An analysis of the effect of topography on rainfall in the Taieri catchment area, Otago

In an area of 2500 square miles, consisting of the Taieri Catchment basin and adjoining areas, there are only 37 rain gauges for which there are records for more than four years. Since the topography is varied, it is difficult to estimate rainfall in ungauged parts of the catchment. This study examines the effects of four topographic factors, altitude, position, exposure and aspect on the variation in measured rainfall, explains these effects in climatological and meteorological terms, and provides the basis of a method for estimating the rainfall on ungauged areas

Is a Dominant Service-Centric Sector Good for Diversity of Provision?

An obvious assumption underpinning the immense interest in service-oriented computing is that it is an inherently Good Thing, by which we mean that robust processes and tools for developing service-based systems will bring benefits for service providers and service consumers. The arguments, in terms of consumer choice and flexibility, are certainly quite convincing. However, in this position paper, we question the nature of the underlying assumption, in a world where requirements are as many and varied as potential users and ask if safeguards are needed to ensure that diversity of provision is maintained

Good timing: Implementing STEM careers strategy in secondary schools

Good Timing is the final report of a three-year programme of work, commissioned by the Department for Education, and carried out by the Centre for Education and Industry at the University of Warwick (CEI), the International Centre for Guidance Studies at the University of Derby (iCeGS) and Isinglass Consultancy Ltd. The programme explored potential to embed STEM careers awareness in the early stages of secondary education.Department for Educatio

Cost-effectiveness of HCV case-finding for people who inject drugs via dried blood spot testing in specialist addiction services and prisons

ObjectivesPeople who inject drugs (PWID) are at high risk for acquiring hepatitis C virus (HCV), but many are unaware of their infection. HCV dried blood spot (DBS) testing increases case-finding in addiction services and prisons. We determine the cost-effectiveness of increasing HCV case-finding among PWID by offering DBS testing in specialist addiction services or prisons as compared to using venepuncture.DesignCost-utility analysis using a dynamic HCV transmission model among PWID, including: disease progression, diagnosis, treatment, injecting status, incarceration and addition services contact.Setting uk interventionDBS testing in specialist addiction services or prisons. Intervention impact was determined by a meta-analysis of primary data.Primary and secondary outcome measuresCosts (in UK £, £1=US$1.60) and utilities (quality-adjusted life years, QALYs) were attached to each state and the incremental cost effectiveness ratio (ICER) determined. Multivariate uncertainty and one-way sensitivity analyses were performed.ResultsFor a £20 000 per QALY gained willingness-to-pay threshold, DBS testing in addiction services is cost-effective (ICER of £14 600 per QALY gained). Under the base-case assumption of no continuity of treatment/care when exiting/entering prison, DBS testing in prisons is not cost-effective (ICER of £59 400 per QALY gained). Results are robust to changes in HCV prevalence; increasing PWID treatment rates to those for ex-PWID considerably reduces ICER (£4500 and £30 000 per QALY gained for addiction services and prison, respectively). If continuity of care is >40%, the prison DBS ICER falls below £20 000 per QALY gained.ConclusionsDespite low PWID treatment rates, increasing case-finding can be cost-effective in specialist addiction services, and in prisons if continuity of treatment/care is ensured

Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury : Consensus statement

BACKGROUND: Two randomised trials assessing the effectiveness of decompressive craniectomy (DC) following traumatic brain injury (TBI) were published in recent years: DECRA in 2011 and RESCUEicp in 2016. As the results have generated debate amongst clinicians and researchers working in the field of TBI worldwide, it was felt necessary to provide general guidance on the use of DC following TBI and identify areas of ongoing uncertainty via a consensus-based approach. METHODS: The International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury took place in Cambridge, UK, on the 28th and 29th September 2017. The meeting was jointly organised by the World Federation of Neurosurgical Societies (WFNS), AO/Global Neuro and the NIHR Global Health Research Group on Neurotrauma. Discussions and voting were organised around six pre-specified themes: (1) primary DC for mass lesions, (2) secondary DC for intracranial hypertension, (3) peri-operative care, (4) surgical technique, (5) cranial reconstruction and (6) DC in low- and middle-income countries. RESULTS: The invited participants discussed existing published evidence and proposed consensus statements. Statements required an agreement threshold of more than 70% by blinded voting for approval. CONCLUSIONS: In this manuscript, we present the final consensus-based recommendations. We have also identified areas of uncertainty, where further research is required, including the role of primary DC, the role of hinge craniotomy and the optimal timing and material for skull reconstruction

Concussion in motorsport: incidence, awareness and future directions.

