Los héroes del Bruch [Texto impreso] : romance histórico

Hay un ejemplar encuadernado con: "Recuerdos de una familia católica / Ángel de las Heras García"(Carreres/4434)Hay un ejemplar encuadernado con: La aparición de la Santisima Virgen de la Saleta de los Alpes (NP849.91/2046).Hay un ejemplar encuadernado con: Bandos divertidísimos contra los borrachos y borrachas, y gente aficionada al vino(NP849.91/3087)Premiado en el Certamen Poético celebrado por la Redacción de La Ilustración Popular Económica, 187

Pressure-temperature phase diagram of the dimorphism of the anti-inflammatory drug nimesulide

Understanding the phase behavior of active pharmaceutical ingredients is important for formulations of dosage forms and regulatory reasons. Nimesulide is an anti-inflammatory drug that is known to exhibit dimorphism; however up to now its stability behavior was not clear, as few thermodynamic data were available. Therefore, calorimetric melting data have been obtained, which were found to be TI-L = 422.4 ± 1.0 K, ¿I ¿ LH = 117.5 ± 5.2 J g-1, TII-L = 419.8 ± 1.0 K and ¿II ¿ LH = 108.6 ± 3.3 J g-1. In addition, vapor-pressure data, high-pressure melting data, and specific volumes have been obtained. It is demonstrated that form II is intrinsically monotropic in relation to form I and the latter would thus be the best polymorph to use for drug formulations. This result has been obtained by experimental means, involving high-pressure measurements. Furthermore, it has been shown that with very limited experimental and statistical data, the same conclusion can be obtained, demonstrating that in first instance topological pressure-temperature phase diagrams can be obtained without necessarily measuring any high-pressure data. It provides a quick method to verify the phase behavior of the known phases of an active pharmaceutical ingredient under different pressure and temperature conditions.Postprint (author's final draft

El mártir del Gólgota [Texto impreso] : romance religioso

Hay un ejemplar encuadernado con: Bandos divertidísimos contra los borrachos y borrachas, y gente aficionada al vino (NP849.91/3087).Hay un ejemplar encuadernado con: La aparición de la Santisima Virgen de la Saleta de los Alpes (NP849.91/2046)Hay un ejemplar encuadernado con: "Recuerdos de una familia católica / Ángel García de las Heras"(Carreres/4434)Premiado con una mención honorífica en el certámen poético celebrado por la redacción de la Ilustración Popular Económica, en febrero de 187

La educación bilingüe: ¿Una respuesta al Aragón trilingüe?

Frente al progresivo reconocimiento de los derechos de las diferentes minorías lingüísticas del Estado español, en el caso de Aragón no ha sido hasta recientemente que el debate sobre el papel de las lenguas minoritarias ha alcanzado cierta notoriedad. Más concretamente, la reforma del Estatuto de Autonomía aprobada en 2007 establece el mandato de desarrollar una Ley de Cortes que determine las zonas de uso predominante de las lenguas y modalidades propias de la región, así como otros aspectos relativos a su recuperación, promoción o enseñanza. En este contexto, el artículo presenta una taxonomía de los modelos de educación bilingüe y describe los resultados de diversos estudios centrados en el análisis de las actitudes lingüísticas manifestadas por los ciudadanos aragoneses. A partir de ello, se plantea una propuesta de educación bilingüe coherente con el conocimiento acumulado sobre el tema y ajustada a la realidad trilingüe de la Comunidad

The paleontological and archaeological record of the localities of the Trinchera del Ferrocarril in the Sierra de Atapuerca

