Virtual porous materials to predict the air void topology and hydraulic conductivity of asphalt roads

This paper investigates the effects of air void topology on hydraulic conductivity in asphalt mixtures with porosity in the range 14%–31%. Virtual asphalt pore networks were generated using the Intersected Stacked Air voids (ISA) method, with its parameters being automatically adjusted by the means of a differential evolution optimisation algorithm, and then 3D printed using transparent resin. Permeability tests were conducted on the resin samples to understand the effects of pore topology on hydraulic conductivity. Moreover, the pore networks generated virtually were compared to real asphalt pore networks captured via X-ray Computed Tomography (CT) scans. The optimised ISA method was able to generate realistic 3D pore networks corresponding to those seen in asphalt mixtures in term of visual, topological, statistical and air void shape properties. It was found that, in the range of porous asphalt materials investigated in this research, the high dispersion in hydraulic conductivity at constant air void content is a function of the average air void diameter. Finally, the relationship between average void diameter and the maximum aggregate size and gradation in porous asphalt materials was investigated

PAS3-HSID: a Dynamic Bio-Inspired Approach for Real-Time Hot Spot Identification in Data Streams

© 2019, Springer Science+Business Media, LLC, part of Springer Nature. Hot spot identification is a very relevant problem in a wide variety of areas such as health care, energy or transportation. A hot spot is defined as a region of high likelihood of occurrence of a particular event. To identify hot spots, location data for those events is required, which is typically collected by telematics devices. These sensors are constantly gathering information, generating very large volumes of data. Current state-of-the-art solutions are capable of identifying hot spots from big static batches of data by means of variations of clustering or instance selection techniques that pre-process the original input data, providing the most relevant locations. However, these approaches neglect to address changes in hot spots over time. This paper presents a dynamic bio-inspired approach to detect hot spots in big data streams. This computational intelligence method is designed and applied to the transportation sector as a case study to identify incidents in the roads caused by heavy goods vehicles. We adapt an immune-based algorithm to account for the temporary aspect of hot spots inspired by the idea of pheromones, which is then subsequently implemented using Apache Spark Streaming. Experimental results on real datasets with up to 4.5 million data points—provided by a telematics company—show that the algorithm is capable of quickly processing large streaming batches of data, as well as successfully adapting over time to detect hot spots. The outcome of this method is twofold, both reducing data storage requirements and demonstrating resilience to sudden changes in the input data (concept drift)

PAS3-HSID: a Dynamic Bio-Inspired Approach for Real-Time Hot Spot Identification in Data Streams

http://dx.doi.org/10.5902/2236130814684http://dx.doi.org/10.5902/2236130814684O gerenciamento de resíduos municipais é um tema que vem se tornando cada vez mais importante no contexto das preocupações mundiais dos governos, e teve um considerável desenvolvimento nas últimas décadas. Tanto os países desenvolvidos como os “em desenvolvimento” emitiram normativas legais restritivas, visando otimizar seus planos de tratamento e destinação final destes resíduos. O objetivo principal do trabalho é investigar a real situação deste cenário no Brasil e nos países desenvolvidos, demonstrando os resultados obtidos e traçando um paralelo comparativo e critico. São transcritos e analisados os dados obtidos, em cada fase de uma Gestão Integrada de Resíduos Sólidos Urbanos – GIRSU. Conclusões importantes são relatadas, tais como, o alto nível de investimento dos países desenvolvidos em relação às campanhas de conscientização para implantação de uma efetiva GIRSU, assim como contrastes marcantes entre os índices de reciclagem no Brasil e neste bloco diferenciado de países, ou seja, 2% e 20%, respectivamente, no montante dos resíduos totais gerados. A avaliação final é de que o diferencial esta nas ações políticas de incentivo econômico destes países desenvolvidos, em termos de subsídios, se comparados com o caso brasileiro

Local perception in Dandeli Wildlife Sanctuary - Karnataka, India

The main goal of this research is to assess the socio-economic and perception correlates of local resident's knowledge and gladness towards a protected area. For the case study we selected Dandeli Wildlife Sanctuary and populations living in and around the protected area, as well as a nearby local city