Concussion in contact sport is a contentious issue and represents a growing proportion of injuries sustained by athletes worldwide. Motorsport is no exception, yet the published evidence on the incidence, severity and recovery from this condition remains scarce [1]. Motorsport is unique among extreme sports, since competitors are frequently subject to high velocity, high G forces with a large rotational component, even without impact [2,3]. The ongoing challenge for practitioners is threefold; making a diagnosis of concussion trackside, evaluating competitors in the medical center and approaching the return-to-race decision.ND Deakin receives expenses in exchange for performing baseline and post-concussion neurocognitive testing for the British Touring Car Championship and its associated racing series. PJ Hutchinson is supported by a NIHR Research Professorship and the BRC Cambridge NIHR. PJ is also Chief Medical Officer for the FIA Formula 1 British Grand Prix at Silverstone. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed

Glycolysis and the significance of lactate in traumatic brain injury

In traumatic brain injury (TBI) patients, elevation of the brain extracellular lactate concentration and the lactate/pyruvate ratio are well-recognized, and are associated statistically with unfavorable clinical outcome. Brain extracellular lactate was conventionally regarded as a waste product of glucose, when glucose is metabolized via glycolysis (Embden-Meyerhof-Parnas pathway) to pyruvate, followed by conversion to lactate by the action of lactate dehydrogenase, and export of lactate into the extracellular fluid. In TBI, glycolytic lactate is ascribed to hypoxia or mitochondrial dysfunction, although the precise nature of the latter is incompletely understood. Seemingly in contrast to lactate's association with unfavorable outcome is a growing body of evidence that lactate can be beneficial. The idea that the brain can utilize lactate by feeding into the tricarboxylic acid (TCA) cycle of neurons, first published two decades ago, has become known as the astrocyte-neuron lactate shuttle hypothesis. Direct evidence of brain utilization of lactate was first obtained 5 years ago in a cerebral microdialysis study in TBI patients, where administration of 13C-labeled lactate via the microdialysis catheter and simultaneous collection of the emerging microdialysates, with 13C NMR analysis, revealed 13C labeling in glutamine consistent with lactate utilization via the TCA cycle. This suggests that where neurons are too damaged to utilize the lactate produced from glucose by astrocytes, i.e., uncoupling of neuronal and glial metabolism, high extracellular levels of lactate would accumulate, explaining the association between high lactate and poor outcome. Recently, an intravenous exogenous lactate supplementation study in TBI patients revealed evidence for a beneficial effect judged by surrogate endpoints. Here we review the current state of knowledge about glycolysis and lactate in TBI, how it can be measured in patients, and whether it can be modulated to achieve better clinical outcome.We gratefully acknowledge financial support as follows. Research support: the Medical Research Council (MRC, Grant Nos. G0600986 ID79068 and G1002277 ID98489) and the National Institute for Health Research Biomedical Research Centre (NIHR BRC) Cambridge (Neuroscience Theme; Brain Injury and Repair Theme). Authors' support: KLHC—NIHR BRC Cambridge (Neuroscience Theme; Brain Injury and Repair Theme); IJ—MRC (Grant no. G1002277 ID 98489) and NIHR BRC Cambridge; PJH—NIHR Research Professorship, Academy of Medical Sciences/Health Foundation Senior Surgical Scientist Fellowship, and the NIHR BRC CambridgeThis is the final published version. It first appeared at http://journal.frontiersin.org/article/10.3389/fnins.2015.00112/full#h8

Visual Servoing

International audienceThis chapter introduces visual servo control, using computer vision data in the servo loop to control the motion of a robot. We first describe the basic techniques that are by now well established in the field. We give a general overview of the formulation of the visual servo control problem, and describe the two archetypal visual servo control schemes: image-based and pose-based visual servo control. We then discuss performance and stability issues that pertain to these two schemes, motivating advanced techniques. Of the many advanced techniques that have been developed , we discuss 2.5-D, hybrid, partitioned, and switched approaches. Having covered a variety of control schemes, we deal with target tracking and controlling motion directly in the joint space and extensions to under-actuated ground and aerial robots. We conclude by describing applications of visual ser-voing in robotics

Letter to John Butler and Eliza (Smith) Butler from Elizabeth Hutchinson ( Lissie ) and Peter Butler

Elizabeth Hutchinson ( Lissie ) sends news of the family and their health. An addendum from Peter Butler inquires if his timber land in Illinois was sold and about other land sale business