21 research outputs found
Living lab for digital literacy and active ageing. Systematic literature review of scientific production in the social sciences
[EN] The aim of this study is to know the state of the art of Living Labs in the field of Social Sciences. To this
end, a Systematic Literature Review was carried out with the aim of answering the following research
questions: a) what types of studies are carried out on Living Labs, b) what are the aims and objectives
of the Living Lab analysed, c) what is its geographical context, d) the type of users it is aimed at and e)
what are the characteristics shared by the different Living Labs analysed in the selected literature. After
analysing the literature, the results show a predominance of both qualitative research and studies carried
out in the European context, as well as heterogeneity in the objectives of the research analysed and
coincidence in the characteristics of the Living Labs analysed. The conclusions point to the need to
develop research on Living Labs in the field of Social Sciences and, specifically, from an educational
perspective that promotes the technological inclusion of the elderly
Data fusion for driver behaviour analysis
A driver behaviour analysis tool is presented. The proposal offers a novel contribution based on low-cost hardware and advanced software capabilities based on data fusion. The device takes advantage of the information provided by the in-vehicle sensors using Controller Area Network Bus (CAN-BUS), an Inertial Measurement Unit (IMU) and a GPS. By fusing this information, the system can infer the behaviour of the driver, providing aggressive behaviour detection. By means of accurate GPS-based localization, the system is able to add context information, such as digital map information, speed limits, etc. Several parameters and signals are taken into account, both in the temporal and frequency domains, to provide real time behaviour detection. The system was tested in urban, interurban and highways scenarios.This work was supported by the Spanish Government through the CICYT project (TRA2013-48314-C3-1-R) and DGT project (SPID2015-01802) and by the company SERCORE Tech. S.L. through the project: “Proyecto de Viabilidad de la Comunicación entre el BUS CAN de un Vehículo Específico con un Dispositivo de Adquisición de Datos Móviles”. SERCORE provided invaluable support in the development of the communication technologies through the CAN BUS, presented in this paper
A Novel Naphthoquinone-Coumarin Hybrid That Inhibits BCR-ABL1-STAT5 Oncogenic Pathway and Reduces Survival in Imatinib-Resistant Chronic Myelogenous Leukemia Cells
BCR-ABL1-STAT5 is an oncogenic signaling pathway in human chronic myelogenous leukemia (CML) and it represents a valid target for anti-CML drug design. Resistance to direct BCR-ABL1 inhibitors is a common clinical issue, so STAT5 inhibition has become an interesting alternative target. In this study, the effects of NPQ-C6, a novel naphtoquinone-coumarin conjugate, were evaluated on human CML-derived K562 cells. Live-Cell Imaging analysis revealed that NPQ-C6 inhibited 2D (IC50AUC = 1.4 ± 0.6 μM) growth of CML cells. NPQ-C6 increased sub-G1 and reduced G0/G1 cell cycle phases in a dose- and time-dependent manner. This effect on cell cycle was related to increased levels of apoptotic nuclei, cleavage of caspase-3, -9, and PARP and annexin V-positive cells. NPQ-C6 increased γH2AX, a double-strand DNA break marker. NPQ-C6 showed a wide range of modulatory effects on cell signaling through an early increased phosphorylation of JNK, P38-MAPK and AKT, and decreased phosphorylation of ERK1/2, BCR-ABL1, and STAT5. NPQ-C6 inhibited expression of c-MYC and PYM-1, two target gene products of BCR-ABL1/STAT5 signaling pathway. Cytokine-induced activation of STAT5/STAT3-dependent transcriptional and DNA binding activities were also inhibited by NPQ-C6. Notably, NPQ-C6 maintained its activity on BCR-ABL1/STAT5/c-MYC/PIM-1 oncogenic pathway in imatinib-resistant cells. Molecular modeling suggested BCR-ABL1 and JAK2 proteins as NPQ-C6 targets. In summary, our data show a novel multikinase modulator that might be therapeutically effective in BCR-ABL1-STAT5-related malignancies