Multigranulation Super-Trust Model for Attribute Reduction

IEEE As big data often contains a significant amount of uncertain, unstructured and imprecise data that are structurally complex and incomplete, traditional attribute reduction methods are less effective when applied to large-scale incomplete information systems to extract knowledge. Multigranular computing provides a powerful tool for use in big data analysis conducted at different levels of information granularity. In this paper, we present a novel multigranulation super-trust fuzzy-rough set-based attribute reduction (MSFAR) algorithm to support the formation of hierarchies of information granules of higher types and higher orders, which addresses newly emerging data mining problems in big data analysis. First, a multigranulation super-trust model based on the valued tolerance relation is constructed to identify the fuzzy similarity of the changing knowledge granularity with multimodality attributes. Second, an ensemble consensus compensatory scheme is adopted to calculate the multigranular trust degree based on the reputation at different granularities to create reasonable subproblems with different granulation levels. Third, an equilibrium method of multigranular-coevolution is employed to ensure a wide range of balancing of exploration and exploitation and can classify super elitists’ preferences and detect noncooperative behaviors with a global convergence ability and high search accuracy. The experimental results demonstrate that the MSFAR algorithm achieves a high performance in addressing uncertain and fuzzy attribute reduction problems with a large number of multigranularity variables

Platinum-Based Nanoformulations for Glioblastoma Treatment : The Resurgence of Platinum Drugs?

Current therapies for treating Glioblastoma (GB), and brain tumours in general, are inefficient and represent numerous challenges. In addition to surgical resection, chemotherapy and radiotherapy are presently used as standards of care. However, treated patients still face a dismal prognosis with a median survival below 15-18 months. Temozolomide (TMZ) is the main chemotherapeutic agent administered; however, intrinsic or acquired resistance to TMZ contributes to the limited efficacy of this drug. To circumvent the current drawbacks in GB treatment, a large number of classical and non-classical platinum complexes have been prepared and tested for anticancer activity, especially platinum (IV)-based prodrugs. Platinum complexes, used as alkylating agents in the anticancer chemotherapy of some malignancies, are though often associated with severe systemic toxicity (i.e., neurotoxicity), especially after long-term treatments. The objective of the current developments is to produce novel nanoformulations with improved lipophilicity and passive diffusion, promoting intracellular accumulation, while reducing toxicity and optimizing the concomitant treatment of chemo-/radiotherapy. Moreover, the blood-brain barrier (BBB) prevents the access of the drugs to the brain and accumulation in tumour cells, so it represents a key challenge for GB management. The development of novel nanomedicines with the ability to (i) encapsulate Pt-based drugs and pro-drugs, (ii) cross the BBB, and (iii) specifically target cancer cells represents a promising approach to increase the therapeutic effect of the anticancer drugs and reduce undesired side effects. In this review, a critical discussion is presented concerning different families of nanoparticles able to encapsulate platinum anticancer drugs and their application for GB treatment, emphasizing their potential for increasing the effectiveness of platinum-based drugs

Instance reduction for one-class classification

Instance reduction techniques are data preprocessing methods originally developed to enhance the nearest neighbor rule for standard classification. They reduce the training data by selecting or generating representative examples of a given problem. These algorithms have been designed and widely analyzed in multi-class problems providing very competitive results. However, this issue was rarely addressed in the context of one-class classification. In this specific domain a reduction of the training set may not only decrease the classification time and classifier’s complexity, but also allows us to handle internal noisy data and simplify the data description boundary. We propose two methods for achieving this goal. The first one is a flexible framework that adjusts any instance reduction method to one-class scenario by introduction of meaningful artificial outliers. The second one is a novel modification of evolutionary instance reduction technique that is based on differential evolution and uses consistency measure for model evaluation in filter or wrapper modes. It is a powerful native one-class solution that does not require an access to counterexamples. Both of the proposed algorithms can be applied to any type of one-class classifier. On the basis of extensive computational experiments, we show that the proposed methods are highly efficient techniques to reduce the complexity and improve the classification performance in one-class scenarios

Sociodemographic determinants of intraurban variations in COVID-19 incidence : the case of Barcelona

