Gestión del talento humano y desempeño laboral de los colaboradores de la Municipalidad Distrital de Santa Rosa de Sacco provincia de Yauli año 2015

La presente investigación titulada “Gestión del Talento Humano y Desempeño Laboral de los colaboradores de la Municipalidad distrital de Santa Rosa de Sacco año 2015”, tuvo como objetivo general determinar la relación que existe entre la Gestión del talento humano y desempeño laboral de los colaboradores de la Municipalidad distrital de Santa rosa de Sacco año 2015. La metodología empleada correspondió a una investigación con un enfoque cuantitativo. Ésta fue de tipo básico, con un alcance descriptivocorrelacional, de diseño transversal. La población estuvo restringida a los colaboradores de la Municipalidad distrital de Santa Rosa de Sacco. El tipo de muestreo fue censal y el tamaño de muestra fue de 60 colaboradores. A nivel de campo se utilizó una encuesta de tipo descriptivo consistente en una interrogación escrita (cuestionario) de 25 preguntas (15 para gestión del talento humano y 10 para desempeño laboral), con una escala de Likert (1-5) y tres niveles (malo, regular y bueno). Se hicieron visitas ad hoc para la toma de datos

Alotanypus vittigera (Edwards) comb. nov.: adult redescription, immature description and a phylogenetic analysis of the genus (Diptera: Chironomidae: Tanypodinae)

Anatopynia vittigera Edwards is transfered to Alotanypus. The male and female of A. vittigera comb. nov. are redescribed and immatures are described and illustrated. A cladistic analysis including one species of each Macropelopiini genus was conducted in order to assess the phylogenetic position of Alotanypus and to provide the first phylogenetic hypothesis for the genus. Adults and immatures were included in the analysis where discrete and continuos characters were considered. The cladistic analysis demonstrated that Alotanypus is a monophyletic genus, with Guassutanypus oliveirai as the sister group.Fil: Siri, Augusto. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Limnología "Dr. Raúl A. Ringuelet". Universidad Nacional de La Plata. Facultad de Ciencias Naturales y Museo. Instituto de Limnología; ArgentinaFil: Donato, Mariano Humberto. Universidad Nacional de La Plata; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Orpella, German Hugo. Administración de Parques Nacionales. Delegación Regional Patagonia; ArgentinaFil: Massaferro, Julieta. Administración de Parques Nacionales. Delegación Regional Patagonia; Argentin

Biogeographical revision of Argentina (Andean and Neotropical Regions): an analysis using freshwater fishes

The following zoogeographic provinces are proposed for Argentine freshwater fish fauna following the International Code of Area Nomenclature: Andean Cuyan, Patagonian, Aymaran, Great Rivers and Pampean. The former two are placed within the Andean Subregion of the Austral Region, and the latter three within the Neotropical Subregion of the Holotropical Region. These provinces, based on results coinciding with PAE and cluster analysis, represent the first classification of Argentine provinces based on objective methods. Some small regions of endemism and some localities remain separated from the proposed regions. The new scheme includes valuable empirical information from previous schemes, and is in agreement with ecological zones and other environmental arrangements proposed earlier.Facultad de Ciencias Naturales y Muse

Levantamento fitossociológico como ferramenta para a restauração florestal da Mata Atlântica, no Médio Paraíba do Sul

