715 research outputs found
Decay-assisted collinear resonance ionization spectroscopy: Application to neutron-deficient francium
This paper reports on the hyperfine-structure and radioactive-decay studies
of the neutron-deficient francium isotopes Fr performed with the
Collinear Resonance Ionization Spectroscopy (CRIS) experiment at the ISOLDE
facility, CERN. The high resolution innate to collinear laser spectroscopy is
combined with the high efficiency of ion detection to provide a
highly-sensitive technique to probe the hyperfine structure of exotic isotopes.
The technique of decay-assisted laser spectroscopy is presented, whereby the
isomeric ion beam is deflected to a decay spectroscopy station for alpha-decay
tagging of the hyperfine components. Here, we present the first
hyperfine-structure measurements of the neutron-deficient francium isotopes
Fr, in addition to the identification of the low-lying states of
Fr performed at the CRIS experiment.Comment: Accepted for publication with Physical Review
Laser spectroscopy of francium isotopes at the borders of the region of reflection asymmetry
The magnetic dipole moments and changes in mean-square charge radii of the
neutron-rich isotopes were measured with the
newly-installed Collinear Resonance Ionization Spectroscopy (CRIS) beam line at
ISOLDE, CERN, probing the to atomic
transition. The values for
and follow the observed increasing
slope of the charge radii beyond . The charge radii odd-even
staggering in this neutron-rich region is discussed, showing that
has a weakly inverted odd-even staggering while
has normal staggering. This suggests that both isotopes
reside at the borders of a region of inverted staggering, which has been
associated with reflection-asymmetric shapes. The value supports a shell model configuration for the
ground state. The values support the tentative
spin, and point to a intruder ground state configuration.Comment: Accepted for publication with Physical Review
Wavelength-scale stationary-wave integrated Fourier-transform spectrometry
Spectrometry is a general physical-analysis approach for investigating
light-matter interactions. However, the complex designs of existing
spectrometers render them resistant to simplification and miniaturization, both
of which are vital for applications in micro- and nanotechnology and which are
now undergoing intensive research. Stationary-wave integrated Fourier-transform
spectrometry (SWIFTS)-an approach based on direct intensity detection of a
standing wave resulting from either reflection (as in the principle of colour
photography by Gabriel Lippmann) or counterpropagative interference
phenomenon-is expected to be able to overcome this drawback. Here, we present a
SWIFTS-based spectrometer relying on an original optical near-field detection
method in which optical nanoprobes are used to sample directly the evanescent
standing wave in the waveguide. Combined with integrated optics, we report a
way of reducing the volume of the spectrometer to a few hundreds of cubic
wavelengths. This is the first attempt, using SWIFTS, to produce a very small
integrated one-dimensional spectrometer suitable for applications where
microspectrometers are essential
Rehabilitation for post-stroke cognitive impairment: an overview of recommendations arising from systematic reviews of current evidence
The roles of specialisation and evidence-based practice in inter-professional jurisdictions : a qualitative study of stroke services in England, Sweden and Poland
This paper investigates how the concepts of clinical specialisation and evidence influence the jurisdictional power of doctors, nurses and therapists involved in stroke care in Sweden, England and Poland. How stroke care has become a distinct specialism across Europe and the role that evidence has played in this development are critically analysed. Five qualitative case studies were undertaken across the three countries, consisting of 119 semi-structured interviews with a range of healthcare workers. The informants were purposively selected and their perspectives of evidence-based practice (EBP) within stroke care were explored. The data were analysed through thematic content analysis. The two key themes that emerged from the data were the health professionals' degrees of EBP and specialisation. The results illustrate how the two concepts of clinical specialisation and evidence are interrelated and work together to influence the different professions' degree of professional jurisdiction. It is concluded that doctors' professional dominance gives them full jurisdiction in stroke care and that nurses' and therapists' degrees of jurisdiction is dependent on their ability to specialise
Head Position in Stroke Trial (HeadPoST)- sitting-up vs lying-flat positioning of patients with acute stroke: study protocol for a cluster randomised controlled trial
Background
Positioning a patient lying-flat in the acute phase of ischaemic stroke may improve recovery and reduce disability, but such a possibility has not been formally tested in a randomised trial. We therefore initiated the Head Position in Stroke Trial (HeadPoST) to determine the effects of lying-flat (0°) compared with sitting-up (â„30°) head positioning in the first 24 hours of hospital admission for patients with acute stroke.
Methods/Design
We plan to conduct an international, cluster randomised, crossover, open, blinded outcome-assessed clinical trial involving 140 study hospitals (clusters) with established acute stroke care programs. Each hospital will be randomly assigned to sequential policies of lying-flat (0°) or sitting-up (â„30°) head position as a âbusiness as usualâ stroke care policy during the first 24 hours of admittance. Each hospital is required to recruit 60 consecutive patients with acute ischaemic stroke (AIS), and all patients with acute intracerebral haemorrhage (ICH) (an estimated average of 10), in the first randomised head position policy before crossing over to the second head position policy with a similar recruitment target. After collection of in-hospital clinical and management data and 7-day outcomes, central trained blinded assessors will conduct a telephone disability assessment with the modified Rankin Scale at 90 days. The primary outcome for analysis is a shift (defined as improvement) in death or disability on this scale. For a cluster size of 60 patients with AIS per intervention and with various assumptions including an intracluster correlation coefficient of 0.03, a sample size of 16,800 patients at 140 centres will provide 90 % power (α 0.05) to detect at least a 16 % relative improvement (shift) in an ordinal logistic regression analysis of the primary outcome. The treatment effect will also be assessed in all patients with ICH who are recruited during each treatment study period.
Discussion
HeadPoST is a large international clinical trial in which we will rigorously evaluate the effects of different head positioning in patients with acute stroke.
Trial registration
ClinicalTrials.gov identifier: NCT02162017 (date of registration: 27 April 2014); ANZCTR identifier: ACTRN12614000483651 (date of registration: 9 May 2014). Protocol version and date: version 2.2, 19 June 2014
Thrombolysis ImPlementation in Stroke (TIPS): Evaluating the effectiveness of a strategy to increase the adoption of best evidence practice - protocol for a cluster randomised controlled trial in acute stroke care
Background: Stroke is a leading cause of death and disability internationally. One of the three effective interventions in the acute phase of stroke care is thrombolytic therapy with tissue plasminogen activator (tPA), if given within 4.5 hours of onset to appropriate cases of ischaemic stroke.Objectives: To test the effectiveness of a multi-component multidisciplinary collaborative approach compared to usual care as a strategy for increasing thrombolysis rates for all stroke patients at intervention hospitals, while maintaining accepted benchmarks for low rates of intracranial haemorrhage and high rates of functional outcomes for both groups at three months.Methods and design: A cluster randomised controlled trial of 20 hospitals across 3 Australian states with 2 groups: multi- component multidisciplinary collaborative intervention as the experimental group and usual care as the control group. The intervention is based on behavioural theory and analysis of the steps, roles and barriers relating to rapid assessment for thrombolysis eligibility; it involves a comprehensive range of strategies addressing individual-level and system-level change at each site. The primary outcome is the difference in tPA rates between the two groups post-intervention. The secondary outcome is the proportion of tPA treated patients in both groups with good functional outcomes (modified Rankin Score (mR
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