98 research outputs found
Cockayne syndrome: report of a Brazilian family with confirmation of impaired RNA synthesis after UV-irradiation
- Author
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Stable carbon isotope signatures of ancient Maize agriculture at El Kinel, Guatemala
- Author
- Agren G.I.
- Aina P.O.
- Amos B.
- Andrew Scherer
- Balesdent J.
- Balesdent J.
- Balesdent J.
- Balzotti C.S.
- Beach T.
- Bender M.M.
- Bolinder M.A.
- Boutton T.
- Brodie C.R.
- Burnett R.L.
- Burnett R.L.
- Cerling T.E.
- Charles Golden
- Chris Balzotti
- Crozier C.R.
- Dwyer L.M.
- Entwistle J.A.
- Evans D.l.
- Farquhar G.D.
- Farquhar G.D.
- Farr G.D.
- Fernandez F.G.
- Folan W.J.
- Gee G.W.
- Golden C.
- Golden C.
- Holliday V.T.
- Houston S.
- Johnson K.D.
- Kuzyakov Y.
- Lane C.S.
- Liu R.
- López C.M.
- Marschner H.
- Molina J.A.E.
- Puleston D.E.
- Pérez Robles G.
- Quiroa F.
- Richard E. Terry
- Scherer A.K.
- Scherer A.K.
- Smith B.N.
- Terry R.E.
- Terry R.E.
- Tykot R.H.
- Vitorello V.A.
- Webb E.
- Webb E.A.
- Wilken G.C.
- Wright D.R.
- Wright L.E.
- Publication venue
- 'Akademiai Kiado Zrt.'
- Publication date
- Field of study
Interaction of inflammatory cytokines and erythropoeitin in iron metabolism and erythropoiesis in anaemia of chronic disease
- Author
- A. Djeha
- A. J. G. Swaak
- A. Mackiewicz
- A. Zoli
- A.F. Remacha
- A.G. Mowat
- A.J. Erslev
- A.M. Konijn
- A.M. Konjin
- A.N. Baer
- A.R. Harvey
- B. Backx
- B.J. Ferguson
- B.S. Skikne
- C.A. Bortner
- C.D.L. Reid
- C.J.P. Maury
- C.J.P. Maury
- C.S. Johnson
- D. Fuchs
- D. Fuchs
- E.L. Raefsky
- G. Birgegaard
- G. Fey
- G. Fillet
- G. Ramadori
- G. Reibnegger
- G. Vreugdenhil
- G. Vreugdenhil
- G. Vreugdenhil
- G. Vreugdenhil
- G. Vreugdenhil
- G. Vreugdenhil
- G. Vreugdenhil
- G. Weis
- G.C. Bagby
- G.D. Roodman
- G.E. Cartwright
- G.R. Lee
- G.S. Panay
- H. Baumann
- H. Baumann
- H. Broxmeyer
- H. Denz
- H. R. M. Peeters
- H.E. Broxmeyer
- H.G. Eijk Van
- H.K. Boyd
- H.P. Roester
- H.W. Murray
- I. Cavill
- I. Graziadei
- I. Graziadei
- I. Kushner
- I.N. Rich
- J. Fuchs
- J. Roger
- J.A. Cash
- J.S. Spivak
- K. Akahane
- K. Nishiya
- K.B. Raja
- L. Ozmen
- L.I. Gordon
- L.L. Moldawer
- M. Jongen-Lavrencic
- M. Jongen-Lavrencic
- M. Jongen-Lavrencic
- M. Sugimoto
- M.C. Bondurant
- M.C. Hochberg
- M.E. Conrad
- M.J. Koury
- M.J. Koury
- N.E. Hansen
- P. Qusenberry
- R. Invernizzi
- R.A. Feelders
- R.A. Feelders
- R.A. Johnson
- R.D. Klausner
- R.L. Duncan
- R.T. Means
- R.T. Means
- R.T. Means
- R.T. Means Jr.
- R.T. Means Jr.
- S.P.M. Crouch
- S.V. Torti
- S.W. Mamus
- T. Houston
- T. Pettersson
- T. Pettersson
- T. Pincus
- W. Jelkman
- W.C. Faquin
- X. Alvarez-Hernandez
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/09/1995
- Field of study
In chronic inflammatory conditions increased endogenous release of specific cytokines (TNFα, IL-1, IL-6, IFNγ and others) is presumed. It has been shown that those of monocyte lineage play a key role in cytokine expression and synthesis. This may be associated with changes in iron metabolism and impaired erythropoiesis and may lead to development of anaemia in patients with rheumatoid arthritis. Firstly, increased synthesis of acute phase proteins, like ferritin, during chronic inflammation is proposed as the way by which the toxic effect of iron and thereby the synthesis of free oxy-radicals causing the damage on the affected joints, may be reduced. This is associated with a shift of iron towards the mononuclear phagocyte system which may participate in the development of anaemia of chronic disease. Secondly, an inhibitory action of inflammatory cytokines (TNFα, IL-1), on proliferation and differentiation of erythroid progenitors as well as on synthesis of erythropoietin has been shown, thereby also contributing to anaemia. Finally, chronic inflammation causes multiple, complex disturbances in the delicate physiologic equilibrium of interaction between cytokines and cells (erythroid progenitors, cells of mononuclear phagocyte system and erythropoietin producing cells) leading to development of anaemia of chronic disease (Fig. 1)
All-sky search for long-duration gravitational wave transients with initial LIGO
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- Abbott B.P.
- Abbott R.
- Abbott T.D.
- Abernathy M.R.
- Acernese F.
- Ackley K.
- Adams C.
- Adams T.
- Addesso P.
- Adhikari R.X.
- Adya V.B.
- Affeldt C.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- Aguiar O.D.
- Ain A.
- Ajith P.
- Allen B.
- Allocca A.
- Amariutei D.V.
- Anderson S.B.
- Anderson W.G.
- Arai K.
- Araya M.C.
- Arceneaux C.C.
- Areeda J.S.
- Arnaud N.
- Arun K.G.
- Ashton G.
- Ast M.
- Aston S.M.
- Astone P.
- Aufmuth P.
- Aulbert C.
- Babak S.
- Baiardi L.Cerboni
- Baker P.T.
- Baldaccini F.
- Ballardin G.
- Ballmer S.W.
- Barayoga J.C.
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- Barish B.C.
- Barker D.
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- Barsuglia M.
- Barta D.
- Bartlett J.
- Bartos I.
- Bassiri R.
- Basti A.
- Batch J.C.
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- Bavigadda V.
- Bazzan M.
- Behnke B.
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- Belczynski C.
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- Berger B.K.
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- Bersanetti D.
- Bertolini A.
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- Bhagwat S.
- Bhandare R.
- Bilenko I.A.
- Billingsley G.
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- Bisht A.
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- Zucker M.E.
- Zuraw S.E.
- Zweizig J.
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2016
- Field of study
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
All-sky search for long-duration gravitational wave transients with initial LIGO
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- Zucker M.E.