The first wave of the COVID-19 epidemic in Spain was associated with early introductions and fast spread of a dominating genetic variant
SeqCOVID-Spain consortium:
Álvaro Chiner-Oms, Irving Cancino-Muñoz, Mariana G. López, Manuela Torres-Puente, Inmaculada Gómez-Navarro, Santiago Jiménez-Serrano, Jordi Pérez-Tur, Darío García de Viedma, Laura Pérez-Lago, Marta Herranz, Jon Sicilia, Pilar Catalán-Alonso, Julia Suárez González, Patricia Muñoz, Mireia Coscolla, Paula Ruiz-Rodríguez, Fernando González-Candelas, Iñaki Comas, Lidia Ruiz-Roldán, María Alma Bracho, Neris García-González, Llúcia Martínez Priego, Inmaculada Galán-Vendrell, Paula Ruiz-Hueso, Griselda De Marco, María Loreto Ferrús-Abad, Sandra Carbó-Ramírez, Giuseppe D’Auria, Galo Adrian Goig, Juan Alberola, Jose Miguel Nogueira, Juan José Camarena, David Navarro, Eliseo Albert, Ignacio Torres, Maitane Aranzamendi Zaldumbide, Óscar Martínez Expósito, Nerea Antona Urieta, María de Toro, María Pilar Bea-Escudero, Jose Antonio Boga, Cristian Castelló-Abietar, Susana Rojo-Alba, Marta Elena Álvarez-Argüelles, Santiago Melón, Elisa Martró, Antoni E. Bordoy, Anna Not, Adrián Antuori, Anabel Fernández-Navarro, Andrés Canut-Blasco, Silvia Hernáez Crespo, Maria Luz Cordón Rodríguez, Maria Concepción Lecaroz Agara, Carmen Gómez-González, Amaia Aguirre-Quiñonero, José Israel López-Mirones, Marina Fernández-Torres, Maria Rosario Almela-Ferrer, Ana Carvajal, Juan Miguel Fregeneda-Grandes, Héctor Argüello, Gustavo Cilla Eguiluz, Milagrosa Montes Ros, Luis Piñeiro Vázquez, Ane Sorarrain, José María Marimón, José J. Costa-Alcalde, Rocío Trastoy, Gema Barbeito Castiñeiras, Amparo Coira, María Luisa Pérez del Molino, Antonio Aguilera, Begoña Palop-Borrás, Inmaculada de Toro Peinado, Maria Concepción Mediavilla Gradolph, Mercedes Pérez-Ruiz, Mirian Fernández-Alonso, Jose Luis del Pozo, Oscar González-Recio, Mónica Gutiérrez-Rivas, Jovita Fernández-Pinero, Miguel Ángel Jiménez Clavero, Begoña Fuster Escrivá, Concepción Gimeno Cardona, María Dolores Ocete Mochón, Rafael Medina-Gonzalez, José Antonio Lepe, Verónica González Galán, Ángel Rodríguez-Villodres, Nieves Gonzalo Jiménez, Jordi Reina, Carla López-Causapé, Maria Dolores Gómez-Ruiz, Eva M. Gonzalez-Barbera, José Luis López-Hontangas, Vicente Martín, Antonio J. Molina, Tania Fernandez-Villa, Ana Milagro Beamonte, Nieves Felisa Martínez-Cameo, Yolanda Gracia-Grataloup, Rosario Moreno-Muñoz, Maria Dolores Tirado Balaguer, José María Navarro-Marí, Irene Pedrosa-Corral, Sara Sanbonmatsu-Gámez, Antonio Oliver, Mónica Parra Grande, Bárbara Gómez Alonso, Francisco José Arjona Zaragozí, Maria Carmen Pérez González, Francisco Javier Chamizo López, Ana Bordes-Benítez, Núria Rabella, Ferran Navarro, Elisenda Miró, Antonio Rezusta, Alexander Tristancho, Encarnación Simarro Córdoba, Julia Lozano-Serra, Lorena Robles Fonseca, Álex Soriano, Francisco Javier Roig Sena, Hermelinda Vanaclocha Luna, Isabel Sanmartín, Daniel García-Souto, Ana Pequeño-Valtierra, Jose M. C. Tubio, Javier Temes, Jorge Rodríguez-Castro, Martín Santamarina García, Manuel Rodríguez-Iglesias, Fátima Galán-Sanchez, Salud Rodríguez-Pallares, José Manuel Azcona-Gutiérrez, Miriam Blasco-Alberdi, Alfredo Mayor, Alberto L. García-Basteiro, Gemma Moncunill, Carlota Dobaño, Pau Cisteró, Oriol Mitjà, Camila González-Beiras, Martí Vall-Mayans, Marc Corbacho-Monné, Andrea Alemany, Cristina Muñoz-Cuevas, Guadalupe Rodríguez-Rodríguez, Rafael Benito, Sonia Algarate, Jessica Bueno, Andrea Vergara-Gómez, Miguel J. Martínez, Jordi