATION: Our findings indicate shared genetic susceptibility to AD and small vessel stroke and highlight potential causal pathways and loci. This article is protected by copyright. All rights reserved.Stroke Association (TSA 2013/01 & TSA 2010/10: H.S.M & M.T.), MRC/Stroke Association (Clinical Training Fellowship: P.A-S.), National Institute for Health Research (NIHR) (Senior Investigator Award: H.S.M.), Wellcome Trust (Collection of the UK Young Lacunar Stroke DNA Study (WT072952): H.S.M); NIHR Comprehensive Biomedical Research Unit at Cambridge University Hospitals Trust (H.S.M.); NIHR Mental Health Biomedical Research Centre at South London and Maudsley NHS Foundation Trust and King’s College London (C.M.L.); NIHR Biomedical Research Centre based at Guy's and St Thomas' NHS Foundation Trust and King's College London (C.M.L.). Additional sources of support are provided in the Supplementary Materials.This is the final version of the article. It first appeared from Wiley via https://doi.org/10.1002/ana.2462

Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease.Peer reviewe

CXCR4 involvement in neurodegenerative diseases

Neurodegenerative diseases likely share common underlying pathobiology. Although prior work has identified susceptibility loci associated with various dementias, few, if any, studies have systematically evaluated shared genetic risk across several neurodegenerative diseases. Using genome-wide association data from large studies (total n = 82,337 cases and controls), we utilized a previously validated approach to identify genetic overlap and reveal common pathways between progressive supranuclear palsy (PSP), frontotemporal dementia (FTD), Parkinson's disease (PD) and Alzheimer's disease (AD). In addition to the MAPT H1 haplotype, we identified a variant near the chemokine receptor CXCR4 that was jointly associated with increased risk for PSP and PD. Using bioinformatics tools, we found strong physical interactions between CXCR4 and four microglia related genes, namely CXCL12, TLR2, RALB, and CCR5. Evaluating gene expression from post-mortem brain tissue, we found that expression of CXCR4 and microglial genes functionally related to CXCR4 was dysregulated across a number of neurodegenerative diseases. Furthermore, in a mouse model of tauopathy, expression of CXCR4 and functionally associated genes was significantly altered in regions of the mouse brain that accumulate neurofibrillary tangles most robustly. Beyond MAPT, we show dysregulation of CXCR4 expression in PSP, PD, and FTD brains, and mouse models of tau pathology. Our multi-modal findings suggest that abnormal signaling across a 'network' of microglial genes may contribute to neurodegeneration and may have potential implications for clinical trials targeting immune dysfunction in patients with neurodegenerative diseases

Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease.

Late onset Alzheimer's disease is the most common form of dementia for which about 30 susceptibility loci have been reported. The aim of the current study is to identify novel genes associated with Alzheimer's disease using the largest up-to-date reference single nucleotide polymorphism (SNP) panel, the most accurate imputation software and a novel gene-based analysis approach which tests for patterns of association within genes, in the powerful genome-wide association dataset of the International Genomics of Alzheimer's Project Consortium, comprising over 7 million genotypes from 17,008 Alzheimer's cases and 37,154 controls. In addition to earlier reported genes, we detected three novel gene-wide significant loci PPARGC1A (p = 2.2 × 10-6), RORA (p = 7.4 × 10-7) and ZNF423 (p = 2.1 × 10-6). PPARGC1A and RORA are involved in circadian rhythm; circadian disturbances are one of the earliest symptoms of Alzheimer's disease. PPARGC1A is additionally linked to energy metabolism and the generation of amyloid beta plaques. RORA is involved in a variety of functions apart from circadian rhythm, such as cholesterol metabolism and inflammation. The ZNF423 gene resides in an Alzheimer's disease-specific protein network and is likely involved with centrosomes and DNA damage repair