- Zuraw S.E.
- Zweizig J.
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2016
- Field of study
We present the results of a search for long-duration gravitational wave transients in two sets of data collected by the LIGO Hanford and LIGO Livingston detectors between November 5, 2005 and September 30, 2007, and July 7, 2009 and October 20, 2010, with a total observational time of 283.0 days and 132.9 days, respectively. The search targets gravitational wave transients of duration 10-500 s in a frequency band of 40-1000 Hz, with minimal assumptions about the signal waveform, polarization, source direction, or time of occurrence. All candidate triggers were consistent with the expected background; as a result we set 90% confidence upper limits on the rate of long-duration gravitational wave transients for different types of gravitational wave signals. For signals from black hole accretion disk instabilities, we set upper limits on the source rate density between 3.4×10-5 and 9.4×10-4 Mpc-3 yr-1 at 90% confidence. These are the first results from an all-sky search for unmodeled long-duration transient gravitational waves. © 2016 American Physical Society
Search for Tensor, Vector, and Scalar Polarizations in the Stochastic Gravitational-Wave Background
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- Xiao S.
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- Zendri J-P.
- Zevin M.
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- Zhang T.
- Zhang Y-H.
- Zhao C.
- Zhou M.
- Zhou Z.
- Zhu S.J.
- Zhu X.J.
- Zucker M.E.
- Zweizig J.
- Publication venue
- College Park, MD : American Physical Society
- Publication date
- 01/01/2018
- Field of study
The detection of gravitational waves with Advanced LIGO and Advanced Virgo has enabled novel tests of general relativity, including direct study of the polarization of gravitational waves. While general relativity allows for only two tensor gravitational-wave polarizations, general metric theories can additionally predict two vector and two scalar polarizations. The polarization of gravitational waves is encoded in the spectral shape of the stochastic gravitational-wave background, formed by the superposition of cosmological and individually unresolved astrophysical sources. Using data recorded by Advanced LIGO during its first observing run, we search for a stochastic background of generically polarized gravitational waves. We find no evidence for a background of any polarization, and place the first direct bounds on the contributions of vector and scalar polarizations to the stochastic background. Under log-uniform priors for the energy in each polarization, we limit the energy densities of tensor, vector, and scalar modes at 95% credibility to Ω0T<5.58×10-8, Ω0V<6.35×10-8, and Ω0S<1.08×10-7 at a reference frequency f0=25 Hz. © 2018 American Physical Society
Livestock 2.0 – genome editing for fitter, healthier, and more productive farmed animals
- Author
- A Clop
- A Fiester
- A Kranis
- A Wargelius
- A-S Van Laere
- Alan L. Archibald
- AM Ramos
- Andrea Doeschl-Wilson
- C Burkard
- C Große-Brinkhaus
- C Patience
- C Proudfoot
- C Robert
- C. Bruce Whitelaw
- C.S. Haley
- CG Elsik
- Christine Tait-Burkard
- Christopher K. Tuggle
- CJ Palgrave
- D Cyranoski
- D Niu
- D Shafran
- DF Carlson
- DJ Macqueen
- DM Bickhart
- E Blesbois
- E Waltz
- EA Maga
- EA Maga
- F Gottardo
- G Lough
- G Luo
- H Ledford
- H Van Gorp
- H Yang
- Helen M. Sang
- I Donatelli
- Ivica Medugorac
- J Jenko
- J Lyall
- JAMES R. FLORINI
- JE Koltes
- Jin-Dan Kang
- K Khalil
- K Wang
- K-E Park
- Kankan Wang
- KM Whitworth
- L Andersson
- L Grobet
- L Lai
- L Taylor
- L Yang
- LW Hillier
- M Crispo
- M Li
- M Watson
- MAM Groenen
- Mark E. Woodcock
- Mick Watson
- Mike J. McGrew
- MP Murtaugh
- Nathanael M. Thompson
- NJ Boddicker
- NJ Boddicker
- NJ Loman
- P Zhang
- R Kambadur
- RD Houston
- RJ Wall
- Ross D. Houston
- RR White
- S Nandi
- S Shanthalingam
- Sarah K. Lowder
- SG Lillico
- Shengbin Rao
- Sophie Rothammer
- SP Golovan
- Suzanne J Rowe
- T Lu
- T Meuwissen
- TC Freeman
- TG Kimman
- TH Meuwissen
- TS Sonstegard
- VG Pursel
- VG Pursel
- X Cheng
- X. Wang
- Y Bi
- Y Moalic
- Y Nakamura
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/11/2018
- Field of study
Abstract The human population is growing, and as a result we need to produce more food whilst reducing the impact of farming on the environment. Selective breeding and genomic selection have had a transformational impact on livestock productivity, and now transgenic and genome-editing technologies offer exciting opportunities for the production of fitter, healthier and more-productive livestock. Here, we review recent progress in the application of genome editing to farmed animal species and discuss the potential impact on our ability to produce food
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation.
- Author
- Abdel-Rahman Mohamed H.
- Abeshouse Adam
- Adebamowo Clement
- Adebamowo Sally N.
- Agnew Kathy
- Ahn Keunsoo
- Ajani Jaffer A.
- Akbani Rehan
- Akeredolu Teniola
- Al-Ahmadie Hikmat
- Albert Monique
- Alexopoulou Iakovina
- Ally Adrian
- Alvaro Domenico
- Anderson Matthew L.
- Andry Chris
- Antenucci Anna
- Anur Pavana
- Appelbaum Elizabeth L.
- Aredes Natália D.
- Armenia Joshua
- Arnaout Angel
- Asa Sylvia L.
- Auman J. Todd
- Aymerich Marta
- Aziz Dina
- Bailey Matthew
- Balasundaram Miruna
- Balu Saianand
- Barnett Gene
- Barnholtz-Sloan Jill S.
- Barrett Wendi
- Bartlett John
- Bathe Oliver
- Baudin Eric
- Baylin Stephen
- Becker Karl-Friedrich
- Beer David
- Behera Madhusmita
- Behrens Carmen
- Bell Debra
- Bell Sue
- Bellair Michelle
- Bennett Joseph
- Benz Christopher
- Berchuck Andrew
- Berger Ashton C.
- Bergeron Alain
- Berkowitz Ross
- Bernard Brady
- Beroukhim Rameen
- Beuschlein Felix
- Bifulco Carlo
- Bigner Darell
- Birrer Michael
- Birsoy Kivanc
- Bocklage Therese
- Bodenheimer Tom
- Bondaruk Jolanta
- Bootwalla Moiz S.
- Borad Mitesh
- Borgia Jeffrey A.
- Bossler Aaron
- Botnariuc Natalia
- Boussioutas Alex
- Bowen Jay
- Bowlby Reanne
- Bowman Rayleen
- Bradford Carol
- Bragazzi Maria Consiglia
- Brat Daniel J.
- Breggia Anne
- Brewer Cathy
- Brimo Fadi
- Broaddus Russell
- Brooks Denise
- Broom Bradley M.
