Challenges for conceptualising EU MOOC for vulnerable learner groups

This exploratory paper picks up elements from the European Commission’s educational vision and philosophy behind Opening up Education, the resulting initiative of the OpenupEd.eu MOOC platform, and takes this as a starting point to look at potential challenges for developing MOOCs that include vulnerable learner groups. In order to align the future conceptualization of MOOCs with the vision and philosophy of Europe, potential tensions of contemporary and future education are listed. The current dichotomy of xMOOC and cMOOC are used to mark some of the unexplored MOOC territory. Practical answers to contemporary, ICT-supported educational challenges are provided as options to fuel the debate. The challenges and options for future online education initiatives are based on insights and ideas of international scholars and researchers reflecting on potential barriers for learners and online education. This paper aims to stimulate discussion of the potential for new educational technologies to ensure social inclusion for virtual and physical vulnerable learner groups

Rethinking Intergenerational Transmission(s): Does a Wellbeing Lens Help? The Case of Nutrition

The intergenerational transmission (IGT) of poverty is a well?established conceptualisation of how poverty is reproduced over time. IGT has been a popular approach but as currently constructed it tends to be overly deterministic, and to overly emphasise material assets. In contrast, ‘wellbeing’ is emerging as a complement to the more traditional ways of conceptualising and measuring poverty and deprivation around material consumption. Wellbeing extends attention from what people can do and be and adds how people feel about what they can do and be. Wellbeing is thus explicitly rather than inferentially about agency and also goes beyond the material to consider the relational and the subjective domains of life. So, can a wellbeing lens help us to rethink IGT? We use an application to an IGT mechanism: the transmission of undernutrition from one generation to the next

GeoOrigins: A new method and R package for trait mapping and geographic provenancing of specimens without categorical constraints

Biologists often seek to geographically provenance organisms using their traits. This is typically achieved by defining spatial groups using distinct patterns of trait variation. Here, we present a new spatial provenancing and trait boundary identification methodology, based on correlations between geographic and trait distances that require no a priori group assumptions. We apply this to three datasets where spatial provenance is sought: morphological rat and vole dentition data (human commensal translocation datasets); and birdsong data (cultural transmission dataset). We also present the results of cross‐validation testing. Spatial provenancing is possible with differing degrees of accuracy for each dataset, with birdsong providing the most accurate geographic origin (identifying an average spatial region of 0.22 km2 as the area of origin with 99.9% confidence). Our method has a wide range of potential applications to diverse data types—including phenotypic, genetic and cultural—to identify trait boundaries and spatially provenance the origin of unknown or translocated specimens where trait differences are geographically structured and correlated with spatial separation

Drivers of future alien species impacts: An expert‐based assessment

Understanding the likely future impacts of biological invasions is crucial yet highly challenging given the multiple relevant environmental, socio‐economic and societal contexts and drivers. In the absence of quantitative models, methods based on expert knowledge are the best option for assessing future invasion trajectories. Here, we present an expert assessment of the drivers of potential alien species impacts under contrasting scenarios and socioecological contexts through the mid‐21st century. Based on responses from 36 experts in biological invasions, moderate (20%–30%) increases in invasions, compared to the current conditions, are expected to cause major impacts on biodiversity in most socioecological contexts. Three main drivers of biological invasions—transport, climate change and socio‐economic change—were predicted to significantly affect future impacts of alien species on biodiversity even under a best‐case scenario. Other drivers (e.g. human demography and migration in tropical and subtropical regions) were also of high importance in specific global contexts (e.g. for individual taxonomic groups or biomes). We show that some best‐case scenarios can substantially reduce potential future impacts of biological invasions. However, rapid and comprehensive actions are necessary to use this potential and achieve the goals of the Post‐2020 Framework of the Convention on Biological Diversity

IPBES Invasive Alien Species Assessment: Summary for Policymakers

Summary for Policymakers of the Thematic Assessment Report on Invasive Alien Species and their Control of the Intergovernmental Science-Policy Platform on Biodiversity and Ecosystem Services

Integrating invasive species policies across ornamental horticulture supply-chains to prevent plant invasions