Vila, Elisa Rubio, Aida Peiró-Mestres, Jessica Navero-Castillejos, David Posada, Diana Valverde, Nuria Estévez, Iria Fernández-Silva, Loretta de Chiara, Pilar Gallego-García, Nair Varela, Ulises Gómez-Pinedo, Mónica Gozalo-Margüello, Maria Eliecer Cano García, José Manuel Méndez-Legaza, Jesus Rodríguez-Lozano, María Siller, Daniel Pablo-Marcos, Maria Montserrat Ruiz-García, Antonio Galiana, Judith Sánchez-Almendro, Maria Isabel Gascón Ros, Cristina Juana Torregrosa-Hetland, Eva María Pastor Boix, Paloma Cascales Ramos, Pedro Luis Garcinuño Enríquez, Salvador Raga Borja, Julia González Cantó, Olalla Martínez Macias, Adolfo de Salazar, Laura Viñuela González, Natalia Chueca, Federico García, Cristina Gómez-Camarasa, Amparo Farga Martí, Rocío Falcón, Victoria Domínguez-Márquez, Anna M. Planas, Israel Fernández-Cádenas, Maria Ángeles Marcos, Carmen Ezpeleta, Ana Navascués, Ana Miqueleiz Zapatero, Manuel Segovia, Antonio Moreno-Docón, Esther Viedma, Raúl Recio Martínez, Irene Muñoz-Gallego, Sara Gonzalez-Bodi, Maria Dolores Folgueira, Jesús Mingorance, Elias Dahdouh, Fernando Lázaro-Perona, María Rodríguez-Tejedor, María Pilar Romero-Gómez, Julio García-Rodríguez, Juan Carlos Galán, Mario Rodríguez-Dominguez, Laura Martínez-García, Melanie Abreu Di Berardino, Manuel Ponce-Alonso, Jose Maria González-Alba, Ivan Sanz-Muñoz, Diana Pérez San José, Maria Gil Fortuño, Juan B. Bellido-Blasco, Alberto Yagüe Muñoz, Noelia Hernández Pérez, Helena Buj Jordá, Óscar Pérez Olaso, Alejandro González Praetorius, Nora Mariela Martínez Ramírez, Aida Ramírez Marinero, Eduardo Padilla León, Alba Vilas Basil, Mireia Canal Aranda, Albert Bernet Sánchez, Alba Bellés Bellés, Eric López González, Iván Prats Sánchez, Mercè García-González, Miguel José Martínez-Lirola, Manuel Ángel Rodríguez Maresca, Maria Teresa Cabezas Fernández, María Eugenia Carrillo Gil, Maria Paz Ventero Martín, Carmen Molina Pardines, Nieves Orta Mira, María Navarro Cots, Inmaculada Vidal Catalá, Isabel García Nava, Soledad Illescas Fernández-Bermejo, José Martínez-Alarcón, Marta Torres-Narbona, Cristina Colmenarejo, Lidia García-Agudo, Jorge A. Pérez García, Martín Yago López, María Ángeles Goberna Bravo, Victoria Simón García, Gonzalo Llop Furquet, Agustín Iranzo Tatay, Sandra Moreno-Marro, Noelia Lozano Rodríguez, Amparo Broseta Tamarit, Juan José Badiola Díez, Amparo Martínez-Ramírez, Ana Dopazo, Sergio Callejas, Alberto Benguría, Begoña Aguado, Antonio Alcamí, Marta Bermejo Bermejo, Ricardo Ramos-Ruíz, Víctor Manuel Fernández Soria, Fernando Simón Soria & Mercedes Roig CardellsThe coronavirus disease 2019 (COVID-19) pandemic has affected the world radically since 2020. Spain was one of the European countries with the highest incidence during the first wave. As a part of a consortium to monitor and study the evolution of the epidemic, we sequenced 2,170 samples, diagnosed mostly before lockdown measures. Here, we identified at least 500 introductions from multiple international sources and documented the early rise of two dominant Spanish epidemic clades (SECs), probably amplified by superspreading events. Both SECs were related closely to the initial Asian variants of SARS-CoV-2 and spread widely across Spain. We inferred a substantial reduction in the effective reproductive number of both SECs due to public-health interventions (Re < 1), also reflected in the replacement of SECs by a new variant over the summer of 2020. In summary, we reveal a notable difference in the initial genetic makeup of SARS-CoV-2 in Spain compared with other European countries and show evidence to support the effectiveness of lockdown measures in controlling virus spread, even for the most successful genetic variants.This work was mainly funded by the Instituto de Salud Carlos III project COV20/00140, with additional funding by Spanish National Research Council project