- Broudy Thomas
- Bryce Alan H.
- Bubley Glenn
- Bueno Raphael
- Burnette Andrew
- Burzykowski Tomasz
- Caesar-Johnson Samantha J.
- Calatozzolo Chiara
- Campo Elias
- Campos Benito
- Caraman Irina
- Cardinale Vincenzo
- Carey Francis
- Carey Thomas
- Carlotti Carlos Gilberto
- Carlsen Rebecca
- Carney Michael
- Carpino Guido
- Carroll Peter R.
- Carter Candace
- Carvalho Andre L.
- Castle Erik
- Castro Patricia D.
- Catto James
- Cebulla Colleen M.
- Cernat Mircea
- Chabot John
- Chakravarty Debyani
- Chambwe Nyasha
- Chan June M.
- Chan Timothy A.
- Chandan Vishal
- Chang Kyle
- Chatila Walid K.
- Chemencedji Inga
- Chen Amy
- Chen Chu
- Cheng Feixiong
- Cherniack Andrew D.
- Chesla David
- Chevalier Simone
- Cheville John
- Cho Juok
- Chuah Eric
- Chudamani Sudha
- Chung Ki
- Cibulskis Carrie
- Clipca Adrian
- Colaprico Antonio
- Colman Howard
- Cope Leslie
- Copland John A.
- Corcoran Niall
- Cordes Matthew G.
- Costello Tony
- Cottingham Sandra
- Couce Marta
- Covington Kyle
- Crain Daniel
- Cramer Daniel
- Creaney Jenette
- Creighton Chad J.
- Cuppini Lucia
- Curley Erin
- Cuzzubbo Stefania
- Czerniak Bogdan
- Czerwińska Patrycja
- Danilova Ludmila
- Davis Amy
- de Bruijn Ino
- de Carvalho Ana C.
- de Krijger Ronald
- De Rienzo Assunta
- De Rose Agostino
- DeFreitas Timothy
- Delman Keith
- Demchok John A.
- Desjardins Laurence
- Devine Karen
- Deyarmin Brenda
- Dhalla Noreen
- Dhanasekaran Renumathy
- Dhankani Varsha
- Dhir Rajiv
- DiMeco Francesco
- Ding Li
- Dinh Huyen
- Dinkin Mikhail
- DiPersio John
- Disaia Philip
- Doddapaneni HarshaVardhan
- Donehower Lawrence A.
- Doruc Serghei
- Dos Santos Jose Sebastião
- Dottino Peter R.
- Drake Bettina
- Drummond Jennifer
- Drwiega Paul
- Dubina Michael
- Duell Rebecca
- Duffy Elizabeth R.
- Eckman John
- Edenfield W. Jeffrey
- Eijckenboom Wil
- Elder J. Bradley
- Engel Jay
- Eschbacher Jennifer
- Esmaeli Bita
- Evason Kimberley
- Facciolo Francesco
- Fan Cheng
- Fan Huihui
- Fantacone-Campbell J. Leigh
- Farnell Michael
- Farver Carol
- Fassnacht Martin
- Fehrenbach Ashley
- Felau Ina
- Feldman Michael
- Feltmate Colleen
- Ferguson Martin L.
- Finocchiaro Gaetano
- Flotte Thomas
- Fong Kwun M.
- Force Seth
- Forgie Ian
- Frazer Scott
- Fregnani José H.
- Fronick Catrina C.
- Fujimoto Junya
- Fulop Jordonna
- Fulton Lucinda A.
- Fulton Robert S.
- Gabra Hani
- Gabriel Stacey B.
- Galbraith Joseph
- Gao Galen F.
- Gao Jianjiong
- Gardner Johanna
- Gastier-Foster Julie M.
- Gaudio Eugenio
- Gehlenborg Nils
- Gentles Andrew J.
- Gerken Mark
- Gershenwald Jeffrey
- Getz Gad
- Gevaert Olivier
- Ghossein Ronald
- Giama Nasra
- Gibbs Richard A.
- Gilbert Sebastien
- Gillis Ad
- Gimenez-Roqueplo Anne-Paule
- Giné Eva
- Giordano Thomas
- Girard Nicolas
- Giuliante Felice
- Glenn Pat
- Glenn Robert
- Godwin Andrew K.
- Godwin Eryn M.
- Gonzalez Ana Maria Angulo
- Goodman Marc
- Gopalan Anuradha
- Goparaju Chandra
- Gorincioi Ghenadie
- Govindan Ramaswamy
- Graefen Markus
- Grazi Gianluca
- Grizzle William E.
- Gross Benjamin E.
- Guillermo Armando López
- Guo Charles
- Ha Gavin
- Haddad Andrea
- Hagedorn Curt H.
- Hale Walker
- Han Yi
- Hanh Phan Thi
- Hansen Paul
- Harr Jodi
- Hartmann Arndt
- Haydu Lauren
- Hayes D. Neil
- Hayward Nicholas
- Heath Sharon
- Hegde Apurva M.
- Heiman David I.
- Heins Zachary J.
- Henderson Joel
- Hermes Beth
- Hernandez Brenda
- Herold-Mende Christel
- Hersey Peter
- Hess Julian
- Heyn Holger
- Hibshoosh Hanina
- Hilty Joe
- Hinoue Toshinori
- Ho Thai
- Hoadley Katherine A.
- Holt Robert
- Hooke Jeffrey A.
- Hoon Dave
- Horowitz Neil
- Houck John
- Hovens Christopher
- Hoyle Alan P.
- Hu Hai
- Hu Jianhong
- Huelsken Joerg
- Huland Hartwig
- Hung Nguyen Phi
- Huntsman David
- Hutter Carolyn M.
- Iacocca Mary
- Ittmann Michael
- Jacobus Laura
- Jakrot Valerie
- Janssen Klaus-Peter
- Jefferys Stuart R.
- Jimeno Antonio
- Jones Corbin D.
- Jones Steven J.M.
- Ju Zhenlin
- Juhl Hartmut
- Jungk Christin
- Junker Kerstin
- Kakavand Hojabr
- Kalkanis Steven
- Kamińska Bożena
- Kanchi Rupa S.
- Kandoth Cyriac
- Kang Koo Jeong
- Karlan Beth Y.
- Kasaian Katayoon
- Kasapi Melpomeni
- Kastl Alison
- Kebebew Electron
- Kefford Richard
- Kelley Robin K.
- Kemp Rafael
- Kendall Sara
- Kendler Ady
- Kendrick Michael
- Khuri Fadlo
- Kibel Adam
- Kim Jaegil
- Knijnenburg Theo
- Knudson Michael
- Knutson Tina
- Kocher Jean-Pierre
- Kohl Bernard
- Kopp Karla
- Korchina Viktoriya
- Korkut Anil
- Korpershoek Esther
- Korst Robert
- Kovatich Albert J.
- Kramer Roger
- Krasnitz Alex
- Kucherlapati Melanie H.
- Kucherlapati Raju S.