1.Ornamental horticulture is the primary pathway for invasive alien plant introductions. We critically appraise published evidence on the effectiveness of four policy instruments that tackle invasions along the horticulture supply chain: pre-border import restrictions, post-border bans, industry codes of conduct and consumer education. 2.Effective pre-border interventions rely on rigorous risk assessment and high industry compliance. Post-border sales bans become progressively less effective when alien species become widespread in a region. 3.A lack of independent performance evaluation and of public disclosure, limits the uptake and effectiveness of voluntary codes of conduct and discourages shifts in consumer preference away from invasive alien species. 4.Policy implications. Closing the plant invasion pathway associated with ornamental horticulture requires government-industry agreements to fund effective pre- and post-border weed risk assessments that can be subsequently supported by widely adopted, as well as verifiable, industry codes of conduct. This will ensure producers and consumers make informed choices in the face of better targeted public education addressing plant invasions

Assessment of ibrutinib plus rituximab in front-line CLL (FLAIR trial): study protocol for a phase III randomised controlled trial

Background Treatment of chronic lymphocytic leukaemia (CLL) has seen a substantial improvement over the last few years. Combination immunochemotherapy, such as fludarabine, cyclophosphamide and rituximab (FCR), is now standard first-line therapy. However, the majority of patients relapse and require further therapy, and so new, effective, targeted therapies that improve remission rates, reduce relapses, and have fewer side effects, are required. The FLAIR trial will assess whether ibrutinib plus rituximab (IR) is superior to FCR in terms of progression-free survival (PFS). Methods/design FLAIR is a phase III, multicentre, randomised, controlled, open, parallel-group trial in patients with previously untreated CLL. A total of 754 participants will be randomised on a 1:1 basis to receive standard therapy with FCR or IR. Participants randomised to FCR will receive a maximum of six 28-day treatment cycles. Participants randomised to IR will receive six 28-day cycles of rituximab, and ibrutinib taken daily for 6 years until minimal residual disease (MRD) negativity has been recorded for the same amount of time as it took to become MRD negative, or until disease progression. The primary endpoint is PFS according to the International Workshop on CLL (IWCLL) criteria. Secondary endpoints include: overall survival; proportion of participants with undetectable MRD; response to therapy by IWCLL criteria; safety and toxicity; health-related quality of life (QoL); and cost-effectiveness. Discussion The trial aims to provide evidence for the future first-line treatment of CLL patients by assessing whether IR is superior to FCR in terms of PFS, and whether toxicity rates are favourable. Trial registration ISRCTN01844152. Registered on 8 August 2014, EudraCT number 2013-001944-76. Registered on 26 April 2013

SARS-CoV-2 anti-spike antibody levels following second dose of ChAdOx1 nCov-19 or BNT162b2 in residents of long-term care facilities in England (VIVALDI)

General population studies have shown strong humoral response following SARS-CoV-2 vaccination with subsequent waning of anti-spike antibody levels. Vaccine-induced immune responses are often attenuated in frail and older populations, but published data are scarce. We measured SARS-CoV-2 anti-spike antibody levels in Long-Term Care Facility residents and staff following second vaccination dose with Oxford-AstraZeneca or Pfizer-BioNTech. Vaccination elicited robust antibody responses in older residents, suggesting comparable levels of vaccine-induced immunity to that in the general population. Antibody levels are higher after Pfizer-BioNTech vaccination but fall more rapidly compared to Oxford-AstraZeneca recipients and are enhanced by prior infection in both groups

Scenario Analyses Concerning Energy Efficiency and Climate Protection in Regional and National Residential Building Stocks. Examples from Nine European Countries. - EPISCOPE Synthesis Report No. 3

This report documents methodological aspects and selected results of the scenario analyses to assess refurbishment as well as energy saving processes and project future energy consumption.. It covers scenario calculations conducted for regional residential building stocks in Salzburg/Austria, the Comunidat Valenciana/Spain, the Piedmont Region/Italy, the national non-profit housing stock in the Netherlands as well as the national residential building stocks in Germany, England, Greece, Norway, and Slovenia. Thereby, the objective of the scenario analysis is not a prediction of future energy demand in the respective building stock. Rather, the objective is to show the potential future impact of predefined assumptions. This may help respective key actors and policy makers to decide on strategies and policies for transforming building stocks towards carbon dioxide neutrality