[ES] El registro paleontológico y arqueológico de los yacimientos de la Trinchera del Ferrocarril representa periodos clave en la evolución biológica y cultural de Homo y en la historia faunística, ambiental y climática de Europa. La parte inferior de la secuencia de Sima del Elefante (TE8-14) tiene una antigüedad proximo a 1 millón de años, y ha proporcionado indicaciones de presencia humana en forma de industria lítica y marcas de corte. Este tiempo señala el principio de una serie de cambios climáticos, ambientales y faunísticos fundamentales. La parte inferior de la secuencia de Gran Dolina (TDW4-TD8inf) se sitúa en la transición del Pleistoceno Inferior a Medio, y permite una caracterización muy precisa de los cambios faunísticos y ambientales alrededor de este límite. El nivel TD6 ha proporcionado una colección abundante de restos de Homo antecessor. El registro arqueológico, incluyendo industria del Modo 1, marcas de corte etc., permite la rara oportunidad de estudiar el comportamiento humano durante este periodo. Galería (TG) y la parte superior de la secuencia de Gran Dolina (TD10-11) pertenecen a la parte central del Pleistoceno Medio y tienen un registro paleontológico y arqueológico abundante, incluyendo restos de Homo heidelbergensis e industria de Modo 2 y Modo 3.[EN] The paleontological and archaeological record of the localities of the Trinchera del Ferrocarril represents key periods in the biological and cultural evolution of man, as well as in faunal, environmental and climatic history of Europe. The lower part of the sequence of Sima del Elefante (TE8-14) is around 1 Ma old and yielded indications of the presence of humans in the form of lithic industry and cutmarks. This time marks the onset of a series of fundamental climatic, environmental and faunal changes. The lower part of the Gran Dolina sequence (TDW4-TD8inf) straddles the Early - Middle Pleistocene limit, and its macro and micro fauna permits a very precise characterisation of the faunal and environmental events around this transition. Level TD6 yielded an abundant collection of remains of Homo antecessor. The archaeological record, including Mode 1 industry, cutmarks etc., provides a rare opportunity to study human behavior of this period. Galería (TG) and the upper part of the Gran Dolina sequence (TD10-11) belong to the central part of the Middle Pleistocene and have an abundant palaeontological and archaeological record, including remains of Homo heidelbergensis and Mode 2 and 3 industry.Agrademos la ayuda de la DGICYT (proyectos BXX2000-1258-CO3-01 y PB98-0513 y el programa de Unidades Asociadas). Jesús Rodríguez es becario postdoctoral de la Comunidad de Madrid. Belén Márquez es becaria predoctoral de la Fundación Duques de Soria. Markus Bastir y Rosa Huguet son becarios del programa de Formación de Investigadores del Ministerio de Ciencia y Tecnología. Esta última disfruta de una beca del Ayuntamiento de Madrid en la Residencia de Estudiantes. Susana Sarmiento es becaria de la Fundación Atapuerca. María Martinón es becaria predoctoral del Plan Galego de Investigación e Desenvolvemento Tecnolóxico de la Xunta de Galícia. El DGICYT y la Consejería de Cultura y Turismo de la Junta de Castillla y León han hecho posibles las excavaciones en la Sierra de Atapuerca.Peer reviewe

El registro paleontológico y arqueológico de los yacimientos de la Trinchera del Ferrocarril en la Sierra de Atapuerca

El registro paleontológico y arqueológico de los yacimientos de la Trinchera del Ferrocarril representa periodos clave en la evolución biológica y cultural de Homo y en la historia faunística, ambiental y climática de Europa. La parte inferior de la secuencia de Sima del Elefante (TE8-14) tiene una antigüedad proximo a 1 millón de años, y ha proporcionado indicaciones de presencia humana en forma de industria lítica y marcas de corte. Este tiempo señala el principio de una serie de cambios climáticos, ambientales y faunísticos fundamentales. La parte inferior de la secuencia de Gran Dolina (TDW4-TD8inf) se sitúa en la transición del Pleistoceno Inferior a Medio, y permite una caracterización muy precisa de los cambios faunísticos y ambientales alrededor de este límite. El nivel TD6 ha proporcionado una colección abundante de restos de Homo antecessor. El registro arqueológico, incluyendo industria del Modo 1, marcas de corte etc., permite la rara oportunidad de estudiar el comportamiento humano durante este periodo. Galería (TG) y la parte superior de la secuencia de Gran Dolina (TD10-11) pertenecen a la parte central del Pleistoceno Medio y tienen un registro paleontológico y arqueológico abundante, incluyendo restos de Homo heidelbergensis e industria de Modo 2 y Modo 3. [ABSTRACT] The paleontological and archaeological record of the localities of the Trinchera del Ferrocarril represents key periods in the biological and cultural evolution of man, as well as in faunal, environmental and climatic history of Europe. The lower part of the sequence of Sima del Elefante (TE8-14) is around 1 Ma old and yielded indications of the presence of humans in the form of lithic industry and cutmarks. This time marks the onset of a series of fundamental climatic, environmental and faunal changes. The lower part of the Gran Dolina sequence (TDW4-TD8inf) straddles the Early - Middle Pleistocene limit, and its macro and micro fauna permits a very precise characterisation of the faunal and environmental events around this transition. Level TD6 yielded an abundant collection of remains of Homo antecessor. The archaeological record, including Mode 1 industry, cutmarks etc., provides a rare opportunity to study human behavior of this period. Galería (TG) and the upper part of the Gran Dolina sequence (TD10-11) belong to the central part of the Middle Pleistocene and have an abundant palaeontological and archaeological record, including remains of Homo heidelbergensis and Mode 2 and 3 industry

Metabolomic-Based Noninvasive Serum Test to Diagnose Nonalcoholic Steatohepatitis: Results From Discovery and Validation Cohorts