- Kumar Bahavna
- Kundra Ritika
- Kvecher Leonid
- Kycler Witold
- La Konnor
- Lacombe Louis
- Ladanyi Marc
- Lai Phillip H.
- Laird Peter W.
- Landen Charles N.
- Landrum Lisa
- Lang James
- Larson Caroline
- Latour Mathieu
- Lau Kevin
- Lawrence Michael S.
- Lazar Alexander J.
- Le Xuan
- Lechan Ronald
- Lee Darlene
- Lee Jung Il
- Lee Kenneth
- Lee Sandra
- Lehman Norman L.
- Leinonen Kalle
- Leraas Kristen M.
- Levine Douglas A.
- Lewis Lora
- Ley Timothy
- Li Jun
- Li Wei
- Liang Han
- Lichtenberg Tara M.
- Lin Pei
- Linehan W. Marston
- Ling Shiyun
- Lipp Eric
- Liptay Michael J.
- Liu Jia
- Liu Wenbin
- Liu Xiuping
- Liu Yuexin
- Logothetis Christopher
- Lohavanichbutr Pawadee
- Lolla Laxmi
- Long Georgina
- Longatto-Filho Adhemar
- Looijenga Leendert
- Lu Yiling
- Luketich James
- Luna Augustin
- Lyadov Vladimir
- Ma Deqin
- Ma Yussanne
- Madan Rashna
- Maglinte Dennis T.
- Magliocca Kelly
- Maithel Shishir
- Mallery David
- Malta Tathiane M.
- Malykh Andrei
- Mandt Randy
- Manikhas George
- Mann Graham
- Mannel Robert
- Mannelli Massimo
- Mardis Elaine R.
- Mariamidze Armaz
- Mariani Odette
- Marino Mirella
- Marks Jeffrey
- Marra Marco A.
- Martignetti John A.
- Martin Julie
- Mattei Luca
- Mayo Michael
- Mazurek Sylwia
- McCall Shannon
- McGraw Mary
- McKercher Ginette
- McLellan Michael D.
- McLendon Roger
- McPherson Christopher
- Meier Sam
- Melamed Jonathan
- Meng Shaowu
- Meric-Bernstam Funda
- Merola Roberta
- Mes-Masson Anne-Marie
- Metwalli Adam R.
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mikkelsen Tom
- Milhem Mohammed
- Miller Christopher A.
- Miller Judy
- Miller Michael
- Mills Gordon B.
- Mirsaidi Cyrus
- Mishra Lopa
- Moiseenko Fedor
- Moncrieff Marc
- Moore Kathleen
- Moore Richard A.
- Moran Cesar
- Morgan Margaret
- Morris Scott
- Morrison Carl
- Morton Donna
- Mose Lisle E.
- Moser Catherine
- Moxley Katherine
- Moyer Jeffey
- Mungall Andrew J.
- Mungall Karen
- Mura Sergiu
- Mural Richard J.
- Murawa Dawid
- Muto Michael
- Muzny Donna
- Myers Jerome
- Nagorney David
- Nair Praveen
- Naresh Rashi
- Naska Theresa
- Nelson Mark
- Ng Kwok-Shing
- Nguyen Phuong
- Nissan Moriah G.
- Noble Michael S.
- Noss Ardene
- Noushmehr Houtan
- Ochoa Angelica
- Olabode Oluwole
- Olson Jeffrey J.
- Omberg Larsson
- Oosterhuis Wolter
- Ostrom Quinn T.
- Owonikoko Taofeek
- O’Brien Daniel
- O’Neill Brian Patrick
- Pacak Karel
- Paklina Oxana
- Parfitt Jeremy
- Park Joong-Won
- Parker Joel S.
- Pass Harvey
- Patel Tushar
- Paulauskis Joseph
- Pennell Nathan A.
- Penny Robert
- Perin Alessandro
- Perou Amy H.
- Perou Charles M.
- Petersen Gloria
- Peterson Lisa
- Peto Myron
- Phillips Joanna
- Phillips Sarah M.
- Phu Bui Duc
- Piché Alain
- Pickens Alan
- Pihl Todd
- Pilarski Robert
- Pinero Edna M. Mora
- Pinto Peter A.
- Pirtac Maria
- Poisson Laila
- Pollo Bianca
- Pool Mark
- Porten Sima
- Postier Russel
- Potapova Olga
- Powers James
- Prados Michael
- Prince Mark
- Que Florencia
- Quinn Michael
- Quintero-Aguilo Mario
- Rabeno Brenda
- Rai Karan
- Ramalingam Suresh
- Ramirez Nilsa C.
- Ramondetta Lois
- Rao Arvind
- Rassl Doris M.
- Rathmell W. Kimryn
- Raut Chandrajit P.
- Raymond Daniel
- Reis Rui M.
- Reuter Victor
- Reynolds Sheila
- Reznik Ed
- Rice David
- Richards William G.
- Rintoul Robert C.
- Rivera Michael
- Roach Jeffrey
- Roberts Lewis
- Robertson A. Gordon
- Robinson Bruce
- Roggin Kevin
- Roman-Roman Sergio
- Rosenthal Howard G.
- Rozek Laura
- Rubin Mark A.
- Ryan Michael
- Saad Fred
- Sadeghi Sara
- Saksena Gordon
- Sanchez-Vega Francisco
- Sander Chris
- Sankarankuty Ajith
- Santibanez Jireh
- Sastre Xavier
- Sauter Guido
- Saw Robyn
- Scapulatempo-Neto Cristovam
- Scarpace Lisa
- Schadendorf Dirk
- Schein Jacqueline E.
- Schiffman Mark
- Schilero Cathy
- Schlomm Thorsten
- Schmidt Heather K.
- Schmidt Laura S.
- Schoenfield Lynn
- Schultz Nikolaus
- Schumacher Steven E.
- Scolyer Richard
- Secord Angeles
- Seder Christopher W.
- Sekhon Harman
- Senecal Kelly
- Sepulveda Antonia
- Setdikova Galiya
- Sexton Katherine C.
- Shabunin Alexey
- Shannon Kerwin
- Sharp Alexis
- Shelley Carl Simon
- Shelton Candace
- Shelton Troy
- Shen Hui
- Sheridan Robert
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shih Juliann
- Shimmel Kristen
- Shin Dong M.
- Shinbrot Eve
- Shipman Cassaundra
- Shmulevich Ilya
- Shriver Craig D.
- Sica Gabriel
- Sifri Suzanne
- Sigmund Rita
- Signoretti Sabina
- Silveira Henrique C.S.
- Simko Jeffry
- Simon Ronald
- Simons Janae V.
- Singer Samuel
- Singh Bhuvanesh
- Singh Rosy
- Sipahimalani Payal
- Skelly Tara
- Sloan Andrew E.
- Slotta-Huspenina Julia
- Smallridge Robert
- Smith Jennifer
- Smith-McCune Karen
- Smolenski Kathy
- Smyrk Thomas
- Sofia Heidi J.
- Sokolov Artem
- Soloway Matthew G.
