Sizing up the Antistrophos View of Pragmatics-Rhetoric Relationship

This paper is an introduction to and comment on Liu & Zhu’s antistrophos view of pragmatics-rhetoric relationship. It unfolds why they choose “antistrophos” rather than “counterpart(s)” for the bilateral positing, holding that “counterpart” is not impossible for that end. Then the paper affirms the merit of their “antistrophos view”, capable of facilitating “reciprocal and reversible transformation” of pragmatics and rhetoric. In terms of the bilateral relations, this paper maintains the stance of radical pragmaticism of the complementarity camp. Finally we discuss the possibility of the disciplinary integration resulting in pragma-rhetoric

The Cognitive Perspective of Yulin Yuan on Modern Chinese Grammar

This paper is mainly a review of Yulin Yuan’s book Cognition-Based Studies on Chinese Grammar which, as one of the book series of Routledge Studies in Chinese Linguistics, was published by Routledge in 2017. On the one hand, Yuan’s cognitive studies of and his Yuanian insight into Chinese grammar are of vital importance to those students and researchers who specialise or are interested in the Chinese language, especially modern Chinese grammar. On the other hand, his research may probably promote the development of cognitive linguistics on the whole with regard to linguistic typology

Non-Probabilistic Time-Varying Reliability-Based Analysis of Corroded Pipelines Considering the Interaction of Multiple Uncertainty Variables

Reliability analysis of corroded pipelines is critical to the integrity and safe working of pipeline infrastructure. Aiming at less probability information is obtained for corrosion pipeline engineering, and the mechanical properties of pipeline with corrosion defects deteriorate caused by the accumulative effect of corrosion growth. Based on the quasi-static analysis method and non-probability theory, this paper presents a reliability model for assessing corroded pipelines with corrosion growth. In fact, reliability analysis of corroded pipelines needs to consider the interaction of multiple uncertainty variables. By introducing interaction theory, a mathematical model of corrosion defects considering the interaction of variables is put forward. Moreover, this paper develops a non-probabilistic time-varying reliability method for pipeline systems with multiple defects. Thus, several numerical examples are investigated to discuss the effectiveness of the proposed methodology. The results show that a two-dimensional or even three-dimensional ellipsoid model with correlation has more accurate results to evaluate corroded pipelines under the interaction of multiple corroded defects with poor information. Furthermore, a non-probabilistic time-varying reliability model is established according to the time-varying characteristics of the corroded pipeline under the influence of multiple factors. An effective complement to the theory of non-probabilistic reliability analysis of system is investigated. The analysis of the results suggests that interaction of corroded pipeline has a negligible impact on reliability. It also provides a theoretical basis for maintenance and is of great significance for risk- and reliability-informed decisions regarding buried oil and gas pipelines

Condition assessment of underground corroded pipelines subject to hydrogen damage and combined internal pressure and axial compression

In this work, a 3D finite element (FE) based model was developed to assess the condition of an underground hydrogen transmission pipeline containing a corrosion defect under combined internal pressure and soil movement-induced axial compression. The use of mechanical properties of X100 pipeline steel under different hydrogen charging time models the degree of hydrogen damage in pipelines. Parameter effects, i.e., axial compressive stress, hydrogen damage, defect geometries, and pipeline diameter-to-thickness ratio, were determined. The results demonstrated that the synergistic effect of axial compression, internal pressure, corrosion, and hydrogen damage can lead to a significant decrease in the failure pressure of pipelines. The failure pressure decreased with the wall thickness reduction and increased hydrogen damage, axial compressive stress, defect length, defect depth, and pipe diameter. The competitive effect was observed between the degree of metal loss and hydrogen damage in determining the burst capacity of pipelines. In situations where the pipeline integrity was severely compromised, the failure pressure exhibited minimal reduction despite the increasing severity of hydrogen damage. The stress distribution at the defect zone was influenced by axial compressive stress but remained unaffected by hydrogen damage under normal operating conditions (i.e., an internal pressure of 10 MPa). This work is expected to help operators understand the applicability of elder and in-service pipelines for hydrogen transmission.Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Safety and Security Scienc

Incidence, Risk Factors, and Outcomes of Symptomatic Bone Cement Displacement following Percutaneous Kyphoplasty for Osteoporotic Vertebral Compression Fracture: A Single Center Study