Phytosociological surveys may consist as decision-making supports for implementation of projects aimed at maintaining the biodiversity or increasing the quality of services provided by the ecosystems. The present study was an immediate making the phytosociological survey of forest formation present at ‘Espaço Ecológico Educativo’, Pinheiral - RJ state, and based on the results, discuss actions needed to restore the remaining. Rectangular plots of 20 x 10 m were installed and distributed randomly in the slopes and alluvial forests, totaling 0.3 ha of the sampling area, about 5.0 % of the forest. All the individuals with Diameter at Breast Height (DBH)> 5.0 cm were recorded. The alluvial forests showed 27 species and density of 1600 ind./ha while in the slope were 37 species and the density of 1393 ind./ha. The Shannon index was 2.98 and the evenness was 0.56 for the forest in the slope and for alluvial forest the diversity was 2.59 and the evenness was 0.48. The floristic composition varied significantly between the forest types. The forest formations present in the area had low richness and diversity of species, demonstrating the need for enrichment in an attempt to restore the biodiversity values found in the reference forest ecosystems.ResumoLevantamentos fitossociológicos constituem uma ferramenta de suporte à tomada de decisão em projetos de restauração florestal, contribuindo com a manutenção da biodiversidade vegetal e com o aumento da qualidade dos serviços prestados por esses ecossistemas. O presente estudo teve como objetivo realizar o levantamento fitossociológico das formações florestais presentes no Espaço Ecológico Educativo, Pinheiral-RJ e, com base nos resultados, discutir ações necessárias para restauração dos remanescentes. Foram instaladas parcelas retangulares de 20 x10 m, distribuídas arbitrariamente nas florestas de encosta e aluvial, totalizando 0,3 ha de área amostral e cerca de 5,0 % da área florestal. Todos os indivíduos com Diâmetro a Altura do Peito (DAP) > 5,0 cm foram registrados. A floresta aluvial apresentou 27 espécies e densidade de 1.600 ind./ha, enquanto na de encosta foram 37 espécies e densidade de 1.393 ind./ha. O índice de Shannon foi 2,98 e a equabilidade foi 0,56 para floresta de encosta e, respectivamente 2,59 e 0,48, para floresta aluvial. A composição florística variou significativamente entre as duas formações florestais analisadas, as quais apresentaram baixos valores de riqueza e diversidade de espécies, demonstrando a necessidade de enriquecimento com espécies florestais, na tentativa de restabelecer os valores de biodiversidade encontrados em ecossistemas florestais de referência

Terceiro molar impactado em região de seio maxilar- Relato de caso

Introdução: Os terceiros molares comumente estão em posições ectópicas, geralmente devido à impacção, causada pela falta de espaço no respectivo arco. Geralmente são encontrados em achados radiográficos, mas podem estar relacionados a sintomas apresentados pelos pacientes, como edema e dor. O tratamento pode ser conservador ou cirúrgico e irá depender das condições clínicas e/ou dos sintomas relatados pelo paciente.Objetivo: O objetivo do artigo é o relato de caso de remoção cirúrgica de um terceiro molar impactado em região íntima ao seio maxilar relacionado a queixa de dor crônica da paciente.Relato de caso: Paciente, gênero feminino, 29 anos, leucoderma, compareceu com queixa principal de dor intensa e contínua, na região maxilar superior esquerda. Os exames de imagem demonstraram a presença de um elemento dentário, intimamente relacionado ao seio maxilar. Esse foi removido por meio de técnica cirúrgica conservadora.Conclusão: O tratamento de dentes impactados requer a avaliação por um profissional capacitado para tomar a melhor decisão acerca da conduta para cada caso, podendo ser um tratamento conservador ou cirúrgico

S100A1: A Multifaceted Therapeutic Target in Cardiovascular Disease

Cardiovascular disease is the leading cause of death worldwide, showing a dramatically growing prevalence. It is still associated with a poor clinical prognosis, indicating insufficient long-term treatment success of currently available therapeutic strategies. Investigations of the pathomechanisms underlying cardiovascular disorders uncovered the Ca2+ binding protein S100A1 as a critical regulator of both cardiac performance and vascular biology. In cardiomyocytes, S100A1 was found to interact with both the sarcoplasmic reticulum ATPase (SERCA2a) and the ryanodine receptor 2 (RyR2), resulting in substantially improved Ca2+ handling and contractile performance. Additionally, S100A1 has been described to target the cardiac sarcomere and mitochondria, leading to reduced pre-contractile passive tension as well as enhanced oxidative energy generation. In endothelial cells, molecular analyses revealed a stimulatory effect of S100A1 on endothelial NO production by increasing endothelial nitric oxide synthase activity. Emphasizing the pathophysiological relevance of S100A1, myocardial infarction in S100A1 knockout mice resulted in accelerated transition towards heart failure and excessive mortality in comparison with wild-type controls. Mice lacking S100A1 furthermore displayed significantly elevated blood pressure values with abrogated responsiveness to bradykinin. On the other hand, numerous studies in small and large animal heart failure models showed that S100A1 overexpression results in reversed maladaptive myocardial remodeling, long-term rescue of contractile performance, and superior survival in response to myocardial infarction, indicating the potential of S100A1-based therapeutic interventions. In summary, elaborate basic and translational research established S100A1 as a multifaceted therapeutic target in cardiovascular disease, providing a promising novel therapeutic strategy to future cardiologists

