In vivo functional and myeloarchitectonic mapping of human primary auditory areas

In contrast to vision, where retinotopic mapping alone can define areal borders, primary auditory areas such as A1 are best delineated by combining in vivo tonotopic mapping with postmortem cyto- or myeloarchitectonics from the same individual. We combined high-resolution (800 μm) quantitative T(1) mapping with phase-encoded tonotopic methods to map primary auditory areas (A1 and R) within the "auditory core" of human volunteers. We first quantitatively characterize the highly myelinated auditory core in terms of shape, area, cortical depth profile, and position, with our data showing considerable correspondence to postmortem myeloarchitectonic studies, both in cross-participant averages and in individuals. The core region contains two "mirror-image" tonotopic maps oriented along the same axis as observed in macaque and owl monkey. We suggest that these two maps within the core are the human analogs of primate auditory areas A1 and R. The core occupies a much smaller portion of tonotopically organized cortex on the superior temporal plane and gyrus than is generally supposed. The multimodal approach to defining the auditory core will facilitate investigations of structure-function relationships, comparative neuroanatomical studies, and promises new biomarkers for diagnosis and clinical studies

Using Seafood Traceability to Teach the Complexities of Natural Resource Management and Sustainability

This lesson plan addresses the challenge of conveying to students the globalized nature and complexity of natural resource management. Specifically, it uses seafood traceability, or the ability to track seafood as it moves through the global seafood supply chain, as a theme for understanding the potential for science and technological innovations to enable traceability as well as the different roles that various stakeholders play in ensuring fisheries sustainability. The lesson plan conveys several themes related to environmental sustainability including: the role of consumer empowerment, the importance of data and information sharing, the need to coordinate multiple stakeholders, and the intersection of science, technology, and policy- making. In one classroom activity, students are guided through a small-group, active-learning exercise that challenges them to make sustainable seafood choices from a restaurant menu. In another activity, students are asked to role-play and consider the information needs of various stakeholders in the seafood supply chain. Overall, the lesson plan is designed to demonstrate that there is no one single solution to realize seafood traceability and ensure fisheries sustainability. Instead, fisheries and natural resource management require multifaceted solutions and the involvement of multiple sectors of society

TEMPERATURE-DEPENDENCE OF DOMAIN-WALL COERCIVE FIELD IN MAGNETIC GARNET-FILMS

The coercive properties of magnetically uniaxial liquid-phase epitaxy garnet films were investigated between 10 K and the Neel temperature (T(N) less-than-or-equal-to 500 K). Two independent methods, the results of which are nearly identical (magnetical response of oscillating domain walls and the method of coercive loops measured in a vibrating sample magnetometer), were used. Besides the usual domain-wall coercive field, H(dw), the critical coercive pressure, p(dw), was also introduced as it describes in a direct way the interactions of the domain walls with the wall-pinning traps. Both H(dw) and p(dw) were found to increase exponentially with decreasing temperature. Three different types of wall-pinning traps were identified in the sample and their strength, their rate of change with temperature, and their temperature range of activity were determined

Vulnerability of Resource Users in Louisiana’s Oyster Fishery to Environmental Hazards

Knowledge of vulnerability provides the foundation for developing actions that minimize impacts on people while maximizing the sustainability of ecosystem goods and services. As a result, it is becoming increasingly important to determine how resource-dependent people are vulnerable to environmental hazards. This idea is particularly true in coastal Louisiana, USA, where the current era of rapid land loss has the potential to undermine oyster fisheries. However, little is known about how such environmental change might differentially affect resource users and stakeholders. We examined social components of vulnerability to environmental hazards using indicators of susceptibility and adaptive capacity within the oyster fishery of Terrebonne Parish, Louisiana. Specifically, we used structured interviews to compare three resource-user roles: oyster fishers, oyster fishers/lease owners, and oyster lease owners only. Results indicated that oyster fishers/lease owners were highly dependent and thus susceptible to changes in the fishery because of high levels of occupational identity. These same people, however, were the most adaptable to change, which was reflected in their willingness to learn about new practices and evolve over time. Higher susceptibility in this group was offset by an increased ability to adapt, cope, and respond to changes in the environment. In contrast to these findings, oyster fishers that did not own any portion of a lease or business in which they operated were bad at coping with change and frequently held negative or fatalistic views on financial planning. These attributes made them the most vulnerable to environmental hazards. Overall, the most vulnerable participants in the Terrebonne Parish oyster fishery were those with low to moderate levels of personal and financial buffers and trust, coupled with high occupational identity and a low motivation to change. Local policy actions that target these attributes are likely to be the best entry points to reducing the vulnerability of stakeholders to hazards