- Somiari Stella
- Sood Anil
- Spellman Paul
- Spillane Andrew
- Stancul Irina
- Stanton Melissa
- Staugaitis Susan M.
- Steele Ruth
- Stepa Serghei
- Stern Marc-Henri
- Stoehr Christine
- Stoehr Robert
- Stoop Hans
- Stretch Jonathan
- Stuart Joshua M.
- Su Tao
- Sumer S. Onur
- Sun Qiang
- Sun Yichao
- Swanson Patricia
- Swisher Elizabeth
- Synott Maria
- Tam Angela
- Tamakawa Raina
- Tamboli Pheroze
- Tan Donghui
- Tang Yufang
- Tarnuzzer Roy
- Taubert Helge
- Tavobilov Mikhail
- Taylor Barry S.
- Tcaciuc Diana
- Tennstedt Pierre
- Thiessen Nina
- Thomas George
- Thompson Eric
- Thompson John
- Thompson R. Houston
- Thompson Timothy
- Thorp Richard
- Thorsson Vesteinn
- Tien Nguyen Viet
- Timmers Henri
- Tirapelli Daniela
- Tischler Arthur
- Torbenson Michael
- Troncoso Patricia
- Tsao Anne
- Tse Kane
- Tucker Kelinda
- Têtu Bernard
- Unterberg Andreas
- Urba Walter
- Valdivieso Federico
- Van Bang Nguyen
- Van Den Berg David J.
- van Kessel Kim E.
- Van Meir Erwin G.
- Van Tine Brian
- VandenBerg Scott
- Veluvolu Umadevi
- Vicha Ales
- Vidal Daniel O.
- Vocke Cathy D.
- Voet Doug
- von Deimling Andreas
- Voronina Olga
- Wach Sven
- Wakely Paul
- Waldmann Jens
- Walker Joan
- Wan Yunhu
- Wang Jing
- Wang Jioajiao
- Wang Linghua
- Wang Min
- Wang Timothy
- Wang Zhining
- Warnick Ronald
- Weinstein John N.
- Weisenberger Daniel J.
- Wentzensen Nicolas
- Westervelt Peter
- Wheeler David A.
- Wilkerson Matthew D.
- Williams Felicia
- Wilmott James
- Wilson Richard K.
- Wise Lisa
- Wistuba Ignacio
- Wiznerowicz Maciej
- Wolf Gregory
- Wolinsky Yingli
- Wong Christopher K.
- Wong Tina
- Worrell Robert
- Wu Ye
- Wullich Bernd
- Xi Liu
- Yang Hannah
- Yang Ian
- Yang Ju Dong
- Yang Liming
- Yau Christina
- Yena Peggy
- Zach Leigh Anne
- Zaren Howard
- Zelinka Tomas
- Zenklusen Jean C.
- Zhang Hailei
- Zhang Hongxin
- Zhang Hongzheng
- Zhang Jiashan (Julia)
- Zhang Jiexin
- Zhang Lizhi
- Zhang Wei
- Zhao Fengmei
- Zhou Wanding
- Zmuda Erik
- Zuna Rosemary
- Zwarthoff Ellen C.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Cancer progression involves the gradual loss of a differentiated phenotype and acquisition of progenitor and stem-cell-like features. Here, we provide novel stemness indices for assessing the degree of oncogenic dedifferentiation. We used an innovative one-class logistic regression (OCLR) machine-learning algorithm to extract transcriptomic and epigenetic feature sets derived from non-transformed pluripotent stem cells and their differentiated progeny. Using OCLR, we were able to identify previously undiscovered biological mechanisms associated with the dedifferentiated oncogenic state. Analyses of the tumor microenvironment revealed unanticipated correlation of cancer stemness with immune checkpoint expression and infiltrating immune cells. We found that the dedifferentiated oncogenic phenotype was generally most prominent in metastatic tumors. Application of our stemness indices to single-cell data revealed patterns of intra-tumor molecular heterogeneity. Finally, the indices allowed for the identification of novel targets and possible targeted therapies aimed at tumor differentiation
Molecular characterization and clinical relevance of metabolic expression subtypes in human cancers.
- Author
- A. Gordon Robertson
- Aaron Bossler
- Ad Gillis
- Adam Abeshouse
- Adam Kibel
- Adam R. Metwalli
- Adhemar Longatto-Filho
- Adrian Ally
- Adrian Clipca
- Ady Kendler
- Agostino De Rose
- Ajith Sankarankuty
- Alain Bergeron
- Alain Piché
- Alan H. Bryce
- Alan P. Hoyle
- Alan Pickens
- Albert J. Kovatich
- Ales Vicha
- Alessandro Perin
- Alex Boussioutas
- Alexander J. Lazar
- Alexey Shabunin
- Alexis Sharp
- Alison Kastl
- Amy Chen
- Amy Davis
- Amy H. Perou
- Ana C. de Carvalho
- Ana Maria Angulo Gonzalez
- Andre L. Carvalho
- Andrea Haddad
- Andreas Unterberg
- Andreas von Deimling
- Andrei Malykh
- Andrew Berchuck
- Andrew Burnette
- Andrew D. Cherniack
- Andrew E. Sloan
- Andrew J. Mungall
- Andrew K. Godwin
- Andrew Spillane
- Angel Arnaout
- Angela Tam
- Angeles Secord
- Angelica Ochoa
- Anil Korkut
- Anil Sood
- Anna Antenucci
- Anne Breggia
- Anne Tsao
- Anne-Marie Mes-Masson
- Anne-Paule Gimenez-Roqueplo
- Antonia Sepulveda
- Antonio Jimeno
- Anuradha Gopalan
- Apurva M. Hegde
- Ardene Noss
- Armando López Guillermo
- Armaz Mariamidze
- Arndt Hartmann
- Arthur Tischler
- Arvind Rao
- Ashley Fehrenbach
- Ashton C. Berger
- Assunta De Rienzo
- Augustin Luna
- Bahavna Kumar
- Barry S. Taylor
- Benito Campos
- Benjamin E. Gross
- Bernard Kohl
- Bernard Têtu
- Bernd Wullich
- Beth Hermes
- Beth Y. Karlan
- Bettina Drake
- Bhuvanesh Singh
- Bianca Pollo
- Bita Esmaeli
- Bogdan Czerniak
- Bradley M. Broom
- Brady Bernard
- Brenda Deyarmin
- Brenda Hernandez
- Brenda Rabeno
- Brian Patrick O’Neill
- Brian Van Tine
- Bruce Robinson
- Bui Duc Phu
- Calena Marchand
- Candace Carter
- Candace Shelton
- Carl Morrison
- Carl Simon Shelley
- Carlo Bifulco
- Carlos Gilberto Carlotti Jr.
