Weak lensing forecasts for dark energy, neutrinos and initial conditions

Weak gravitational lensing provides a sensitive probe of cosmology by measuring the mass distribution and the geometry of the low-redshift Universe. We show how an all-sky weak lensing tomographic survey can jointly constrain different sets of cosmological parameters describing dark energy, massive neutrinos (hot dark matter) and the primordial power spectrum. In order to put all sectors on an equal footing, we introduce a new parameter β, the second-order running spectral index. Using the Fisher matrix formalism with and without cosmic microwave background (CMB) priors, we examine how the constraints vary as the parameter set is enlarged. We find that weak lensing with CMB priors provides robust constraints on dark energy parameters and can simultaneously provide strong constraints on all three sectors. We find that the dark energy sector is largely insensitive to the inclusion of the other cosmological sectors. Implications for the planning of future surveys are discusse

Brucellosis in man and animals

Revised EditionContents : Chapter 1 : The genus Brucella - Chapter 2 : Methods of isolating Brucella - Chapter 3 : Differentiation of the species of the genus Brucella - Chapter 4 : Brucellosis in human beings : Part one : Historical Survey - Chapter 4 : Brucellosis in human beings : Part two : Brucellosis in the United States / A.V. Hardy - Chapter 4 : Brucellosis in human beings : Part 3 : Brucellosis in Malta / J.E. Debono - Chapter 4 : Brucellosis in human beings : Part 4 : Treatment - Chapter 5 : Brucellosis in animals - Chapter 6 : Laboratory diagnosis of Brucellosis - Chapter 7 : Eradication or control of sources of Brucellosis infection / Ward Giltner - Appendix, Case Reports - Bibliography - IndexN/

« Droit de réponse » au compte-rendu de l’ouvrage Corpus numériques, langues et sens par Damon Mayaffre (Corpus n° 14, 2015)

Préalables S’il nous paraît important de poursuivre la discussion, appelée de nos vœux, avec les tenants de l’herméneutique « matérielle » / « numérique » (Mayaffre 2006), cette « réplique » (cf. Jullien 2007) aux commentaires que Damon Mayaffre (désormais DM) a pris le temps de nous adresser sera brève, l’ouvrage collectif Corpus numérique, langues et sens. Enjeux épistémologiques et politiques (Debono [dir.], 2014) proposant d’assez larges développements quant aux termes de ce débat. Dans ..

Weak lensing forecasts for dark energy, neutrinos and initial conditions

Weak gravitational lensing provides a sensitive probe of cosmology by measuring the mass distribution and the geometry of the low redshift universe. We show how an all-sky weak lensing tomographic survey can jointly constrain different sets of cosmological parameters describing dark energy, massive neutrinos (hot dark matter), and the primordial power spectrum. In order to put all sectors on an equal footing, we introduce a new parameter $\beta$, the second order running spectral index. Using the Fisher matrix formalism with and without CMB priors, we examine how the constraints vary as the parameter set is enlarged. We find that weak lensing with CMB priors provides robust constraints on dark energy parameters and can simultaneously provide strong constraints on all three sectors. We find that the dark energy sector is largely insensitive to the inclusion of the other cosmological sectors. Implications for the planning of future surveys are discussed

The snake with the scorpion’s sting: Novel three-finger toxin sodium channel activators from the venom of the long-glanded blue coral snake (Calliophis bivirgatus)

FWN – Publicaties zonder aanstelling Universiteit Leide

Primary leptomeningeal oligodendrogliomatosis

Primary leptomeningeal oligodendrogliomas (PLOs) are rare intracranial malignancies where tumors grow in the subarachnoid space without an obvious connection to the brain or spinal cord parenchyma. Adding to the three previously reported cases of PLO with no parenchymal involvement we report a fourth case of the same in this paper in a 50-year-old woman presenting with unrelenting headaches. CT scan of her head revealed hydrocephalus and MRI revealed diffuse enhancement of her leptomeninges throughout her brain and spine, prominent over the basilar region. Biopsy obtained using a frameless stereotactic biopsy showed sharply defined cell borders, clear cytoplasm, and rounded nuclei consistent with an oligodendroglioma. Our case suggests that PLO can mimic diffuse forms of granulomatous meningitis and should be suspected in patients that clinically and radiographically present like granulomatous meningitis but without blood or CSF markers for the same

Why are family carers of people with dementia dissatisfied with general hospital care?: a qualitative study