CSIC-COV19-021, Ministerio de Ciencia project PID2019-104477RB-100, ERC StG 638553 and ERC CoG 101001038 to I.C., and BFU2017-89594R to F.G.C. M.C. is supported by Ramón y Cajal program from Ministerio de Ciencia and grants RTI2018-094399-A-I00 and Generalitat Valenciana (Regional Government) project SEJI/2019/011. We gratefully acknowledge Hospital Universitari Vall d’Hebron, Instituto de Salud Carlos III, IrsiCaixa AIDS Research Lab and all the international researchers and institutions that submitted sequenced SARS-CoV-2 genomes to the GISAID’s EpiCov Database (Supplementary Table 1), as an important part of our analyses has been made possible by the sharing of their work. We also thank Unidad de Bioinformática y Estadística, Centro de Investigación Príncipe Felipe, for allowing us to use the Computer Cluster to perform some of the bioinformatic analysis.Peer reviewe
Performance of 'Clausellina' mandarin on four rootstocks
This study, carried out in Almeria (Spain), evaluates the performance of 'Clausellina' mandarin on four rootstocks: Carrizo citrange [Citrus sinensis (L.) Osb. x Poncirus trifoliata (L.) Raft C. volkameriana Ten. and Pasq.; and, the two new hybrids 'C-13' (C. depressa Hay. x P trifoliata) obtained at the University of California Citrus Research Center and '020326' [Troyer citrange (C. sinensis x P trifoliata) x Cleopatra mandarin] obtained at the Instituto Valenciano de Investigaciones Agrarias in Valencia (Spain). Soil was sandy, with pH>8 and electric conductivity below 4.5 mmhos cm(-1) in the saturation extract. Yield was weighed during the first nine harvests, fruit quality was determined in the 5(th) and 9(th) harvests and tree size was evaluated annually from 3 to 11 years after planting. Trees on C. volkameriana rootstock were biggest and produced the highest yield, followed by trees on Carrizo citrange. Trees on the C-13 hybrid selection were most efficient in yield m(-3) of canopy volume. There were few differences between rootstocks in terms of fruit quality
Effects of citrus rootstocks on growth, yield and fruit quality of Navelate orange
The aim was to study the performance of Navelate sweet orange on five rootstocks: Carrizo citrange [Citrus sinensis (L.) Osb. x Poncirus trifoliata (L.) Raf.]; Cleopatra mandarin (C. reshni Hort. ex Tan.); C. volkameriana Ten. & Pasq. and two new hybrids C-13 (C. depressa Hay. x P trifoliata) developed at the University of California Citrus Research Center and 020326 [Troyer citrange (C. sinensis x P trifoliata) x Cleopatra mandarin] developed at the Instituto Valenciano de Investigaciones Agrarias in Valencia, Spain. The investigation was conducted in Almeria, Spain. The soil was sandy, with pH>8 and electric conductivity in the saturation extract below 4.5 mmhos cm(-1). The design was a complete-block with randomised single-tree plots and eight replications. Tree spacing was 4.5 m x 4 m. Yield was recorded during the first nine harvests, fruit quality was determined for the 50(th), 6(th) and 9(th) harvests and tree size was evaluated 11 years after planting. Trees on C. volkameriana rootstock produced the highest yield and largest fruits. Trees on the C-13 hybrid selection were the most yield-efficient on a canopy volume basis, and had fruit with the highest soluble solid content, but there were few differences between rootstocks for the latter parameter. Cleopatra mandarin and 020326 induced the lowest individual fruit weight and diameter
Prevalencia de hogares libres de humo y exposición pasiva al tabaco en población pediátrica (niños de 3 a 36 meses)
Introduction: Pediatric population is the most vulnerable
to secondhand smoke (SHS), exposure being households
the main source of exposure in children. The objective
of this study is to describe smoke-free households
and the prevalence of SHS in the pediatric population
(from 3 to 36 months) in Spain.
