Inclusive Scholarship: Developing Balck Studies In The United States

Entering the public domain as part of the proliferating scholarship on African American Studies, this retrospective provides an appropriate occasion to assess the Ford Foundation's role in the institutionalization and legitimization of African American Studies in the academy, to offer a critical review of the four Foundation-sponsored reports, to assess the responses of the Foundation to the suggestions of the authors as regards future support, and to consider the consequences of the foundation's funding decisions over the last 25 years on the future of AfricanAmerican Studies. From this review, the conclusions drawn suggest how the foundation might continue its historic role in helping to support the field through its next stage of development

Inclusive Scholarship: Developing Black Studies in the United States

Brings together four reports commissioned between 1982 and 2000 that examine the history of African American Studies, its impact, and its institutionalization. Reviews Ford's grantmaking to African American Studies programs from 1982 to 2007

Design of a Green Monopropellant Propulsion System for the Lunar Flashlight CubeSat Mission

Lunar Flashlight is a 6U CubeSat mission from NASA\u27s Jet Propulsion Laboratory that will search for water-ice deposits near the lunar south pole. Lunar Flashlight aims to add to the flight experience of deep-space CubeSats by demonstrating an orbit insertion using a green monopropellant propulsion system designed uniquely for this mission. Developed by NASA Marshall Spaceflight Center (MSFC) and Georgia Tech\u27s Space Systems Design Laboratory (SSDL), the Lunar Flashlight Propulsion System (LFPS) delivers over 2500N-s of total impulse for the orbit insertion and necessary attitude maneuvers. The custom propulsion system fits within a 2.5U volume and has a total wet mass of less than six kilograms. It will be fueled byAF-M315E, which is a green monopropellant developed by the Air Force Research Laboratory (AFRL) as a safer alternative to hydrazine. Additive manufacturing is utilized to fabricate several components of its primary structure. Upon completion, Lunar Flashlight may become the first CubeSat to achieve orbit around a celestial body besides Earth. The LFPS aims to be a pathfinder device for CubeSat missions by demonstrating how monopropellant systems, green monopropellant fuel, and additive manufacturing can be utilized to expand the reach of small satellite space exploration

ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial

Background: Elevated triglyceride levels are a risk factor for cardiovascular disease. Angiopoietin-like protein 4 (Angptl4) is a metabolic factor that raises plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). In nondiabetic individuals, the ANGPTL4 coding variant E40K has been associated with lower plasma triglyceride levels while the T266M variant has been associated with more modest effects on triglyceride metabolism. The objective of this study was to determine whether ANGPTL4 E40K and T266M are associated with triglyceride levels in the setting of obesity and T2D, and whether modification of triglyceride levels by these genetic variants is altered by a lifestyle intervention designed to treat T2D. Methods: The association of ANGPTL4 E40K and T266M with fasting triglyceride levels was investigated in 2,601 participants from the Look AHEAD Clinical Trial, all of whom had T2D and were at least overweight. Further, we tested for an interaction between genotype and treatment effects on triglyceride levels. Results: Among non-Hispanic White Look AHEAD participants, ANGPTL4 K40 carriers had mean triglyceride levels of 1.61 +/- 0.62 mmol/L, 0.33 mmol/L lower than E40 homozygotes (p = 0.001). Individuals homozygous for the minor M266 allele (MAF 30%) had triglyceride levels of 1.75 +/- 0.58 mmol/L, 0.24 mmol/L lower than T266 homozygotes (p = 0.002). The association of the M266 with triglycerides remained significant even after removing K40 carriers from the analysis (p = 0.002). There was no interaction between the weight loss intervention and genotype on triglyceride levels. Conclusions: This is the first study to demonstrate that the ANGPTL4 E40K and T266M variants are associated with lower triglyceride levels in the setting of T2D. In addition, our findings demonstrate that ANGPTL4 genotype status does not alter triglyceride response to a lifestyle intervention in the Look AHEAD study

The Mutational signature comprehensive analysis toolkit (musicatk) for the discovery, prediction, and exploration of mutational signatures

