ABC-CapsNet: Attention based Cascaded Capsule Network for Audio Deepfake Detection

In response to the escalating challenge of audio deepfake detection, this study introduces ABC-CapsNet (Attention-Based Cascaded Capsule Network), a novel architecture that merges the perceptual strengths of Mel spectrograms with the robust feature extraction capabilities of VGG18, enhanced by a strategically placed attention mechanism. This architecture pioneers the use of cascaded capsule networks to delve deeper into complex audio data patterns, setting a new standard in the precision of identifying manipulated audio content. Distinctively, ABC-CapsNet not only addresses the inherent limitations found in traditional CNN models but also showcases remarkable effectiveness across diverse datasets. The proposed method achieved an equal error rate EER of 0.06% on the ASVspoof2019 dataset and an EER of 0.04% on the FoR dataset, underscoring the superior accuracy and reliability of the proposed system in combating the sophisticated threat of audio deepfakes

Evaluation of Antioxidant Activity, Quantitative Estimation of Phenols and Flavonoids of Oak Acorn From Erbil/Kurdistan

In this study, antioxidant activity and total phenolic content of aqueous extract of oak acorn Quercus robur (belongs to fagaceae family) was investigated by using in vitro antioxidant models including total antioxidant capacity, reducing power and metal chelating activity. The total contents of phenol, flavonoid and alkaloid were quantitatively estimated in oak’s acorn and its shell. Result showed that total phenolic, flavonoid, and alkaloid contents were higher in acorn than in its shell. The antioxidant activity of aqueous extract of acorn and its shell were determined according to the phosphomolybdenum method, reducing power and metal chelating was determined by using spectrophotometer. The results were compared to standard compounds such as ascorbic acid, rutin, gallic acid and colchicine. The overall result showed that oak acorn can serve as good sources of bioactive poly phenol in human diet and can be considered as a good candidate for nutritional supplement formulation due to their high concentrations of phenolic compounds, flavonoids, as well as their strong antioxidant activity

Nonequilibrium Modeling of the Elementary Step in PDZ3 Allosteric Communication

While allostery is of paramount importance for protein signaling and regulation, the underlying dynamical process of allosteric communication is not well understood. PDZ3 domain represents a prime example of an allosteric single-domain protein, as it features a well-established long-range coupling between the C-terminal $\alpha_3$-helix and ligand binding. In an intriguing experiment, Hamm and coworkers employed photoswitching of the $\alpha_3$-helix to initiate a conformational change of PDZ3 that propagates from the C-terminus to the bound ligand within 200 ns. Performing extensive nonequilibrium molecular dynamics simulations, the modeling of the experiment reproduces the measured timescales and reveals a detailed picture of the allosteric communication in PDZ3. In particular, a correlation analysis identifies a network of contacts connecting the $\alpha_3$-helix and the core of the protein, which move in a concerted manner. Representing a one-step process and involving direct $\alpha_3$-ligand contacts, this cooperative transition is considered as elementary step in the propagation of conformational change

Gene action studies in early maturing maize (Zea mays L.) inbred lines

The present investigation was aimed to investigate the gene action in early maturing maize (Zea mays L.) inbred lines. The experimental material comprised of 30 crosses generated by crossing six maize inbred lines in a diallel mating design during Kharif 2013. These 30 crosses along with standard checks viz., SMH-2 and VMH-45 were evaluated in randomized block design in three replications during Kharif 2014 and Kharif 2015. Significant variation was observed for all studied traits during both the seasons. Both additive (D) and dominance (H1 and H2) components of genetic variance were found significant under the study. Preponderance of non-additive gene action was observed for all traits under study. Average degree of dominance was in over dominance range for all characters. The gene distribution was asymmetrical for all traits. The value of KD / KR indicated presence of excess of dominant genes for all traits except 100-grain weight and ear girth. Heritability of most of the traits was low to medium

Some contributions to optimality criteria and duality in Multiobjective mathematical programming.

This thesis entitled, “some contributions to optimality criteria and duality in multiobjective mathematical programming”, offers an extensive study on optimality, duality and mixed duality in a variety of multiobjective mathematical programming that includes nondifferentiable nonlinear programming, variational problems containing square roots of a certain quadratic forms and support functions which are prominent nondifferentiable convex functions. This thesis also deals with optimality, duality and mixed duality for differentiable and nondifferentiable variational problems involving higher order derivatives, and presents a close relationship between the results of continuous programming problems through the problems with natural boundary conditions between results of their counter parts in nonlinear programming. Finally it formulates a pair of mixed symmetric and self dual differentiable variational problems and gives the validation of various duality results under appropriate invexity and generalized invexity hypotheses. These results are further extended to a nondifferentiable case that involves support functions.Digital copy of Thesis.University of Kashmir

Cross-tolerance to abiotic stresses in halophytes: Application for phytoremediation of organic pollutants

International audienceHalopytes are plants able to tolerate high salt concentrations but no clear definition was retained for them. In literature, there are more studies that showed salt-enhanced tolerance to other abiotic stresses compared to investigations that found enhanced salt tolerance by other abiotic stresses in halophytes. The phenomenon by which a plant resistance to a stress induces resistance to another is referred to as cross-tolerance. In this work, we reviewed cross-tolerance in halophytes at the physiological, biochemical, and molecular levels. A special attention was accorded to the cross-tolerance between salinity and organic pollutants that could allow halophytes a higher potential of xenobiotic phytoremediation in comparison with glycophytes

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Global mobility of professionals and the transfer of tacit knowledge in multinational service firms

Purpose: The use of expatriates to transfer individual and organizational know-how and knowledge is a practice widely used by multinational enterprises (MNEs). However, for service firms, the mobility of employees across national borders depends on the commitments made by countries under the General Agreement on Trade in Services (GATS). In particular, the Mode 4 form of supply under GATS can limit the ability of professionals to enter a particular country and can restrict the intra-organizational transfer of knowledge in multinational service firms. The purpose of this paper is to investigate how MNEs attempt to overcome these barriers and transfer knowledge through their global network. Design/methodology/approach: Using Nonaka and Takeuchi’s SECI model of knowledge transfer, the authors study the intra-organizational knowledge transfer practices of an Indian multinational service firm. Semi-structured interviews were conducted with 20 key informants involved with the organization. Findings: The company uses global teams to transfer tacit knowledge and facilitates inpatriation through an internship program that helps the firm overcome nationality requirement that restricts the movement of their managers to other countries, which in turn limits their ability to transfer knowledge in the intra-organizational setting. The company uses the services of a not-for-profit youth organization that helps recruit interns for the program and also facilitates the relationship with the Indian Government, which provides support for this initiative by reducing barriers to entry for the interns. Originality/value: This study takes the unique approach of studying barriers to movement of professionals and a firm’s strategic response. It identifies the pressures and barriers that companies face in the global economy and highlights the role of government agencies and other stakeholders in facilitating or restricting the transfer of knowledge within a firm’s international network. The paper articulates the implications for policy and practice, and a future research agenda