Hacia un modelo teórico explicativo de la innovación en los distritos de turismo cultural

This paper presents a theoretical model that analyses the direct effect of social capital on innovation, as well as the mediating effect of acquisition of knowledge between both variables in firms in a cultural tourist district. We analyse the bidimensional nature of social capital —bonded capital and bridging capital—. It is an approach to the context and characteristics of cultural tourist districts. We point out several future investigation lines related to the differentiation between types of knowledge and innovation. We propose recommendations about the orientation of relations between companies and institutions of cultural tourist districts.En este trabajo se plantea un modelo teórico que analiza el efecto directo, y mediado por la adquisición de conocimiento, del capital social sobre la innovación desarrollada por las empresas pertenecientes a un distrito turístico cultural. Se analiza el carácter bidimensional del capital social —bonded capital y bridging capital—. Se realiza una aproximación al contexto y las caracteristicas de los distritos turísticos culturales. Se establecen diversas líneas futuras de trabajo vinculadas a la diferenciación entre tipos de conocimiento y de innovación. Se proponen recomendaciones sobre la orientación de las relaciones entre las empresas y con las instituciones de los distritos turísticos culturales

Amniotic membrane transplantation with fibrin glue as treatment of refractory conjunctivochalasis

Case report: A 63-year-old man with bilateral conjunctivochalasis presented with tearing, irritation, foreign body sensation and a delayed fluorescein clearance test. After no symptomatic improvement with topical treatment, surgery was carried out, with amniotic membrane transplantation and fibrin sealant. Discussion: Conjunctivochalasis is a frequent disorder that shares symptoms with dry eye syndrome. When there is no response to topical treatment, surgical treatment is needed. The surgical technique described by Tseng, and based on amniotic membrane transplantation without suture, resulted in a very useful response, due to less inflammation and a rapid resolution and improvement of symptom

Refined Multiscale Fuzzy Entropy to Analyse Post-Exercise Cardiovascular Response in Older Adults With Orthostatic Intolerance

[EN] Orthostatic intolerance syndrome occurs when the autonomic nervous system is incapacitated and fails to respond to the demands associated with the upright position. Assessing this syndrome among the elderly population is important in order to prevent falls. However, this problem is still challenging. The goal of this work was to determine the relationship between orthostatic intolerance (OI) and the cardiovascular response to exercise from the analysis of heart rate and blood pressure. More specifically, the behavior of these cardiovascular variables was evaluated in terms of refined composite multiscale fuzzy entropy (RCMFE), measured at different scales. The dataset was composed by 65 older subjects, 44.6% (n = 29) were OI symptomatic and 55.4% (n = 36) were not. Insignificant differences were found in age and gender between symptomatic and asymptomatic OI participants. When heart rate was evaluated, higher differences between groups were observed during the recovery period immediately after exercise. With respect to the blood pressure and other hemodynamic parameters, most significant results were obtained in the post-exercise stage. In any case, the symptomatic OI group exhibited higher irregularity in the measured parameters, as higher RCMFE levels in all time scales were obtained. This information could be very helpful for a better understanding of cardiovascular instability, as well as to recognize risk factors for falls and impairment of functional status.This research was funded by the Ministerio de Economia y Competitividad from the Spanish Government, through its research program Programa Estatal de I+D+i Orientada a los Retos de la Sociedad, grant number DPI2015-70821-R.Hortelano, M.; Reilly, R.; Castells, F.; Cervigón, R. (2018). Refined Multiscale Fuzzy Entropy to Analyse Post-Exercise Cardiovascular Response in Older Adults With Orthostatic Intolerance. Entropy. 20(11):1-12. https://doi.org/10.3390/e20110860S112201

IL-10 released by a new inflammation-regulated lentiviral system efficiently attenuates zymosan-induced arthritis

We thank Dr Filip Lim for critical reading of the manuscript, and Dr S. Bartlett for English editing and helpful discussions. We also thank Drs. David Sancho and M. A. del Pozo for providing us with DCs and immortalized MEFs, respectively. AR is supported by Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica (I+D+I) and Instituto de Salud Carlos III (FIS; PI060122), the Spanish Ministry of Science and Innovation (MICINN;SAF2009-10691) and the Comunidad Autónoma de Madrid (S2006/BIO-0236 and S2010/BMD-2312). JMR is supported by MICINN (RECAVA RD06/0014/005) and by from Fundació La Marató de TV3 (Grant 080731

Regeneración de la superficie ocular: stem cells/células madre y técnicas reconstructivas Regeneration of the ocular

La córnea es un tejido transparente constituido microscópicamente por 5 capas bien diferenciadas. El epitelio corneal es esencial para la transparencia corneal y se encuentra en continua renovación a lo largo de la vida a partir de la población de células madre limbocorneales. La localización de estas células madre limbocorneales parece residir en las capas basales del epitelio limbocorneal, de vital importancia para mantener el microambiente de estas células madre limbocorneales, que depende de una variedad de factores intrínsecos y extrínsecos. La insuficiencia límbica se produce cuando ocurre una pérdida parcial o total de estas células madre limbocorneales. Este cuadro lleva a una opacificación corneal con la consiguiente pérdida de visión. En estos casos, el trasplante corneal supone únicamente un reemplazo temporal del epitelio corneal; es necesario llevar a cabo un tratamiento previo con trasplante de limbo autólogo o alogénico, que permita regenerar la población de células limbocorneales dañadas. Para disminuir el riesgo que supone el trasplante de limbo en el ojo donante, se han propuesto técnicas de cultivo de células limbocorneales a partir de pequeñas biopsias limbocorneales