- Carmen Behrens
- Carol Bradford
- Carol Farver
- Caroline Larson
- Carolyn M. Hutter
- Carrie Cibulskis
- Cassaundra Shipman
- Catherine Moser
- Cathy Brewer
- Cathy D. Vocke
- Cathy Schilero
- Catrina C. Fronick
- Cesar Moran
- Chad J. Creighton
- Chandra Goparaju
- Chandrajit P. Raut
- Charles Guo
- Charles M. Perou
- Charles N. Landen
- Cheng Fan
- Chiara Calatozzolo
- Chris Andry
- Chris Sander
- Christel Herold-Mende
- Christin Jungk
- Christina Yau
- Christine Stoehr
- Christopher A. Miller
- Christopher Benz
- Christopher Hovens
- Christopher K. Wong
- Christopher Logothetis
- Christopher McPherson
- Christopher W. Seder
- Chu Chen
- Clement Adebamowo
- Colleen Feltmate
- Colleen M. Cebulla
- Corbin D. Jones
- Craig D. Shriver
- Cristovam Scapulatempo-Neto
- Curt H. Hagedorn
- Cyriac Kandoth
- Cyrus Mirsaidi
- D. Neil Hayes
- Daniel Crain
- Daniel Cramer
- Daniel J. Brat
- Daniel J. Weisenberger
- Daniel O. Vidal
- Daniel O’Brien
- Daniel Raymond
- Daniela Tirapelli
- Darell Bigner
- Darlene Lee
- Dave Hoon
- David A. Wheeler
- David Beer
- David Chesla
- David Huntsman
- David I. Heiman
- David J. Van Den Berg
- David Mallery
- David Nagorney
- David Rice
- Dawid Murawa
- Debra Bell
- Debyani Chakravarty
- Denise Brooks
- Dennis T. Maglinte
- Deqin Ma
- Di Du
- Diana Tcaciuc
- Dina Aziz
- Dirk Schadendorf
- Domenico Alvaro
- Dong M. Shin
- Donghui Tan
- Donna Morton
- Donna Muzny
- Doris M. Rassl
- Doug Voet
- Douglas A. Levine
- Ed Reznik
- Edna M. Mora Pinero
- Elaine R. Mardis
- Electron Kebebew
- Elias Campo
- Elizabeth L. Appelbaum
- Elizabeth R. Duffy
- Elizabeth Swisher
- Ellen C. Zwarthoff
- Eric Baudin
- Eric Chuah
- Eric Lipp
- Eric Thompson
- Erik Castle
- Erik Zmuda
- Erin Curley
- Erwin G. Van Meir
- Eryn M. Godwin
- Esther Korpershoek
- Eugenio Gaudio
- Eva Giné
- Eve Shinbrot
- Fadi Brimo
- Fadlo Khuri
- Farshad Farshidfar
- Federico Valdivieso
- Fedor Moiseenko
- Feixiong Cheng
- Feixiong Cheng
- Felice Giuliante
- Felicia Williams
- Felix Beuschlein
- Fengmei Zhao
- Florencia Que
- Francesco DiMeco
- Francesco Facciolo
- Francis Carey
- Francisco Sanchez-Vega
- Fred Saad
- Funda Meric-Bernstam
- Gabriel Sica
- Gad Getz
- Gaetano Finocchiaro
- Galen F. Gao
- Galiya Setdikova
- Gavin Ha
- Gene Barnett
- George Manikhas
- George Thomas
- George V. Thomas
- Georgina Long
- Ghenadie Gorincioi
- Gianluca Grazi
- Ginette McKercher
- Glenn Bubley
- Gloria Petersen
- Gordon B. Mills
- Gordon Saksena
- Graham Mann
- Gregory Wolf
- Guido Carpino
- Guido Sauter
- Hai Hu
- Hailei Zhang
- Han Liang
- Han Liang
- Hani Gabra
- Hanina Hibshoosh
- Hannah Yang
- Hans Stoop
- Harman Sekhon
- HarshaVardhan Doddapaneni
- Hartmut Juhl
- Hartwig Huland
- Harvey Pass
- Heather K. Schmidt
- Heidi J. Sofia
- Helge Taubert
- Henri Timmers
- Henrique C.S. Silveira
- Hikmat Al-Ahmadie
- Hojabr Kakavand
- Hongxin Zhang
- Hongzheng Zhang
- Houtan Noushmehr
- Howard Colman
- Howard G. Rosenthal
- Howard Zaren
- Hui Shen
- Huihui Fan
- Huiwen Zhang
- Huyen Dinh
- Iakovina Alexopoulou
- Ian Forgie
- Ian Yang
- Ignacio Wistuba
- Ilya Shmulevich
- Ina Felau
- Inga Chemencedji
- Ino de Bruijn
- Irina Caraman
- Irina Stancul
- J. Bradley Elder
- J. Leigh Fantacone-Campbell
- J. Todd Auman
- Jacqueline E. Schein
- Jaegil Kim
- Jaffer A. Ajani
- James Catto
- James Lang
- James Luketich
- James Powers
- James Wilmott
- Janae V. Simons
- Jay Bowen
- Jay Engel
- Jean C. Zenklusen
- Jean-Pierre Kocher
- Jeffey Moyer
- Jeffrey A. Borgia
- Jeffrey A. Hooke
- Jeffrey Gershenwald
- Jeffrey J. Olson
- Jeffrey Marks
- Jeffrey Roach
- Jeffry Simko
- Jenette Creaney
- Jennifer Drummond
- Jennifer Eschbacher
- Jennifer Smith
- Jens Waldmann
- Jeremy Parfitt
- Jerome Myers
- Jia Liu
- Jianhong Hu
- Jianjiong Gao
- Jiashan (Julia) Zhang
- Jiexin Zhang
- Jill S. Barnholtz-Sloan
- Jing Wang
- Jioajiao Wang
- Jireh Santibanez
- Joan Walker
- Joanna Phillips
- Jodi Harr
- Joe Hilty
- Joel Henderson
- Joel S. Parker
- Johanna Gardner
- John A. Copland
- John A. Demchok
- John A. Martignetti
- John Bartlett
- John Chabot
- John Cheville
- John DiPersio
- John Eckman
- John Houck
- John N. Weinstein
- John N. Weinstein
- John Thompson
- Jolanta Bondaruk
- Jonathan Melamed
- Jonathan Stretch
- Joong-Won Park
- Jordonna Fulop
- Jose Sebastião Dos Santos
- Joseph Bennett
- Joseph Galbraith
- Joseph Paulauskis
- Joshua Armenia
- Joshua M. Stuart
- José H. Fregnani
- Ju Dong Yang
- Judy Miller
- Julia Slotta-Huspenina
- Julian Hess
- Juliann Shih
- Julie M. Gastier-Foster
- Julie Martin
- Jun Li
- Jun Li
- June M. Chan
- Jung Il Lee
- Junya Fujimoto
- Juok Cho
- Kalle Leinonen
- Kamalika Mojumdar
- Kane Tse
- Karan Rai
- Karel Pacak
- Karen Devine
- Karen Mungall
- Karen Smith-McCune
- Karl-Friedrich Becker
- Karla Kopp
- Katayoon Kasaian
- Katherine A. Hoadley
- Katherine C. Sexton
- Katherine Moxley
- Kathleen Moore
- Kathy Agnew
- Kathy Smolenski
- Keith Delman
- Kelinda Tucker
- Kelly Magliocca
- Kelly Senecal
- Kenneth Lee
- Kerstin Junker
- Kerwin Shannon
- Keunsoo Ahn
- Kevin Lau
- Kevin Roggin
- Ki Chung
- Kim E. van Kessel
- Kimberley Evason
- Kivanc Birsoy
- Kivanc Birsoy
- Klaus-Peter Janssen
- Konnor La