Pheno-genotyping of inherited thrombocytopenias: our experience in 50 families

Dada la heterogeneidad de las entidades comprendi- das en las trombocitopenias hereditarias y la escasez de marcadores distintivos, su diagnóstico constituye un verdadero desafío. El abordaje clásico se basa en la caracterización fenotípica seguida del estudio mo- lecular de genes candidatos, orientado según la sos- pecha clínica. La introducción de la secuenciación de nueva generación (NGS), que permite evaluar múltiples genes simultáneamente, constituye una al- ternativa diagnóstica de alto costo, siendo de acceso limitado en nuestro medio. Nos propusimos evaluar la utilidad del abordaje clásico en una cohorte conse- cutiva de 50 familias y describir la aplicación de NGS en un subgrupo de pacientes sin diagnóstico etioló- gico luego del enfoque clásico. Mediante el abordaje clásico se efectuó el diagnóstico en 27 (54%) familias. Posteriormente, 8 familias que quedaron sin diag- nóstico luego del algoritmo clásico, se evaluaron me- diante NGS, identificando el gen causal en 4 de ellas. Considerando ambos abordajes, el rédito diagnóstico fue 31/50 (62%) familias, con la siguiente distribu- ción: 38% desorden relacionado a MYH9, 8% síndro- me de Bernard-Soulier (4% clásico, 4% monoalélico), 4% síndrome de plaquetas grises, 4% desorden pla- quetario con predisposición a leucemia, 6% trom- bocitopenia relacionada a ANKRD26, 2% síndrome Wiskott-Aldrich. Los pacientes en los que no se pudo efectuar un diagnóstico etiológico presentaban trom- bocitopenia aislada leve, con aumento moderado del tamaño plaquetario y sangrado escaso.En conclusión, la aplicación de NGS permitió au- mentar el rédito diagnóstico, si bien sería necesa- rio ampliar la población estudiada para establecer el valor real de este abordaje en nuestro medio. Por lo tanto, el uso inicial del abordaje clásico, reserván- dose la aplicación posterior de NGS a los casos que permanecen sin diagnóstico luego de este enfoque, constituiría una alternativa útil en países con pocos recursos, apuntando a un diagnóstico adecuado que posibilite la pesquisa de complicaciones sindrómicas, oriente al tratamiento y consejo genético acertado.Diagnosis of inherited thrombocytopenias represents a true challenge owing to heterogeneity of these disorders and the absence of distinctive features in a substantial proportion of patients. Classical diagnostic approach is based on phenotypic characterization followed by molecular analysis of candidate genes guided by clinical suspicion. The introduction of next generation sequencing (NGS), that allows multiple genes analysis, is a high-cost alternative with limited access in our country. The aim of this work was to evaluate the utility of the classical approach in a consecutive cohort of 50 families and to describe the application of NGS in a subgroup of patients without an etiological diagnosis after the initial approach. Through the conventional approach, an etiologic diagnosis was made in 27 (54%) families. NGS was performed in 8 that remained without diagnosis after initial characterization, attaining a diagnosis in 4. Combining both approaches, the diagnostic yield was 31/50 (62%) families: 38% MYH9-related disorder, 8% Bernard-Soulier syndrome, 4% gray platelet syndrome, 4% familial platelet disorder with predisposition to leukemia, 6% ANKRD26-related thrombocytopenia, 2% Wiskott-Aldrich syndrome. Most patients without diagnosis had isolated macrothrombocytopenia and mild bleeding. NGS increased the diagnostic rate in this cohort, although it would be necessary to expand the population to establish its actual value in our setting. Therefore, the use of the classical approach and subsequent application of NGS in undiagnosed patients would represent a useful alternative in low-income countries, pointing out that a correct etiological diagnosis enables the detection of syndromic complications, appropriate treatment and adequate genetic counseling.Fil: Heller, Paula Graciela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Goette, Nora Paula. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Marin Oyarzún, Cecilia Paola. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Baroni Pietto, Maria Constanza. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Ayala, Daniela. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Altuna, Diana R.. Instituto Universidad Escuela de Medicina del Hospital Italiano; ArgentinaFil: Arrieta, Maria Elizabeth. Hospital Público Descentralizado Dr. Guillermo Rawson.; ArgentinaFil: Arbesú, Guillermo. Hospital Dr. Humberto Notti; ArgentinaFil: Basqueira, Ana L.. Hospital Privado Universitario de Cordoba.; ArgentinaFil: Bazack, Nora. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Bonacorso, Silvina. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Brodsky, Andrés. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; ArgentinaFil: Castro Rios, Miguel. No especifíca;Fil: Cosentini, María L.. Hospital Materno Infantil Doctor Hector Quintana ; Gobierno de la Provincia de Jujuy;Fil: Donato, Hugo Sebastian. Hospital Municipal del Niño de San Justo ; Municipalidad de la Matanza (buenos Aires);Fil: Korin, Jorge D.. No especifíca;Fil: Gomez, Silvina. No especifíca;Fil: Guglielmone, Hugo. Sanatorio Allende; ArgentinaFil: Lagrotta, Pablo. Hospital Nacional Profesor Alejandro Posadas.; ArgentinaFil: Marti, Alejandra. Provincia de Buenos Aires. Ministerio de Salud. Hospital Alta Complejidad en Red El Cruce Dr. Néstor Carlos Kirchner Samic; ArgentinaFil: Negro, Fernando Javier. Sanatorio Sagrado Corazon; ArgentinaFil: Rapetti, María C.. Hospital Municipal del Niño de San Justo ; Municipalidad de la Matanza (buenos Aires);Fil: Rosso, Diego. Universidad de Buenos Aires. Facultad de Medicina. Hospital de Clínicas General San Martín; Argentina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Ponzinibbio, Carlos. Hospital Italiano de La Plata; ArgentinaFil: Veber, Ernesto. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños Pedro Elizalde (ex Casa Cuna); ArgentinaFil: Zerga, Marta Elisa. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Molinas, Felisa Concepción. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Savoia, Anna. Instituto para la Salud Materna e Infancia; Italia. Università degli Studi di Trieste; ItaliaFil: Pecci, Alessandro. Universita Degli Studi Di Pavia; ItaliaFil: Marta, Rosana Fernanda. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; ArgentinaFil: Glembotsky, Ana Claudia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Médicas. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Médicas; Argentin

