1,148 research outputs found
Investigation of Dose Minimisation Protocol for 18F-FDG PET-CT in the Management of Lymphoma Postchemotherapy Followup
Introduction. 18F-FDG-PET-CT plays an important role in the management of lymphoma postchemotherapy followup. Some centres perform prechemotherapy baseline CT and postchemotherapy PETCT. With a concern of radiation burden, especially in young patients, this study aimed to assess if PETCT radiation dose could be reduced. Methods. Retrospective analysis of 100 lymphoma patients was performed to record sites of disease on prechemotherapy CT and postchemotherapy PETCT. The potential reduction in radiation and time achieved with PETCT limited to sites of known disease identified on prechemotherapy CT was calculated. Results. No FDG-uptake was seen in 72 cases. FDG uptake at known disease sites was seen in 24. Of the remaining 4, one had clinically significant pathology, a rectal adenocarcinoma. PETCT did not reveal any unexpected sites of lymphoma. Limiting PETCT to sites of known disease would have saved a mean radiation dose of 4âmSv (27.3%), with a mean time of 16âminutes. Conclusion. Our study suggests that young patients may benefit from reduced radiation by limiting PETCT to sites of known disease with low risk of missing significant pathology. However, in older patients, with increased incidence of asymptomatic synchronous malignancies, whole-body PETCT is advisable unless prechemotherapy PETCT has been performed
The Analysis of Receptor-binding Cancer Antigen Expressed on SiSo Cells (RCAS1) immunoreactivity within the microenvironment of the ovarian cancer lesion relative to the applied therapeutic strategy
RCAS1 is involved in generating the suppressive profile of the tumor microenvironment that helps cancer cells evade immune surveillance. The status of the cells surrounding the cancer nest may affect both the progression of the cancer and the development of metastases. In cases of ovarian cancer, a large number of patients do not respond to the applied therapy. The patientâs response to the applied therapy is directly linked to the status of the tumor microenvironment and the intensity of its suppressive profile. We analyzed the immunoreactivity of RCAS1 on the cells present in the ovarian cancer microenvironment in patients with the disease; these cells included macrophages and carcinoma-associated fibroblasts. Later we analyzed the immunoreactivity levels within these cells, taking into consideration the clinical stage of the cancer and the therapeutic strategy applied, such as the number of chemotherapy regiments, primary cytoreductive surgery, or the presence of advanced ascites. In the patients who did not respond to the therapy we observed significantly higher immunoreactivity levels of RCAS1 within the cancer nest than in those patients who did respond; moreover, in the non-responsive patients we found RCAS1 within both macrophages and carcinoma-associated fibroblasts. RCAS1 staining may provide information about the intensity of the immuno-suppressive microenvironment profile found in cases of ovarian cancer and its intensity may directly relate to the clinical outcome of the disease
Precision mass measurements of radioactive nuclei at JYFLTRAP
The Penning trap mass spectrometer JYFLTRAP was used to measure the atomic
masses of radioactive nuclei with an uncertainty better than 10 keV. The atomic
masses of the neutron-deficient nuclei around the N = Z line were measured to
improve the understanding of the rp-process path and the SbSnTe cycle.
Furthermore, the masses of the neutron-rich gallium (Z = 31) to palladium (Z =
46) nuclei have been measured. The physics impacts on the nuclear structure and
the r-process paths are reviewed. A better understanding of the nuclear
deformation is presented by studying the pairing energy around A = 100.Comment: 4 pages and 4 figures, RNB7 conf. pro
On the Point-Splitting Method of the Commutator Anomaly of the Gauss Law Operators
We analyze the generalized point-splitting method and Jo's result for the
commutator anomaly. We find that certain classes of general regularization
kernels satisfying integral conditions provide a unique result, which, however
differs from Faddeev's cohomological result.Comment: 16 pages, RevTex, 1 figure + 1 table, uses psbox.te
Machine Learning Optimisation for Realistic 2D and 3D PET-CT Phantom Study
An experimental study using artificial neural network (ANN) is carried out to achieve the optimal network architecture for proposed positron emission tomography (PET) application. 55 experimental phantom datasets acquired under clinically realistic conditions with different 2-D and 3-D acquisitions and image reconstruction parameters along with 2min, 3min and 4min scan times
per bed are used in this study. The best scanner parameters are determined based on the ANN experimental evaluation of the proposed datasets. The analysis methodology of phantom PET data has shown promising results and can successfully classify and quantify malignant lesions in clinically realistic datasets
Large-Area Scintillator Hodoscope with 50 ps Timing Resolution Onboard BESS
We describe the design and performance of a large-area scintillator hodoscope
onboard the BESS rigidity spectrometer; an instrument with an acceptance of 0.3
m^{2}sr.