Background Families and other carers report widespread dissatisfaction with general hospital care for confused older people. Methods We undertook a qualitative interviews study of 35 family carers of 34 confused older patients to ascertain their experiences of care on geriatric and general medical, and orthopaedic wards of a large English hospital. Transcripts were analysed using a grounded theory approach. Themes identified in interviews were categorised, and used to build a model explaining dissatisfaction with care. Results The experience of hospital care was often negative. Key themes were events (illness leading to admission, experiences in the hospital, adverse occurrences including deterioration in health, or perceived poor care); expectations (which were sometimes unrealistic, usually unexplored by staff, and largely unmet from the carers’ perspective); and relationships with staff (poor communication and conflict over care). Expectations were influenced by prior experience. A cycle of discontent is proposed. Events (or ‘crises’) are associated with expectations. When these are unmet, carers become uncertain or suspicious, which leads to a period of ‘hyper vigilant monitoring’ during which carers seek out evidence of poor care, culminating in challenge, conflict with staff, or withdrawal, itself a crisis. The cycle could be completed early during the admission pathway, and multiple cycles within a single admission were seen. Conclusion People with dementia who have family carers should be considered together as a unit. Family carers are often stressed and tired, and need engaging and reassuring. They need to give and receive information about the care of the person with dementia, and offered the opportunity to participate in care whilst in hospital. Understanding the perspective of the family carer, and recognising elements of the ‘cycle of discontent’, could help ward staff anticipate carer needs, enable relationship building, to pre-empt or avoid dissatisfaction or conflict

Genetic aetiologies for childhood speech disorder: Novel pathways co-expressed during brain development

Childhood apraxia of speech (CAS), the prototypic severe childhood speech disorder, is characterized by motor programming and planning deficits. Genetic factors make substantive contributions to CAS aetiology, with a monogenic pathogenic variant identified in a third of cases, implicating around 20 single genes to date. Here we aimed to identify molecular causation in 70 unrelated probands ascertained with CAS. We performed trio genome sequencing. Our bioinformatic analysis examined single nucleotide, indel, copy number, structural and short tandem repeat variants. We prioritised appropriate variants arising de novo or inherited that were expected to be damaging based on in silico predictions. We identified high confidence variants in 18/70 (26%) probands, almost doubling the current number of candidate genes for CAS. Three of the 18 variants affected SETBP1, SETD1A and DDX3X, thus confirming their roles in CAS, while the remaining 15 occurred in genes not previously associated with this disorder. Fifteen variants arose de novo and three were inherited. We provide further novel insights into the biology of child speech disorder, highlighting the roles of chromatin organization and gene regulation in CAS, and confirm that genes involved in CAS are co-expressed during brain development. Our findings confirm a diagnostic yield comparable to, or even higher, than other neurodevelopmental disorders with substantial de novo variant burden. Data also support the increasingly recognised overlaps between genes conferring risk for a range of neurodevelopmental disorders. Understanding the aetiological basis of CAS is critical to end the diagnostic odyssey and ensure affected individuals are poised for precision medicine trials

Outcomes after urgent thyroidectomy following rapid control of thyrotoxicosis in Graves’ disease are similar to those after elective surgery in well-controlled disease

Background Surgery for Graves’ disease (GD) is usually performed after adequate control with medical treatment. Occasionally, rapid pre-operative optimization is required. The primary objective was to compare the outcomes of patients undergoing elective surgery for well-controlled GD with those undergoing rapid pre-operative treatment. We also propose a formal treatment protocol for future use. Methods A retrospective cohort study in a tertiary referral centre included 247 patients with well-controlled GD undergoing elective surgery and 19 patients with poorly controlled disease undergoing surgery after rapid optimization. The latter group did not respond well to thionamides (carbimazole and/or propylthiouracil) or had intolerance or side effects to thionamides and were treated with a range of non-thionamide drugs, including Lugol’s iodine, cholestyramine, beta blockers and steroids (with or without thionamides), and closely monitored for 1–2 weeks before surgery. Outcome measures included thyroid storm, hypoparathyroidism and recurrent laryngeal nerve palsy. Results In total, 266 patients with male-to-female ratio of 1:6 and median (interquartile range) age of 39 (31–51) were included. Overall, long-term recurrent laryngeal palsy and hypoparathyroidism occurred in 1 (0.38%) and 13 (4.9%) patients, respectively. No patient had thyroid storm. There was no significant difference in hypoparathyroidism (p = 1), vocal cord palsy (p = 0.803) and post-operative bleeding (p = 0.362), between elective surgery and rapid optimization groups. Conclusion Rapid pre-operative treatment is effective, safe and is associated with similar outcomes compared to usual treatment. A rapid pre-operative optimization protocol is proposed