WISE 2005: responses of women to sublingual nitroglycerin before and after 56 days of 6 degrees head-down bed rest

This study tested the hypothesis that cardiovascular effects of sublingual nitroglycerin (NG) would be exaggerated after 56 days of 6 degrees head-down bed rest (HDBR) in women, and that an aerobic and resistive exercise countermeasure (EX, n = 8) would reduce the effect compared with HDBR without exercise (CON, n = 7). Middle cerebral artery maximal blood flow velocity (CBFV), cardiac stroke volume (SV), and superficial femoral artery blood flow (Doppler ultrasound) were recorded at baseline rest and for 5 min following 0.3 mg sublingual NG. Post-HDBR, NG caused greater increases in heart rate (HR) in CON compared with EX (+24.9 +/- 7.7 and +18.8 +/- 6.6 beats/min, respectively, P < 0.0001). The increase in HR combined with reductions in SV to maintain cardiac output. Systolic, mean, and pulse pressures were reduced 5-10 mmHg by NG, but total peripheral resistance was only slightly reduced at 3 min after NG. Reductions in CBFV of -12.5 +/- 3.8 cm/s were seen after NG, but a reduction in the Doppler resistance index suggested dilation of the middle cerebral artery with no differences after HDBR. The femoral artery dilated with NG and blood flow was reduced approximately 50% with the appearance of large negative waves suggesting a marked increase in downstream resistance, but there were no effects of HDBR. In general, responses of women to NG were not altered by HDBR; the greater increase in HR in CON but not EX was probably a consequence of cardiovascular deconditioning. These results contrast with the hypothesis and a previous investigation of men after HDBR by revealing no change in cardiovascular responses to exogenous nitric oxide

Faster femoral artery blood velocity kinetics at the onset of exercise following short-term training.

OBJECTIVE: The hypothesis that the adaptation to endurance exercise training included a faster increase in blood flow at the onset of exercise was tested in 12 healthy young men who endurance-trained (ET) 2 h/day, for 10 days at 65% VO2 peak on a cycle ergometer, and in 11 non-training control (C) subjects. METHODS: Blood flow was estimated from changes in femoral artery mean blood velocity (MBV) by pulsed Doppler. Beat-by-beat changes in cardiac output (CO) and mean arterial pressure (MAP) were obtained by impedance cardiography and a Finapres finger cuff, respectively. MBV, MAP and CO were measured at rest and during 5 min of dynamic knee extension exercise. Both legs worked alternately with 2 s raising and lowering a weight (15% maximal voluntary contraction) followed by 2 s rest while the other leg raised and lowered the weight. RESULTS: In the ET group the time to 63% (T63%) of the approximately exponential increase in MBV following 10 days of training (8.6 +/- 1.2 s, mean +/- s.e.) was significantly faster than the Day 0 response (14.2 +/- 2.1 s, P \u3c 0.05). The T63% of femoral artery vascular conductance (VCfa) was also faster following 10 days of ET (9.4 +/- 0.9 s) versus Day 0 (16.0 +/- 2.5 s) (0.05). There was no change in the T63% of both MBV and VCfa for the C group. The kinetics of CO were not significantly affected by ET, but the amplitude of CO in the adaptive phase, and at steady state, were significantly greater (P \u3c 0.05) at Day 10 compared to Day 0 for the ET group with no change in the C group. CONCLUSIONS: These data supported the hypothesis that endurance training resulted in faster adaptation of blood flow to exercising muscle, and further showed that this response occurred early in the training program

Sustainable Management of Water Resources

The Dawn spacecraft arrived at dwarf planet Ceres in spring 2015 and imaged its surface from four successively lower polar orbits at ground sampling dimensions between ∼1.3 km/px and ∼35 m/px. To understand the geological history of Ceres a mapping campaign was initiated to produce a set of 15 quadrangle-based geological maps using the highest-resolution Framing Camera imagery. Here we present the geological map of the Ac-10 Rongo Quadrangle, which is located at the equator encompassing the region from 22°N to 22°S and 288° to 360°E. The total relief within the quadrangle is 11.1 km with altitudes ranging from about −7.3 km to +3.8 km. We identified nine geological units based on surface morphology and surface textural characteristics. The dominant and most widespread unit is the cratered terrain (crt) representing ancient reworked crustal material. Its consistent formation age across the quadrangle is 1.8 Ga. Two edifices (unit th), Ahuna Mons and an unnamed tholus within Begbalel Crater, are interpreted to be of (cryo)volcanic origin. The southwest portion of the quadrangle is dominated by ejecta material (Ye) emplaced during the formation of the 260-km diameter Yalode impact basin at about 580 Ma. Rayed crater ejecta material (cr) is dominant in the eastern part of the quadrangle but also occurs in isolated patches up to a distance of 455 km from the 34 km diameter source crater Haulani. The remaining five geological units also represent impact crater materials: degraded rim (crdeg), bright crater (cb), hummocky floor (cfh), talus (ta), and crater (c) materials. Widespread Yalode and Haulani ejecta materials can potentially be utilised as stratigraphic markers. Therefore, it is essential to consistently map their full areal extent and to date their formations using impact crater statistics