Methods: Cross-sectional study with 1,368 parents,
mothers or guardians with children from 3 to 36 months
carried out in Spain from March to November of 2017
through an online questionnaire as part of the EPISON
study. Information was collected on the voluntary adoption
of tobacco use regulations at home and SHS exposure
at home and other environments. We calculated prevalences
and Odds Ratio adjusted (ORa) for sex, age, level of
education, and smoking status.
Results: 87.6% of respondents claimed to have a
smoke-free home. 12.4% of respondents had partial regulation
or did not have regulation at home, increasing
up to 26.0% when the parent was a smoker or to 21.8%
when the parent had primary or lower education. 5.4% of
parents reported SHS exposure in their children at their
homes, rising to 14.5% when it occurs in other environments,
increasing with statistically significant differences
between smoking parents and parents with lower educational
level.
Conclusion: The smoke-free homes are the majority;
but SHS exposure to tobacco at home persists in children
under 3 years of age, especially in families with a lower
educational level. Therefore, awareness-raising campaigns
on the effects of passive exposure on minors among
families with a lower socioeconomic status should be encouraged.Fundamentos: La población pediátrica es la más
vulnerable a la exposición pasiva al humo ambiental del
tabaco (HAT), siendo los hogares la fuente principal de
exposición en niños. El objetivo de este estudio fue describir
los hogares libres de humo y la prevalencia de exposición
pasiva al HAT en la población pediátrica (de 3 a
36 meses) en España.
Métodos: Estudio transversal con 1.368 padres,
madres o tutores con hijos de 3 a 36 meses realizado en
España de marzo a noviembre de 2017 mediante cuestionario
online como parte del estudio EPISON. Se recogió
información sobre la adopción voluntaria de normas de
consumo de tabaco en el hogar y exposición al HAT en
casa y otros ambientes. Se calcularon las prevalencias y
las Odds Ratio ajustadas (ORa) por sexo, edad, nivel educativo
y consumo de tabaco.
Resultados: El 87,6% de los encuestados afirmó tener
un hogar libre de humo. El 12,4% de los encuestados
tenían regulación parcial o no tenían ninguna regulación
en el hogar, incrementándose hasta el 26% cuando el progenitor
era fumador o al 21,8% cuando tenía estudios primarios
o inferiores. El 5,4% de los padres refirió exposición
pasiva al tabaco en niños en sus hogares, elevándose
hasta el 14,5% cuando la exposición se produjo en otros
ambientes, incrementándose de forma estadísticamente
significativa la diferencia entre los padres fumadores y
con menor nivel educativo.
Conclusión: Los hogares libres de humo son mayoritarios,
pero persiste la exposición pasiva al tabaco en el
hogar con niños menores de 3 años, especialmente en familias
con menor nivel educativo. Por ello, se deberían
incentivar campañas de sensibilización sobre los efectos
de la exposición pasiva en menores, especialmente en familias
con menos recursos
Delivery GIG Workers: Use of Protectıve Equipment and Road‑traffıc Hazards in Barcelona (SPAIN), 2018
Caracterización hidrogeológica y propuesta de protección de manantiales y áreas ganadoras en cauces (LIH) en las demarcaciones hidrográficas del Guadalete y Barbate, y del Tinto, Odiel y Piedras.