Mutational signatures are patterns of somatic alterations in the genome caused by carcinogenic exposures or aberrant cellular processes. To provide a comprehensive workflow for preprocessing, analysis, and visualization of mutational signatures, we created the Mutational Signature Comprehensive Analysis Toolkit (musicatk) package. musicatk enables users to select different schemas for counting mutation types and to easily combine count tables from different schemas. Multiple distinct methods are available to deconvolute signatures and exposures or to predict exposures in individual samples given a pre-existing set of signatures. Additional exploratory features include the ability to compare signatures to the Catalogue Of Somatic Mutations In Cancer (COSMIC) database, embed tumors in two dimensions with uniform manifold approximation and projection, cluster tumors into subgroups based on exposure frequencies, identify differentially active exposures between tumor subgroups, and plot exposure distributions across user-defined annotations such as tumor type. Overall, musicatk will enable users to gain novel insights into the patterns of mutational signatures observed in cancer cohorts. SIGNIFICANCE: The musicatk package empowers researchers to characterize mutational signatures and tumor heterogeneity with a comprehensive set of preprocessing utilities, discovery and prediction tools, and multiple functions for downstream analysis and visualization.R21 CA226188 - NCI NIH HHS; T32 GM100842 - NIGMS NIH HHShttps://cancerres.aacrjournals.org/content/81/23/5813.full-text.pd

Red supergiants as potential Type IIn supernova progenitors: Spatially resolved 4.6 micron CO emission around VY CMa and Betelgeuse

We present high-resolution 4.6micron CO spectra of the circumstellar environments of two RSGs that are potential SN progenitors: Betelgeuse and VY CMa. Around Betelgeuse, 12CO emission within 3arcsec follows a mildly clumpy but otherwise spherical shell, smaller than its 55arcsec shell in KI lambda7699. In stark contrast, 4.6micron CO emission around VY CMa is coincident with bright KI in its clumpy asymmetric reflection nebula, within 5arcsec of the star. Our CO data reveal redshifted features not seen in KI spectra of VY CMa, indicating a more isotropic distribution of gas punctuated by randomly distributed asymmetric clumps. The relative CO and KI distribution in Betelgeuse arises from ionization effects within a steady wind, whereas in VY CMa, KI is emitted from skins of CO cloudlets resulting from episodic mass ejections 500--1000 yr ago. In both cases, CO and KI trace potential pre-SN circumstellar matter: we conclude that an extreme RSG like VY CMa might produce a Type IIn event like SN1988Z if it were to explode in its current state, but Betelgeuse will not. VY CMa demonstrates that LBVs are not necessarily the only progenitors of SNe IIn, but it underscores the requirement that SNe IIn suffer enhanced episodic mass loss shortly before exploding.Comment: 16 pages, AJ accepte

ANGPTL4 variants E40K and T266M are associated with lower fasting triglyceride levels in Non-Hispanic White Americans from the Look AHEAD Clinical Trial

<p>Abstract</p> <p>Background</p> <p>Elevated triglyceride levels are a risk factor for cardiovascular disease. Angiopoietin-like protein 4 (Angptl4) is a metabolic factor that raises plasma triglyceride levels by inhibiting lipoprotein lipase (LPL). In non-diabetic individuals, the <it>ANGPTL4 </it>coding variant E40K has been associated with lower plasma triglyceride levels while the T266M variant has been associated with more modest effects on triglyceride metabolism. The objective of this study was to determine whether ANGPTL4 E40K and T266M are associated with triglyceride levels in the setting of obesity and T2D, and whether modification of triglyceride levels by these genetic variants is altered by a lifestyle intervention designed to treat T2D.</p> <p>Methods</p> <p>The association of <it>ANGPTL4 </it>E40K and T266M with fasting triglyceride levels was investigated in 2,601 participants from the Look AHEAD Clinical Trial, all of whom had T2D and were at least overweight. Further, we tested for an interaction between genotype and treatment effects on triglyceride levels.</p> <p>Results</p> <p>Among non-Hispanic White Look AHEAD participants, <it>ANGPTL4 </it>K40 carriers had mean triglyceride levels of 1.61 ± 0.62 mmol/L, 0.33 mmol/L lower than E40 homozygotes (p = 0.001). Individuals homozygous for the minor M266 allele (MAF 30%) had triglyceride levels of 1.75 ± 0.58 mmol/L, 0.24 mmol/L lower than T266 homozygotes (p = 0.002). The association of the M266 with triglycerides remained significant even after removing K40 carriers from the analysis (p = 0.002). There was no interaction between the weight loss intervention and genotype on triglyceride levels.</p> <p>Conclusions</p> <p>This is the first study to demonstrate that the <it>ANGPTL4 </it>E40K and T266M variants are associated with lower triglyceride levels in the setting of T2D. In addition, our findings demonstrate that <it>ANGPTL4 </it>genotype status does not alter triglyceride response to a lifestyle intervention in the Look AHEAD study.</p