Byron Lands in Korea: Translation and Literary/Cultural Changes in Early Twentieth‑Century Korea

Byron en Corée : traduction et changements littéraires/culturels en Corée au tournant du siècle — Cet article étudie le rôle qu'a joué la traduction dans l'émergence de la poésie coréenne moderne. La plupart des chercheurs croient qu'au tournant du siècle, les poètes/traducteurs tels Ch'oe Namson se sont attachés à transmettre davantage le message que la forme. Nous croyons qu'il est nécessaire de reconsidérer le lien étroit qui unit les images et rythmes poétiques créés par Ch'oe et le développement, dans la poésie coréenne des années vingt, de nouvelles formes.Byron Lands in Korea : Translation and Literary/Cultural Changes in Early Twentieth-Century Korea — This article deals with the role of translation during the formative phase of modern Korean poetry. Most scholars think that the work of poet/translators of the early twentieth century like Ch'oe Namson emphasized transmitting a message rather than technique. I assert that we need to re-examine the crucial relationship of the new poetic rhythms and images used by Ch'oe and the development of modern Korean poetic forms in the 1920s

Charge of a quasiparticle in a superconductor

Non-linear charge transport in SIS Josephson junctions has a unique signature in the shuttled charge quantum between the two superconductors. In the zero-bias limit Cooper pairs, each with twice the electron charge, carry the Josephson current. An applied bias $V_{SD}$ leads to multiple Andreev reflections (MAR), which in the limit of weak tunneling probability should lead to integer multiples of the electron charge $ne$ traversing the junction, with $n$ integer larger than $2{\Delta}/eV_{SD}$ and ${\Delta}$ the superconducting order parameter. Exceptionally, just above the gap, $eV_{SD}>2{\Delta}$, with Andreev reflections suppressed, one would expect the current to be carried by partitioned quasiparticles; each with energy dependent charge, being a superposition of an electron and a hole. Employing shot noise measurements in an SIS junction induced in an InAs nanowire (with noise proportional to the partitioned charge), we first observed quantization of the partitioned charge $q=e^*/e=n$, with $n=1-4$; thus reaffirming the validity of our charge interpretation. Concentrating next on the bias region $eV_{SD}{\approx}2{\Delta}$, we found a reproducible and clear dip in the extracted charge to $q{\approx}0.6$, which, after excluding other possibilities, we attribute to the partitioned quasiparticle charge. Such dip is supported by numerical simulations of our SIS structure

Concert recording 2019-03-14

[Track 1]. Her voice for oboe d\u27amore and piano / Robert Mueller -- [Tracks 2-3]. Bells and grass for oboe and soprano / Julianna Hall -- [Tracks 4-6]. Up and away: the story of a balloon / Alyssa Morris -- [Track 7]. Rachel weeping for her children for oboe, pre-recorded sounds, and digital delay / Robert Mueller -- [Tracks 8-10]. Trio for flute, oboe, and piano / Madeleine Dring

Phenolsäuregehalte und antioxidative Kapazität in Wurzelextrakten von Salvia miltiorrhiza Bunge

In den Jahren 2008-2009 wurden in der Versuchsstation Groß-Gerau (Sandboden) Feldversuche mit Chinesischem Salbei durchgeführt. Die erzielten Ergebnisse bringen zum Ausdruck, dass die Gehalte an Salvianolsäure B und Rosmarinsäure sowie die antioxidative Kapazität signifikant durch den Erntetermin beeinflusst sind. Die Gehalte beider Phenolcarbonsäuren und die antioxidative Kapazität waren im Frühjahr nach der Überwinterung des Salbeis deutlich höher als in den Herbstmonaten. Der höchste Gehalt an Salvianolsäure B wurde im Frühjahr (28. 04. 2009) mit einem Mittelwert von 5,26 % erreicht. Die Ergebnisse belegen, dass Salvianolsäure B am stärsten zur antioxidativen Kapzität in den Salbeiwurzeln beiträgt. Einen weiteren Beitrag zur antioxidativen Kapazität leisten auch die Rosmarinsäure und das Tanshinon I. Stichwörter: Salvia miltiorrhiza, Salvianolsäure B. Rosmarinsäure, Tanshinone, antioxidative KapazitätPhenolic acid contents and antioxidant capacity in root extracts of Salvia miltiorrhiza BungeIn 2008-2009 field experiments with Salvia miltiorrhiza were carried out in the research station Gross-Gerau (sand soil). The received data show that the contents of salvianolic acid B, rosmarinic acid and antioxidant capacity significantly depend on the harvest time of S. miltiorrhiza. Content of both phenolic acids and antioxidant capacity were significantly higher in spring after overwintering than in autumn. The highest level of salvianolic acid B was reached in spring with an average of 5.26 % dry matter. The results show that salvianolic acid B contributes most to enhancing antioxidant capacity in root extracts of S. miltiorrhiza. Rosmarinic acid and tanshinon I provide another contribution to antioxidative capacity. Keywords: Salvia miltiorrhiza, salvianolic acid B, rosmarinic acid, tanshinones, antioxidant capacit