Simposio de Hidrogeología (10º. 2013. Granada)Como parte de la estrategia de conservación de los ecosistemas acuáticos relacionados con las masas de agua subterránea en Andalucía se presenta la caracterización hidrogeológica y la propuesta de protección de manantiales o sectores que engloban manantiales y áreas ganadoras en cauces, considerados como Lugares de Interés Hidrogeológico (LIH), en las Demarcaciones Hidrográficas (DDHH) del Guadalete y Barbate, y del Tinto, Odiel y Piedras. Se ha realizado una catalogación inicial de 27 manantiales o sectores emplazados en las provincias de Cádiz y Huelva, para los que se ha realizado una aproximación de su conocimiento hidrogeológico y estado de conservación, elaborándose una base de datos que contiene sus principales características. A partir de esta primera catalogación se han seleccionado 11 sectores en los que se ha realizado un análisis más detallado. El objetivo de este trabajo ha sido el de establecer propuestas para la conservación de un determinado número de manantiales y áreas ganadoras, situadas en cauces de cabecera localizados en la DDHH anteriores (IGME-Junta de Andalucía, 2011). La Fuente de la Peña de Arias Montano se incluye como ejemplo del trabajo realizado para cada uno de los 11 sectores seleccionados.Instituto Geológico y Minero de España, EspañaJunta de Andalucí
Apoyo a la regulación de fumar en el interior de vehículos privados y espacios públicos al aire libre
Fundamentos: Conocer el apoyo a la regulación del consumo
de tabaco es una pieza clave para avanzar en las políticas
de control del tabaquismo y reducir la exposición pasiva al tabaco.
El objetivo de este trabajo fue describir las actitudes hacia la
prohibición de fumar en los vehículos privados y espacios públicos
al aire libre.
Métodos: Estudio transversal de una muestra representativa
(n=736) de la población adulta (mayor de 24 años) de la ciudad
de Barcelona, España, realizado en 2013-2014. Se calcularon el
porcentaje de individuos que tenían una actitud favorable a la regulación
del consumo de tabaco en el interior de vehículos privados
y espacios públicos al aire libre, las Odds Ratio ajustadas
(ORa) y sus intervalos de confianza al 95% (IC95%) según sexo,
edad, nivel de estudios y estatus de consumo de tabaco mediante
un modelo de regresión logística. Se utilizaron pesos de probabilidad
inversa para mantener la representatividad de la población de
Barcelona en 2013-2014.
Resultados: El 61,7% de los participantes estuvo a favor
de la prohibición de fumar dentro de los vehículos privados y el
89,5% de prohibirlo sólo en presencia de menores. El apoyo a
la regulación del consumo de tabaco en espacios exteriores varió
entre 42,5% hasta 84,7% dependiendo del ambiente. Los fumadores
mostraron una actitud menos favorable a la ampliación
de la regulación a otros espacios: zonas exteriores de los centros
universitarios, zonas exteriores de los centros comerciales y playas
y piscinas descubiertas.
Conclusiones: Existe un amplio apoyo a la extensión de
la regulación del consumo del tabaco en el interior de vehículos
privados, especialmente en presencia de menores, y espacios públicos
al aire libre. Este amplio apoyo podría favorecer la ampliación
de la regulación del consumo de tabaco a estos espacios a fin
de mejorar la salud de la población y al mismo tiempo contribuir
a la desnormalización del consumo de tabaco entre la poblaciónBackground: To know the support of tobacco regulation
is a very important issue to advance in the tobacco control
policies and reduce the passive exposure to tobacco. The aim
of this study was to describe the attitudes towards forbidding
smoking in private vehicles and public outdoor spaces.
Methods: This is a cross-sectional study of a representative
sample (n=736) of the adult population (24+ years
old) from Barcelona, Spain in 2013-2014. We calculated the
percentages of individuals who had a favourable attitude
towards smoking regulation in private vehicles and public
outdoor spaces, their adjusted Odds ratios (aOR) and their
95% confidence intervals (95%CI) according to sex, age,
educational level and smoking status through logistic regression.
We used weighted data for all analyses in order to
keep the representativeness of the population of Barcelona
in 2013-2014.
Results: 61.7% of participants supported forbidding
smoking in private vehicles and 89.5% supported forbidding
it only in the presence of minors. The support to smoking regulation
in public outdoor spaces varied from 42.5% to 84.7%
in different settings. Smokers showed a less favourable attitude
towards an extension of the smoking regulation to other
settings: outdoor areas of university centres, outdoor areas of
shopping centres and beaches and outdoor pools.
Conclusions: A wide support exists to extend the
smoking regulation to private vehicles, especially in the
presence of children, and public outdoor spaces. This wide
support could favour the extension of smoking regulation to
these places to improve the population’s health and to contribute
to denormalise tobacco use among the population