The Artification of Football: A Sociological Reconsideration of the ‘Beautiful Game'

Football is widely referred to as the ‘beautiful game’. This gives the impression that the sport can be aesthetically appreciated by its human observers. However, while many people might acknowledge that some of the physical movements made by top level football players exhibit grace, even beauty, this does not equate to football being accepted as a form of culture comparable to other areas of human activity described collectively as ‘the arts’. While this article takes an interest in philosophical inquiry into the aesthetic possibilities of football, it is primarily concerned with a sociological explanation as to how football has become ‘artified’. In doing so, the article draws upon the concept ‘artification’ as developed by Roberta Shapiro and Nathalie Heinich. The approach is not concerned with definitions of art according to aesthetic criteria or notions of appreciation, but with ‘how and under what circumstances art comes about’. This requires examining football in relation to discernible ‘constituent processes’ of artification. For reasons explained in the article, the contextual focus is on the artification of football in England. Artification is not a closed and finished matter. In that it can be said to have occurred, artification must be balanced against ‘de-artification’ in the form of potentially countervailing tendencies. Such consideration is taken up in the conclusion, via reflection upon the damaging impact of the excesses of commercial organisational control. Overall, artification is advocated as a sociological model that offers insight into the cultural significance of football in contemporary life

Feminist phenomenology and the woman in the running body

Modern phenomenology, with its roots in Husserlian philosophy, has been taken up and utilised in a myriad of ways within different disciplines, but until recently has remained relatively under-used within sports studies. A corpus of sociological-phenomenological work is now beginning to develop in this domain, alongside a longer standing literature in feminist phenomenology. These specific social-phenomenological forms explore the situatedness of lived-body experience within a particular social structure. After providing a brief overview of key strands of phenomenology, this article considers some of the ways in which sociological, and particularly feminist phenomenology, might be used to analyse female sporting embodiment. For illustrative purposes, data from an autophenomenographic project on female distance running are also included, in order briefly to demonstrate the application of phenomenology within sociology, as both theoretical framework and methodological approach

Sporting embodiment: sports studies and the (continuing) promise of phenomenology

Whilst in recent years sports studies have addressed the calls ‘to bring the body back in’ to theorisations of sport and physical activity, the ‘promise of phenomenology’ remains largely under-realised with regard to sporting embodiment. Relatively few accounts are grounded in the ‘flesh’ of the lived sporting body, and phenomenology offers a powerful framework for such analysis. A wide-ranging, multi-stranded, and interpretatively contested perspective, phenomenology in general has been taken up and utilised in very different ways within different disciplinary fields. The purpose of this article is to consider some selected phenomenological threads, key qualities of the phenomenological method, and the potential for existentialist phenomenology in particular to contribute fresh perspectives to the sociological study of embodiment in sport and exercise. It offers one way to convey the ‘essences’, corporeal immediacy and textured sensuosity of the lived sporting body. The use of Interpretative Phenomenological Analysis (IPA) is also critically addressed. Key words: phenomenology; existentialist phenomenology; interpretative phenomenological analysis (IPA); sporting embodiment; the lived-body; Merleau-Pont