Aceite de silicona para el tratamiento de la maculopatía hipotónica

Case report: We report a case of a man who developed hypotonic maculopathy after vitreoretinal surgery for anterior proliferative vitreoretinopathy. After an injection of intravitreal triamcinolone, the ocular pressure did not increase, therefore silicone oil was injected. After this, the visual acuity increased and the choroidal and retinal folds regressed. Discussion: Hypotonic maculopathy is a frustrating problem, often resulting in poor visual acuity. There are not many effective treatments. The injection of silicone oil could be an alternative to increase the intraocular pressure and re-establish the normal anatomy of the eye, improving the visual acuity in some patient

Influence of metal organic chemical vapour deposition growth conditions on vibrational and luminescent properties of ZnO nanorods

Producción CientíficaA detailed optical characterization by means of micro Raman and cathodoluminescence spectroscopy of catalyst-free ZnO nanorods grown by atmospheric-metal organic chemical vapour deposition has been carried out. This characterization has allowed correlating the growth conditions, in particular the precursors partial-pressures and growth time, with the optical properties of nanorods. It has been shown that a high Zn supersaturation can favor the incorporation of nonradiative recombination centers, which can tentatively be associated with ZnI-related defects. Characterization of individual nanorods has evidenced that ZnI-related defects have a tendency to accumulate in the tip part of the nanorods, which present dark cathodoluminescence contrast with respect to the nanorods bottom. The effect of a ZnO buffer layer on the properties of the nanorods has been also investigated, showing that the buffer layer improves the luminescence efficiency of the ZnO nanorods, revealing a significant reduction of the concentration of nonradiative recombination centers.Ministerio de Ciencia e Innovación (Projects MAT2007-66129, MAT-2010-20441-C02, MAT-2010-16116, and TEC2011-28076-C02-02)Generalitat Valenciana (Prometeo/2011-035 and ISIC/2012/008, Institute of Nanotechnologies for Clean Energies

Parkinsonism secondary to metastatic lesions within the central nervous system: a case report

<p>Abstract</p> <p>Introduction</p> <p>Colorectal cancer is one of the most common human diseases worldwide, and metastases are detected in approximately 20% of patients at diagnosis. Brain metastases occur in only 4% of cases, however, and usually present with hemiparesis or other motor or sensory symptoms. There have been only a few reports of parkinsonism secondary to a brain tumor-related mass effect.</p> <p>Case presentation</p> <p>We present an unusual case of parkinsonism secondary to multiple brain metastases. A 57-year-old Caucasian man had recently been diagnosed with primary carcinoma of the colon and had multiple metastases in the lungs and liver. He subsequently developed bilateral symmetrical parkinsonism, and multiple brain tumors were detected by computed tomography scanning. The condition of our patient deteriorated rapidly, and he became akinetic and dependent for all activities of daily living. He was followed up and treated at home by our palliative care unit team and died two weeks after the onset of his neurologic symptoms.</p> <p>Conclusion</p> <p>Although primary and secondary brain tumors are uncommon causes of parkinsonism, their clinical presentation may resemble that of idiopathic Parkinson's disease. An awareness of this rare differential diagnosis is therefore important in ensuring early diagnosis and treatment, thus improving prognosis and quality of life. A rapid progression in neurologic symptoms was observed in our patient, and clinicians should be alert to this atypical presentation of secondary parkinsonism.</p

Cell encapsulation:Promise and progress

In cell encapsulation, transplanted cells are protected from immune rejection by an artificial, semipermeable membrane, potentially allowing transplantation (allo-or xenotransplantation) without the need for immunosuppression. Yet, despite some promising results in animal studies, the field has not lived up to expectations, and clinical products based on encapsulated cell technology continue to elude the scientific community. This commentary discusses the reasons for this, summarizes recent progress in the field and outlines what is needed to bring this technology closer to clinical application

Artrodesis subtalar primaria como tratamiento de fracturas conminutas de calcáneo Sanders tipo IV

Las fracturas conminutas Sanders IV de calcáneo dan lugar, en la mayoría de los casos, a una artrosis subtalar postraumática dolorosa e incapacitante, que en muchas ocasiones, requiere una artrodesis subtalar secundaria. Esta artrodesis puede ser técnicamente compleja, ya que no se trata de una fijación in situ, sino que requiere la realización de osteotomías de corrección a nivel del cuerpo del calcáneo en la misma cirugía.Material y métodos. Presentamos 4 pacientes con fracturas conminutas de calcáneo Sanders tipo IV que fueron tratadas mediante una artrodesis subtalar primaria con reconstrucción concomitante del cuerpo del calcáneo. El seguimiento medio fue de 15 meses. Resultados. Obtuvimos la consolidación ósea, tanto de la artrodesis como de la fractura, alrededor de los 4 meses, sin existir signos de artrosis en otras articulaciones. No hubo ninguna complicación de herida quirúrgica, ni aparecieron otras complicaciones típicas de estas lesiones, como impingement de peroneos, problemas con el calzado o bloqueo o degeneración de la articulación tibio talar durante el seguimiento. La puntuación AOFAS media a los 12 meses fue de 78. Conclusiones. La artrodesis subtalar primaria con la corrección inicial de las deformidades asociadas en el cuerpo del calcáneo (acortamiento, ensanchamiento y varo) evita complicaciones posteriores y obtiene buenos resultados