1,099 research outputs found
States of an Ensemble of Two-Level Atoms with Reduced Quantum Uncertainty
We generate entangled states of an ensemble of 5*10^4 rubidium-87 atoms by
optical quantum nondemolition measurement. The resonator-enhanced measurement
leaves the atomic ensemble, prepared in a superposition of hyperfine clock
levels, in a squeezed spin state. By comparing the resulting reduction of
quantum projection noise (up to 8.8(8) dB) with the concomitant reduction of
coherence, we demonstrate a clock input state with spectroscopic sensitivity
3.0(8) dB beyond the standard quantum limit.Comment: Letter (4 pages, 3 figures) followed by Auxiliary Material (10 pages,
6 figures). Minor changes in presentation and analysis of data. Significant
expansion of Auxiliary Material. Broken images fixe
Revealing large-scale homogeneity and trace impurity sensitivity of GaAs nanoscale membranes
III-V nanostructures have the potential to revolutionize optoelectronics and
energy harvesting. For this to become a reality, critical issues such as
reproducibility and sensitivity to defects should be resolved. By discussing
the optical properties of MBE grown GaAs nanomembranes we highlight several
features that bring them closer to large scale applications. Uncapped membranes
exhibit a very high optical quality, expressed by extremely narrow neutral
exciton emission, allowing the resolution of the more complex excitonic
structure for the first time. Capping of the membranes with an AlGaAs shell
results in a strong increase of emission intensity but also to a shift and
broadening of the exciton peak. This is attributed to the existence of
impurities in the shell, beyond MBE-grade quality, showing the high sensitivity
of these structures to the presence of impurities. Finally, emission properties
are identical at the sub-micron and sub-millimeter scale, demonstrating the
potential of these structures for large scale applications.Comment: just accepted in Nano Letters,
http://pubs.acs.org/doi/abs/10.1021/acs.nanolett.7b0025
Characterization of potential biomarkers of reactogenicity of licensed antiviral vaccines: randomized controlled clinical trials conducted by the BIOVACSAFE consortium
Funding text The authors are grateful for the vital contributions of the participating study volunteers, clinicians, nurses, and laboratory technicians at the Surrey study site. The work by Roberto Leone, laboratory technician at Humanitas Clinical and Research Center, is gratefully acknowledged. Finally, they thank Ellen Oe (GSK) for scientific writing assistance. The research leading to these results has received support from the Innovative Medicines Initiative Joint Undertaking under grant agreement n°115308, resources of which are composed of financial contribution from the European Union’s Seventh Framework Programme (FP7/2007–2013) and EFPIA companies’ in-kind contribution. The contribution of the European Commission to the Advanced Immunization Technologies (ADITEC) project (grant agreement n° 280873) is also gratefully acknowledged. Publisher Copyright: © 2019, The Author(s).Biomarkers predictive of inflammatory events post-vaccination could accelerate vaccine development. Within the BIOVACSAFE framework, we conducted three identically designed, placebo-controlled inpatient/outpatient clinical studies (NCT01765413/NCT01771354/NCT01771367). Six antiviral vaccination strategies were evaluated to generate training data-sets of pre-/post-vaccination vital signs, blood changes and whole-blood gene transcripts, and to identify putative biomarkers of early inflammation/reactogenicity that could guide the design of subsequent focused confirmatory studies. Healthy adults (N = 123; 20–21/group) received one immunization at Day (D)0. Alum-adjuvanted hepatitis B vaccine elicited vital signs and inflammatory (CRP/innate cells) responses that were similar between primed/naive vaccinees, and low-level gene responses. MF59-adjuvanted trivalent influenza vaccine (ATIV) induced distinct physiological (temperature/heart rate/reactogenicity) response-patterns not seen with non-adjuvanted TIV or with the other vaccines. ATIV also elicited robust early (D1) activation of IFN-related genes (associated with serum IP-10 levels) and innate-cell-related genes, and changes in monocyte/neutrophil/lymphocyte counts, while TIV elicited similar but lower responses. Due to viral replication kinetics, innate gene activation by live yellow-fever or varicella-zoster virus (YFV/VZV) vaccines was more suspended, with early IFN-associated responses in naïve YFV-vaccine recipients but not in primed VZV-vaccine recipients. Inflammatory responses (physiological/serum markers, innate-signaling transcripts) are therefore a function of the vaccine type/composition and presence/absence of immune memory. The data reported here have guided the design of confirmatory Phase IV trials using ATIV to provide tools to identify inflammatory or reactogenicity biomarkers.Peer reviewe
Anomalous f-electron Hall Effect in the Heavy-Fermion System CeTIn (T = Co, Ir, or Rh)
The in-plane Hall coefficient of CeRhIn, CeIrIn, and
CeCoIn and their respective non-magnetic lanthanum analogs are reported
in fields to 90 kOe and at temperatures from 2 K to 325 K. is
negative, field-independent, and dominated by skew-scattering above 50 K
in the Ce compounds. becomes increasingly negative below 50 K
and varies with temperature in a manner that is inconsistent with skew
scattering. Field-dependent measurements show that the low-T anomaly is
strongly suppressed when the applied field is increased to 90 kOe. Measurements
on LaRhIn, LaIrIn, and LaCoIn indicate that the same
anomalous temperature dependence is present in the Hall coefficient of these
non-magnetic analogs, albeit with a reduced amplitude and no field dependence.