Nonalcoholic fatty liver disease (NAFLD) is the most common type of chronic liver disease worldwide and includes a broad spectrum of histologic phenotypes, ranging from simple hepatic steatosis or nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH). While liver biopsy is the reference gold standard for NAFLD diagnosis and staging, it has limitations due to its sampling variability, invasive nature, and high cost. Thus, there is a need for noninvasive biomarkers that are robust, reliable, and cost effective. In this study, we measured 540 lipids and amino acids in serum samples from biopsy-proven subjects with normal liver (NL), NAFL, and NASH. Using logistic regression analysis, we identified two panels of triglycerides that could first discriminate between NAFLD and NL and second between NASH and NAFL. These noninvasive tests were compared to blinded histology as a reference standard. We performed these tests in an original cohort of 467 patients with NAFLD (90 NL, 246 NAFL, and 131 NASH) that was subsequently validated in a separate cohort of 192 patients (7 NL, 109 NAFL, 76 NASH). The diagnostic performances of the validated tests showed an area under the receiver operating characteristic curve, sensitivity, and specificity of 0.88 +/- 0.05, 0.94, and 0.57, respectively, for the discrimination between NAFLD and NL and 0.79 +/- 0.04, 0.70, and 0.81, respectively, for the discrimination between NASH and NAFL. When the analysis was performed excluding patients with glucose levels >136 mg/dL, the area under the receiver operating characteristic curve for the discrimination between NASH and NAFL increased to 0.81 +/- 0.04 with sensitivity and specificity of 0.73 and 0.80, respectively. Conclusion: The assessed noninvasive lipidomic serum tests distinguish between NAFLD and NL and between NASH and NAFL with high accuracy.Supported by the National Institutes of Health Blueprint for Neuroscience Research (R01AT001576 to S.C.L., J.M.M.), Agencia Estatal de Investigacion of the Ministerio de Economia, Industria y Competitividad (SAF2014-52097R to J.M.M.), CIBER Hepatic and Digestive Diseases and Instituto de Salud Carlos III (PIE14/0003 to J.M.M.), Etorgai 2015-Gobierno Vasco (ER-2015/00015 to R.M., I.M.A., C.A., A.C.), Plan de Promocion de la Innovacion 2015-Diputacion Foral de Bizkaia (6/12/IN/2015/00131 to A.C., C.A.), National Institute of Diabetes and Digestive and Kidney Diseases (RO1DK81410 to A.J.S.), and Czech Ministry of Health (RVO VFN64165 to L.V.)

Blood test dynamics in hospitalized COVID-19 patients: Potential utility of D-dimer for pulmonary embolism diagnosis

Background: A higher incidence of thrombotic events, mainly pulmonary embolism (PE), has been reported in hospitalized patients with COVID-19. The main objective was to assess clinical and laboratory differences in hospitalized COVID-19 patients according to occurrence of PE. Methods: This retrospective study included all consecutive patients hospitalized with COVID-19 who underwent a computed tomography (CT) angiography for PE clinical suspicion. Clinical data and median blood test results distributed into weekly periods from COVID-19 symptoms onset, were compared between PE and non-PE patients. Results: Ninety-two patients were included, 29 (32%) had PE. PE patients were younger (63.9 (SD 13.7) vs 69.9 (SD 12.5) years). Clinical symptoms and COVID-19 CT features were similar in both groups. PE was diagnosed after a mean of 20.0 (SD 8.6) days from the onset of COVID-19 symptoms. Corticosteroid boluses were more frequently used in PE patients (62% vs. 43%). No patients met ISTH DIC criteria. Any parameter was statistically significant or clinically relevant except for D-Dimer when comparing both groups. Median values [IQR] of D-dimer in PE vs non-PE patients were: week 2 (2010.7 [770.1-11208.9] vs 626.0 [374.0-2382.2]; p = 0.004); week 3 (3893.1 [1388.2-6694.0] vs 1184.4 [461.8-2447.8]; p = 0.003); and week 4 (2736.3 [1202.1-8514.1] vs 1129.1 [542.5-2834.6]; p = 0.01). Median fold-increase of D-dimer between week 1 and 2 differed between groups (6.64 [3.02-23.05] vs 1.57 [0.64-2.71], p = 0.003); ROC curve AUC was 0.879 (p = 0.003) with a sensitivity and specificity for PE of 86% and 80%, respectively. Conclusions: Among hospitalized COVID-19 patients, D-dimer levels are higher at weeks 2, 3 and 4 after COVID-19 symptom onset in patients who develop PE. This difference is more pronounced when the fold increase between weeks 1 and 2 is compared