Background: Intraurban sociodemographic risk factors for COVID-19 have yet to be fully understood. We investigated the relationship between COVID-19 incidence and sociodemographic factors in Barcelona at a fine-grained geography.Methods This cross-sectional ecological study is based on 10 550 confirmed cases of COVID-19 registered during the first wave in the municipality of Barcelona (population 1.64 million). We considered 16 variables on the demographic structure, urban density, household conditions, socioeconomic status, mobility and health characteristics for 76 geographical units of analysis (neighbourhoods), using a lasso analysis to identify the most relevant variables. We then fitted a multivariate Quasi-Poisson model that explained the COVID-19 incidence by neighbourhood in relation to these variables. Results: Neighbourhoods with: (1) greater population density, (2) an aged population structure, (3) a high presence of nursing homes, (4) high proportions of individuals who left their residential area during lockdown and/or (5) working in health-related occupations were more likely to register a higher number of cases of COVID-19. Conversely, COVID-19 incidence was negatively associated with (6) percentage of residents with post-secondary education and (7) population born in countries with a high Human Development Index. Conclusion: Like other historical pandemics, the incidence of COVID-19 is associated with neighbourhood sociodemographic factors with a greater burden faced by already deprived areas. Because urban social and health injustices already existed in those geographical units with higher COVID-19 incidence in Barcelona, the current pandemic is likely to reinforce both health and social inequalities, and urban environmental injustice all together

Forced vital capacity trajectories in patients with idiopathic pulmonary fibrosis: a secondary analysis of a multicentre, prospective, observational cohort

BACKGROUND: Idiopathic pulmonary fibrosis is a progressive fibrotic lung disease with a variable clinical trajectory. Decline in forced vital capacity (FVC) is the main indicator of progression; however, missingness prevents long-term analysis of patterns in lung function. We aimed to identify distinct clusters of lung function trajectory among patients with idiopathic pulmonary fibrosis using machine learning techniques. METHODS: We did a secondary analysis of longitudinal data on FVC collected from a cohort of patients with idiopathic pulmonary fibrosis from the PROFILE study; a multicentre, prospective, observational cohort study. We evaluated the imputation performance of conventional and machine learning techniques to impute missing data and then analysed the fully imputed dataset by unsupervised clustering using self-organising maps. We compared anthropometric features, genomic associations, serum biomarkers, and clinical outcomes between clusters. We also performed a replication of the analysis on data from a cohort of patients with idiopathic pulmonary fibrosis from an independent dataset, obtained from the Chicago Consortium. FINDINGS: 415 (71%) of 581 participants recruited into the PROFILE study were eligible for further analysis. An unsupervised machine learning algorithm had the lowest imputation error among tested methods, and self-organising maps identified four distinct clusters (1-4), which was confirmed by sensitivity analysis. Cluster 1 comprised 140 (34%) participants and was associated with a disease trajectory showing a linear decline in FVC over 3 years. Cluster 2 comprised 100 (24%) participants and was associated with a trajectory showing an initial improvement in FVC before subsequently decreasing. Cluster 3 comprised 113 (27%) participants and was associated with a trajectory showing an initial decline in FVC before subsequent stabilisation. Cluster 4 comprised 62 (15%) participants and was associated with a trajectory showing stable lung function. Median survival was shortest in cluster 1 (2·87 years [IQR 2·29-3·40]) and cluster 3 (2·23 years [1·75-3·84]), followed by cluster 2 (4·74 years [3·96-5·73]), and was longest in cluster 4 (5·56 years [5·18-6·62]). Baseline FEV1 to FVC ratio and concentrations of the biomarker SP-D were significantly higher in clusters 1 and 3. Similar lung function clusters with some shared anthropometric features were identified in the replication cohort. INTERPRETATION: Using a data-driven unsupervised approach, we identified four clusters of lung function trajectory with distinct clinical and biochemical features. Enriching or stratifying longitudinal spirometric data into clusters might optimise evaluation of intervention efficacy during clinical trials and patient management. FUNDING: National Institute for Health and Care Research, Medical Research Council, and GlaxoSmithKline

Resonant Lifetime of Core-Excited Organic Adsorbates from First Principles

We investigate by first-principles simulations the resonant electron-transfer lifetime from the excited state of an organic adsorbate to a semiconductor surface, namely isonicotinic acid on rutile TiO$_2$(110). The molecule-substrate interaction is described using density functional theory, while the effect of a truly semi-infinite substrate is taken into account by Green's function techniques. Excitonic effects due to the presence of core-excited atoms in the molecule are shown to be instrumental to understand the electron-transfer times measured using the so-called core-hole-clock technique. In particular, for the isonicotinic acid on TiO$_2$(110), we find that the charge injection from the LUMO is quenched since this state lies within the substrate band gap. We compute the resonant charge-transfer times from LUMO+1 and LUMO+2, and systematically investigate the dependence of the elastic lifetimes of these states on the alignment among adsorbate and substrate states.Comment: 24 pages, 6 figures, to appear in Journal of Physical Chemistry