Criteria for the diagnosis of corticobasal degeneration

Current criteria for the clinical diagnosis of pathologically confirmed corticobasal degeneration (CBD) no longer reflect the expanding understanding of this disease and its clinicopathologic correlations. An international consortium of behavioral neurology, neuropsychology, and movement disorders specialists developed new criteria based on consensus and a systematic literature review. Clinical diagnoses (early or late) were identified for 267 nonoverlapping pathologically confirmed CBD cases from published reports and brain banks. Combined with consensus, 4 CBD phenotypes emerged: corticobasal syndrome (CBS), frontal behavioral-spatial syndrome (FBS), nonfluent/agrammatic variant of primary progressive aphasia (naPPA), and progressive supranuclear palsy syndrome (PSPS). Clinical features of CBD cases were extracted from descriptions of 209 brain bank and published patients, providing a comprehensive description of CBD and correcting common misconceptions. Clinical CBD phenotypes and features were combined to create 2 sets of criteria: more specific clinical research criteria for probable CBD and broader criteria for possible CBD that are more inclusive but have a higher chance to detect other tau-based pathologies. Probable CBD criteria require insidious onset and gradual progression for at least 1 year, age at onset ≥50 years, no similar family history or known tau mutations, and a clinical phenotype of probable CBS or either FBS or naPPA with at least 1 CBS feature. The possible CBD category uses similar criteria but has no restrictions on age or family history, allows tau mutations, permits less rigorous phenotype fulfillment, and includes a PSPS phenotype. Future validation and refinement of the proposed criteria are needed

Revisiting protein aggregation as pathogenic in sporadic Parkinson and Alzheimer diseases.

The gold standard for a definitive diagnosis of Parkinson disease (PD) is the pathologic finding of aggregated α-synuclein into Lewy bodies and for Alzheimer disease (AD) aggregated amyloid into plaques and hyperphosphorylated tau into tangles. Implicit in this clinicopathologic-based nosology is the assumption that pathologic protein aggregation at autopsy reflects pathogenesis at disease onset. While these aggregates may in exceptional cases be on a causal pathway in humans (e.g., aggregated α-synuclein in SNCA gene multiplication or aggregated β-amyloid in APP mutations), their near universality at postmortem in sporadic PD and AD suggests they may alternatively represent common outcomes from upstream mechanisms or compensatory responses to cellular stress in order to delay cell death. These 3 conceptual frameworks of protein aggregation (pathogenic, epiphenomenon, protective) are difficult to resolve because of the inability to probe brain tissue in real time. Whereas animal models, in which neither PD nor AD occur in natural states, consistently support a pathogenic role of protein aggregation, indirect evidence from human studies does not. We hypothesize that (1) current biomarkers of protein aggregates may be relevant to common pathology but not to subgroup pathogenesis and (2) disease-modifying treatments targeting oligomers or fibrils might be futile or deleterious because these proteins are epiphenomena or protective in the human brain under molecular stress. Future precision medicine efforts for molecular targeting of neurodegenerative diseases may require analyses not anchored on current clinicopathologic criteria but instead on biological signals generated from large deeply phenotyped aging populations or from smaller but well-defined genetic-molecular cohorts

Logopenic and nonfluent variants of primary progressive aphasia are differentiated by acoustic measures of speech production

Differentiation of logopenic (lvPPA) and nonfluent/agrammatic (nfvPPA) variants of Primary Progressive Aphasia is important yet remains challenging since it hinges on expert based evaluation of speech and language production. In this study acoustic measures of speech in conjunction with voxel-based morphometry were used to determine the success of the measures as an adjunct to diagnosis and to explore the neural basis of apraxia of speech in nfvPPA. Forty-one patients (21 lvPPA, 20 nfvPPA) were recruited from a consecutive sample with suspected frontotemporal dementia. Patients were diagnosed using the current gold-standard of expert perceptual judgment, based on presence/absence of particular speech features during speaking tasks. Seventeen healthy age-matched adults served as controls. MRI scans were available for 11 control and 37 PPA cases; 23 of the PPA cases underwent amyloid ligand PET imaging. Measures, corresponding to perceptual features of apraxia of speech, were periods of silence during reading and relative vowel duration and intensity in polysyllable word repetition. Discriminant function analyses revealed that a measure of relative vowel duration differentiated nfvPPA cases from both control and lvPPA cases (r2 = 0.47) with 88% agreement with expert judgment of presence of apraxia of speech in nfvPPA cases. VBM analysis showed that relative vowel duration covaried with grey matter intensity in areas critical for speech motor planning and programming: precentral gyrus, supplementary motor area and inferior frontal gyrus bilaterally, only affected in the nfvPPA group. This bilateral involvement of frontal speech networks in nfvPPA potentially affects access to compensatory mechanisms involving right hemisphere homologues. Measures of silences during reading also discriminated the PPA and control groups, but did not increase predictive accuracy. Findings suggest that a measure of relative vowel duration from of a polysyllable word repetition task may be sufficient for detecting most cases of apraxia of speech and distinguishing between nfvPPA and lvPPA

SURVEY OF THE DEPENDENCE ON TEMPERATURE OF THE COERCIVITY OF GARNET-FILMS

The temperature dependence of the domain-wall coercive field of epitaxial magnetic garnets films has been investigated in the entire temperature range of the ferrimagnetic phase, and has been found to be described by a set of parametric exponents. In subsequent temperature regions different slopes were observed, with breaking points whose position was found to be sample dependent. A survey ba.ed on literature Data as well as on a large number of our own samples shows the general existence of this piecewise exponential dependence and the presence of the breaking points. This type of domain-wall coercive field temperature dependence was found in all samples in the large family of the epitaxial garnets (about 30 specimens of more than ten chemical compositionsj and also in another strongly anisotropic material (TbFeCo)