Fifth European Dirofilaria and Angiostrongylus Days (FiEDAD) 2016

Peer reviewe

A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death

: The clinical manifestations of SARS-CoV-2 infection vary widely among patients, from asymptomatic to life-threatening. Host genetics is one of the factors that contributes to this variability as previously reported by the COVID-19 Host Genetics Initiative (HGI), which identified sixteen loci associated with COVID-19 severity. Herein, we investigated the genetic determinants of COVID-19 mortality, by performing a case-only genome-wide survival analysis, 60 days after infection, of 3904 COVID-19 patients from the GEN-COVID and other European series (EGAS00001005304 study of the COVID-19 HGI). Using imputed genotype data, we carried out a survival analysis using the Cox model adjusted for age, age2, sex, series, time of infection, and the first ten principal components. We observed a genome-wide significant (P-value < 5.0 × 10-8) association of the rs117011822 variant, on chromosome 11, of rs7208524 on chromosome 17, approaching the genome-wide threshold (P-value = 5.19 × 10-8). A total of 113 variants were associated with survival at P-value < 1.0 × 10-5 and most of them regulated the expression of genes involved in immune response (e.g., CD300 and KLR genes), or in lung repair and function (e.g., FGF19 and CDH13). Overall, our results suggest that germline variants may modulate COVID-19 risk of death, possibly through the regulation of gene expression in immune response and lung function pathways