Hall angle () measurements find that the ratio
varies as below 20 K for all
three Ce-115 compounds. The Hall angle of the La-115 compounds follow this
T-dependence as well. These data suggest that the electronic-structure
contribution dominates the Hall effect in the 115 compounds, with -electron
and Kondo interactions acting to magnify the influence of the underlying
complex band structure. This is in stark contrast to the situation in most
and heavy-fermion compounds where the normal carrier contribution to the
Hall effect provides only a small, T-independent background to Comment: 23 pages and 8 figure
Enumeration and Decidable Properties of Automatic Sequences
We show that various aspects of k-automatic sequences -- such as having an
unbordered factor of length n -- are both decidable and effectively enumerable.
As a consequence it follows that many related sequences are either k-automatic
or k-regular. These include many sequences previously studied in the
literature, such as the recurrence function, the appearance function, and the
repetitivity index. We also give some new characterizations of the class of
k-regular sequences. Many results extend to other sequences defined in terms of
Pisot numeration systems
Evidence for antiferromagnetism coexisting with charge order in the trilayer cuprate HgBaCaCuO
Multilayered cuprates possess not only the highest superconducting
temperature transition but also offer a unique platform to study disorder-free
CuO planes and the interplay between competing orders with
superconductivity. Here, we study the underdoped trilayer cuprate
HgBaCaCuO and we report the first quantum oscillation
and Hall effect measurements in magnetic field up to 88 T. A careful analysis
of the complex spectra of quantum oscillations strongly supports the
coexistence of an antiferromagnetic order in the inner plane and a charge order
in the outer planes. The presence of an ordered antiferromagnetic metallic
state that extends deep in the superconducting phase is a key ingredient that
supports magnetically mediated pairing interaction in cuprates.Comment: 6+5 pages, 4+6 figure
Cymantrene–Triazole "Click" Products: Structural Characterization and Electrochemical Properties
We report the first known examples of triazole-derivatized cymantrene complexes (η5-[4-substituted triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I), obtained via a “click” chemical synthesis, bearing a phenyl, 3-aminophenyl, or 4-aminophenyl moiety at the 4-position of the triazole ring. Structural characterization data using multinuclear NMR, UV–vis, ATR-IR, and mass spectrometric methods are provided, as well as crystallographic data for (η5-[4-phenyltriazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I) and (η5-[4-(3-aminophenyl)triazol-1-yl]cyclopentadienyl)tricarbonylmanganese(I). Cyclic voltammetric characterization of the redox behavior of each of the three cymantrene–triazole complexes is presented together with digital simulations, in situ infrared spectroelectrochemistry, and DFT calculations to extract the associated kinetic and thermodynamic parameters. The trypanocidal activity of each cymantrene–triazole complex is also examined, and these complexes are found to be more active than cymantrene alone
A phase II, open-label, multicentre study to evaluate the immunogenicity and safety of an adjuvanted prepandemic (H5N1) influenza vaccine in healthy Japanese adults
<p>Abstract</p> <p>Background</p> <p>Promising clinical data and significant antigen-sparing have been demonstrated for a pandemic H5N1 influenza split-virion vaccine adjuvanted with AS03<sub>A</sub>, an α-tocopherol-containing oil-in-water emulsion-based Adjuvant System. Although studies using this formulation have been reported, there have been no data for Japanese populations. This study therefore aimed to assess the immunogenicity and tolerability of a prepandemic (H5N1) influenza vaccine adjuvanted with AS03<sub>A </sub>in Japanese adults.</p> <p>Methods</p> <p>This open-label, single-group study was conducted at two centres in Japan in healthy Japanese males and females aged 20-64 years (n = 100). Subjects received two doses of vaccine, containing 3.75 μg haemagglutinin of the A/Indonesia/5/2005-like IBCDC-RG2 Clade 2.1 (H5N1) strain adjuvanted with AS03<sub>A</sub>, 21 days apart. The primary endpoint evaluated the humoral immune response in terms of H5N1 haemagglutination inhibition (HI) antibody titres against the vaccine strain (Clade 2.1) 21 days after the second dose. Ninety five percent confidence intervals for geometric mean titres, seroprotection, seroconversion and seropositivity rates were calculated. Secondary and exploratory endpoints included the assessment of the humoral response in terms of neutralising antibody titres, the response against additional H5N1 strains (Clade 1 and Clade 2.2), as well as the evaluation of safety and reactogenicity.</p> <p>Results</p> <p>Robust immune responses were elicited after two doses of the prepandemic influenza vaccine adjuvanted with AS03<sub>A</sub>. Overall, vaccine HI seroconversion rates and seroprotection rates were 91% 21 days after the second vaccination. This fulfilled all regulatory acceptance criteria for the vaccine-homologous HI antibody level. A substantial cross-reactive humoral immune response was also observed against the virus strains A/turkey/Turkey/1/2005 (Clade 2.2) and A/Vietnam/1194/2004 (Clade 1) after the second vaccine administration. A marked post-vaccination response in terms of neutralising antibody titres was demonstrated and persistence of the immune response was observed 6 months after the first dose. The vaccine was generally well tolerated and there were no serious adverse events reported.</p> <p>Conclusions</p> <p>The H5N1 candidate vaccine adjuvanted with AS03<sub>A </sub>elicited a strong and persistent immune response against the vaccine strain A/Indonesia/5/2005 in Japanese adults. Vaccination with this formulation demonstrated a clinically acceptable reactogenicity profile and did not raise any safety concerns in this population.</p> <p>Trial registration</p> <p>Clinicaltrials.gov NCT00742885</p
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