The hodoscope is configured such that 10 and 12 counters are respectively
situated in upper and lower layers.
Each counter is viewed from its ends by 2.5 inch fine-mesh photomultiplier
tubes placed in a stray magnetic field of 0.2 Tesla.
Various beam-test data are presented.
Use of cosmic-ray muons at ground-level confirmed 50 ps timing resolution for
each layer, giving an overall time-of-flight resolution of 70 ps rms using a
pure Gaussian resolution function.
Comparison with previous measurements on a similar scintillator hodoscope
indicates good agreement with the scaling law that timing resolution is
proportional to 1/, where is the effective
number of photoelectrons.Comment: 16 pages, 14 figure
Conformal Symmetry and the Three Point Function for the Gravitational Axial Anomaly
This work presents a first study of a radiative calculation for the
gravitational axial anomaly in the massless Abelian Higgs model. The two loop
contribution to the anomalous correlation function of one axial current and two
energy-momentum tensors, , is computed
at an order that involves only internal matter fields. Conformal properties of
massless field theories are used in order to perform the Feynman diagram
calculations in the coordinate space representation. The two loop contribution
is found not to vanish, due to the presence of two independent tensor
structures in the anomalous correlator.Comment: 34 pages, 5 figures, RevTex, Minor changes, Final version for Phys.
Rev.
Beta-decay branching ratios of 62Ga
Beta-decay branching ratios of 62Ga have been measured at the IGISOL facility
of the Accelerator Laboratory of the University of Jyvaskyla. 62Ga is one of
the heavier Tz = 0, 0+ -> 0+ beta-emitting nuclides used to determine the
vector coupling constant of the weak interaction and the Vud quark-mixing
matrix element. For part of the experimental studies presented here, the
JYFLTRAP facility has been employed to prepare isotopically pure beams of 62Ga.
The branching ratio obtained, BR= 99.893(24)%, for the super-allowed branch is
in agreement with previous measurements and allows to determine the ft value
and the universal Ft value for the super-allowed beta decay of 62Ga
High-energy spectroscopic study of the III-V nitride-based diluted magnetic semiconductor GaMnN
We have studied the electronic structure of the diluted magnetic
semiconductor GaMnN ( = 0.0, 0.02 and 0.042) grown on Sn-doped
-type GaN using photoemission and soft x-ray absorption spectroscopy. Mn
-edge x-ray absorption have indicated that the Mn ions are in the
tetrahedral crystal field and that their valence is divalent. Upon Mn doping
into GaN, new state were found to form within the band gap of GaN, and the
Fermi level was shifted downward. Satellite structures in the Mn 2 core
level and the Mn 3 partial density of states were analyzed using
configuration-interaction calculation on a MnN cluster model. The deduced
electronic structure parameters reveal that the - exchange coupling in
GaMnN is stronger than that in GaMnAs.Comment: 6pages, 10figures. To be published to Phys. Rev.
Q-value of the superallowed beta decay of Ga-62
Masses of the radioactive isotopes 62Ga, 62Zn and 62Cu have been measured at
the JYFLTRAP facility with a relative precision of better than 18 ppb. A Q_EC
value of (9181.07 +- 0.54) keV for the superallowed decay of 62Ga is obtained
from the measured cyclotron frequency ratios of 62Ga-62Zn, 62Ga-62Ni and
62Zn-62Ni ions. The resulting Ft-value supports the validity of the conserved
vector current hypothesis (CVC). The mass excess values measured were (-51986.5
+-1.0) keV for 62Ga, (-61167.9 +- 0.9) keV for 62Zn and (-62787.2 +- 0.9) keV
for 62Cu.Comment: 12 pages, 3 figures, 2 tables, submitted to Phys. Lett. B. v2: added
acknowledgement
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