Concert recording 2022-11-11

[Track 1]: Sonata in C minor, HWV 366. I. Adagio ; [Track 2]: II. Bourrée / Georg Frideric Handel -- [Track 3]: Sonata in G Major. I. Andante / Giovanni Sammartini -- [Track 4 and 5]: Sonata in E minor Francesco Geminiani (1687–1762) -- [Track 6]: Sonata in A minor. I. Siciliana ; II. Sprirtuoso / Georg Phillipp Telemann -- [Track 7]: Trois pieces, Op. 31. II. Mélodie / Arthur Foote -- [Track 8]: Souvenir de Madrid / Pedro Soler -- [Track 9]: Concerto for oboe and strings. I. Pastorale / Ralph Vaughan Williams

Concert recording 2022-11-11

[Track 1]: Sonata in C minor, HWV 366. I. Adagio ; [Track 2]: II. Bourrée / Georg Frideric Handel -- [Track 3]: Sonata in G Major. I. Andante / Giovanni Sammartini -- [Track 4 and 5]: Sonata in E minor Francesco Geminiani (1687–1762) -- [Track 6]: Sonata in A minor. I. Siciliana ; II. Sprirtuoso / Georg Phillipp Telemann -- [Track 7]: Trois pieces, Op. 31. II. Mélodie / Arthur Foote -- [Track 8]: Souvenir de Madrid / Pedro Soler -- [Track 9]: Concerto for oboe and strings. I. Pastorale / Ralph Vaughan Williams

Sex differences in the genetic architecture of cognitive resilience to Alzheimer\u27s disease.

Approximately 30% of elderly adults are cognitively unimpaired at time of death despite the presence of Alzheimer\u27s disease neuropathology at autopsy. Studying individuals who are resilient to the cognitive consequences of Alzheimer\u27s disease neuropathology may uncover novel therapeutic targets to treat Alzheimer\u27s disease. It is well established that there are sex differences in response to Alzheimer\u27s disease pathology, and growing evidence suggests that genetic factors may contribute to these differences. Taken together, we sought to elucidate sex-specific genetic drivers of resilience. We extended our recent large scale genomic analysis of resilience in which we harmonized cognitive data across four cohorts of cognitive ageing, in vivo amyloid PET across two cohorts, and autopsy measures of amyloid neuritic plaque burden across two cohorts. These data were leveraged to build robust, continuous resilience phenotypes. With these phenotypes, we performed sex-stratified [n (males) = 2093, n (females) = 2931] and sex-interaction [n (both sexes) = 5024] genome-wide association studies (GWAS), gene and pathway-based tests, and genetic correlation analyses to clarify the variants, genes and molecular pathways that relate to resilience in a sex-specific manner. Estimated among cognitively normal individuals of both sexes, resilience was 20-25% heritable, and when estimated in either sex among cognitively normal individuals, resilience was 15-44% heritable. In our GWAS, we identified a female-specific locus on chromosome 10 [rs827389, β (females) = 0.08, P (females) = 5.76 × 10-09, β (males) = -0.01, P(males) = 0.70, β (interaction) = 0.09, P (interaction) = 1.01 × 10-04] in which the minor allele was associated with higher resilience scores among females. This locus is located within chromatin loops that interact with promoters of genes involved in RNA processing, including GATA3. Finally, our genetic correlation analyses revealed shared genetic architecture between resilience phenotypes and other complex traits, including a female-specific association with frontotemporal dementia and male-specific associations with heart rate variability traits. We also observed opposing associations between sexes for multiple sclerosis, such that more resilient females had a lower genetic susceptibility to multiple sclerosis, and more resilient males had a higher genetic susceptibility to multiple sclerosis. Overall, we identified sex differences in the genetic architecture of resilience, identified a female-specific resilience locus and highlighted numerous sex-specific molecular pathways that may underly resilience to Alzheimer\u27s disease pathology. This study illustrates the need to conduct sex-aware genomic analyses to identify novel targets that are unidentified in sex-agnostic models. Our findings support the theory that the most successful treatment for an individual with Alzheimer\u27s disease may be personalized based on their biological sex and genetic context

31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two

Background The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd. Methods We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background. Results First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001). Conclusions In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival

Retrieval of Selected Serial Citations: An Analysis Through User Interviews

published or submitted for publicatio