- Koo Jeong Kang
- Kristen M. Leraas
- Kristen Shimmel
- Kwok-Shing Ng
- Kwun M. Fong
- Kyle Chang
- Kyle Covington
- Larsson Omberg
- Laura Jacobus
- Laura Rozek
- Laura S. Schmidt
- Lauren Haydu
- Laurence Desjardins
- Lawrence A. Donehower
- Laxmi Lolla
- Leendert Looijenga
- Leigh Anne Zach
- Leonid Kvecher
- Leslie Cope
- Lewis Roberts
- Li Ding
- Liming Yang
- Lin Tan
- Linghua Wang
- Lingxiang Liu
- Lisa Landrum
- Lisa Peterson
- Lisa Scarpace
- Lisa Wise
- Lisle E. Mose
- Liu Xi
- Lizhi Zhang
- Lois Ramondetta
- Lora Lewis
- Louis Lacombe
- Luca Mattei
- Lucia Cuppini
- Lucinda A. Fulton
- Ludmila Danilova
- Lynn Schoenfield
- Maciej Wiznerowicz
- Madhusmita Behera
- Marc Goodman
- Marc Ladanyi
- Marc Moncrieff
- Marc-Henri Stern
- Marco A. Marra
- Margaret Morgan
- Margi Sheth
- Maria Consiglia Bragazzi
- Maria Pirtac
- Maria Synott
- Mario Quintero-Aguilo
- Mark A. Rubin
- Mark Gerken
- Mark Nelson
- Mark Pool
- Mark Prince
- Mark Schiffman
- Mark Sherman
- Markus Graefen
- Marta Aymerich
- Marta Couce
- Martin Fassnacht
- Martin L. Ferguson
- Mary Iacocca
- Mary McGraw
- Massimo Mannelli
- Mathieu Latour
- Matthew Bailey
- Matthew D. Wilkerson
- Matthew G. Cordes
- Matthew G. Soloway
- Matthew L. Anderson
- Matthew Meyerson
- Melanie H. Kucherlapati
- Melissa Stanton
- Melpomeni Kasapi
- Michael Birrer
- Michael Carney
- Michael D. McLellan
- Michael Dubina
- Michael Farnell
- Michael Feldman
- Michael Ittmann
- Michael J. Liptay
- Michael Kendrick
- Michael Knudson
- Michael Mayo
- Michael Miller
- Michael Muto
- Michael Prados
- Michael Quinn
- Michael Rivera
- Michael Ryan
- Michael S. Lawrence
- Michael S. Noble
- Michael Torbenson
- Michelle Bellair
- Mikhail Dinkin
- Mikhail Tavobilov
- Min Wang
- Mircea Cernat
- Mirella Marino
- Miruna Balasundaram
- Mitesh Borad
- Mohamed H. Abdel-Rahman
- Mohammed Milhem
- Moiz S. Bootwalla
- Monique Albert
- Moriah G. Nissan
- Myron Peto
- Nasra Giama
- Natalia Botnariuc
- Nathan A. Pennell
- Natália D. Aredes
- Neil Horowitz
- Nguyen Phi Hung
- Nguyen Van Bang
- Nguyen Viet Tien
- Niall Corcoran
- Nicholas Hayward
- Nicolas Girard
- Nicolas Wentzensen
- Nikolaus Schultz
- Nils Gehlenborg
- Nilsa C. Ramirez
- Nina Thiessen
- Noreen Dhalla
- Norman L. Lehman
- Nyasha Chambwe
- Odette Mariani
- Olga Potapova
- Olga Voronina
- Oliver Bathe
- Oliver F. Bathe
- Oluwole Olabode
- Oxana Paklina
- Pat Glenn
- Patricia D. Castro
- Patricia Swanson
- Patricia Troncoso
- Paul Drwiega
- Paul Hansen
- Paul Spellman
- Paul Wakely
- Pavana Anur
- Pawadee Lohavanichbutr
- Payal Sipahimalani
- Peggy Yena
- Pei Lin
- Peter A. Pinto
- Peter Hersey
- Peter R. Carroll
- Peter R. Dottino
- Peter W. Laird
- Peter Westervelt
- Phan Thi Hanh
- Pheroze Tamboli
- Philip Disaia
- Philip L. Lorenzi
- Phillip H. Lai
- Phuong Nguyen
- Pierre Tennstedt
- Piotr A. Mieczkowski
- Praveen Nair
- Qiang Sun
- Quinn T. Ostrom
- R. Houston Thompson
- Rafael Kemp
- Raina Tamakawa
- Rajiv Dhir
- Raju S. Kucherlapati
- Ramaswamy Govindan
- Rameen Beroukhim
- Randy Mandt
- Raphael Bueno
- Rashi Naresh
- Rashna Madan
- Rayleen Bowman
- Reanne Bowlby
- Rebecca Carlsen
- Rebecca Duell
- Rehan Akbani
- Renumathy Dhanasekaran
- Richard A. Gibbs
- Richard A. Moore
- Richard J. Mural
- Richard K. Wilson
- Richard Kefford
- Richard Scolyer
- Richard Thorp
- Rita Sigmund
- Ritika Kundra
- Robert C. Rintoul
- Robert Glenn
- Robert Holt
- Robert Korst
- Robert Mannel
- Robert Penny
- Robert Pilarski
- Robert S. Fulton
- Robert Sheridan
- Robert Smallridge
- Robert Stoehr
- Robert Worrell
- Roberta Merola
- Robin K. Kelley
- Robyn Saw
- Roger Kramer
- Roger McLendon
- Ronald de Krijger
- Ronald Ghossein
- Ronald Lechan
- Ronald Simon
- Ronald Warnick
- Rosemary Zuna
- Ross Berkowitz
- Rosy Singh
- Roy Tarnuzzer
- Rui M. Reis
- Rupa S. Kanchi
- Russel Postier
- Russell Broaddus
- Ruth Steele
- S. Onur Sumer
- Sabina Signoretti
- Saianand Balu
- Sally N. Adebamowo
- Sam Meier
- Samantha J. Caesar-Johnson
- Samuel Singer
- Sandra Cottingham
- Sandra Lee
- Sara Kendall
- Sara Sadeghi
- Sarah M. Phillips
- Scott Frazer
- Scott Morris
- Scott VandenBerg
- Sebastien Gilbert
- Serghei Doruc
- Serghei Stepa
- Sergio Roman-Roman
- Sergiu Mura
- Seth Force
- Shannon McCall
- Shaowu Meng
- Sharon Heath
- Sheila Reynolds
- Shishir Maithel
- Shiyun Ling
- Sima Porten
- Simone Chevalier
- Stacey B. Gabriel
- Stefania Cuzzubbo
- Stella Somiari
- Stephen Baylin
- Steven E. Schumacher
- Steven J.M. Jones
- Steven Kalkanis
- Stuart R. Jefferys
- Sudha Chudamani
- Sue Bell
- Suresh Ramalingam
- Susan M. Staugaitis
- Suzanne Sifri
- Sven Wach
- Sylvia L. Asa
- Tao Su
- Taofeek Owonikoko
- Tara M. Lichtenberg
- Tara Skelly
- Teniola Akeredolu
- Thai Ho
- Theo Knijnenburg
- Theresa Naska
- Therese Bocklage
- Thomas Broudy
- Thomas Carey
- Thomas Flotte
- Thomas Giordano
- Thomas Smyrk
- Thorsten Schlomm
- Timothy A. Chan
- Timothy DeFreitas
- Timothy Ley
- Timothy Thompson
- Timothy Wang
- Tina Knutson
- Tina Wong
- Todd Pihl
- Tom Bodenheimer
- Tom Mikkelsen
- Tomas Zelinka
- Tony Costello
- Toshinori Hinoue
- Troy Shelton
- Tushar Patel
- Umadevi Veluvolu
- Valerie Jakrot
- Varsha Dhankani
