Afzal, Shoaib

Avery, Daniel

Bennett, Derrick

Bian, Zheng

Boxall, Ruth

Chang, Liang

Chang, Yumei

Chen, Biyun

Chen, Jinyan

Chen, Junshi

Chen, Lingli

Chen, Naying

Chen, Ningyu

Chen, Xiaofang

Chen, Yiping

Chen, Zhengming

Cheng, Liang

Clarke, Robert

Collins, Rory

Dong, Caixia

Du, Huaidong

Du, Ranran

Ellervik, Christina

Fan, Lei

Feng, Shixian

Fu, Yan

Fu, Zhenwang

Fu, Zhifang

Fu, Zhongxi

Gao, Ruqin

Gao, Yulian

Ge, Pengfei

Gilbert, Simon

Gu, Qijun

Guo, Yu

Guo, Zhendong

Guo, Ziyan

Hacker, Alex

Han, Xiao

He, Hui

He, Pan

He, Tianyou

Hill, Mike

Holmes, Michael

Hou, Can

Hou, Wei

Hu, Chen

Hu, Ruying

Hu, Ximin

Hu, Yihe

Huang, Tao

Huang, Ying

Huang, Yuelong

Iona, Andri

Jiang, Ge

Jiang, Qilian

Jin, Jianrong

Kang, Quan

Kartsonaki, Christiana

Kerosi, Rene

Kong, Ling

Kurmi, Om

Lan, Jian

Lancaster, Garry

Lewington, Sarah

Li, Feifei

Li, Huimei

Li, Jianguo

Li, Liming

Li, Mingqiang

Li, Shanpeng

Li, Xianzhi

Li, Yanjie

Li, Yilei

Lin, Kuang

Liu, Chao

Liu, Fang

Liu, Huilin

Liu, Jiaqiu

Liu, Jingchao

Liu, Yongmei

Liu, Yun

Long, Huajun

Lu, Yan

Luo, Guojin

Lv, Jun

Lv, Silu

Ma, Liangcai

Mao, Enke

McDonnell, John

Meng, Fanwen

Meng, Jinhuai

Millwood, Iona Y.

Nie, Qunhua

Ning, Feng

Nordestgaard, Børge G.

Pan, Dongxia

Pan, Rong

Pang, Zengchang

Pei, Pei

English

Background: Randomised control trials and genetic analyses have demonstrated that vitamin D or 25-hydroxyvitamin D (25[OH]D) levels may not play a causal role in the development of cardiovascular disease. However, it is unclear if 25(OH)D is causally associated with cause-specific vascular disease and lipids. Therefore, we examined the causal association of 25(OH)D with myocardial infarction, stroke, ischaemic heart disease, ischaemic stroke, subarachnoid haemorrhage, intracerebral haemorrhage, and lipid levels among both Chinese and Europeans. Methods: We used a Mendelian randomisation (MR) design in the China Kadoorie Biobank, the Copenhagen City Heart Study, and the Copenhagen General Population Study. The 25(OH)D-related genetic variants in the CYP2R1 and DCHR7 genes were genotyped in 99,012 Chinese adults and 106,911 Danish adults. Results: In Chinese adults, plasma 25(OH)D levels were not significantly associated with cause-specific vascular disease or mortality, with the exception of intracerebral haemorrhage (HR, 1.09 [95% CI, 1.01,1.18] per 25 nmol/L higher plasma 25(OH)D). In Europeans, plasma 25(OH)D levels were inversely associated with all types of vascular diseases and mortality. However, MR analysis did not demonstrate causal associations of genetically increased 25(OH)D levels with cause-specific vascular diseases, or mortality in both Chinese and European adults. In addition, each 25 nmol/L higher 25(OH)D was observationally associated with lower total cholesterol and low-density lipoprotein cholesterol levels, but higher high-density lipoprotein cholesterol levels. Likewise, MR analysis showed that 25(OH)D levels were not causally associated with lipids in both Chinese and European adults after Bonferroni correction. Conclusions: We found no evidence to support that genetically increased 25(OH)D was associated with a lower risk of ischaemic stroke, intracerebral haemorrhage, subarachnoid haemorrhage, and lipid levels in both Chinese and European adults. These results suggest that the inverse associations of vitamin D with vascular disease could be the result of confounding.</p

Yu, Canqing

Yang, Ling

Walters, Robin G.

Peto, Richard

Radhakrishnan, Jayakrishnan

Ryder, Paul

Sansome, Sam

Schmidt, Dan

Sherliker, Paul

Sohoni, Rajani

Stevens, Becky

Turnbull, Iain

Wang, Jenny

Wang, Lin

Wright, Neil

Yang, Xiaoming

Tan, Yunlong

Wang, Shaojie

Zang, Yajing

Tian, Xiaocao

Zhang, Hua

Zhai, Yaoming

Sun, Xiaohui

Wang, Junzheng

Zeng, Mingyuan

Zhou, Xue

Yang, Liqiu

Yu, Bo

Xu, Qinai

Wang, Dan

Wang, Xiaohuan

Weng, Min

Wu, Shukuan

Wu, Ming

Zhou, Yonglin

Zhou, Jinyi

Tao, Ran

Yang, Jie

Su, Jian

Copenhagen University Research Information System

Vitamin D and cause-specific vascular disease and mortality:a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

https://curis.ku.dk/ws/files/241215024/Vitamin_D_and_cause_specific_vascular_disease_and_mortality.pdf

Vitamin D and cause-specific vascular disease and mortality:a Mendelian randomisation study involving 99,012 Chinese and 106,911 European adults

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