Study design: Retrospective. Background: Symptomatic bone cement displacement (BCD) is a rare complication following percutaneous kyphoplasty (PKP) interventions for osteoporotic vertebral compression fracture (OVCF). This study aimed to investigate the incidence and the outcomes of symptomatic BCD comprehensively and identify its risk factors. Methods: The clinical data of patients treated with PKP for OVCF between January 2012 and December 2020 were extracted. Patients who developed BCD following PKP during follow-up were divided into the symptomatic and asymptomatic groups. Patients who did not develop BCD were assigned to the control group. Univariate and multiple logistic regression analyses were used to compare the three clinical groups’ features to assess the independent risk factors for the symptomatic and asymptomatic groups. Results: A total of 896 patients were enrolled. Twenty-one patients (2.3%) were identified as having symptomatic BCD following PKP for OVCF, and 35 (3.9%) developed asymptomatic BCD. Compared with the control group, the symptomatic and asymptomatic groups had a higher incidence of anterior leakage, intravertebral vacuum cleft (IVC) signs, and a lower cement distribution score. The symptomatic group had a lower relative cross-sectional area (rCSA) of the paraspinal muscle (PSM), higher PSM fatty degeneration, and higher kyphotic angle (at the last follow-up) than the asymptomatic and control groups. For outcomes, the symptomatic group had a higher VAS/ODI score and a higher incidence of new vertebral fractures compared with the asymptomatic and control groups. Anterior leakage (OR: 1.737, 95% CI: 1.215–3.300), the IVC sign (OR: 3.361, 95% CI: 1.605–13.036), the cement distribution score (OR: 0.476, 95% CI: 0.225–0.904), PSM rCSA (OR: 0.953, 95% CI: 0.917–0.992), and PSM fatty degeneration (OR: 1.061, 95% CI: 1.005–1.119) were identified as independent risk factors for the symptomatic group. Anterior leakage (OR: 1.839, 95% CI: 1.206–2.803), the IVC sign (OR: 2.936, 95% CI: 1.174–9.018), and cement distribution score (OR: 0.632, 95% CI: 0.295–0.858) were independent risk factors for the asymptomatic group. Conclusion: The incidence of symptomatic BCD is 2.3% in patients treated with PKP. Anterior leakage, the IVC sign, and the distribution score were independent risk factors for BCD, and paraspinal muscle degeneration was a specific risk factor for symptomatic BCD. Symptomatic BCD can lead to poor outcomes

Additional file 1: of SMURF1 facilitates estrogen receptor ɑ signaling in breast cancer cells

Figure S1A. Public available ChIP sequence data indicates that ER alpha could bind to SMURF1 promoter region at the first intron. Figure S1B. ChIP assay shows that ER alpha and H3K27AC are recruited to SMURF1 promoter region. Figure S2A. SMURF1 depletion inhibits the cell proliferation in breast cancer cells in T47D cells. Figure S2B. MCF-7 cells were stably transfected with lentivirus carrying scrambe shRNA (N = 4) or SMURF1 shRNA (N = 4). The mice were sacrificed at two month after transplant, and the tumors were weighted. The tumor growth curve and photograph were shown respectively. Figure S3A. Wound healing assay of T47D transfected with the indicated siRNA. Figure S3B. Clone formation assay of T47D cells transfected with indicated siRNA. Figure S4A. SMURF1 depletion decreases ERα target genes using two different siRNA oligos in T47D cells. Figure S4B and C SMURF1 inhibition decreases ERα target genes expression in MCF-7 and T47D cells. Figure S5. Pulldown assay shows that SMURF1 fails to directly interact with N-terminal or C-terminal of ER alpha. Figure S6. Three independent repeats of SMURF1 effect on ERα half-life in HEK293 cells. Figure S7A. TGFβ does not change ER alpha protein level in MCF-7 cells. MCF-7 cells were transfected with siSMURF1 or siControl. Figure S7B. HECT domain is required for the stabilization effect on ER alpha protein. Table S1. Primer sequences used in this study. Table S2. ER alpha target genes list by SMURF1 depleiton in MCF-7 cells. (PPTX 1594 kb