- Vesteinn Thorsson
- Victor Reuter
- Viktoriya Korchina
- Vincenzo Cardinale
- Vishal Chandan
- Vladimir Lyadov
- W. Jeffrey Edenfield
- W. Kimryn Rathmell
- W. Marston Linehan
- Walid K. Chatila
- Walker Hale
- Walter Urba
- Wanding Zhou
- Wei Li
- Wei Zhang
- Wenbin Liu
- Wendi Barrett
- Wil Eijckenboom
- William E. Grizzle
- William G. Richards
- Witold Kycler
- Wolter Oosterhuis
- Xavier Sastre
- Xiaoyan Xu
- Xinxin Peng
- Xiuping Liu
- Xuan Le
- Yan Shi
- Ye Wu
- Yi Han
- Yichao Sun
- Yiling Lu
- Yingli Wolinsky
- Yuexin Liu
- Yufang Tang
- Yumeng Wang
- Yunhu Wan
- Yussanne Ma
- Zachary J. Heins
- Zhenlin Ju
- Zhining Wang
- Zhongming Zhao
- Zhongqi Ge
- Zhongyuan Chen
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven major metabolic processes and assessed their clinical relevance. Our metabolic expression subtypes correlated extensively with clinical outcome: subtypes with upregulated carbohydrate, nucleotide, and vitamin/cofactor metabolism most consistently correlated with worse prognosis, whereas subtypes with upregulated lipid metabolism showed the opposite. Metabolic subtypes correlated with diverse somatic drivers but exhibited effects convergent on cancer hallmark pathways and were modulated by highly recurrent master regulators across cancer types. As a proof-of-concept example, we demonstrated that knockdown of SNAI1 or RUNX1—master regulators of carbohydrate metabolic subtypes-modulates metabolic activity and drug sensitivity. Our study provides a system-level view of metabolic heterogeneity within and across cancer types and identifies pathway cross-talk, suggesting related prognostic, therapeutic, and predictive utility
On the progenitor of binary neutron star merger GW170817
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- Abbott B.P.
- Abbott R.
- Abbott T.D.
- Acernese F.
- Ackley K.
- Adams C.
- Adams T.
- Addesso P.
- Adhikari R.X.
- Adya V.B.
- Affeldt C.
- Afrough M.
- Agarwal B.
- Agathos M.
- Agatsuma K.
- Aggarwal N.
- Aguiar O.D.
- Aiello L.
- Ain A.
- Ajith P.
- Allen B.
- Allen G.
- Allocca A.
- Altin P.A.
- Amato A.
- Ananyeva A.
- Anderson S.B.
- Anderson W.G.
- Angelova S.V.
- Antier S.
- Appert S.
- Arai K.
- Araya M.C.
- Areeda J.S.
- Arnaud N.
- Arun K.G.
- Ascenzi S.
- Ashton G.
- Ast M.
- Aston S.M.
- Astone P.
- Atallah D.V.
- Aufmuth P.
- Aulbert C.
- AultONeal K.
- Austin C.
- Avila-Alvarez A.
- Babak S.
- Bacon P.
- Bader M.K.M.
- Bae S.
- Bakel N.V.
- Baker P.T.
- Baldaccini F.
- Ballardin G.
- Ballmer S.W.
- Banagiri S.
- Barayoga J.C.
- Barclay S.E.
- Barish B.C.
- Barker D.
- Barkett K.
- Barone F.
- Barr B.
- Barsotti L.
- Barsuglia M.
- Barta D.
- Bartlett J.
- Bartos I.
- Bassiri R.
- Basti A.
- Batch J.C.
- Bawaj M.
- Bayley J.C.
- Bazzan M.
- Beer C.
- Bejger M.
- Belahcene I.
- Bell A.S.
- Berger B.K.
- Bergmann G.
- Bero J.J.
- Berry C.P.L.
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- Bertolini A.
- Betzwieser J.
- Beuzekom M.V.
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- Chamberlin S.J.
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- Cheng H.-P.
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- Chu Q.
- Chua A.J.K.
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- Ciani G.
- Ciolfi R.
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- Cleva F.
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- Constancio M.
- Conti L.
- Cooper S.J.
- Corban P.
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- Cordero-Carrión I.
- Corley K.R.
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- Zucker M.E.
- Zweizig J.
- Álvarez M.D.
- Publication venue
- American Astronomical Society
- Publication date
- 01/12/2017
- Field of study
On 2017 August 17 the merger of two compact objects with masses consistent with two neutron stars was discovered through gravitational-wave (GW170817), gamma-ray (GRB 170817A), and optical (SSS17a/AT 2017gfo) observations. The optical source was associated with the early-type galaxy NGC 4993 at a distance of just ∼40 Mpc, consistent with the gravitational-wave measurement, and the merger was localized to be at a projected distance of ∼2 kpc away from the galaxy's center. We use this minimal set of facts and the mass posteriors of the two neutron stars to derive the first constraints on the progenitor of GW170817 at the time of the second supernova (SN). We generate simulated progenitor populations and follow the three-dimensional kinematic evolution from binary neutron star (BNS) birth to the merger time, accounting for pre-SN galactic motion, for considerably different input distributions of the progenitor mass, pre-SN semimajor axis, and SN-kick velocity. Though not considerably tight, we find these constraints to be comparable to those for Galactic BNS progenitors. The derived constraints are very strongly influenced by the requirement of keeping the binary bound after the second SN and having the merger occur relatively close to the center of the galaxy. These constraints are insensitive to the galaxy's star formation history, provided the stellar populations are older than 1 Gyr
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