the geomorphology of ceres

### INTRODUCTION Observations of Ceres, the largest object in the asteroid belt, have suggested that the dwarf planet is a geologically differentiated body with a silicate core and an ice-rich mantle. Data acquired by the Dawn spacecraft were used to perform a three-dimensional characterization of the surface to determine if the geomorphology of Ceres is consistent with the models of an icy interior. ### RATIONALE Instruments on Dawn have collected data at a variety of resolutions, including both clear-filter and color images. Digital terrain models have been derived from stereo images. A preliminary 1:10 M scale geologic map of Ceres was constructed using images obtained during the Approach and Survey orbital phases of the mission. We used the map, along with higher-resolution imagery, to assess the geology of Ceres at the global scale, to identify geomorphic and structural features, and to determine the geologic processes that have affected Ceres globally. ### RESULTS Impact craters are the most prevalent geomorphic feature on Ceres, and several of the craters have fractured floors. Geomorphic analysis of the fracture patterns shows that they are similar to lunar Floor-Fractured Craters (FFCs), and an analysis of the depth-to-diameter ratios shows that they are anomalously shallow compared with average Ceres craters. Both of these factors are consistent with FFC floors being uplifted due to an intrusion of cryomagma. Kilometer-scale linear structures cross much of Ceres. Some of these structures are oriented radially to large craters and most likely formed due to impact processes. However, a set of linear structures present only on a topographically high region do not have any obvious relationship to impact craters. Geomorphic analysis suggests that they represent subsurface faults and might have formed due to crustal uplift by cryomagmatic intrusion. Domes identified across the Ceres surface present a wide range of sizes ( 100 km), basal shapes, and profiles. Whether a single formation mechanism is responsible for their formation is still an open question. Cryovolcanic extrusion is one plausible process for the larger domes, although most small mounds (<10-km diameter) are more likely to be impact debris. Differences in lobate flow morphology suggest that multiple emplacement processes have operated on Ceres, where three types of flows have been identified. Type 1 flows are morphologically similar to ice-cored flows on Earth and Mars. Type 2 flows are comparable to long-runout landslides. Type 3 flows morphologically resemble the fluidized ejecta blankets of rampart craters, which are hypothesized to form by impact into ice-rich ground. ### CONCLUSION The global trend of lobate flows suggests that differences in their geomorphology could be explained by variations in ice content and temperature at the near surface. Geomorphic and topographic analyses of the FFCs suggest that cryomagmatism is active on Ceres, whereas the large domes are possibly formed by extrusions of cryolava. Although spectroscopic analysis to date has identified water ice in only one location on Ceres, the identification of these potentially ice-related features suggests that there may be more ice within localized regions of Ceres' crust. ![Figure][1] Dawn high-altitude mapping orbit imagery (140 meters per pixel) of example morphologic features. ( A ) Occator crater; arrows point to floor fractures. ( B ) Linear structures, denoted by arrows. ( C ) A large dome at 42° N, 10° E, visible in the elevation map. ( D ) A small mound at 45.5° S, 295.7° E. ( E ) Type 1 lobate flow; arrows point to the flow front. Analysis of Dawn spacecraft Framing Camera image data allows evaluation of the topography and geomorphology of features on the surface of Ceres. The dwarf planet is dominated by numerous craters, but other features are also common. Linear structures include both those associated with impact craters and those that do not appear to have any correlation to an impact event. Abundant lobate flows are identified, and numerous domical features are found at a range of scales. Features suggestive of near-surface ice, cryomagmatism, and cryovolcanism have been identified. Although spectroscopic analysis has currently detected surface water ice at only one location on Ceres, the identification of these potentially ice-related features suggests that there may be at least some ice in localized regions in the crust. [1]: pending:ye

Survival analysis modeling with hidden censoring

There are well-established survival analysis methodologies for data sets that are complete, with accurate information on censoring. But what if they are not complete? In this article we consider how to analyze cases where “hidden censoring” occurs, where individuals have effectively left the study but the hospital is unaware of this. We develop a new Markov chain-based methodology for generating survival curves and hazard functions, and demonstrate this using a breast cancer data set from the Kurdistan region of Iraq

Normal Faults on Ceres: Insights Into the Mechanical Properties and Thermal History of Nar Sulcus

We characterized two sets of extensional faults that comprise the Nar Sulcus region of Ceres by applying a cantilever model for fault related flexure and derived flexural rigidity values for Nar Sulcus between 2.0 · 10E15 and 1.8 · 10E16 N·m. This range of flexural rigidity makes Nar Sulcus mechanically akin to extensional structures on Ganymede, Europa, and Enceladus. We combine these observations with an inferred strength profile for the upper mechanical layer of Ceres and estimate its thickness to be 2.9–9.5 km. Surface heat fluxes at Nar Sulcus during its formation were likely ≥10 mW/m2 for estimated strain rates of 10E−17–10E−14 sE−1, which is at least one order of magnitude larger than the current estimated global average. For geologically plausible heat fluxes between 10 and 100 mW/m2, we estimate an upper bound of ~30 vol.% mechanically silicate‐like phases in the near surface at Nar Sulcus, neglecting the effects of porosity

CD39, NTPDase 1, is attached to the plasma membrane by two transmembrane domains. Why?

Since the identification of CD39 and other members of the e-NTPDase (ecto-nucleoside triphosphate diphosphohydrolase) family as the primary enzymes responsible for cell surface nucleotide hydrolysis, one of their most intriguing features has been their unusual topology. The active site lies in the large extracellular region, but instead of being anchored in the membrane by a single transmembrane domain or lipid link like other ectoenzymes, CD39 has two transmembrane domains, one at each end. In this review we discuss evidence that the structure and dynamics of the transmembrane helices are intricately connected to enzymatic function. Removal of either or both transmembrane domains or disruption of their native state by detergent solubilization reduces activity by 90%, indicating that native function requires both transmembrane domains to be present and in the membrane. Enzymatic and mutational analysis of the native and truncated forms has shown that the active site can exist in distinct functional states characterized by different total activities, substrate specificities, hydrolysis mechanisms, and intermediate ADP release during ATP hydrolysis, depending on the state of the transmembrane domains. Disulfide crosslinking of cysteines introduced within the transmembrane helices revealed that they interact within and between molecules, in particular near the extracellular domain, and that activity depends on their organization. Both helices exhibit a high degree of rotational mobility, and the ability to undergo dynamic motions is required for activity and regulated by substrate binding. Recent reports suggest that membrane composition can regulate NTPDase activity. We propose that mechanical bilayer properties, potentially elasticity, might regulate CD39 by altering the balance between stability and mobility of its transmembrane domains